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COVID-19:immunopathogenesis and Immunotherapeutics

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1327-1334页

作者： Li Yang Shasha liu jinyan liu Zhixin Zhang Xiaochun Wan Bo Huang Youhai Chen Yi Zhang Biotherapy Center The First Affiliated Hospital of Zhengzhou University450052 ZhengzhouChina Institute of Health Management Health Management CenterSichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of China611731 ChengduChina Shenzhen Laboratory of Human Antibody Engineering Institute of Biomedicine and BiotechnologyShenzhen Institutes of Advanced TechnologyChinese Academy of Sciences518055 ShenzhenChina Department of Immunology&National Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences(CAMS)&Peking Union Medical College100005 BeijingChina Department of Pathology and Laboratory Medicine School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA

The recent novel coronavirus disease(COVID-19)outbreak,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is seeing a rapid increase in infected patients *** host immune response to SARS-CoV-2 appears to play a critical role in disease pathogenesis and clinical ***-CoV-2 not only activates antiviral immune responses,but can also cause uncontrolled inflammatory responses characterized by marked pro-inflammatory cytokine release in patients with severe COVID-19,leading to lymphopenia,lymphocyte dysfunction,and granulocyte and monocyte *** SARS-CoV-2-induced immune abnormalities may lead to infections by microorganisms,septic shock,and severe multiple organ ***,mechanisms underlying immune abnormalities in patients with COVID-19 must be elucidated to guide clinical management of the ***,rational management of the immune responses to SARSCoV-2,which includes enhancing anti-viral immunity while inhibiting systemic inflammation,may be key to successful *** this review,we discuss the immunopathology of COVID-19,its potential mechanisms,and clinical implications to aid the development of new therapeutic strategies against COVID-19.

关键词： pathogenesis immunity clinical

Overcoming resistance to immunotherapy by targeting GPR84 in myeloid-derived suppressor cells

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2408-2422页

作者： Guohui Qin Shasha liu jinyan liu Hongwei Hu Li Yang Qitai Zhao Congcong Li Bin Zhang Yi Zhang Biotherapy Center and Cancer Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan450052China Department of Medicine-Division of Hematology/Oncology Feinberg School of Medicine Northwestern UniversityChicagoIL60611USA School of Life Sciences Zhengzhou UniversityZhengzhouHenan450001China Henan Key Laboratory for Tumor Immunology and Biotherapy ZhengzhouHenan450052China State Key Laboratory of Esophageal Cancer Prevention&Treatment Zhengzhou UniversityZhengzhouHenan450052China

Myeloid-derived suppressor cells(MDSCs)were found to gradually accumulate in the orthotopic esophageal cancer mouse model during tumor *** the roles of MDSCs in promoting tumor growth and inhibiting immune response have been extensively explored,currently,there are still no effective means for targeting MDSCs *** deficiency of specific markers of MDSCs was responsible for the limited strategy to eliminating in *** study identified that GPR84 was exclusively overexpressed on *** was further found that GPR84 was prominently expressed on MDSCs in clinical samples and tumor mouse models,which drives the immunosuppression on CD8^(+)T cells by inhibiting PD-L1 degradation in ***,G-CSF and GM-CSF were found to induce GPR84 expression through the STAT3/C/EBPβsignaling *** addition,GPR84+MDSCs and PD-L1^(+)MDSCs were highly accumulated in anti-PD-1 therapy-resistant patients with esophageal cancer,and high GPR84 signature risk was verified as a negative factor for the overall survival of patients with anti-PD-1 ***,GPR84 antagonism combined with an anti-PD-1 antibody enhanced the antitumor ***,targeting GPR84 enhanced anti-PD-1 efficacy in esophageal cancer and other malignant *** combination therapy has the potential for tumor therapy in clinics.

关键词： esophageal inhibiting suppressor

The littlest Higgs model with T-parity and some lepton flavor violation decay processes

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Science China(Physics,Mechanics & Astronomy) 2010年第11期53卷 1968-1974页

作者： YUE ChongXing,MA Wei,ZHANG TingTing,liu Wei & liu jinyan Department of Physics,Liaoning Normal University,Dalian 116029,China 1. Department of Physics Liaoning Normal University Dalian 116029 China

The new particles predicted by the littlest Higgs model with T-parity (called LHT model) can induce the lepton flavor violation (LFV) couplings at the one-loop level,which can add contributions to some LFV *** into account the constraints of the experimental data on the relevant free parameters,we calculate the branching ratios of the LFV decay processes Z → l ˉl and τ-→μ-P 1 P 2 with P 1 P 2 = π + π-,K + K-,and K0 ˉK 0 in the context of this new physics *** find that the LHT model can indeed make significant contributions to some of these LFV decay *** Z factory option for the future high energy e + e-collider experiments will give severe constraints on the LHT model.

关键词： littlest Higgs model lepton flavor violation branching ratios

PD-1 abrogates the prolonged persistence of CD8+CAR-T cells with 4-1BB co-stimulation

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1033-1036页

作者： Feng Li Zhen Zhang Yujing Xuan Daiqun Zhang jinyan liu Aitian Li Shumin Wang Ting Li Xiaojuan Shi Yi Zhang Biotherapy Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Cancer Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina State Key Laboratory of Esophageal Cancer Prevention&Treatment ZhengzhouHenanChina Henan Key Laboratory for Tumor Immunology and Biotherapy ZhengzhouHenanChina School of Life Sciences Zhengzhou UniversityZhengzhouHenanChina

Dear Editor,The central memory differentiation critically dictates CAR-T cell persistence,which is closely associated with the therapeutic effectiveness in the *** is well accepted that 4-1BB costimulation is superior over CD28 to promote the central memory differentiation and persistence of CAR-T cells.1 However,it is also noticed that CAR-T cells with either co-stimulations are comparably differentiated and persisted,2 especially under immunosuppressive *** contributing to the discrepancy remain *** evidences show that programmed cell death protein 1(PD-1)directly affects memory differentiation of T cells upon PD-L1 engagement,3 in addition to limiting *** is unclear whether PD-1 is involved in the diminished difference in memory differentiation and persistence between CAR-T cells with different ***,we examined the memory differentiation of CAR-T cells when PD-1 is activated or not,and consequently the persistence and anti-tumor effects.

关键词： stimulation CAR death

Modeling and Real-ti me Performance Analysis of Switched Ethernet by Network Calculus

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工程科学（英文版） 2005年第4期3卷 74-77页

作者： Wang Xiaoxin liu Luyuan liu Kun Ma jinyan School of Electrical ＆ Automation Engineering of Tianjin University Tianjin 300072

The real-time performance of switched Ethernet is a hot research field. However, there isn’t any effective modeling to describe it until now. Through analyzing the structure of classical switch, a switch model by network calculus is proposed, in which the data flow is divided into real-time flow and non real-time flow and the arrival curve, service curve, the max delay and max storage needed are got. The max delay provides theory direction for transmitting real-time data in switched Ethernet and the max storage provides the theory reference for constructing switch in real-time industrial Ethernet.

关键词：交换以太网网络计算实时性能网络结构

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缺陷混凝土抗氯离子渗透性能试验研究

建筑材料学报 2014年第6期17卷 978-983页

作者：刘燕刘晋艳易成河北农业大学城乡建设学院河北保定071001 山西大学土木工程系山西太原030000 中国矿业大学力学与建筑工程学院北京100083

对4组配合比的混凝土试件进行多向劈拉试验.利用数字散斑分析技术对其多向劈拉下的微裂纹扩展规律进行分析研究,建立损伤参量——微裂纹损伤面积ω和弹性模量损伤变量DE;同时进行混凝土试件劈拉前后的饱盐混凝土电导率法(NEL法)氯离子... 详细信息

对4组配合比的混凝土试件进行多向劈拉试验.利用数字散斑分析技术对其多向劈拉下的微裂纹扩展规律进行分析研究,建立损伤参量——微裂纹损伤面积ω和弹性模量损伤变量DE;同时进行混凝土试件劈拉前后的饱盐混凝土电导率法(NEL法)氯离子渗透性试验,探讨微裂纹损伤场对混凝土氯离子渗透性的影响.结果表明:微裂纹损伤对低水胶比混凝土的渗透性影响更大;随着弹性模损伤变量DE值的增加,氯离子扩散系数变化率β呈现线性递增的趋势,并近似拟合得到二者的关系式;水泥浆的强度、骨料的级配、孔隙率的大小以及损失场的确定等因素都会对氯离子渗透性能产生影响.

关键词：微裂纹缺陷多向劈拉数字散斑技术氯离子渗透

EFFECTS OF REINFORCING AND REDUCING METHODS BY TWIRLING AND ROTATING THE NEEDLE FOR LEFT VENTRICULAR DAMAGE OF SPONTANEOUSLY HYPERTENSIVE RATS

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Journal of Integrative Medicine 2014年第3期 219-220页

作者： Yingying Zhang Qingguo liu Meng Xu Yan Guo jinyan liu Beijing University of Chinese Medicine

Objective: To explore the different effects of reinforcing and reducing methods by twirling and rotating the needle on prevention for left ventricular damage of spontaneously hypertensive rats(SHRs).Methods: Sixty male SHRs were randomly divided into a model group(A), group(B) with twirling reinforcement method,group(C) with twirling reducing method, group(D) without manipulation, and a normal Wistar rat group(E) without *** B, C, and D were all treated on "Taichong" point(LR3), ten minutes every ***-eight days later, myocardial hypertrophy and myocardial fibrosis situation of each group were observed with biochemistry methods, and their blood pressure was also ***: The systolic pressure and diastolic pressure of the group C were lower than those of the groups A, B, and D, but higher than the group E; the levels of I, and III collagen mRNA were lower in group C than groups A, B, and *** and Masson pictures showed myocardial hypertrophy and myocardial fibrosis on the groups A, B, and D, but less serious on the group *** expression of endothelin-1 was also lower in the group C, but higher than normal group ***: Acupuncture with twirling reducing method can effectively decrease the blood pressure in SHRs, as well as the levels of I, III collagen mRNA and endothelin-1 in left ***, no significant similar effect was found by using reinforcing *** twirling reducing method has an important role in preventing myocardial damage caused by ***, twirling reducing and twirling reinforcing method have different biomedical effect on hypertension.

关键词： mRNA EFFECTS OF REINFORCING AND REDUCING METHODS BY TWIRLING AND ROTATING THE NEEDLE FOR LEFT VENTRICULAR DAMAGE OF SPONTANEOUSLY HYPERTENSIVE RATS

四甲基氢氧化铵改性聚偏氟乙烯接枝苯乙烯磺化膜的制备和性能

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高等学校化学学报 2018年第9期39卷 2062-2070页

作者：刘琪郭贵宝安胜利刘金彦内蒙古科技大学化学与化工学院包头014010 内蒙古科技大学材料与冶金学院包头014010

使用四甲基氢氧化铵(TMAH)甲醇溶液在液相中改性聚偏氟乙烯(PVDF),挥发溶剂得到改性聚偏氟乙烯膜(g-PVDF-M),再以过氧化苯甲酰(BPO)为引发剂,将苯乙烯接枝到g-PVDF-M膜中,磺化后制得改性聚偏氟乙烯接枝苯乙烯磺化(PVDF-g-PSSA)膜.利用... 详细信息

使用四甲基氢氧化铵(TMAH)甲醇溶液在液相中改性聚偏氟乙烯(PVDF),挥发溶剂得到改性聚偏氟乙烯膜(g-PVDF-M),再以过氧化苯甲酰(BPO)为引发剂,将苯乙烯接枝到g-PVDF-M膜中,磺化后制得改性聚偏氟乙烯接枝苯乙烯磺化(PVDF-g-PSSA)膜.利用傅里叶变换红外光谱(FTIR)和能谱仪的扫描电子显微镜分析了PVDF-g-PSSA膜(TMAH-25)的结构、形貌及硫元素分布情况.通过电化学工作站和气相色谱仪研究了TMAH在甲醇中的不同含量对PVDF-g-PSSA膜质子电导率和甲醇渗透率的影响.结果表明,TMAH使PVDF脱去HF生成碳碳双键,并且苯乙烯接枝到改性的聚偏氟乙烯膜中,磺化后S元素在PVDF-g-PSSA膜内部均匀分布;PVDF-g-PSSA膜的质子电导率和甲醇渗透率随TMAH在甲醇溶液中质量分数的增加而增大;TMAH的质量分数为25%时,PVDF-g-PSSA膜的电导率达1.28×10^(-2)S/cm,甲醇渗透率为4.58×10^(-7)cm^2/s.热重分析(TGA)表明,PVDF-g-PSSA膜的热稳性良好,耐热温度高达195℃,PVDF-g-PSSA膜作为电解质材料的直接甲醇燃料单电池(DMFC)功率密度达到16.45 mW/cm^2.

关键词：直接甲醇燃料电池聚偏氟乙烯四甲基氢氧化铵苯乙烯

STAT3/p53 pathway activation disrupts IFN-β-induced dormancy in tumor-repopulating cells

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STAT3/p53 pathway activation disrupts IFN-β-induced dormanc...