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Milk fat globule membrane supplementation protects againstβ-lactoglobul-ininduced food allergy in mice via upregulation of regulatory T cells and enhancement of intestinal barrier in a microbiota-derived short-chain fatty acids manner

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Food Science and Human Wellness 2024年第1期13卷 124-136页

作者： Han Gong Tiange Li Dong Liang Jingxin Gao xiaohan liu Xueying Mao Key Laboratory of Functional Dairy Ministry of EducationCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Henan Engineering Technology Research Center of Food Processing and Circulation Safety Control College of Food Science and TechnologyHenan Agricultural UniversityZhengzhou 450002China Applied Nutrition I China National Center for Food Safety Risk AssessmentBeijing 100022China

Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and *** aim of this study was to evaluate the protective effects and possible underlying mechanisms of MFGM on cow’s milk allergy(CMA)in aβ-lactoglobulin(BLG)-induced allergic mice *** was supplemented to allergic mice induced by BLG at a dose of 400 mg/kg body *** demonstrated that MFGM alleviated food allergy symptoms,decreased serum levels of lipopolysaccharide,pro-inflammatory cytokines,immunoglobulin(Ig)E,Ig G1,and Th2 cytokines including interleukin(IL)-4,while increased serum levels of Th1 cytokines including interferon-γand regulatory T cells(Tregs)cytokines including IL-10 and transforming growth factor-β.MFGM modulated gut microbiota and enhanced intestinal barrier of BLG-allergic mice,as evidenced by decreased relative abundance of Desulfobacterota,Rikenellaceae,Lachnospiraceae,and Desulfovibrionaceae,while increased relative abundance of Bacteroidetes,Lactobacillaceae and Muribaculaceae,and enhanced expressions of tight junction proteins including Occludin,Claudin-1 and zonula ***,MFGM increased fecal short-chain fatty acids(SCFAs)levels,which elevated G protein-coupled receptor(GPR)43 and GPR109A *** increased expressions of GPR43 and GPR109A induced CD103+dendritic cells accumulation and promoted Tregs differentiation in mesenteric lymph node to a certain *** summary,MFGM alleviated CMA in a BLG-induced allergic mice model through enhancing intestinal barrier and promoting Tregs differentiation,which may be correlated with SCFAs-mediated activation of *** findings suggest that MFGM may be useful as a promising functional ingredient against CMA.

关键词： Cow’s milk allergy Milk fat globule membrane Gut microbiota Short-chain fatty acid G protein-coupled receptor Regulatory T cell

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Thirty-year trends of anxiety disorders among adolescents based on the 2019 Global Burden of Disease Study

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General Psychiatry 2024年第2期37卷 242-253页

作者： xiaohan liu Fan Yang Ning Huang Shan Zhang Jing Guo School of Public Health Peking University Health Science CenterNo.38 Xueyuan RdHaidian DistrictBeijingChina

Background Anxiety disorders are the most common psychiatric problems,affecting approximately 1 in 12 children and 1 in 4 *** the incidence,burden and correlated risks of anxiety disorders among children and adolescents can help identify areas of success,stagnation and emerging threats,thereby facilitating effective improvement *** To estimate the incidence and burden trends of anxiety disorders in children and adolescents from 1990 to 2019 in 204 countries and compare the incidence and disease burden in different *** examine the association between anxiety disorders and social indicators(healthcare access and quality of life).Methods Data were obtained from the Global Burden of Disease Study *** age-standardised incidence rates(ASIRs)and disability-adjusted life years(DALYs)were reported to assess the burden of anxiety disorders,and the estimated annual percentage change was calculated to quantify the temporal ***’s correlation was used to investigate country-level risk factors for incidence and *** Globally,there were 932 million incident cases of anxiety disorders in children and adolescents,739.29 per 100000 ASIRs and 380.62 million DALYs in *** 1990 to 2019,the estimated annual percentage change of incidence of anxiety disorders decreased by 2.2%.Significant variations were observed in the age-standardised burden rate and the changing trend of anxiety disorders among *** reported the highest ASIR of anxiety disorders,while Mexico had the largest increase rate of *** 2019,Portugal reported the highest number of DALYs(1001.71 million),and India(212.09 million)reported the lowest number of *** burden of anxiety disorders was positively correlated with the average number of psychiatrists,psychologists and nurses in the mental health sector(per 100000),and quality of life and the correlation coefficients were 0.58,0.67,0.43 and 0.53,*** The incide

关键词： disorders adolescent nurse

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Evolution of template-assisted two-dimensional porphyrin chiral grating structure by directed self-assembly using chiral second harmonic generation microscopy

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Chinese Chemical Letters 2024年第10期35卷 170-174页

作者： Changhui Yu Peng Shang Huihui Hu Yuening Zhang Xujin Qin Linyu Han Caihe liu xiaohan liu Minghua liu Yuan Guo Zhen Zhang Beijing National Laboratory for Molecular Sciences State Key Laboratory of Molecular Reaction DynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Beijing National Laboratory for Molecular Science CAS Key Laboratory of ColloidInterface and Chemical ThermodynamicsInstitute of ChemistryChinese Academyof SciencesBeijing100190China

Directed self-assembly has been used to create micro-nano scale patterns,including chiral periodic structures of organic molecules,for potential applications in optics,photonics,metamaterials,and medical and sensing *** study presents a straightforward approach for fabricating large-scale chiral grating porphyrin assemblies through template-assisted *** solution of tetrakis(4-sulfonatophenyl)porphyrin(TPPS)was induced by chiral amino acids(L/D-arginine and L/D-serine)to selfassemble into highly ordered chiral grating structures with the assistance of sodium dodecyl sulfate(SDS).The structures show precise line widths(5.5μm)and gaps(18μm).Using in situ optical microscopy and second harmonic generation(SHG)microscopy,the chiral characteristics and dynamic evolution of the template-assisted self-assembly are *** is found that the chirality of amino acids induced TPPS self-assembled into chiral structures and the liquid contraction interface significantly enhanced the chirality of the *** study is significant for understanding the mechanism of chiral evolution and designing novel micro-nano materials with predetermined chiral properties.

关键词： Second harmonic generation microscopy Chiral assembly Porphyrin Chiral evolution Template-assisted self-assembly Micro-nano structure

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PE6c greatly enhances prime editing in transgenic rice plants

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Journal of Integrative Plant Biology 2024年第9期66卷 1864-1870页

作者： Zhenghong Cao Wei Sun Dexin Qiao Junya Wang Siyun Li xiaohan liu Cuiping Xin Yu Lu Syeda Leeda Gul Xue‐Chen Wang Qi-Jun Chen State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing100193China Center for Crop Functional Genomics and Molecular Breeding China Agricultural UniversityBeijing 100193China

Prime editing is a versatile CRISPR/Cas-based precise genome-editing technique for crop *** new types of prime editors(PEs)named PE6a–d were recently generated using evolved and engineered reverse transcriptase(RT)variants from three different *** this study,we tested the editing efficiencies of four PE6 variants and two additional PE6 constructs with double-RT modules in transgenic rice(Oryza sativa)***6c,with an evolved and engineered RT variant from the yeast Tf1 retrotransposon,yielded the highest prime-editing *** average fold change in the editing efficiency of PE6c compared with PEmax exceeded 3.5 across 18 agronomically important target sites from 15 *** also demonstrated the feasibility of using two RT modules to improve prime-editing *** results suggest that PE6c or its derivatives would be an excellent choice for prime editing in monocot *** addition,our findings have laid a foundation for prime-editing-based breeding of rice varieties with enhanced agronomically important traits.

关键词： genome editing PE6 PE6c prime editing prime editor rice

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YAP Inactivation by Soft Mechanotransduction Relieves MAFG for Tumor Cell Dedifferentiation

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Research 2024年第2期6卷 401-415页

作者： Jiadi Lv xiaohan liu Yabo Zhou Feiran Cheng Haoran Chen Shunshun Li Dianheng Wang Li Zhou Zhenfeng Wang Nannan Zhou Jie Chen Bo Huang Department of Immunology&State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical College(PUMC)Beijing100005China Department of Histology and Embryology Basic Medical CllegeChina Medical UniversityShenyangLiaoning 11122China Department of Immunology Basic Medical Cllege China Medical UniversityShenyangLiaoning 110122China Department of Biochemistry&Molecular Biology Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430030China

Solid tumor cells live in a highly dynamic mechanical *** the extracellular-matrix-generated mechanotransduction regulates tumor cell development and differentiation remains an ***,we show that a low mechanical force generated from the soft matrix induces dedifferentiation of moderately stiff tumor cells to soft stem-cell-like ***,integrin?was identified to transduce mechano-signaling to trigger tumor cell dedifferentiation by recruiting RhoGDI1 to inactivate RhoA and subsequently Yes-associated protein(YAP).YAP inactivation relieved the inhibition of v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G(MAFG),allowing MAFG to transactivate the stemness genes NANOG,SOX2,and *** also restoredβ8 expression,thereby forming a closed mechanical ***,MAFG expression is correlated with worse *** findings provide mechanical insights into the regulation of tumor cell dedifferentiation,which has therapeutic implications for exploring innovative strategies to attack malignancies.

关键词： activation thereby MAF

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An immunogenic cell death-related signature for prediction of prognosis and response to immunotherapy in breast cancer

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Chinese Medical Journal 2024年第4期137卷 487-489页

作者： Cong Li Fengzhu Guo Jingtong Zhai xiaohan liu Zhijun Li Binghe Xu Department of Medical Oncology National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China Department of Medical Oncology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Department of Histology and Embryology Basic Medical CollegeChina Medical UniversityShenyangLiaoning 110122China

To the Editor:Tumor immune microenvironment plays a key role in breast cancer development and progression,which determines the long-term survival of breast cancer *** data have revealed that the application of cancer immunotherapy has some limitations,including generating weak immune responses due to inadequate delivery of immunostimulants to the immune cells.^([1])Thus,current clinical efforts are primarily focused on developing immune-based chemotherapy that can convert non-responders to responders.^([2])Immunogenic cell death(ICD)is a form of regulated cell death that is sufficient to activate an adaptive immune response.

关键词： breast immunotherapy chemotherapy

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据出土文献说“言”“谳”同源兼及郭店简《六德》“狱■”的释读

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出土文献 2024年第2期 39-48,170页

作者：刘晓晗清华大学人文学院

上博六《景公疟》简4“听狱”,传世文献异文作“治言”。邬可晶先生指出“言”读为“谳”,表狱讼义。本文在此基础上,从语音、字用和语义方面详细论证了“言”“谳”应该是一组同源词。“言”从“言语”义引申出“讼”义,“谳”应是战... 详细信息

上博六《景公疟》简4“听狱”,传世文献异文作“治言”。邬可晶先生指出“言”读为“谳”,表狱讼义。本文在此基础上,从语音、字用和语义方面详细论证了“言”“谳”应该是一组同源词。“言”从“言语”义引申出“讼”义,“谳”应是战国秦汉时期从“言”分化而来的。“谳”继承了“言”从下言上的核心语义,但其整体语义域比“言”缩小很多,是一个专用于司法刑狱的综合性动词。“言”“谳”亦可以从动词引申为表示动作关联的对象名词“狱讼”。本文还讨论了郭店简《六德》中的“狱■”,认为“狱■”当读为“狱彦(言—谳)”。

关键词：言谳同源词综合性动词六德

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等离子体改性增强农林生物质复合材料界面相容性研究进展

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材料导报 2024年第13期38卷 295-305页

作者：刘筱涵杨培周晓燕南京林业大学林业资源高效加工利用协同创新中心南京林业大学材料科学与工程学院

生物质复合材料的开发是促进生物质资源向高值化、多元化、环境化和功能化利用的重要方式，对此，生物质材料表面改性技术及其内在作用机制是当前生物质复合材料领域的主要研究内容。等离子体改性技术以速度快、能量高、功能强、污染小... 详细信息

生物质复合材料的开发是促进生物质资源向高值化、多元化、环境化和功能化利用的重要方式，对此，生物质材料表面改性技术及其内在作用机制是当前生物质复合材料领域的主要研究内容。等离子体改性技术以速度快、能量高、功能强、污染小等优势从众多改性方法中脱颖而出，被广泛应用于改善生物质复合材料的界面结合性能。等离子体技术基于对材料表面的活化作用以及表面刻蚀作用改善生物质材料与其他异质材料的界面相容性，进而提升农林生物质复合材料的物理力学性能。本文介绍了等离子体改性生物质材料的发展历程，总结了等离子体技术对生物质材料的改性机理，重点阐述了等离子体改性技术在增强木竹/树脂复合材料、木竹/塑料复合材料、木竹/金属复合材料、木竹/增强纤维复合材料界面相容性方面的研究进展。最后，对等离子体改性农林生物质复合材料的发展方向进行了展望。

关键词：等离子体农林生物质表面改性界面相容性复合材料

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基于Stacking策略的集成BN网络目标威胁评估

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系统工程与电子技术 2024年第2期46卷 586-598页

作者：王紫东高晓光刘晓寒西北工业大学电子信息学院陕西西安710129

现有基于贝叶斯网络的威胁评估采用专家经验确定的朴素结构,其推理评估结果精度欠佳。为此,提出一种融合专家经验与数据观测的基于Stacking策略的集成贝叶斯网络(ensemble Bayesian network,EBN)。首先使用不同搜索空间内的评分优化算... 详细信息

现有基于贝叶斯网络的威胁评估采用专家经验确定的朴素结构,其推理评估结果精度欠佳。为此,提出一种融合专家经验与数据观测的基于Stacking策略的集成贝叶斯网络(ensemble Bayesian network,EBN)。首先使用不同搜索空间内的评分优化算法获得数据观测模型集并进行模型平均;然后使用专家经验朴素模型对平均网络进行修剪,形成威胁约束集合;最后以动态规划为基础,通过该集合限制节点序图扩展,以求取全局最优威胁评估网络。在作战想定中,EBN模型单目标威胁概率推理精度比朴素贝叶斯模型高出10%,在多目标威胁排序任务中,其Spearman系数分布亦优于朴素模型。

关键词：威胁评估贝叶斯网络结构学习约束优化

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结核感染T细胞γ干扰素释放试验及结核杆菌抗体在肺结核患者诊断中的应用

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中外医学研究 2024年第1期22卷 67-70页

作者：刘小寒荆州市第三人民医院湖北荆州434000

目的:探讨对结核感染T细胞γ干扰素释放试验(TB-IGRA)及结核杆菌抗体(TB-Ab)在肺结核患者诊断中的应用价值。方法:选择2022年1—12月荆州市第三人民医院收治的216例疑似肺结核患者,将病理学诊断作为“金标准”,依据是否存在结核病进行分... 详细信息

目的:探讨对结核感染T细胞γ干扰素释放试验(TB-IGRA)及结核杆菌抗体(TB-Ab)在肺结核患者诊断中的应用价值。方法:选择2022年1—12月荆州市第三人民医院收治的216例疑似肺结核患者,将病理学诊断作为“金标准”,依据是否存在结核病进行分组,分为肺结核组(n=151)和非肺结核组(n=65),采集患者清晨空腹静脉血分别检测TB-IGRA、TB-Ab水平,观察两项指标检测肺结核阳性结果,观察不同检查方式诊断效能。结果:肺结核组中TB-IGRA阳性检出率、TB-Ab阳性检出率均高于非肺结核组,差异有统计学意义(P0.05),TB-IGRA诊断肺结核的敏感度、阴性预测值高于TB-Ab,差异有统计学意义(P60岁肺结核患者TB-IGRA阳性检出率、TB-Ab阳性检出率高于≤60岁肺结核患者,差异有统计学意义(P<0.05)。结论:临床肺结核诊断中应用TB-IGRA、TB-Ab检查均有较高诊断效能,但相对而言TB-IGRA检查方式更优,且该检查方式阳性率易受年龄因素影响。

关键词：肺结核结核感染T细胞γ干扰素释放试验结核杆菌抗体阳性检出率诊断效能

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