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Agricultural Biotechnology 2019年第1期8卷 57-60页

作者： Jinhua liu Qian liu Jia LI yongqing zhang Jining Center for Drug and Food Control Shandong University of Traditional Chinese Medicine

[Objectives]This study was conducted to study the Germination characteristics and secondary metabolism regulation of Scutellaria baicalensis Georgi under osmotic stress.[Methods]The activity of praline,soluble sugar and protein was detected with ultraviolet *** activity of phenylalanine ammonia-lyase(PAL)and cinnamic acid 4-hydroxylase(C_4H)was determined with ultraviolet *** secondary metabolites were detected by high performance liquid chromatography(HPLC).[Results]The germination percentage,germination potentiality and germination index decreased at first and increased subsequently along with the enhancement of PEG *** praline content,the soluble sugar content and the soluble protein content in *** seedlings increased along with the enhancement of PEG concentration and the differences from the CK were significant(P<0.05).The PAL and C_4H in *** seedlings decreased after osmotic stress and the differences from the CK were significant(P<0.05).The results indicate that,the scutellarin,baicalin,wogonoside,baicalein,wogonin and oroxylinA contents decreased after osmotic stress and the differences from the CK were significant(P<0.05).[Conclusions]The quality of the skullcaps could be improved by improving the activity of PAL and C_4H.

关键词： Germination characteristics PAL C 4H Secondary metabolites

PEG-asparaginase in BFM-90 regimen improves outcomes in adults with newly diagnosed lymphoblastic lymphoma

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Chinese Journal of Cancer Research 2017年第1期29卷 66-74页

作者： Wen Zheng Hanyun Ren Xiaoyan Ke Mei Xue yongqing zhang Yan Xie Ningjing Lin Meifeng Tu Weiping liu Lingyan Ping Zhitao Ying Chen zhang Lijuan Deng Xiaopei Wang Yuqin Song Jun Zhu Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Lymphoma Peking University Cancer Hospital & Institute Department of Hematology Peking University First Hospital Department of Hematology Peking University Third Hospital Department of Hematology Air Force General Hospital of Chinese People’s Liberation Army Department of Hematology the 309th Hospital of Chinese People’s Liberation Army

Objective： Although L-asparaginase（L-ASP） is a standard treatment for lymphoblastic lymphoma（LBL）,hypersensitivity reactions by some patients limit its application. Polyethylene glycol-conjugated asparaginase（PEGASP） has a lower immunogenicity and is a standard treatment in all pediatric acute lymphoblastic leukemia（ALL）.In this study, we investigated the efficacy and toxicity of PEG-ASP instead of L-ASP as used in the BFM-90regimen（PEG-ASP-BFM-90） for adult ***： Between June 2012 and July 2015, we treated 30 adult patients with newly diagnosed LBL, using PEGASP-BFM-90 in a prospective, multicenter and single-arm clinical study at 5 participating institutions in ***： All the 30 patients, including 19 males and 11 females with a median age of 30（range： 18–62） years,completed 128 times of the PEG-ASP, with the median of 4（range： 2–6） times. Patients did not receive radiotherapy at this time. The overall response rate was 86.7%（26/30）, with 50.0%（15/30） complete response and36.7%（11/30） partial response. The 3-year overall survival was 46.0% [95% confidence interval（95% CI）,28.2%–64.8%], and the 3-year progression-free survival was 43.0%（95% CI, 25.7%–62.0%）. Major adverse events were myelosuppression, reduced fibrinogen, liver dysfunction and digestive tract toxicities. No allergic reaction and no treatment-related mortality or severe complications were ***： Our clinical data and observed outcomes indicate that 1 dose of PEG-ASP can replace multiple doses of native L-ASP in BFM-90, with predominantly grade 3–4 neutropenia for adult LBL, and no therapyrelated deaths. The effect is similar to previous reports of PEG-ASP-containing regimens for adult ALL. Major advantages include less serious allergic reactions, 2–3 weeks of action duration, and convenience for patients and physicians.

关键词： PEG-asparaginase lymphoblastic lymphoma treatment

Emergence of superconductivity from fully incoherent normal state in an iron-based superconductor (Ba_(0.6)K_(0.4))Fe_2As_2

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Science Bulletin 2019年第1期64卷 11-19页

作者： Jianwei Huang Lin Zhao Cong Li Qiang Gao Jing liu Yong Hu Yu Xu yongqing Cai Dingsong Wu Ying Ding Cheng Hu Huaxue Zhou Xiaoli Dong Guodong liu Qingyan Wang Shenjin zhang Zhimin Wang Fengfeng zhang Feng Yang Qinjun Peng Zuyan Xu Chuangtian Chen Xingjiang Zhou Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Technical Institute of Physics and Chemistry Chinese Academy of Sciences Songshan Lake Materials Laboratory Collaborative Innovation Center of Quantum Matter

In unconventional superconductors, it is generally believed that understanding the physical properties of the normal state is a pre-requisite for understanding the superconductivity mechanism. In conventional superconductors like niobium or lead, the normal state is a Fermi liquid with a well-defined Fermi surface and well-defined quasipartcles along the Fermi surface. Superconductivity is realized in this case by the Fermi surface instability in the superconducting state and the formation and condensation of the electron pairs(Cooper pairing). The high temperature cuprate superconductors, on the other hand, represent another extreme case that superconductivity can be realized in the underdoped region where there is neither well-defined Fermi surface due to the pseudogap formation nor quasiparticles near the antinodal regions in the normal state. Here we report a novel scenario that superconductivity is realized in a system with well-defined Fermi surface but without quasiparticles along the Fermi surface in the normal *** resolution laser-based angle-resolved photoemission measurements have been performed on an optimally-doped iron-based superconductor(Ba_(0.6)K_(0.4))Fe_2As_2. We find that, while sharp superconducting coherence peaks emerge in the superconducting state on the hole-like Fermi surface sheets, no quasiparticle peak is present in the normal state. Its electronic behaviours deviate strongly from a Fermi liquid system. The superconducting gap of such a system exhibits an unusual temperature dependence that it is nearly a constant in the superconducting state and abruptly closes at Tc. These observations have provided a new platform to study unconventional superconductivity in a non-Fermi liquid system.

关键词： (Ba0.6K0.4)Fe2As2 ARPES Superconducting gap Normal state Non-Fermi liquid

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基于按运输批转移的生产系统物流优化方法

控制理论与应用 2000年第4期17卷 609-612页

作者：张毕西刘永清广东工业大学经济管理学院广州510643 华南理工大学自动控制工程系广州510640

分析了物料按运输批在工序间转移的生产系统物流情况 ,建立了大量连续生产条件下的出货批量、成批生产条件下的生产批量、大量和成批生产过程的转移批量优化新模型 ;根据多品种成批轮番生产的特点 ,提出用生产重叠系数修正传统资源约... 详细信息

分析了物料按运输批在工序间转移的生产系统物流情况 ,建立了大量连续生产条件下的出货批量、成批生产条件下的生产批量、大量和成批生产过程的转移批量优化新模型 ;根据多品种成批轮番生产的特点 ,提出用生产重叠系数修正传统资源约束条件 ;对多资源约束问题 ,提出用关键资源约束系数调整各产品批量的方法 ,与传统的物流优化模型相比 ,建立的模型简单、有效 ,更加符合于生产实际 .

关键词：生产系统运输批量工业企业物流优化方法

A　New　ANN　Method　of　Aggregation　and　Stability　Analtsis　for　Large－Scale　System　with　Time　Delay

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Systems Science and Systems Engineering 1996年第4期6卷 437-443页

作者： zhang Jian liu yongqing SHEN Jianjing(Dept. of Automation, South China Univ. of Tech., China, 510641)

This paper is the first to introduce the Artificial Neural Network(ANN) theory and techniques in the aggregation and stability analysis of large scale dynamic system with time *** presents a new intelligent method of the aggregation and stability analysis for large scale system with time delays. The method proposed in this paper can be used not only on linear constant large scale systems with time delays, but also on times-varying large scale systems with multi-group real time delays. Simulation results show the effectiveness of the method.

关键词： Large-scale systems Stability Aggregation M-matrix Neural Network

Topological Structure of Many Vortices Solution in Jackiw-Pi Model

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2006年第1期 12-13页

作者： Li Xiguo liu Ziyu Li yongqing zhang Pengming Supported by Chinese Academy of Sciences Knowledge Innovation Project National Natural Science Foundation of China.

Effects of Macronutrients on Primary and Secondary Metabolism in Scutellaria baicalensis Georgi

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Agricultural Biotechnology 2019年第2期8卷 28-31页

作者： Jinhua liu Yanjing BIAN Zhixia LI yongqing zhang Jining Institute for Drug Control Shandong University of Traditional Chinese Medicine

[Objectives] This study was conducted to clarify the roles of macronutrients in regulating plant primary and secondary metabolism of Scutellaria baicalensis Georgi. [Methods] The contents of chlorophyll(Chl) and soluble sugar were detected with ultraviolet spectrophotometry. The activities of phenylalanine ammonia-lyase(PAL), cinnamate 4-hydroxylase(C_4H) and chalcone synthase(CHS) were determined with ultraviolet spectrophotometry. Secondary metabolites were detected by high performance liquid chromatography(HPLC). [Results] The content of chlorophyll in treatments N, P and K was increased, showing significant difference from that of the control(PN>P>CK) was increased considerably and had significant difference from that of the control(PN>P) were increased, and had significant difference from that of the control(P<0.05). [Conclusions] The results showed that macronutrients can increase leaf chlorophyll content, soluble sugar content, PAL activity, C_4H activity and secondary metabolites of S. baicalensis.

关键词： Macronutrients PAL C 4H CHS Secondary metabolites Scutellaria baicalensis

Topological Structure of SU（2） Chern-Simons Vortices1

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2006年第1期 11-12页

作者： Li Xiguo liu Ziyu zhang Pengming Li yongqing Supported by Chinese Academy of Sciences Knowledge Innovation Project National Natural Science Foundation of China.

The Design and Discuss of the Traffic and Road Management Information System

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Systems Science and Systems Engineering 1998年第4期8卷 457-461页

作者： zhang Hao liu yongqing(Automation Department, South China University of Technology,Guangzhou, 510641 P.R.China)

In this paper, coupled with the developing and designing of the Traffic and Road Management information System, the character and framework of Management information System(MIS) arediscussed. The design and realization of MIS under Client/Server construction are brought up. A neweffective developing method of MIS is given. At last the advantage of developing Database applicationsystem by means of PowerBuilder 5.0 as tool software is put forward.

关键词： MIS Client/Server PowerBuilder Database

Electronic structure of exfoliated millimeter-sized monolayer WSe2 on silicon wafer

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Nano Research 2019年第12期12卷 3095-3100页

作者： Wenjuan Zhao Yuan Huang Cheng Shen Cong Li yongqing Cai Yu Xu Hongtao Rong Qiang Gao Yang Wang Lin Zhao Lihong Bao Qingyan Wang Guangyu zhang Hongjun Gao Zuyan Xu Xingjiang Zhou Guodong liu Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China Beijing Academy of Quantum Information Sciences Beijing 100193China

The mono layer WSe2 is in teresting and important for future application in nanoelectronics,spintronics and valleytronics devices,because it has the largest spin splitting and Ion gest valley coherence time among all the known monolayer transition-metal dichalcogenides(TMDs).Toobtain the large-area monolayer TMDs'crystal is the first step to manu facture scalable and high-performance electronic *** this letter,we have successfully fabricated millimeter-sized mono layer WSe2 single crystals with very high quality,based on our improved mecha nicalexfoliation *** such superior samples,using standard high resolution angle-resolved photoemission spectroscopy,we didcomprehe nsive electronic band structure measurements on our mono layer *** overall band features point it to be a 1.2 eV direct bandgap semico *** spin splitting of the valence band at K point is found as 460 meV,which is 30 meV less than the corresponding band splitting in its bulk *** effective hole masses of valence bands are determined as 2.344 me atГ,and 0.529 me as well as 0.532 meat K for the upper and lower branch of splitting ban ds,*** screening effect from substrate is shown to substa ntially impact onthe electronic *** results provide importa nt insights into band structure engineering in mono layer *** mono layer WSe2 crystals may constitute a valuable device platform.

关键词： transition-metal dichalcogenides WSe2 monolayer electronic structure angle-resolved photoemission spectroscopy