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Influence of irbesartan on expression of ILK and its relationship with epithelial-mesenchymal transition in mice with unilateral ureteral obstruction

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Acta Pharmacologica Sinica 2007年第11期28卷 1810-1818页

作者： Bi-cheng liu~1,Hui-ling XIA,Ji-ning WU,Xiao-liang ZHANG,Dian-ge liu,Yu-xiang GONGInstitute of Nephrology,Zhong Da Hospital,Southeast University.Nanjing 210009,China ute of Nephrology Zhong Da Hospital Southeast University Nanjing 210009 China. liubc64@***.

Aim:Irbesartan,a new antagonist of the type Ⅰ angiotensin Ⅱ receptor,has beenproven to be renal protective in both diabetic and non-diabetic nephropathy,butits exact mechanism is still *** we investigated the influence ofirbesartan on the expression of the integrin-linked kinase (ILK) and its relation-ship with epithelial-mesenchymal transition (EMT) in mice with unilateral ureteralobstruction (UUO).Methods:The mice were randomly divided into 3 groups:sham operation (C,n=20),UUO (n=40),and UUO with irbesartan treatment(UUO+irbesartan,n=40).Irbesartan was given at a dose of 50 mg/kg body weightper day by *** experimental animals in the control group received thesame volume of vehicle (0.9% saline solution).The animals were sacrificed at d 1,3,7,and 14,respectively,after the ***:The expression of the ILK atmRNA and protein levels were significantly increased in the UUO group 1 d afterthe surgery,which was significantly decreased by treatment with irbesartan (P<0.01,respectively).The expression of α-smooth muscle actin (α-SMA) was sig-nificantly increased,while E-cadherin was decreased in mice with UUO at d 3 afterthe *** with irbesartan significantly abrogated such effects (P<0.01).The immunohistochemistry analysis indicated that the protein expressionof the ILK was positively correlated with α-SMA,but negatively with ***:These results suggested that irbesartan attenuated renaltubulointerstitial fibrosis in UUO mice,which may be related to the inhibition ofILK expression,subsequently preventing the tubular EMT.

关键词： irbesartan integrin-linked kinase epithelialmesenchymal transition tubulointerstitial fibrosis

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不同电导率盐碱土壤固碳潜力

中国环境科学 2022年第9期42卷 4362-4368页

作者：刘宇斌焦燕杨文柱张婧王艳灵灵内蒙古自治区环境化学重点实验室内蒙古呼和浩特010022 内蒙古师范大学化学与环境科学学院内蒙古呼和浩特010022

采集内蒙古河套灌区盐碱土壤(电导率EC为0.27mS/cm),利用NaCl调节土壤电导率为(0,10,20,40,80mS/cm),基于稳定碳同位素分析不同电导率土壤添加定量δ^(13)C-CO_(2)后,土壤CO_(2)吸收量以及土壤难溶性无机碳含量(SIC)-δ^(13)C值.结果表... 详细信息

采集内蒙古河套灌区盐碱土壤(电导率EC为0.27mS/cm),利用NaCl调节土壤电导率为(0,10,20,40,80mS/cm),基于稳定碳同位素分析不同电导率土壤添加定量δ^(13)C-CO_(2)后,土壤CO_(2)吸收量以及土壤难溶性无机碳含量(SIC)-δ^(13)C值.结果表明,盐碱土壤能够吸收CO_(2),随土壤电导率(EC)升高,土壤CO_(2)累积吸收量增加,S5(EC=80mS/cm)CO_(2)累积吸收量比S1(0.27mS/cm)高1.6640mg.土壤SIC含量(R^(2)=0.7080,P<0.05)和土壤可溶性无机碳含量(DIC)(R^(2)=0.6096,P<0.05)与土壤EC显著负相关关系.盐碱土壤吸收CO_(2)部分固存于土壤无机碳中,外源添加δ^(13)C-CO_(2),盐碱土壤SIC-δ^(13)C值(-5.299‰~-0.8341‰)显著增加.EC为20mS/cm土壤固相保存δ^(13)C-CO_(2)总量最高1.276mg,固存δ^(13)C-CO_(2)总量占土壤吸收^(13)CO_(2)总量比例30.28%最高;EC为80mS/cm固碳量最低为0.2749mg,固存δ^(13)C-CO_(2)总量占土壤吸收^(13)CO_(2)总量比例5.579%.

关键词：盐碱土固碳潜力碳吸收碳汇碳同位素土壤

A novel, recovery, and reproducible minimally invasive cardiopulmonary bypass model with lung injury in rats

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Chinese Medical Journal 2013年第24期126卷 4715-4719页

作者： LI ling-ke CHENG Wei liu Dong-hai ZHANG Jing ZHU Yao-bin QIAO Chen-hui ZHANG Yan-bo Department of Cardiovascular Surgery Air Force General HospitalBeijing 100142 China Department of Emergency Shanghai Tongji Hospital Shanghai200065 China Department of Cardiovascular Surgery First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450052 China Department of Pediatric Heart Center Beijing Anzhen HospitalCapital Medical University Beijing 100029 China Department of Pediatric Heart Center State Key Laboratory ofCardiovascular Disease Fuwai Hospital National Center forCardiovascular Disease Chinese Academy of Medical Sciences andPeking Union Medical College Beijing 100037 China

Background Cardiopulmonary bypass （CPB） has been shown to be associated with a systemic inflammatory response leading to postoperative organ dysfunction. Elucidating the underlying mechanisms and developing protective strategies for the pathophysiological consequences of CPB have been hampered due to the absence of a satisfactory recovery animal model. The purpose of this study was to establish a good rat model of CPB to study the pathophysiology of potential complications. Methods Twenty adult male Sprague-Dawley rats weighing 450-560 g were randomly divided into a CPB group （n=10） and a control group （n=10）. All rats were anaesthetized and mechanically ventilated. The carotid artery and jugular vein were cannulated. The blood was drained from the right atrium via the right jugular and transferred by a miniaturized roller pump to a hollow fiber oxygenator and back to the rat via the left carotid artery. Priming consisted of 8 ml of homologous blood and 8 ml of colloid. The surface of the hollow fiber oxygenator was 0.075 m~. CPB was conducted for 60 minutes at a flow rate of 100-120 ml. kg-1. min-1 in the CPB group. Oxygen flow/perfusion flow was 0.8 to 1.0, and the mean arterial pressure remained 60-80 mmHg. Blood gas analysis, hemodynamic investigations, and lung histology were subsequently examined. Results All CPB rats recovered from the operative process without incident. Normal cardiac function after successful weaning was confirmed by electrocardiography and blood pressure measurements. Mean arterial pressure remained stable. The results of blood gas analysis at different times were within the normal range. Levels of IL-113 and TNF-a were higher in the lung tissue in the CPB group （P 〈0.005）. Histological examination revealed marked increases in interstitialcongestion, edema, and inflammation in the CPB group. Conclusion This novel, recovery, and reproducible minimally invasive CPB model may open the field for various studies on the pathophysiological proces

关键词： lung injury cardiopulmonary bypass model rats animal model

Diffuse panbronchiolitis in China:analysis of 45 cases

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Chinese Medical Journal 2007年第22期120卷 2046-2048页

作者： DING Ke liu Miao-bing WU Jin-ling MA Hui-qing FANG Xiang-yang MIAO Guo-bin ZHANG Lin Department of General Practice Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China

Diffuse panbronchiolitis （DPB） is a relatively recently recognized, idiopathic progressive disease, originally described-in Japan in 1969. It has distinctive clinicopathological features characterized by chronic pulmonary inflammation in the respiratory bronchioles of the lung and paranasal sinuses. It has been reported more extensively among Japanese than other ethnic populations. The first case of DPB in China was reported in 1996. Since then, an increasing number of cases have been described, which suggest that this disease may not be rare in China.

关键词： diffuse panbronchiolitis macrolides

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基于熵权云模型的精细化工园区脆弱性评价

安全与环境学报 2023年第1期23卷 1-7页

作者：刘丹孙晓云王喆范铃铃武汉理工大学中国应急管理研究中心武汉430070 武汉理工大学安全科学与应急管理学院武汉430070

为防范精细化工园区事故风险,提出了基于熵权-云模型的脆弱性评价方法。首先,引入物料的脆弱性,构建“人员、设施、物料、环境”4个维度的脆弱性评估指标体系,其次采用熵权法确定评价指标权重,运用云模型对精细化工园区进行脆弱性等级评... 详细信息

为防范精细化工园区事故风险,提出了基于熵权-云模型的脆弱性评价方法。首先,引入物料的脆弱性,构建“人员、设施、物料、环境”4个维度的脆弱性评估指标体系,其次采用熵权法确定评价指标权重,运用云模型对精细化工园区进行脆弱性等级评价,最后以3个典型的精细化工园区为例开展实例分析,验证方法的合理性与有效性。结果表明:所采用的先逆向后正向正态云发生器,能够有效将定性概念和定量数据相互转换;脆弱性从大到小依次为响水化工园区、杭州湾上虞经济技术开发区、连云港化学工业园区;人员素质、物料存放、园区选址、园区内企业布局是研究脆弱性最重要的影响因素。

关键词：安全工程精细化工园区脆弱性熵权法云模型

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基于Monte-Carlo方法的耳垂动态光谱检测研究

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光学精密工程 2006年第5期14卷 816-821页

作者：李刚刘玉良林凌王焱天津大学精仪学院天津300072

选择耳垂作为测量部位,建立了多层耳垂组织仿真模型,利用Monte-Carlo方法研究了不同光源特性(光束半径,入射能量大小及分布等)及模型参数下耳垂组织模型的光透射能量及分布规律,由透射光能量分布、光电二极管光敏面积和探测灵敏度推出... 详细信息

选择耳垂作为测量部位,建立了多层耳垂组织仿真模型,利用Monte-Carlo方法研究了不同光源特性(光束半径,入射能量大小及分布等)及模型参数下耳垂组织模型的光透射能量及分布规律,由透射光能量分布、光电二极管光敏面积和探测灵敏度推出特定测量信噪比要求的入射光能量。研究结果表明,耳垂组织的实际入射光能量能够满足动态光谱检测的要求,获得了更高的动态光谱测量精度,可满足动态光谱法的血液成分检测的要求。

关键词：动态光谱法组织模型耳垂 Monte-Carlo法

Ethnic Differences in Body Mass Index and Prevalence of Obesity in School Children of Urumqi City, Xinjiang, China

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Biomedical and Environmental Sciences 2006年第6期19卷 469-473页

作者： WEI-LI YAN YU-JIAN ZHENG JUN WU SHU-FENG CHEN XIAO-KAI TI ling LI XIAO-RUI liu School of Public Health Xinjiang Medical University Urumqi 830054 Xinjiang China Division of Population Genetics and Prevention Fuwai Hospital Peking Union Medical College ＆ Chinese Academy of Medical Science 167 Beilishi Road Beijing 100037 China the Health Care Center for Primary and Senior School Students Urumqi 830002 Xinjiang China

Objective To investigate the prevalence of obesity and distribution of body mass index （BMI） in school children of four ethnic groups in Urumqi, Xinjiang, China. Methods A total of 55 508 school children of Han, Hui, Uygur and Kazak nationalities aged 8-18 years were selected by a cluster sampling from a districts of Urumqi City for anthropometrie measurement and demographic survey. Prevalence of obesity and overweight and distribution of body mass index （BMI） by gender, age, and nationality were analyzed and compared. Cutoff points of BMI for defining obesity and overweight were based on the proposal set by the Working Group on Obesity in China （WGOC） to assess age-, gender- and nationality-specific prevalence of obesity and overweight. Results Prevalence of obesity was 5.34%, 6.78%, 3.39 %, and 1.22% for boys and 2.61%, 1.83%, 1.78%, and 1.40% for girls of Han, Hui, Uygur and Kazak nationalities, respectively. Prevalence of obesity tended to decrease with age overall, whereas that of overweight increased with age in Han children. Conclusions Prevalence of obesity in school children in Urumqi varies with their nationalities and is lower than that of an average national level and a level of western countries. Obesity is more prevalent in boys than in girls of Urmuqi overall, which is just the opposite in Kazak children. Han boys and Hui girls have the highest prevalence of obesity and Kazak boys and girls have the lowest ones. Prevalence of obesity decreases with age, but that of overweight shows a different trend.

关键词： Child Obesity Overweight Ethnicity Body mass index

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全应变梯度挠曲电纳米梁有限单元法研究

计算力学学报 2020年第5期37卷 545-552页

作者：陈玲玲杨旭刘洋王炳雷山东大学土建与水利学院工程力学系济南250061

挠曲电效应是一种存在于所有电介质材料中的特殊的力电耦合效应,本质上是应变梯度与电极化之间的线性耦合。然而,应变梯度会引入位移的高阶偏量,常给挠曲电问题的理论求解带来困难。且已有研究表明应变梯度弹性项会影响纳米结构中的力... 详细信息

挠曲电效应是一种存在于所有电介质材料中的特殊的力电耦合效应,本质上是应变梯度与电极化之间的线性耦合。然而,应变梯度会引入位移的高阶偏量,常给挠曲电问题的理论求解带来困难。且已有研究表明应变梯度弹性项会影响纳米结构中的力电耦合响应,但是现有的挠曲电研究大多忽略了应变梯度弹性的影响。因此,本文提出了一种既考虑应变梯度弹性,又考虑挠曲电效应的有效数值方法。基于全应变梯度弹性理论,建立了包含3个独立材料尺度参数的纳米欧拉梁的理论模型和有限元模型,提出了满足C2弱连续的两节点六自由度单元。基于本文的有限单元法,以简支欧拉梁为例,通过分析讨论挠度、电势和能量效率,得到了挠曲电效应和应变梯度弹性项对梁的力电响应的影响。结果表明,挠曲电效应存在尺寸依赖性,且应变梯度弹性项在纳米电介质结构的挠曲电研究中的影响不可忽略。

关键词：挠曲电效应全应变梯度弹性理论有限单元法欧拉梁尺寸依赖性

Changes in human sperm motility and DNA fragmentation index after incubation at different temperatures following density gradient centrifugation and swim-up procedures

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Reproductive and Developmental Medicine 2022年第4期6卷 243-248页

作者： Yan-Nan Yang ling Wang Yu-Bing liu Yun-Jing Xue Chen-Chen liu Fei Shi Xue Dai Ri-Cheng Chian Center for Reproductive Medicine Shanghai 10th People’s Hospital of Tongji UniversityShanghai 200072China

Objective:The purpose of this study was to evaluate the sperm motility and DNA integrity at different temperatures to analyze whether the sperms are suitable on the second day for insemination of in vitro matured oocytes by intra-cytoplasmic sperm injection(ICSI)following density gradient centrifugation(DGC)and swim-up(SU)***:Semen samples were collected from 30 outpatients who visited the Center for Reproductive Medicine for semen *** sperm selection by DGC and SU procedures,the liquified semen samples were divided into three groups and incubated at 4,25,and 37°C,*** incubation for 24,48,and 72 hours,the sperm motility and sperm DNA fragmentation index(DFI)were ***:Following the combination of DGC and SU procedures,the sperm motility(91.8%±8.6%vs.50.8%±13.1%)and DFI(5.1%±7.9%vs.13.0%±11.6%)were significantly improved(P<0.01)compared to those without any *** sperm motility of the 3 groups significantly declined(P<0.05)post-incubation compared to that of the groups prior ***,sperm motility significantly increased(76.9%±10.4%)(P<0.05)at 25°C compared to that of the other 2 groups(53.5%±11.0%and 47.6%±10.2%).Sperm DFI significantly increased(P<0.05)at 37°C following incubation for 24 and 72 hours in comparison to that of the other 2 ***,the sperm DFI did not significantly increase when the sperm samples were incubated at 4(5.7%±5.9%)and 25°C(6.8%±5.6%)for 24 hours compared to that before incubation(5.1%±7.9%).Conclusions:These results indicate that the sperm quality,in terms of motility and DFI,can be efficiently improved by DGC in combination with *** which,the sperm samples can be incubated at 25°C and be used on the second day for insemination of in vitro matured oocytes by ICSI.

关键词： Sperm motility Density gradient centrifugation Swim-up DNA fragmentation index matured oocytes