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Journal of Advanced Ceramics 2023年第12期12卷 2149-2246页

作者： Mobashar Hassan Siwei liu Zhiping Liang Shahid Hussain junlin liu Guiwu liu Guanjun Qiao School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China

Two-dimensional nanomaterials(2DNMs)have attracted significant research interest due to their outstanding structural properties,which include unique electrical nanostructures,large surface areas,and high surface *** adaptable materials have outstanding physicochemical characteristics,making them useful in a variety of applications such as gas-sensing,electronics,energy storage,and *** research has been conducted in the pursuit of high performance room-temperature(RT)gas sensors with good selectivity,high sensitivity,long-term stability,and rapid response/recovery *** oxides,transition metal chalcogenides,MXenes,graphene,phosphorene,and boron nitride have all been discovered as 2DNMs with strong potential for gas *** review presents an in-depth analysis of current advances in 2DNM *** includes synthetic techniques,structural stabilities,gas-sensing mechanisms,critical performance parameters,and factors influencing gas-sensing capabilities of ***,the present study emphasizes structural engineering and optimization methodologies that improve gas-sensing *** also highlights current challenges and outlines future research directions in the domain of tailoring 2DNMs for advanced RT gas *** systematically designed comprehensive review article aims to provide readers with profound insights into gas detection,thereby inspiring the generation of innovative ideas to develop cutting-edge 2DNMs-based gas sensors.

关键词： 2D nanomaterials synthetic strategies structural stability gas-sensing mechanism

Comprehensive Innovation Path of Marxism-Leninism in China in the Postmodern Cultural Context

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学术界 2016年第4期 293-297页

作者： liu junlin Zheng liuyun Dai Jiabao Office of Enrollment and Employment Xi'an Medical University Marxist College Jishou University

The comprehensive understanding of Chinese spirit of innovation is the major developing trend in the postmodern cultural context at this *** localization of Marxism- Leninism in China not only reproduces the external characteristics of foreign thoughts and culture but also seeks the integration of *** paper discusses it from three aspects:the features and trend of postmodern cultural context,the comprehensive innovation path of Marxism- Leninism in China and the comprehensive innovation path of Marxism- Leninism in China in postmodern cultural *** theoretical innovation of Marxism- Leninism in China should be integrated into practice rationally with a focus on the application and developing trend of archetypal theory generated in the postmodern cultural context in the comprehensive innovation path of Marxism-Leninism in China.

关键词： postmodern culture Marxism-Leninism innovation path

Computing Power Network:A Survey

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China Communications 2024年第9期21卷 109-145页

作者： Sun Yukun Lei Bo liu junlin Huang Haonan Zhang Xing Peng Jing Wang Wenbo School of Information and Communications Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China Research Institute of China Telecom Co. Ltd.Beijing 102209China Beijing Branch of China Telecom Co. Ltd.Beijing 100032China

With the rapid development of cloud computing,edge computing,and smart devices,computing power resources indicate a trend of ubiquitous *** traditional network architecture cannot efficiently leverage these distributed computing power resources due to computing power island *** overcome these problems and improve network efficiency,a new network computing paradigm is proposed,i.e.,Computing Power Network(CPN).Computing power network can connect ubiquitous and heterogenous computing power resources through networking to realize computing power scheduling *** this survey,we make an exhaustive review on the state-of-the-art research efforts on computing power *** first give an overview of computing power network,including definition,architecture,and ***,a comprehensive elaboration of issues on computing power modeling,information awareness and announcement,resource allocation,network forwarding,computing power transaction platform and resource orchestration platform is *** computing power network testbed is built and *** applications and use cases in computing power network are ***,the key enabling technologies for computing power network are ***,open challenges and future research directions are presented as well.

关键词： computing power modeling computing power network computing power scheduling information awareness network forwarding

Correlation between the gut microbiome and neurodegenerative diseases:a review of metagenomics evidence

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Neural Regeneration Research 2024年第4期19卷 833-845页

作者： Xiaoyan liu Yi liu junlin liu Hantao Zhang Chaofan Shan Yinglu Guo Xun Gong Mengmeng Cui Xiubin Li Min Tang School of Life Sciences Jiangsu University Institute of Animal Husbandry Jiangsu Academy of Agricultural Sciences Department of Rheumatology&Immunology Affiliated Hospital of Jiangsu University Department of Neurology The Second Affiliated Hospital of Shandong First Medical University

A growing body of evidence suggests that the gut microbiota contributes to the development of neurodegenerative diseases via the microbiota-gut-brain *** a contributing factor,microbiota dysbiosis always occurs in pathological changes of neurodegenerative diseases,such as Alzheimer’s disease,Parkinson’s disease,and amyotrophic lateral ***-throughput sequencing technology has helped to reveal that the bidirectional communication between the central nervous system and the enteric nervous system is facilitated by the microbiota’s diverse microorganisms,and for both neuroimmune and neuroendocrine ***,we summarize the bioinformatics analysis and wet-biology validation for the gut metagenomics in neurodegenerative diseases,with an emphasis on multi-omics studies and the gut *** pathogen-associated signaling biomarkers for identifying brain disorders and potential therapeutic targets are also ***,we discuss the role of diet,prebiotics,probiotics,postbiotics and exercise interventions in remodeling the microbiome and reducing the symptoms of neurodegenerative diseases.

关键词： biomarker diet pattern gut microbiota gut-brain axis metagenomics mitochondrial dysfunction multi-omics neurodegenerative disease neuroinflammation probiotic

Multipliers on the Dirichlet Space for the Annulus

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Journal of Mathematical Research with Applications 2018年第2期38卷 169-182页

作者： Zelong CAO junlin liu Li HE Zhixin High School Department of Mathematics Guangzhou University

Multipliers on the classic Dirichlet space of the unit disk are much more complex than those on the Hardy space and the Bergman space, many basic problems have not been solved, such as the boundedness, which is still an open problem. The annulus, as a kind of typical complex connected domain, has more complicated function structure. This paper focuses on discussing the invertibility and Fredholmness of multipliers on the Dirichlet space of the annulus. The spectra and essential spectra of multipliers with Laurent polynomials symbols are calculated. In addition, we anwser a problem proposed by Guangfu CAO and Li HE on spectrum and essential spectrum for general multipliers.

关键词： annulus multiplier spectra essential spectra

Cartilage-inspired self-assembly glycopeptide hydrogels for cartilage regeneration via ROS scavenging

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Bioactive Materials 2024年第2期32卷 319-332页

作者： Zhijian Zhao Xiaowei Xia junlin liu Mingzhuang Hou Yang liu Zhangzhe Zhou Yong Xu Fan He Huilin Yang Yijian Zhang Changshun Ruan Xuesong Zhu Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou215006China Orthopaedic Institute Medical CollegeSoochow UniversitySuzhou215007China Center for Human Tissue and Organs Degeneration Institute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China University of Chinese Academy of Sciences Beijing100049China

Cartilage injury represents a frequent dilemma in clinical practice owing to its inherently limited self-renewal *** strategy-based engineered biomaterial,capable of coordinated regulation for cellular and microenvironmental crosstalk,provides an adequate avenue to boost cartilage *** level of oxidative stress in microenvironments is verified to be vital for tissue regeneration,yet it is often overlooked in engineered biomaterials for cartilage ***,inspired by natural cartilage architecture,a fibril-network glycopeptide hydrogel(Nap-FFGRGD@FU),composed of marine-derived polysaccharide fucoidan(FU)and naphthalenephenylalanine-phenylalanine-glycine-arginine-glycine-aspartic peptide(Nap-FFGRGD),was presented through a simple supramolecular self-assembly *** Nap-FFGRGD@FU hydrogels exhibit a native cartilage-like architecture,characterized by interwoven collagen fibers and attached *** structural simulation,fucoidan-exerted robust biological effects and Arg-Gly-Asp(RGD)sequence-provided cell attachment sites realized functional reinforcement,synergistically promoted extracellular matrix(ECM)production and reactive oxygen species(ROS)elimination,thus contributing to chondrocytes-ECM *** vitro co-culture with glycopeptide hydrogels not only facilitated cartilage ECM anabolic metabolism but also scavenged ROS accumulation in ***,the chondro-protective effects induced by glycopeptide hydrogels rely on the activation of endogenous antioxidant pathways associated with nuclear factor erythroid 2-related factor 2(NRF2).In vivo implantation of glycopeptide hydrogels successfully improved the de novo cartilage generation by 1.65-fold,concomitant with coordinately restructured subchondral bone ***,our ingeniously crafted bionic glycopeptide hydrogels simultaneously rewired chondrocytes’function by augmenting anabolic metabolism and rebuilt ECM microenvironment

关键词： Cartilage repair Self-assembly glycopeptide hydrogels Fucoidan ROS scavenging

Cryo-EM structure of cannabinoid receptor CB1-β-arrestincomplex

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Protein & Cell 2024年第3期15卷 230-234页

作者： Yuxia Wang Lijie Wu Tian Wang junlin liu Fei Li Longquan Jiang Zhongbo Fan Yanan Yu Na Chen Qianqian Sun Qiwen Tan Tian Hua Zhi-Jie liu iHuman Institute ShanghaiTech UniversityShanghai 201210China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Institute of Molecular and Clinical Medicine Kunming Medical UniversityKunming 650500China

Dear Editor,G protein-coupled receptors(GPCRs)play a vital role in regulating almost every aspect of human physiology,making up more than one-third of marketed drug targets(Santos et al.,2017).GPCRs orchestrate their signalling through interactions with three distinct downstream protein families:G proteins,G protein-coupled receptor kinases(GRKs),and arrestins(Santos et al.,2017).While G protein-mediated signalling is initiated upon GPCR stimulation,activated GPCRs return to their basal levels through a GRK-and arrestin-regulated desensitization process(Santos et al.,2017).In addition to modulating receptor desensitization,β-arrestin also regulates downstream events that are distinct from classical G protein signalling(Ahn et al.,2020).

关键词： stimulation return

The Study of Tubing Vibration Mechanism in High Pressure Gas Well

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World Journal of Engineering and Technology 2021年第1期9卷 128-137页

作者： Jingbing Luo Kui Zhang junlin liu Lingyu Mu Fujun Wang Research Institute on Drilling & Production of PetroChina Qinghai Oilfield Company Jiuquan China CNPC Engineering & Technology Research Institute Co. Ltd. Beijing China

Deep gas wells and gas fields have the characteristics of high pressure. The vibration of the tubing string during the production of gas wells causes the string to be subjected to severe stress and even dynamic fatigue failure. Therefore, this article is based on the dynamic finite element theory, aiming at the characteristics of large-size tubing strings in deep gas wells. The finite element mechanics model and mathematical model of the tubing string vibration of the packer of high-pressure gas wells were established, and the ANSYS software was re-developed. The finite element analysis program for the vibration dynamics of the unbuckled and buckled strings of gas wells was compiled with APDL, and the displacement of the longitudinal vibration of the tubing string of high-pressure gas wells was studied. According to different sizes of tubing strings currently used in deep gas wells and gas fields, simulation calculations are carried out, and the axial impact load and buckling damage laws of the tubing strings of the entire well section under different production rates are obtained. It provides a theoretical basis for the prediction of tubing string vibration law and measures to prevent tubing string vibration.

关键词： Deep Gas Well High Pressure Gas Well Tubing Vibration Damage Buckling Finite Element

In vitro expression and analysis of the 826 human G protein-coupled receptors

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Protein & Cell 2016年第5期7卷 325-337页

作者： Xuechen Lv junlin liu Qiaoyun Shi Qiwen Tan Dong Wu John J. Skinner Angela L. Walker Lixia Zhao Xiangxiang Gu Na Chen Lu Xue Pei Si Lu Zhang Zeshi Wang Vsevolod Katritch Zhijie liu Raymond C. Stevens iHuman Institute ShanghaiTech University Shanghai 201210 China Department of Biological Sciences Bridge Institute University of Southern California Los Angeles CA 90089 USA

G protein-coupled receptors （GPCRs） are involved in all human physiological systems where they are responsible for transducing extracellular signals into cells. GPCRs signal in response to a diverse array of stimuli including light, hormones, and lipids, where these signals affect downstream cascades to impact both health and disease states. Yet, despite their importance as therapeutic tar- gets, detailed molecular structures of only 30 GPCRs have been determined to date. A key challenge to their structure determination is adequate protein expression. Here we report the quantification of protein expression in an insect cell expression system for all 826 human GPCRs using two different fusion constructs. Expression char- acteristics are analyzed in aggregate and among each of the five distinct subfamilies. These data can be used to identify trends related to GPCR expression between dif- ferent fusion constructs and between different GPCR families, and to prioritize lead candidates for future structure determination feasibility.

关键词： G protein-coupled receptors insect,protein expression surface expression analysis fusionconstruct

Common-anode LED on a Si substrate for beyond 15 Gbit/s underwater visible light communication

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Photonics Research 2019年第9期7卷 1019-1029页

作者： YINGJUN ZHOU XIN ZHU FANGCHEN HU JIANYANG SHI FUMIN WANG PENG ZOU junlin liu FENGYI JIANG NAN CHI Department of Communication Science and Engineering Key Laboratory for Information Science of Electromagnetic Waves(MoE)Fudan UniversityShanghai 200433China National Institute of LED on Silicon Substrate Nanchang UniversityNanchang 330096China

Visible light communication based on light-emitting diodes(LEDs) has become a promising candidate by providing high data rates, low latency, and secure communication for underwater environments. In this paper,a self-designed common-anode GaN-based five-primary-color LED(RGBYC LED) on a Si substrate is proposed and fabricated. The design of a common anode is used to mitigate the saturation effect for a low-frequency component. Additionally, compared with commercially available LEDs that suffer from nonlinearity distortion,applying the designed LED can provide much better and broader linearity according to the measurement ***, the modulation depth and system performance can be further improved to implement a high-speed underwater visible light communication(UVLC) system. There is no nonlinearity compensation algorithm applied due to the good linearity of the proposed LED;thus, the offline digital signal processing is simplified. We experimentally demonstrate 14.81 Gbit/s 64 quadrature amplitude modulation(QAM)-discrete multitone(DMT)and 15.17 Gbit/s bit-loading-DMT transmissions through a 1.2-m-long underwater channel based on the proposed RGBYC LED with an intrasymbol frequency-domain averaging channel estimation and zero-forcing *** far as we know, this is the highest data rate for an LED-based UVLC system.

关键词： red QAM LED GaN Common-anode LED on a Si substrate for beyond 15 Gbit/s underwater visible light communication