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Motion-based pH sensing using spindle-like micromotors

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Nano Research 2016年第5期9卷 1310-1318页

作者： limei liu Yonggang Dong Yunyu Sun Mei liu Yajun Su Hui Zhang Bin Dong Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices and Collaborative Innovation Center (CIC) of Suzhou Nano Science and Technology Soochow University Suzhou 215123 China

In this study, we report a spindle-like micromotor. This device, which is fabricated using a one-step electrospinning method, consists of biodegradable polycaprolactone and an anionic surfactant. Intriguingly, not only can the resulting micromotor move autonomously on the surface of water for a long period of time （-40 min） due to the Marangoni effect, but it also exhibits a pH sensing behavior due to variations in the surface tension caused by the release of surfactant under different pH conditions. More interestingly, we reveal that the motion-based pH sensing property is size-dependent, with smaller structures exhibiting a higher sensitivity. In addition, since polycaprolactone is a biode- gradable material, the micromotor described in this study can be easily degraded in solution. Hence, features such as one-step fabrication, motion readout, and biodegradability render this micromotor an attractive candidate for sensing algplications.

关键词： micromotor autonomous movement self-propelling motion-based sensing

Dual-Fuel-Driven Bactericidal Micromotor

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Nano-Micro Letters 2016年第2期8卷 157-164页

作者： Ya Ge Mei liu limei liu Yunyu Sun Hui Zhang Bin Dong Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices and Collaborative Innovation Center (CIC) of Suzhou Nano Science and Technology Soochow University

In this paper, we report fabrication of the bimetallic Janus microsphere, a magnesium microsphere with a silver surface coating, through thermal evaporation technique. Because of the Janus structure, this micromotor can be propelled in two different directions by the surface silver or magnesium ‘engine' and hydrogen peroxide or water fuel. In addition, due to the bactericidal property of silver, this autonomous micromotor is capable of killing bacteria in solution. As compared to the static one, the micromotor is able to kill the bacteria at a much faster rate(about nine times of that of the static one),demonstrating the superiority of the motion one. We thus believe that the micromotor shown in the current study is potentially attractive for the environmental hygiene applications.

关键词： Micromotor Self-propelling Bacterial killing Janus E.coli

Busuishengxue ranules mediate their effects upon non-severe aplastic anemia via mitogen-activated protein kinase/extracellular signal-regulated kinase pathway

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Journal of Traditional Chinese Medicine 2014年第1期34卷 23-29页

作者： Jinhuan Wang Feng Sun Weizheng Sun Yanli Yong Haitao Shi Sijia liu limei liu Department of Hematology First Affiliated HospitalHeilongjiang University of Chinese Medicine Department of Traditional Chinese Medicine Longnan Hospital of Daqing City Department of Encephalopathy Chinese Medicine Hospital of Harbin Renal Department of Internal Medicine Heilongjiang Provincial Academy of Traditional Chinese Medicine

OBJECTIVE:To observe the clinical efficacy of Busuishengxue granules on non-severe aplastic anemia(NSAA)and investigate its effect on the mitogen-activated protein kinase/extracellular signal-regulated kinase(MAPK/ERK)***:Sixty NSAA patients were divided equally into two *** in the experimental group were treated with Busuishengxue granules,and the control group with Zaizaoshengxue *** treatment course was 6 months and cu-rative efficacy was compared between the two groups as well as with 10 healthy *** cytometry(FCM)was used to detect the intracellular concentration of Ca2+([Ca2+]i).Western blotting was employed to detect the expression of enzymes in the MAPK/ERK ***:The efficacy of Busuishengxue granules was significantly better than that of Zaizaoshengxue tablets(P<0.05).Before treatment,expression of JNK,phospho-ERK 1/2 and p-JNK was higher,and[Ca2+]i higher,than that of the control group(P<0.05).After treatment with Busuishengxue granules,expression of all enzymes related to signal transduction pathways in the blood cells of NSSA patients were altered to different ***:Busuishengxue granules had a better effect with regard to improving symptom scores,increasing the number of blood leukocytes,and increasing hemoglobin levels than Zaizaoshengxue tablets,and they differed slightly in terms of increasing the number of platelets.

关键词： Anemia aplastic MAP kinase signaling system Busuishengxue granule Zaizaoshengxue tablet

Effect of esculetin on bone metabolism in ovariectomized rats

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Journal of Traditional Chinese Medicine 2018年第6期38卷 896-903页

作者： liu Meijie Wang Ruihai Li Yan Bai Dong Pan Jinghua liu Hong Wang Shaojun Wu Jiaying Sun Gang Miao Qing Ju Dahong liu limei Bone and Joint Diseases Laboratory Experimental Research CenterChina Academy of Chinese Medicine Science 100700China The Basic Research Center of Recipe and Syndrome in Traditional Chinese Medicine Institute of Basic Theory for Chinese MedicineChina Academy of Chinese Medicine ScienceBeijing 100700China

OBJECTIVE: To determine the effect of an esculetin formulation(at 97.4% purity) on osteoporosis, and to investigate the potential underlying molecular mechanism(s).METHODS: Sixty specific pathogen free-grade female Wistar rats were randomly assigned to three groups: blank control(n = 12), sham(n = 12), and model(n = 36). The model group were bilaterally ovariectomized. The sham group had the tissue surrounding the ovaries removed, while the ovaries were retained. After 3 months, the model group was randomly divided into three subgroups: OVX(n = 12), positive control(n = 12), and esculetin(n =12). The positive control group and the esculetin group were intragastrically administered diethylstilbestrol(0.046 mgkd^(-1)), respec·kg^(-1)tively,·d^(-1)) or esculetin(384 mgg^(-1) once per day for 6 consecu··-tive days; medication administration was then stopped for 1 d, before being administered for another 6 consecutive days. All rats were treated for 3months. Samples were collected at the end of the treatment period. An Osteocore3 Digital 2D bone densitometer was used to test the bone mineral density, and histomorphometric analysis was performed to measure bone mass, bone formation,and bone resorption. Enzyme-linked immunosorbent assay analysis was used to measure the serum concentrations of interleukin-6(IL-6), osteoprotegerin(OPG), and receptor activator of nuclear factor-kappa B ligand(RANKL). Immunohistochemistry and in situ hybridization were performed to detect the protein and mRNA expressions of OPG and RANKL in osteoblasts and bone marrow stromal ***: Compared with the OVX group, the esculetin group had significantly greater femoral bone mineral density and tibial trabecular bone volume,and significantly smaller trabecular resorption surface. The percentage of trabecular formation surface, average osteoid width, trabecular bone mineralization rate, and cortical bone mineralization rate did not significantly differ between groups. Compared with the sham g

关键词： Esculetin Osteoporosis Osteoprotegerin RANK ligand Bone resorption

Entrapment of Inclusions in Diamond Crystals Grown from Fe-Ni-C System

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Journal of Materials Science & Technology 2002年第2期18卷 171-172页

作者： Yuxian liu, limei XIAO and Longwei YINCollege of Materials Science and Engineering, Shandong University, Jinan 250061, China [ Manuscript received June 28, 2001, in revised form October 18, 2001] Coll. of Mat. Sci. and Eng. Shandong Univ. Jinan 250061 China

Diamond single crystals grown from Fe-Ni-C system at high temperature-high pressure (HPHT) usually contain inclusions related to the metallic catalyst. During the diamond growth, the metallic inclusions are trapped by the growth front or are formed through reaction between the contaminants trapped in the diamond. In the present paper, the metallic inclusions related to the catalyst were systematically examined by transmission electron microscopy (TEM). The chemical composition and crystal structure of the metallic inclusions were for the first time determined by selected area electron diffraction pattern (SADP) combined with energy dispersive X-ray spectrometry (EDS). It is shown that the inclusions are mainly composed of orthorhombic FeSi2, fcc (FeNi)23C6, and orthorhombic Fe3C, hexagonal Ni3C.

关键词： Synthetic diamond Fe-Ni-C system Inclusion Transmission electron microscopy

Intelligent Predictive Analysis of the Performance Level of Discipline Construction in Local Universities Based on Grey Prediction

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Intelligent Predictive Analysis of the Performance Level of ...

Microstructure and wear resistance of PTA clad Cr7C3/γ-Fe ceramal composite coating

作者： limei liu Xiuling Li School of Applied Mathematics Jilin University of Finance and Economics

In order to overcome the difficulties in measurement data collecting of the performance level of discipline construction in local universities,GM（1,1） grey prediction model was used to predict and analyze the performance level of discipline construction in local universities,which combined with the general performance indicator system of discipline *** research shows that to improve the performance level of discipline construction,we must strengthen the construction of teaching staff,ensure sufficient and high-quality teaching resources,optimize the process of personnel training,promote the development of students,strengthen quality supervision and guarantee,enhance the scientific research ability and awareness of teachers and students,clarify the orientation and goals of universities and actively promote the economic and social development of the country and the region.

关键词： Discipline Construction Local Universities Performance Level Grey Prediction Intelligent Prediction

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Progress in Natural Science:Materials International 2006年第8期16卷 874-878页

作者： liu Junbo, WANG limei and HUANG Jihua (Weifang University, Weifang 261061, China School of Materials Science and Engineering, University of Science and Technology, Beijing 100083, China) Weifang University Weifang 261061 China School of Materials Science and Engineering University of Science and Technology Beijing 100083 China

A wear resistant Cr7C3/γ-Fe ceramal composite coating was fabricated on substrate of the hardening and tempering C degree steel by PTA (plasma transferred arc) cladding with (wt%) Fe-25Cr-7C elemental powder blends. Microstructure of the coating was characterized by OM, SEM, XRD and EDS. Wear resistance of the coating was tested under dry sliding wear condition at room temperature. The results indicate that the PTA clad ceramal composite coating has a rapidly solidified fine microstructure consisting of Cr7C3 primary particles uniformly distributed in theγ-Fe matrix and is metallurgically bonded to the C degree steel substrate. The PTA clad Cr7C3/γ-Fe ceramal composite coating has high hardness and excellent wear resistance under dry sliding wear test conditions. The excellent wear resistance of the Cr7C3/γ-Fe ceramal composite coating is attributed to the coating's high hardness, strong covalent atomic bonding and refined microstructure.

关键词： PTA clad Cr7C3/γ-Fe composite coating microstructure wear resistance.

基于改进的粒子群优化的FastSLAM方法

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高技术通讯 2011年第4期21卷 422-427页

作者：刘利枚蔡自兴中南大学信息科学与工程学院智能系统与智能软件研究所长沙410083 湖南商学院计算机与电子工程学院长沙410205

提出了一种基于改进的粒子群优化（IPSO）的快速同时定位和地图创建（FastSLAM）方法——IPSO FastSLAM算法。该算法在粒子预估过程中引入观测信息，调整了粒子的提议分布，增强了位置预测的准确性。改进的粒子群优化采用两步优化策略... 详细信息

提出了一种基于改进的粒子群优化（IPSO）的快速同时定位和地图创建（FastSLAM）方法——IPSO FastSLAM算法。该算法在粒子预估过程中引入观测信息，调整了粒子的提议分布，增强了位置预测的准确性。改进的粒子群优化采用两步优化策略，即首先通过种群速度自适应调整惯性权重，有效地克服了粒子退化问题，改善了算法的实时性，然后针对粒子耗尽问题，在粒子群优化算法中引入遗传算法的变异运算对其进行改进，扩大解空间的范围，从而保持了种群的多样性。仿真和实时数据实验验证了该方法正确、可行。

关键词：粒子群优化(PSO) 快速同时定位和地图创建(FastSLAM) 惯性权重遗传算法提议分布

Researches on New Fault Diagnosis Method for Process Industry Based on Improved SVM Reduction Algorithm

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Researches on New Fault Diagnosis Method for Process Industr...