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基于医院感染预警系统的江西省某三甲医院就诊患者HCV微消除模式探索及评价

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中国感染控制杂志 2024年第8期23卷 993-1000页

作者：徐祎琳涂嘉欣曾凌章吉威康怡刘菁刘珉玉南昌大学第一附属医院感染控制处江西南昌330000

目的探索并评价江西省某综合医院就诊患者丙型肝炎病毒(HCV)微消除模式,为省内制定消除HCV公共健康危害策略提供参考依据。方法收集该院2021年1月—2022年12月就诊并进行HCV筛查的住院患者相关数据,其中2021年为基线数据,2022年为HCV微... 详细信息

目的探索并评价江西省某综合医院就诊患者丙型肝炎病毒(HCV)微消除模式,为省内制定消除HCV公共健康危害策略提供参考依据。方法收集该院2021年1月—2022年12月就诊并进行HCV筛查的住院患者相关数据,其中2021年为基线数据,2022年为HCV微消除模式运行数据,分析其性别、年龄、送检科室、抗-HCV阳性率、HCV-RNA阳性率等指标,以专科就诊率、治疗率、失访率分析其运行效果,以SWOT-AHP法定量评价模式发展。结果2021—2022年共有397744例住院患者进行抗-HCV筛查,男女性别比为1.34∶1,平均年龄为54岁,送检科室主要以感染科/消化科为主。62份患者标本HCV基因亚型分型主要以1b亚型(43份)为主,其次为6亚型(9份)。模式运行后首次HCV预警率为81.20%,预警后抗-HCV送检率达93.15%,后续弹窗预警抗-HCV送检率为100%。与2021年比较,2022年HCV住院患者治疗率上升,差异有统计学意义(P0.05)。模式运行重心坐标计算P(X,Y)=(0.0182,0.0069),位于第一象限。结论江西省某综合医院就诊患者HCV微消除模式可行且成效明显,下一步模式优化应重视SO策略(依靠内部优势,利用外部机会)。

关键词：丙型肝炎病毒微消除医院感染系统预警系统模式探索 HCV

Fuzzy Shape Control Based on El man Dynamic Recursion Network Prediction Model

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Journal of Iron and Steel Research International 2006年第1期13卷 31-35页

作者： JIA Chun-yu liu Hong-min College of Mechanical Engineering Yanshan University Qinhuangdao 066004 Hebei China

In the strip rolling process, shape control system possesses the characteristics of nonlinearity, strong coupling, time delay and time variation. Based on self adapting Elman dynamic recursion network prediction model, the fuzzy control method was used to control the shape on four-high cold mill. The simulation results showed that the system can be applied to real time on line control of the shape.

关键词： shape prediction shape control Elman dynamic recursion network parameter self-adjusting fuzzy control

A new ceramide from transgenic crown galls of Panax quinquefolium

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Chinese Chemical Letters 2009年第4期20卷 447-449页

作者： Jian Hua Zhu Sha liu Rong min yu College of Pharmacy Jinan University Guangzhou 510632 China

A new ceramide （1） was isolated from transgenic crown galls of Panax quinquefolium. The structure was elucidated as （2S, 3S, 4R, 20E）-2-[（2＇R）-2＇-hydroxylpalmitoylamino]-20-hexacosene- 1, 3, 4-triol on the bas... 详细信息

关键词： Transgenic crown galls Panax quinquefolium Ceramide

Effect of the structural parameters of photonic crystal fibers on propagation characteristics

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The Journal of China Universities of Posts and Telecommunications 2009年第2期16卷 89-93,128页

作者： TIAN Hong-da yu Zhong-yuan HAN Li-hong liu yu-min Institute of Optical Communication and Optoclcctronics Bcijing University of Posts and Telecommunications Beijing 100876 China Key Laboratory of Optical Communication and Lightwave Technologies Beijing University of Posts and Telecommunications Beijing 100876 China

Using a full-vector finite-difference time-domain （FDTD） method, this article explores the propagation characteristics of photonic crystal fiber （PCF） theoretically. The dependence of structural parameters on the effective index of the fundamental guided mode, effective index of the fundamental cladding mode, mode field diameter, confinement loss, effective mode area, and chromatic dispersion in PCF have been studied, respectively. The research presents a reference for designing of PCF with a specific purpose.

关键词： PCFs propagation characteristic numerical modeling structural parameter

Ultra-small MoS2 nanodots with rapid body clearance for photothermal cancer therapy

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Nano Research 2016年第10期9卷 3003-3017页

作者： Teng liu yu Chao min Gao Chao Liang Qian Chen Guosheng Song Liang Cheng Zhuang liu Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & DevicesSoochow University 199 Ren'ai Road Suzhou 215123 China

The clinical translation of many inorganic nanomaterials is severely hampered by toxicity issues because of the long-term retention of these nanomaterials in the body. In this study, we developed a bio-clearable theranostic agent based on ultra-small MoS2 nanodots, which were synthesized by a facile bottom-up approach through one-step solvothermal decomposition of ammonium tetrathiomolybdate. After modification by glutathione （GSH）, the obtained MoS2-GSH nanodots exhibited sub-10-nm hydrodynamic diameters without aggregation in various physiological buffers. Without showing appreciable in vitro toxicity, such MoS2-GSH nanodots with strong near-infrared （NIR） absorbance could induce remarkable photothermal ablation of cancer cells. Upon intravenous （i.v.） injection, efficient tumor accumulation of MoS2-GSH nanodots was observed by photoacoustic imaging, and further confirmed by analysis of the biodistribution of Mo. Notabl）4 the MoS2-GSH nanodots, in contrast to conventional MoS2 nanoflakes with larger sizes, showed rather efficient body clearance via urine, where the majority of the injected dose was cleared within just seven days. Photothermal ablation of tumors on mice was then realized with the MoS2-GSH nanodots, achieving excellent therapeutic efficacy. This study presents a new type of ultra-small nanoparticle with efficient tumor homing/treatment abilities, as well as rapid body clearance behavior, making it promising for cancer theranostics without long-term toxiciW concerns.

关键词： ultra-small MoS2 nanodots photoacoustic imaging rapid body clearance photothermal therapy

Hypolipidemic effect of SIPI-7623,a derivative of an extract from oriental wormwood,through farnesoid X receptor antagonism

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Chinese Journal of Natural Medicines 2018年第8期16卷 572-579页

作者： DENG Yi-Fang HUANG Xiao-Ling SU Mei yu Peng-Xia ZHANG Zhen liu Quan-Hai WANG Guo-Ping liu min-yu Department of Pharmacology Shanghai Institute of Pharmaceutical Industry Jiangsu Carephar Pharmaceutical Co. Ltd.

Farnesoid X receptor(FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription *** a metabolic regulator,FXR plays key roles in bile acid and cholesterol metabolism and lipid and glucose ***,FXR is a potential drug target for several metabolic syndromes,especially those related to lipidemia *** the present study,we identified small molecule SIPI-7623,a derivative of an extract from Oriental wormwood(Artemisia capillaris),and found that it specifically upregulated the expression of cholesterol-7-alpha-hydroxylase(CYP7 A1),downregulated the expression of sterol-regulatory element-binding protein 1 c(SREBP-1 c) in the liver,and inhibited the expression of ileal bile acid binding-protein(IBABP) in the ileum of *** found that inhibition of FXR by SIPI-7623 decreased the level of cholesterol and ***-7623 reduced the levels of cholesterol and triglyceride in in vitro Hep G2 cell models,ameliorated diet-induced atherosclerosis,and decreased the serum lipid content on rats and rabbits model of atherosclerosis in ***,SIPI-7623 decreased the extent of atherosclerotic *** resutls demonstrated that antagonism of the FXR pathway can be employed as a therapeutic strategy to treat metabolic diseases such as hyperlipidemia and *** conclusion,SIPI-7623 could be a promising lead compound for development of drugs to treat hyperlipidemia and atherosclerosis.

关键词： Farnesoid X receptor antagonist Hypolipidemic Bile acid enterohepatic circulation Cholesterol-7-alpha-hydroxylase Sterol-regulatory element-binding protein 1c

Quality Control for Expert Base and the Principle for Short Run Control

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Systems Science and Systems Engineering 2000年第4期10卷 406-413页

作者： XU Ji-chao liu yu-min Research Division for Quality Engineering Zhengzhou Institute of AeronauticsZhengzhouHenan450052China

The concept of the objective distribution of the evaluated objects is proposed in this paper. The random response model of the expert evaluation process is depicted, and the quality control principle of expert base is established based on the control philosophy for short run processes. The statistical quality improvement techniques for expert base are developed.

关键词： expert evaluation decision making quality contr?

Cu,N codoped carbon nanosheets encapsulating ultrasmall Cu nanoparticles for enhancing selective 1,2-propanediol oxidation

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Journal of Energy Chemistry 2024年第4期91卷 27-35页

作者： Yonghai Feng min yu minjia Meng Lei liu Dewei Rao Institute for Advanced Materials School of Materials Science and EngineeringJiangsu UniversityZhenjiang 212013JiangsuChina School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina

In the selective oxidation of biomass-based 1,2-propanediol(PDO)with oxygen as the terminal oxidant,it is challenging to improve the lactic acid(LA)selectivity for nonnoble metal nanoparticles(NPs)due to their limited oxygen reduction rate and easy C-C *** the high economic feasibility of nonnoble metals,i.e.,Cu,in this work,copper and nitrogen codoped porous carbon nanosheets encapsulating ultrafine Cu nanoparticles(Cu@Cu-N-C)were developed to realize highly selective of PDO oxidation to *** carbon-encapsulated ultrasmall Cu^(0)NPs in Cu@Cu-N-C have high PDO dehydrogenation activity while N-coordinated Cu(Cu-N)sites are responsible for the high oxygen reduction ***,the performance of catalytic PDO conversion to LA is optimized by a proposed pathway of PDO→hydroxylacetone→lactaldehyde→***,the enhanced LA selectivity is 88.5%,and the PDO conversion is up to 75.1%in an O_(2)-pressurized reaction system(1.0 MPa O_(2)),superior to other Cu-based catalysts,while in a milder nonpressurized system(O_(2)flow rate of 100 mL min-1),a remarkable LA selectivity(94.2%)is obtained with 39.8%PDO conversion,2.2 times higher than that of supported Au nanoparticles(1%Au/C).Moreover,carbon encapsulation offers Cu@Cu-N-C with strong leaching resistance for better recycling.

关键词： Selective oxidation Copper and nitrogen doped carbon 1,2-Propanediol Ultrasmall Cu nanoparticles Lactic acid

Exploiting blockchain for dependable services in zero-trust vehicular networks

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Frontiers of Computer Science 2024年第2期18卷 157-166页

作者： min HAO Beihai TAN Siming WANG Rong yu Ryan Wen liu Lisu yu School of Automation Guangdong University of TechnologyGuangzhou 510006China School of Integrated Circuits Guangdong University of TechnologyGuangzhou 510006China School of Navigation Wuhan University of TechnologyWuhan 430063China School of Information Engineering Nanchang UniversityNanchang 330031China

The sixth-generation(6G)wireless communication system is envisioned be cable of providing highly dependable services by integrating with native reliable and trustworthy ***-trust vehicular networks is one of the typical scenarios for 6G dependable *** the technical framework of vehicle-and-roadside collaboration,more and more on-board devices and roadside infrastructures will communicate for information *** reliability and security of the vehicle-and-roadside collaboration will directly affect the transportation *** a zero-trust vehicular environment,to prevent malicious vehicles from uploading false or invalid information,we propose a malicious vehicle identity disclosure approach based on the Shamir secret sharing ***,a two-layer consortium blockchain architecture and smart contracts are designed to protect the identity and privacy of benign vehicles as well as the security of their private *** that,in order to improve the efficiency of vehicle identity disclosure,we present an inspection policy based on zero-sum game theory and a roadside unit incentive mechanism jointly using contract theory and subjective logic *** verify the performance of the entire zero-trust solution through extensive simulation *** the premise of protecting the vehicle privacy,our solution is demonstrated to significantly improve the reliability and security of 6G vehicular networks.

关键词： sixth-generation(6G) zero-trust block-chain vehicular networks privacy preservation