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Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3068-3085页

作者： Dongping Li Rongjuan Wei Xianglong Zhang Shenhai Gong Meijuan Wan Fangzhao Wang Jiaxin Li Meiling Chen Ruofan liu Yantong Wan Yinghao Hong Zhenhua Zeng Peng Gu Zhang Wang Kutty Selva Nandakumar Yong Jiang Hongwei zhou Peng Chen department of Pathophysiology Guangdong Provincial Key Laboratory of ProteomicsSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510000China department of Critical Care Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China department of Gastroenterology Shenzhen HospitalSouthern Medical UniversityShenzhen 518000China Institute of Ecological Sciences School of Life SciencesSouth China Normal UniversityGuangzhou 510000China department of Environmental and Biosciences School of BusinessInnovation and SustainabilityKristian IV’s vag 3Halmstad UniversityHalmstad 30004Sweden Microbiome Medicine Center Zhujiang HospitalSouthern Medical UniversityGuangzhou 510000China

Sepsis progression is significantly associated with the disruption of gut ***,the modulatory mechanisms of gut microbiota operating during sepsis are still ***,we investigated how gut commensals impact sepsis development in a pre-clinical *** ligation and puncture(CLP)surgery was used to establish polymicrobial sepsis in *** depleted of gut microbiota by an antibiotic cocktail(ABX)exhibited a significantly higher level of mortality than *** determined by metabolomics analysis,ABX treatment has depleted many metabolites,and subsequent supplementation with L-rhamnose(rhamnose,Rha),a bacterial carbohydrate metabolite,exerted profound immunomodulatory properties with a significant enhancement in macrophage phagocytosis,which in turn improved organ damage and ***,rhamnose binds directly to and activates the solute carrier family 12(potassium-chloride symporter),member 4(SLC12A4)in macrophages and promotes phagocytosis by activating the small G-proteins,Ras-related C3 botulinum toxin substrate1(Rac1)and cell division control protein 42 homolog(Cdc42).Interestingly,rhamnose has enhanced the phagocytosis capacity of macrophages from sepsis *** conclusion,by identifying SLC12A4 as the host interacting protein,we disclosed that the gut commensal metabolite rhamnose is a functional molecular that could promote the phagocytosis capacity of macrophages and protect the host against sepsis.

关键词： Gut microbiota Sepsis Rhamnose SLC12A4 GTP-Rac1 GTP-Cdc42 Macrophage Phagocytosis

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Single-atom catalysts based on polarization switching of ferroelectric In_(2)Se_(3)for N2 reduction

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Chinese Journal of Catalysis 2024年第8期63卷 244-257页

作者： Nan Mu Tingting Bo Yugao Hu Ruixin Xu Yanyu liu Wei zhou department of Physics Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing TechnologySchool of ScienceTianjin UniversityTianjin 300072China College of Physics and Materials Science Tianjin Normal UniversityTianjin 300387China

The polarization switching plays a crucial role in controlling the final products in the catalytic *** effect of polarization orientation on nitrogen reduction was investigated by anchoring transition metal atoms to form active centers on ferroelectric material In_(2)Se_(3).During the polariza-tion switching process,the difference in surface electrostatic potential leads to a redistribution of electronic *** affects the interaction strength between the adsorbed small molecules and the catalyst substrate,thereby altering the reaction *** addition,the surface states must be considered to prevent the adsorption of other small molecules(such as*O,*OH,and*H).Further-more,the V@↓-In_(2)Se_(3)possesses excellent catalytic properties,high electrochemical and thermody-namic stability,which facilitates the catalytic *** learning also helps us further ex-plore the underlying *** systematic investigation provides novel insights into the design and application of two-dimensional switchable ferroelectric catalysts for various chemical processes.

关键词： In_(2)Se_(3)monolayer Density functional theory Ferroelectric switching Single atom catalysts Nitrogen reduction reaction Machine learning

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Enhanced rainfall in North china in July 2021:Role of the North Pacific SST gradient

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Atmospheric and Oceanic Science Letters 2024年第2期17卷 39-44页

作者： Zhaoyang Du Lian-Tong zhou Kui liu Xiaoxue Yin Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina College of Earth Sciences University of Chinese Academy of SciencesBeijingChina Ningxia Key Laboratory for Meteorological Disaster Prevention and Reduction YinchuanChina Ningxia Meteorological Observatory YinchuanChina College of geography and Tourism Hengyang Normal UniversityHengyangChina department of Navigation China Coast Guard AcademyNingboChina

2021年7月,华北地区的降水量突破1980年以来的极值,这与太平洋海温异常的经向梯度相吻合.研究表明,西北太平洋正海温异常与热带中太平洋负海温异常之间的梯度是2021年7月华北地区降水异常偏多的主要原因,该梯度使得西北太平洋反气旋及... 详细信息

2021年7月,华北地区的降水量突破1980年以来的极值,这与太平洋海温异常的经向梯度相吻合.研究表明,西北太平洋正海温异常与热带中太平洋负海温异常之间的梯度是2021年7月华北地区降水异常偏多的主要原因,该梯度使得西北太平洋反气旋及其南部的气旋北移,汇合的偏东风将大量水汽从海洋输送到华北地区,使得华北地区降水偏多.同时,太平洋海温异常的经向梯度可能在对流层低层触发异常的反向哈德利环流,伴随着南风异常,使得季风环流增强,雨带偏北.

关键词：降水华北地区海温径向梯度

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CHCHD2 Thr61Ile mutation impairs F1F0-ATPase assembly in in vitro and in vivo models of Parkinson's disease

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Neural Regeneration Research 2024年第1期19卷 196-204页

作者： Xiang Chen Yuwan Lin Zhiling Zhang Yuting Tang Panghai Ye Wei Dai Wenlong Zhang Hanqun liu Guoyou Peng Shuxuan Huang Jiewen Qiu Wenyuan Guo Xiaoqin Zhu Zhuohua Wu Yaoyun Kuang Pingyi Xu Miaomiao zhou department of Neurology The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina department of Neurology The People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina School of Basic Medical Sciences Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina department of Neurology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Mitochondrial dysfunction is a significant pathological alte ration that occurs in Parkinson's disease(PD),and the Thr61lle(T61I)mutation in coiled-coil helix coiled-coil helix domain containing 2(CHCHD2),a crucial mitochondrial protein,has been reported to cause Parkinson's ***-ATPase participates in the synthesis of cellular adenosine triphosphate(ATP)and plays a central role in mitochondrial energy ***,the specific roles of wild-type(WT)CHCHD2 and T611-mutant CHCHD2 in regulating F1FO-ATPase activity in Parkinson's disease,as well as whether CHCHD2 or CHCHD2 T61I affects mitochondrial function through regulating F1FO-ATPase activity,remain unclea ***,in this study,we expressed WT CHCHD2 and T61l-mutant CHCHD2 in an MPP^(+)-induced SH-SY5Y cell model of *** found that CHCHD2 protected mitochondria from developing MPP^(+)-induced *** normal conditions,ove rexpression of WT CHCHD2 promoted F1FO-ATPase assembly,while T61I-mutant CHCHD2 appeared to have lost the ability to regulate F1FO-ATPase *** addition,mass spectrometry and immunoprecipitation showed that there was an interaction between CHCHD2 and *** weeks after transfection with AAV-CHCHD2 T61I,we intraperitoneally injected 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into mice to establish an animal model of chronic Parkinson's disease and found that exogenous expression of the mutant protein worsened the behavioral deficits and dopaminergic neurodegeneration seen in this *** findings suggest that WT CHCHD2 can alleviate mitochondrial dysfunction in PD by maintaining F1F0-ATPase structure and function.

关键词： ATP synthase(F1F0-ATPase) coiled-coil helix coiled-coil helix domain containing 2 dopaminergic neuron mitochondrial dysfunction neurodegeneration oligomycin sensitivity-conferring protein Parkinson's disease T61I mutation tyrosine hydroxylase

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Protective effect of probiotics on intestinal barrier function in malnourished rats after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2011年第5期10卷 489-496页

作者： Zhi-Gang Ren, Hui liu, Jian-Wen Jiang, Li Jiang, Hui Chen, Hai-Yang Xie, Lin zhou and Shu-Sen Zheng Key Laboratory of Combined Multi-organ Transplan- tation, Ministry of Public Health, and department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang university School of Medicine, Hangzhou 310003, china and Institute of Immunology, Zhejiang university School of Medicine, Hangzhou 310058, china [a] Key Laboratory of Combined Multi-organ Transplantation Ministry of Public Health and Department of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China [b] Institute of Immunology Zhejiang University School of Medicine Hangzhou 310058 China

BACKGROUND: Most patients waiting for liver transplantation have end-stage liver diseases with malnutrition, which is prone to induce intestinal barrier dysfunction after liver transplantation. We aimed to study the effect of probiotics on intestinal barrier function in malnourished rats following liver transplantation with long-term antibiotics. METHODS: Twelve Lewis rats were selected as donors. Twelve BN rats, which served as recipients, were subjected to malnutrition by semi-starvation for 4-5 weeks. They were randomly divided into two groups: a control group which received phosphate-buffered saline and a probiotics group which received Bifidobacterium and Lactobacillus. All recipients were injected with intramuscular imipenem and subcutaneous cyclosporine A. Furthermore, six normal BN rats without any drugs or operations served as a normal group. Eight days after operation, all rats were sacrificed for examination of the following parameters: serum levels of endotoxin and TNF-α, bacterial translocation, intestinal microflora, ileocecal sIgA, lymphocyte numbers, and phenotypes (CD4, CD8, αβTCR, γδTCR)ofPeyer’spatches. RESULTS: In recipients subjected to malnutrition, weight decreased by 20% and they survived until 8 days after operation. Compared with the normal group, all recipients on postoperative day 8 showed increased levels of serum endotoxin and TNF-α as well as increased counts oftranslocated bacteria. Meanwhile, there were decreases in counts of Bifidobacterium and Lactobacillus in the ileocecum, sIgA concentration, and lymphocytes of Peyer’s patches. Moreover, partial alteration in lymphocyte phenotypes was evidenced by elevated ratios of CD8 + and γδTCR + lymphocytes. In contrast, compared to the control group, supplementation with probiotics reduced the levels of serum endotoxin, TNF-α and bacterial translocation, increased the counts of Bifidobacterium and Lactobacillus, the concentration of sIgA and lymphocytes of Peyer’s patches, and also slightly

关键词： liver transplantation probiotics intestinal microflora intestinal barrier function

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Heteropolyacids Catalysis in Synthesizing Butylacrylate

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Chemical Research in Chinese Universities 1998年第2期14卷 8-11页

作者： ZHU Zhi ping , zhou De feng and liu Jing fu (department of Chemisty, Northeast normal university, Changchun, 130024) NE normal Univ Dept Chem Changchun 130024 Peoples R China

The catalytic activities of some heteropolyacids(HPAs) in synthesizing butyl acrylate are reported. It has been demonstrated that 12 tungstophosphoric acid is the most effective catalyst among more than 20 HPA(salts). Various factors concerned in this reaction have been investigated. The optimum conditions have been found, that is, the molar ratio of alcohol to acid is 1.2∶1.0 , the catalyst concentration 1%(mass fraction), the reaction time 2 h, the temperature 98—124 ℃ and a certain amount of polymerization inhibitor exists.

关键词： n Butyl acrylate Acrylic acid n Butyl alcohol Heteropolyacid

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机体水合状态与减压病

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环境与职业医学 2024年第7期41卷 834-840页

作者：周梦如朱包良庆龙周英杰衣洪杰王晔炜张坤徐伟刚上海理工大学健康科学与工程学院上海200940 海军军医大学海军特色医学中心上海200433 海军军医大学第一附属医院高压氧治疗科上海200433

水合状态是指机体水的摄入和排出的平衡情况,当摄入与排出的水分大体相等、机体处于水平衡状态时即为正常水合状态,水分摄入过少或过多时则为“脱水”或“过水合状态”。机体水合状态不仅会影响新陈代谢,还会影响泌尿系统、心血管系统... 详细信息

水合状态是指机体水的摄入和排出的平衡情况,当摄入与排出的水分大体相等、机体处于水平衡状态时即为正常水合状态,水分摄入过少或过多时则为“脱水”或“过水合状态”。机体水合状态不仅会影响新陈代谢,还会影响泌尿系统、心血管系统、神经系统等的功能。为了深入阐明机体水合状态与减压病(DCS)发生的关系,本文梳理既往研究,分析水合状态与潜水减压安全的交互影响。潜水造成脱水的原因主要包括高压性利尿、浸泡性利尿、呼吸干燥气体、高温、寒冷等,而脱水不仅会促进DCS的发生,还会降低潜水员的有氧工作效率和运动表现,并且影响认知和情绪。研究发现,潜水前、中适当补液可降低DCS的发生风险,这可能与血容量增加、血浆表面张力升高、血管收缩有关。对于已经罹患DCS者,补液治疗同样具有重要意义。本文针对上述环节中涉及的补液量、性质、时机、方式以及效果进行分析,全面梳理了水合状态与潜水安全之间的关系,总结了存在的问题,为实践应用和未来研究提供借鉴。

关键词：潜水减压病水合状态补液预处理

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Chiral phonon activated spin Seebeck effect in chiral materials

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Science china(Physics,Mechanics & Astronomy) 2024年第3期67卷 149-155页

作者： Xiao Li Jinxin Zhong Jinluo Cheng Hao Chen Huiqian Wang Jun liu Dali Sun Lifa Zhang Jun zhou Phonon Engineering Research Center of Jiangsu Province Center for Quantum Transport and Thermal Energy ScienceSchool of Physics and TechnologyNanjing Normal UniversityNanjing 210023China Center for Phononics and Thermal Energy Science China-EU Joint Lab for NanophononicsSchool of Physics Science and EngineeringTongji UniversityShanghai 200092China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of ScienceChangchun 130033China department of Mechanical and Aerospace Engineering North Carolina State UniversityRaleigh NC 27606USA department of Physics North Carolina State UniversityRaleigh NC 27695USA Organic and Carbon Electronics Laboratories(ORaCEL) North Carolina State UniversityRaleigh NC 27606USA

Efficient generation of spin polarization is very important for spintronics and quantum computation. In chiral materials without magnetic order nor spin-orbit coupling, we find a new spin selectivity effect—chiral phonon activated spin Seebeck(CPASS)effect. Starting with the nonequilibrium distribution of chiral phonons under a temperature gradient, the CPASS coefficients are computed based on the Boltzmann transport theory. With both the phonon-drag and band transport contributions, the spin accumulations generated by the CPASS effect exhibit quadratic dependence on the temperature gradient. The strength of the CPASS effect and the relative magnitude of both contributions are tunable by the chemical potential modulation. The CPASS effect, which gives a promising explanation on the traditional chiral-induced spin selectivity effect, provides opportunities for the exploration of advanced spintronic devices based on chiral materials even in the absence of any magnetic order and spin-orbit coupling.

关键词： spin Seebeck effect chiral phonon phonon-drag contribution efficient spin generation

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Long-time Fulvic Acid Supplementation Modulates Hydroxylysyl Glycosylation of Collagen in Mice

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Journal of Huazhong university of Science and Technology(Medical Sciences) 2004年第5期24卷 427-429页

作者：朱少华朱金龙肖坚任亮刘良周亦武 department of Forensic Medicine Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China department of Forensic Medicine Tongji Medical College Huazhong University of Science and Technology

In order to investigate the impact of fulvic acid (FA) on the hydroxylysyl glycosylation in collagen bio-synthesis, 40 NMRI mice were divided into two groups (n=20 in each group, consisting 10 females and 10 males). The animal was maintained for two generations by different diets: control group with normal water and food and study group with water containing 30mg/L FA and normal food. The second generation of the animal was slaughtered, and the biochemical parameters of collagen content and the degree of collagen hydroxylysyl glycosylation in skin, rib and tibia were detected by biochemical methods. The mean value of collagen in the study group was increased slightly, and no significant difference between study group and control group was found (P> 0.05), but the content of glucose-glactose-hydroxylysine (GGH) was significantly decreased in the study group in comparison with the control group (P<0.01). It was suggested that through the decrease of GGH 30 mg/L FA could inhibit the activity of galactosyl-hydroxylysylglucosyl-transferase and further disturb the post-translational modification of collagen intracellularly.

关键词： fulvic acid collagen Kashin-Beck disease

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双重攻击模型的实证研究

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心理科学 2009年第1期32卷 137-140页

作者：周颖刘俊升中国浦东干部学院科研部上海201204 上海师范大学心理学系上海200234

本研究通过两个实验对双重攻击模型进行了验证。实验一借助实验性分离的逻辑,发现性别对内隐攻击性和外显攻击性存在不同影响,初步证明内隐攻击性和外显攻击性的分离论。实验二通过实证性因素分析,证明双重攻击模型具有较高的拟合参数... 详细信息

本研究通过两个实验对双重攻击模型进行了验证。实验一借助实验性分离的逻辑,发现性别对内隐攻击性和外显攻击性存在不同影响,初步证明内隐攻击性和外显攻击性的分离论。实验二通过实证性因素分析,证明双重攻击模型具有较高的拟合参数。本研究证明内隐攻击性和外显攻击性分属两个不同的结构,构成双重攻击模型。

关键词：双重攻击模型内隐攻击性外显攻击性

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