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NASICON-structured Na3.1Zr1.95Mg0.05Si2PO12 solid electrolyte for solid-state sodium batteries

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Rare Metals 2018年第6期37卷 480-487页

作者： jing Yang HongLi wan Zhihua zhang GaoZhan liu XiaoXiong Xu YongSheng hu Xia-Yin yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo 315201 China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory for Renewable Energy Beijing Key Laboratory for New Energy Materials and Devices Institute of PhysicsChinese Academy of Sciences Beijing 100190 China

Using stable inorganic solid electrolyte to replace organic liquid electrolyte could significantly reduce potential safety risks of rechargeable batteries. Na-superionic conductor （NASICON）-structured solid electrolyte is one of the most promising sodium solid electrolytes and can be employed in solid-state sodium batteries. In this work, a NASICON-structured solid electrolyte Na3.1Zr1.95Mg0.05Si2PO12 was synthesized through a facile solid-state reaction, yielding high sodium-ionic conductivity of 1.33 × 10-3 ***^-1 at room temperature. The results indicate that Mg^2＋ is a suitable and economical substitution ion to replace Zr^4＋, and this synthesis route can be scaled up for powder preparation with low cost. In addition to electrolyte material preparation, solid-state batteries with Na3.1Zr1.95Mg0.05Si2PO12 as electrolyte were assembled. A specific capacity of 57.9 mAh·g^-1 is maintained after 100 cycles under a current density of 0.5C rate at room temperature. The favorable cycling performance of the solid-state battery suggests that Na3.1Zr1.95Mg0.05Si2PO12 is an ideal electrolyte candidate for solid-state sodium batteries.

关键词： Solid electrolyte NASICON-type structure Sodium-ionic conductivity Solid-state sodium battery

Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats

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World Journal of Gastroenterology 2014年第6期20卷 1614-1622页

作者： jing-yao zhang Qi-Fei Wu Yong wan Si-dong Song Jia Xu Xin-Sen Xu hu-Lin Chang Ming-hui Tai Ya-Feng dong Chang liu Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong University Health Science Center Department of Thoracic Surgery The First Affiliated Hospital of Xi’an Jiaotong University Health Science Center Department of Obstetrics and Gynecology University of Kansas School of Medicine

AIM: To investigate the role of the hydrogen-rich water (HRW) in the prevention of aspirin-induced gastric mucosal injury in rats.

关键词： Hydrogen Aspirin Gastric lesion Oxidative stress Cytokines Cyclooxygenase 2

Identification of candidate genes related to soluble sugar contents in soybean seeds using multiple genetic analyses

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维普期刊数据库

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Journal of Integrative Agriculture 2022年第7期21卷 1886-1902页

作者： PAN Wen-jing HAN Xue huANG Shi-yu YU jing-yao ZHAO Ying QU Ke-xin zhang ze-xin YIN Zhen-gong QI hui-dong YU Guo-long zhang Yong XIN Da-wei Zhu Rong-sheng liu Chun-yan WU Xiao-xia JIANG Hong-wei hu Zhen-bang ZUO Yu-hu CHEN Qing-shan QI Zhao-ming College of Agriculture Northeast Agricultural UniversityHarbin 150030P.R.China Heilongjiang Bayi Agricultural University Daqing 163000P.R.China Keshan Branch of Heilongjiang Academy of Agricultural Sciences Qiqihar 161300P.R.China

Soluble sugar content in seeds is an important quality trait of soybean. In this study, 57 quantitative trait loci(QTLs) related to soluble sugar contents in soybean seeds were collected from databases and published papers. After meta-overview-collinearity integrated analysis to refine QTL intervals, eight consensus QTLs were identified. To further verify the consensus QTLs, a population of chromosome segment substitution lines(CSSLs) was analyzed. Two lines containing fragments covering the regions of consensus QTLs and the recurrent parent were selected: one line showed high soluble sugar contents associated with a consensus QTL fragment, and the other line showed low soluble sugar contents. Transcriptome sequencing was conducted for these two lines at the early, middle, and late stages of seed development, which identified 158, 109 and 329 differentially expressed genes, respectively. Based on the analyses of re-sequencing data of the CSSLs and the consensus QTL region, three candidate genes(Glyma.19 G146800, Glyma.19 G122500, and Glyma.19 G128500) were identified in the genetic fragments introduced from wild soybean. Sequence comparisons between the two CSSL parents SN14 and ZYD00006 revealed a single nucleotide polymorphism(SNP) mutation in the coding sequence of Glyma.19 G122500, causing a nonsynonymous mutation in the amino acid sequence that affected the predicted protein structure. A Kompetitive allele-specific PCR(KASP) marker was developed based on this SNP and used to evaluate the CSSLs. These results lay the foundation for further research to identify genes related to soluble sugar contents in soybean seeds and for future soybean breeding.

关键词： soybean soluble sugar contents consensus QTL meta-overview-collinearity integrated analysis population validation RNA-seq and candidate gene mining

Ratios of T-helper 2 Cells to T-helper 1 Cells and Cytokine Levels in Patients with Hepatitis B

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Chinese Medical Journal 2017年第15期130卷 1810-1815页

作者： Ming-hui Li Dan zhang Lu zhang Xiao-jing Qu yao Lu Ge Shen Shu-Ling Wu Min Chang Ru-Yu liu Lei-Ping hu Hong-Xiao Hao Wen-Hao hua Shu-jing Song Gang wan Shun-Ai liu yao xie Liver Diseases Center Beijing Ditan Hospital Capital Medical University Beijing 100015 China Clinical Laboratory Beijing Ditan Hospital Capital Medical University Beijing 100015 China

Background：Hepatitis B is an immune response-mediated *** aim of this study was to explore the differences of ratios of T-helper （Th） 2 cells to Thl cells and cytokine levels in acute hepatitis B （AHB） patients and chronic hepatitis B virus （HBV）-infected patients in immune-tolerance and immune-active ***：Thirty chronic HBV-infected patients in the immune-tolerant phase （IT group） and 50 chronic hepatitis B patients in the immuneactive （clearance） phase （IC group）,32 AHB patients （AHB group）,and 13 healthy individuals （HI group） were enrolled in the *** cell proportions in peripheral blood,cytokine levels in plasma,and serum levels of HBV DNA,hepatitis B surface antigen,and hepatitis B e antigen were ***：The Th1 cell percentage and Th2/Th1 ratio in the HBV infection group （including IT,IC,and AHB groups） were significantly different from those in HI group （24.10% ± 8.66% and 1.72 ± 0.61 vs.15.16% ± 4.34% and 2.40 ± 0.74,respectively;all P 〈 0.001）.However,there were no differences in the Th1 cell percentages and Th2/Th1 ratios among the IT,IC,and AHB *** HBV infection group,the median levels of Flt3 ligand （Flt3L）,interferon （IFN）-γ,and interleukin （IL）-17A were significantly lower than those in HI group （29.26 pg/ml,33.72 pg/ml,and 12.27 pg/ml vs.108.54 pg/ml,66.48 pg/ml,and 35.96 pg/ml,respectively;all P 〈 0.05）.IFN-α2,IL-10,and transforming growth factor （TGF）-β2 median levels in hepatitis group （including patients in AHB and IC groups） were significantly higher than those in IT group （40.14 pg/ml,13.58 pg/ml,and 557.41 pg/ml vs.16.74 pg/ml,6.80 pg/ml,and 419.01 pg/ml,respectively;all P 〈 0.05）,while patients in hepatitis group had significant lower Flt3L level than IT patients （30.77 vs.59.96 pg/ml,P =0.021）.Compared with IC group,patients in AHB group had significant higher median level s of IL-1 0,TGF-β 1,and TGF-β2 （22.77 pg/ml,10,447.00 pg/ml,and 782.28 pg/ml vs.8.66 pg/ml,3755.50 pg/ml,and 482.87 pg/ml,respectively

关键词： Acute Hepatitis B Chronic Hepatitis B, Cytokine: Immune-tolerance T Lymphocytes

Negative Correlation of Serum Hepatitis B Surface Antigen and Hepatitis B e Antigen Levels with the Severity of Liver Inflammation in Treatment-naive Patients with Chronic Hepatitis B Virus Infection

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Chinese Medical Journal 2017年第22期130卷 2697-2702页

作者： Lu zhang Ming-hui Li wei-hua Cao Tian-Lin Qi yao Lu Shu-Ling Wu Hong-Xiao Hao Ge Shen Ru-Yu liu Lei-Ping hu Min Chang Wen-Hao hua Shu-jing Song Gang wan yao xie Liver Diseases Center Beijing Ditan Hospital Capital Medical University Beijing 100015 China Clinical Test Center Beijing Ditan Hospital Capital Medical University Beijing 100015 China

Background： Estimating the grades of liver inflammation is critical in the determination ofantiviral therapy in patients chronically infected with hepatitis B virus （HBV）. The aim of this study was to investigate the correlation ofserum levels of hepatitis B surface antigen （HBsAg） and hepatitis B e antigen （HBeAg） with the liver inflammation grades in treatment-naTve patients with chronic HBV infection. Methods： We retrospectively enrolled 584 treatment-na＇l＇ve HBeAg-positive patients who underwent liver biopsy in Ditan Hospital from January 2008 to January 2016. Based on the severity of liver inflammation, the patients were divided into minimal, mild, and moderate groups. SPSS software was used lbr statistical analysis of all relevant data. Results： The liver histological examinations showed that 324, 194, and 66 patients had minimal, mild, and moderate liver inflammation, respectively. The median age of the three groups was 30, 33, and 38 years, respectively （X2 =26.00, P 〈 0.001 ）. The median HBsAg levels in minimal, mild, and moderate inflammation groups were 4.40, 4.16, and 3.67 log U/ml, respectively, and the median HBeAg levels in the three groups were 3.12, 2.99, and 1.86 log sample/cutoff. respectively; both antigens tended to decrease as the grade of inflammation increased （X2 = 99.68 and X2 =99.23, respectively; both P 〈 0.001 ）. The cutoff values of receiver operating characteristic curve in the age, HBsAg and HBeAg levels were 36 years, 4.31 log U/ml, and 2.86 Iog S/CO, respectively, 1 to distinguish minimal grade and other grades of treatment-naTve HBeAg-positive patients with chronic HBV infection. Conclusions： Serum HBsAg and HBeAg quantitation might gradually decrease with aggravated liver inflammation and the corresponding cutoff values rnight help us to distinguish rninimal grades and other grades and detect those who do not need antiviral therapy in treatment-naive HBeAg-positive patients with chronic HBV infection.

关键词： Chronic Hepatitis B Virus Infection Hepatitis B e Antigen Hepatitis B Surface Antigen Liver Inflammation

The Predictive Value of Baseline HBs Ag Level and Early Response for HBs Ag Loss in Patients with HBe Ag-positive Chronic Hepatitis B during Pegylated Interferon Alpha-2a Treatment

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Biomedical and Environmental Sciences 2017年第3期30卷 177-184页

作者： LI Ming hui zhang Lu QU Xiao jing LU yao SHEN Ge LI Zhen Zhen WU Shu Ling liu Ru Yu CHANG Min hu Lei Ping huA Wen Hao SONG Shu jing wan Gang xie yao Liver Diseases Center Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Clinical Test Center Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective To explore the predictive value of baseline HBs Ag level and early response for HBs Ag loss in patients with HBe Ag-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. Methods A total of 121 patients with HBe Ag-positive chronic hepatitis B who achieved HBs Ag loss were enrolled; all patients were treated with PEG-IFNα-2a 180 μg/week. Serum HBV DNA and serological indicators （HBs Ag, anti-HBs, HBe Ag, and anti-HBe） were determined before and every 3 months during treatment. Results The median treatment time for HBs Ag loss was 84 weeks （7-273 weeks）, and 74.38% （90 cases） of the patients needed extended treatment （〉 48 weeks）. The correlation between baseline HBs Ag levels and the treatment time of HBs Ag loss was significant （B = 14.465, t = 2.342, P = 0.021）. Baseline HBs Ag levels together with the decline range of HBs Ag at 24 weeks significantly correlated with the treatment time of HBs Ag loss （B = 29.862, t = 4.890, P = 0.000 and B = 27.993, t = 27.993, P = 0.005）. Conclusion Baseline HBs Ag levels and extended therapy are critical steps toward HBs Ag loss. Baseline HBs Ag levels together with early response determined the treatment time of HBs Ag loss in patients with HBe Ag-positive chronic hepatitis B during pegylated interferon alpha-2a treatment.

关键词： Chronic hepatitis B HBs Ag loss HBe Ag Pegylated interferon alpha-2a

Association of Cytokines with Alanine Aminotransferase, Hepatitis B Virus Surface Antigen and Hepatitis B Envelope Antigen Levels in Chronic Hepatitis B

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Chinese Medical Journal 2018年第15期131卷 1813-1818页

作者： Ming-hui Li yao Lu Lu zhang Xing-Yue wang Chong-Ping Ran Hong-Xiao Hao Dan zhang Xiao-jing Qu Ge Shen Shu-Ling Wu wei-hua Cao Tian-Lin Qi Ru-Yu liu Lei-Ping hu Min Chang Wen-Hao hua Shun-Ai liu Gang wan yao xie Liver Diseases Center Beijing Ditan Hospital Capital Medical University Beijing 100015 China Beijing Key laboratory of Emerging Infectious Diseases Institute of Infectious Diseases Beijing Ditan Hospital Capital Medical University Beijing 100015 China Clinical Test Center Beijing Ditan Hospital Capital Medical University Beijing 100015 China Ming-Hui Li and Yao Lu contributed equally to this work

Background： Cytokines play an important role in occorrence and recovery of hepatitis B virus （HBV） infection. The aim of this study was to investigate the changes ofcytokines concentration and its correlation to alanine aminotransferase （ALT）, HBV deoxyribonucleic acid （HBV-DNA）, hepatitis B envelope antigen （HBeAg）, and HBV surface antigen （HBsAg） in the development of chronic hepatitis B （CHB）. Methods： Thirteen healthy individuals （HI）, 30 chronic HBV-infected patients in immune tolerant （IT） phase, and 55 CHB patients were enrolled between August 2015 and May 2017. The peripheral blood samples were collected from all individuals. Tile levels of interferon （IFN）-α2, interleukin （IL）-10, transforming growth factor （TGF）-β1, HBV-DNA, HBsAg, and HBeAg and liver function were measured. The quantitative determinations of cytokines levels, including I FN-ct2, IL-10, and TGF-[31 were performed using Luminex multiplex technology. The correlation of cytokines to ALT, HBV-DNA, HBsAg, and HBeAg was analyzed by linear regression analysis. Results： IFN-ct2 levels were similar between HI and IT groups （15.35 [5.70, 67.65] pg/ml vs. 15.24 [4.07, 30.73] pg/ml, Z = -0.610, P - 0.542）, while it elevated significantly in CH B group （35.29 [ 15.94, 70.15] pg/ml vs. 15.24 [4.07, 30.73] pg/ml; Z = -2.522, P = 0.012）. Compared with HI group （3.73 [2.98, 11.92] pg/ml）, IL-10 concentrations in IT group （5.02 [2,98, 10.11] pg/ml）, and CHB group （7.48 [3. I 0, 18.00] pg/ml） slightly increased （X^2 = 2.015, P - 0.365）, and there was no significant difference between IT and CHB group （Z =- 1.419, P = 0.156）. The TGF-β1 levels among HI （3.59 ±0.20 pg/ml）, IT （3.62 ±0.55 pg/ml）, and CHB groups （3.64±0.30 pg/ml） were similar （X^2=2.739, P = 0.254）. In all chronic HBV-infected patients （including patients in IT and CHB groups）, the elevation of IFN-α2 level was significantly associated with ALT level （β = 0.389, t = 2.423, P = 0.018）, and was also negatively correlated to HBV-DNA load （β = -0.35

关键词： Chronic Hepatitis B Hepatitis B Virus Deoxyribonucleic Acid Hepatitis B Virus Surface Antigen Intertferon-α2: lnterleukin- 10

Plasmacytoid Dendritic Cell Function and Cytokine Network Profiles in Patients with Acute or Chronic Hepatitis B Virus Infection

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Chinese Medical Journal 2018年第1期131卷 43-49页

作者： Ming-hui Li Lu zhang Dan zhang wei-hua Cao Tian-Lin Qi Hong-Xiao Hao Xing-Yue wang Chong-Ping Ran Xiao-jing Qu Shun-Ai liu yao Lu Ge Shen Shu-Ling Wu Min Chang Ru-Yu liu Lei-Ping hu Wen-Hao hua Gang wan Jun Cheng yao xie Liver Diseases Center Beijing Ditan Hospital Capital Medical University Beijing 100015 China Institute of Infectious Diseases Beijing DitanHospitai Capital Medical University Beijing 100015 China Clinical Test Center Beijing Ditan Hospital Capital Medical University Beijing 100015 China

Background： Plasmacytoid dendritic cells （pDCs） and cytokines play an important role in occurrence and recovery of hepatitis B virus （HBV） infection. The aim of this study was to explore the frequency and function ofpDC and serum cytokine network profiles in patients with acute or chronic HBV infection. Methods： The healthy individuals （HI group）, hepatitis B envelope antigen （HBeAg）-positive chronic HBV patients in immune tolerance （IT） phase （IT group）, HBeAg-positive chronic HBV patients （CHB group）, and acute HBV patients （AHB group） were enrolled in this study. The frequency of cluster of differentiation antigen 86 （CD86）＋ pDC and the counts of CD86 molecular expressed on surface ofpDC were tested by flow cytometer. The quantitative determinations ofcytokines, including Fins-like tyrosine kinase 3 ligand （FIt-3L）, interferon （1FN）-α2, IFN-γ, interleukin （IL）-17A, IL-6, IL-10, transforming growth factor （TGF）-β1 and TGF-β2, were performed using Luminex multiplex technology. Results： In this study, there were 13 patients in HI group, 30 in IT group, 50 in CHB group, and 32 in AHB group. Compared with HI group, HBV infected group （including all patients in IT, CHB and AHB groups） had significantly higher counts of CD86 molecular expressed on the surface ofpDC （4596.5 ± 896.5 vs. 7097.7 ± 3124.6; P 〈 0.001）. The counts of CD86 molecular expressed on the surface of pDC in CriB group （7739.2 ±4125.4） was significantly higher than that of IT group （6393.4 ± 1653.6, P=0.043）. Compared with IT group, the profile of cytokines of FIt-3L, IFN-γ, and IL-17A was decreased, IFN-α2 was significantly increased （P =0.012） in CH B group. The contents of IL-10, TGF-{31, and TGF-132 in AHB group were significantly increased compared with IT and CHB groups （all P 〈 0.05）. Conclusions： This study demonstrated that the function of pDC was unaffected in HBV infection. The enhanced function of pDC and IFN-α2 might involve triggering the immune response from IT to hepatitis active phase

关键词： Acute Hepatitis B Virus Infection Chronic Hepatitis B Virus Infection Interferon-α2 Interleukin-10 PlasmacytoidDendritic Cells

Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-human Primates

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Virologica Sinica 2021年第5期36卷 879-889页

作者： Yan-Feng yao ze-Jun wang Ren-Di Jiang Xue hu hua-Jun zhang Yi-Wu Zhou Ge Gao Ying Chen Yun Peng Mei-Qin liu Ya-Nan zhang Juan Min Jia Lu Xiao-Xiao Gao jing Guo Cheng Peng Xu-Rui Shen Qian Li Kai Zhao Lian Yang Xin wan Bo zhang Wen-hui wang Jia Wu Peng Zhou Xing-Lou Yang Shuo Shen Chao Shan Zhi-Ming Yuan Zheng-Li Shi Center for Biosafety Mega-Science Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China Wuhan Institute of Biological Products Co.Ltd Jiangxia DistrictWuhan 430024China University of Chinese Academy of Sciences Beijing 100049China Department of Forensic Medicine Tongji Medical College of Huazhong University of Science and TechnologyWuhan 430074China Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China

The ongoing coronavirus disease 2019(COVID-19)pandemic caused more than 96 million infections and over 2 million deaths worldwide so ***,there is no approved vaccine available for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the disease causative *** is the most effective approach to eradicate a *** tests of safety and efficacy in animals are pivotal for developing a vaccine and before the vaccine is applied to human *** we evaluated the safety,immunogenicity,and efficacy of an inactivated vaccine based on the whole viral particles in human ACE2 transgenic mouse and in non-human *** data showed that the inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in mice and non-human primates,and subsequently provided partial(in low dose)or full(in high dose)protection of challenge in the tested *** addition,passive serum transferred from vaccine-immunized mice could also provide full protection from SARS-CoV-2 infection in *** results warranted positive outcomes in future clinical trials in humans.

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Inactivated vaccine Transgenic mouse Non-human primate