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近代物理研究所和兰州重离子加速器实验室年报：英文版 2009年第1期 143-144页

作者： liu xinguo li qiang dai zhongying ye fei jin xiaodong wu qingfeng li ping

Progress in heavy ion cancer therapy at IMP and future development

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Malignancy Spectrum 2024年第2期1卷 91-98页

作者： qiang li xinguo liu zhongying dai Pengbo He Yuanyuan Ma Guosheng Shen xiaodong jin fei ye Xiaogang Zheng Ting Zhao Hui Zhang Zheng li Bingwen Zou Yuehu Pu Weiqiang Chen Institute of Modern Physics Chinese Academy of SciencesLanzhouGansuChina Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences LanzhouGansuChina Gansu Provincial Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine LanzhouGansuChina University of Chinese Academy of Sciences BeijingChina Division of Thoracic Tumor Multimodality Treatment and Department of Radiation Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuanChina Medical Equipment Innovation Research Center West China HospitalSichuan UniversityChengduSichuanChina

Basic research on heavy ion cancer therapy such as radiobiology, medicalphysics, and therapeutic technique has been conducted at the Institute ofModern Physics (IMP), Chinese Academy of Sciences since 1995. Based on theachievements acquired in the basic research and the requirements for a heavyion accelerator for radiotherapy purposes, a dedicated heavy ion therapy facilitynamed Heavy Ion Medical Machine (HIMM) was designed at IMP andconstructed in wuwei, China. The HIMM facility consists of two electroncyclotron resonance ion sources, one cyclotron as the injector and onesynchrotron as the main accelerator, and four different treatment roomsequipped with passive or active beam delivery systems, and accelerates carbonions up to 400 MeV/u. After the performance inspection of HIMM organized bythe National Medical Device Inspection Center, preclinical tests like cell andanimal radiobiological experiments and dosimetric verification using anthropomorphicphantoms for elucidating the biophysical properties of the carbon ionbeams provided by HIMM were carried out. According to the Chinese medicaldevice regulations, a clinical trial in which 46 tumor patients were recruited andtwo hospitals participated was conducted in the HIMM facility, aiming atevaluating the treatment safety and short-term efficacy of the medical *** success of the clinical trial helped the HIMM facility be authorized by theChinese government as a class III medical device. In this paper, all the aspectsmentioned above are introduced and discussed, and implications for futureimprovements are also given.

关键词： heavy ion cancer therapy clinical trial performance inspection dosimetric verification medical device

Therapeutic Techniques Used in Heavy Ion Therapy Project at IMP

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2009年第1期 140-141页

作者： li qiang dai zhongying liu xinguo wu qingfeng jin xiaodong li ping Tao Jiajun ye fei

3 -53 Active Spot Scanning Test in Deep-seated Tumor Therapy Terminal with Heavy Ions at HIRFL-CSR

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IMP & HIRFL Annual Report 2010年第1期 149-150页

作者： li qiang dai zhongying liu xinguo jin xiaodong ye fei wu qingfeng li ping Gong li Cui Dachao Huang Qiyan Xu Hushan Xiao Guoqing

A Preliminary Version of Heavy Ion Treatment Planning System at IMP

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2009年第1期 142-142页

作者： liu xinguo li qiang dai zhongying jin xiaodong wu qingfeng li ping ye fei

Reducing Distal Dose Penumbra of a Spread-out Bragg Peak for Therapeutic Ion Beam

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IMP & HIRFL Annual Report 2011年第1期 136-136页

作者： li qiang liu xinguo dai zhongying jin xiaodong wu qingfeng li ping ye fei Huang Qiyan

3-46 Heavy Ion Cancer Therapy-related Research in the Group of Medical Physics

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IMP & HIRFL Annual Report 2015年第1期 145-145页

作者： li qiang liu xinguo dai zhongying jin xiaodong li ping liu Xiongxiong He Pengbo ye fei Chen Weiqiang liu Yan 不详

With the construction of the Heavy Ion Mecial Machine (HIMM) in wuwei, more and more work related to the research and development of heavy ion cancer therapy have been done in the group of Medical Physics this year. On the one hand, we focused our work on setting up a heavy ion radiotherapy treatment planning system for the HIMM project, aiming at building a bridge between the HIMM facility and clinical application; on the other hand, we continued to explore the mechanisms underlying heavy ion radiation-induced biological effects in order to provide theoretical basis for heavy ion cancer therapy, trying either to improve the efficacy of heavy ion therapy or to reduce the radiation-induced damage to normal tissues as much as possible.

关键词： Group Medical Physics