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中华检验医学杂志 2018年第11期41卷 897-900页

作者：刘航齐贾玫北京大学人民医院检验科 100044

脂蛋白（a）[Lp（a）]是动脉粥样硬化（As）形成与进展的高危因素，血浆中高浓度的Lp（a）已成为公认的冠心病预测因子。研究表明，与Lp（a）相连的氧化磷脂（OxPL）成分可能是其致AS的关键因素，而与Lp（a）相连的另一个组分——脂蛋... 详细信息

脂蛋白（a）[Lp（a）]是动脉粥样硬化（As）形成与进展的高危因素，血浆中高浓度的Lp（a）已成为公认的冠心病预测因子。研究表明，与Lp（a）相连的氧化磷脂（OxPL）成分可能是其致AS的关键因素，而与Lp（a）相连的另一个组分——脂蛋白相关磷脂酶A2（LV—PLA2）可水解OxPL，其水解产物溶血磷脂酰胆碱（***）和游离氧化脂肪酸（oxFFA）是促进AS发生发展的重要炎症因子。脂蛋白相关磷脂酶A2水解脂蛋向（a）连接的氧化磷脂可产生炎性因子，促进动脉粥样硬化的发生发展。OxPL和Lp—PLA2可作为心血管疾病（CVD）新靶标，具有潜在预测指标的临床应用价值。

关键词：动脉粥样硬化心血管疾病 1-烷基-2-乙酰甘油磷酸胆碱酯酶脂蛋白(A) 氧化还原磷脂类炎症

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临床检验危急值的内部管理

中华临床实验室管理电子杂志 2018年第1期6卷 47-51页

作者：刘航齐贾玫北京大学人民医院检验科 100044

危急值报告涉及实验室、信息科、护理部、临床医生的工作,直接关系到患者的生命安全。危急值项目的选择、报告范围和时限的确定、危急值报告制度的建立、实验室信息系统(laboratory information system,LIS)的改进和优化,是临床实验室... 详细信息

危急值报告涉及实验室、信息科、护理部、临床医生的工作,直接关系到患者的生命安全。危急值项目的选择、报告范围和时限的确定、危急值报告制度的建立、实验室信息系统(laboratory information system,LIS)的改进和优化,是临床实验室高效准确的提供报告单,保障患者医疗质量和医疗安全的良好举措。

关键词：危急值医疗质量实验室信息管理

脂蛋白相关磷脂酶A2与冠心病严重程度的相关性研究

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中华检验医学杂志 2018年第6期41卷 425-429页

作者：黄立纲王春燕刘炼华刘航齐贾玫北京大学人民医院检验科 100044

目的探讨人血浆脂蛋白相关磷脂酶A2（Lp－PLA2）活性与冠心病严重程度之间的关系。方法采用病例对照研究，选择北京华信医院冠脉造影检查结果阳性（根据冠脉造影结果，至少有一支冠状动脉管腔狭窄程度≥50%，即判断为阳性）患者231例，... 详细信息

目的探讨人血浆脂蛋白相关磷脂酶A2（Lp－PLA2）活性与冠心病严重程度之间的关系。方法采用病例对照研究，选择北京华信医院冠脉造影检查结果阳性（根据冠脉造影结果，至少有一支冠状动脉管腔狭窄程度≥50%，即判断为阳性）患者231例，根据是否服用他汀类降脂药，分成两组（未服药组：147例；服药组：84例），健康对照者99名。未服药组中，所有男性患者，根据心脏冠状动脉病变支数、Gensini积分等标准分别进行分组。采集临床资料，检测血清Lp－PLA2、总胆固醇（CHOL）、低密度脂蛋白（LDL）等冠状动脉粥样硬化血清标志物含量。患者组由经皮冠状动脉介入术（PCI）确认累及冠状动脉的病变血管数量，病变位置、狭窄程度。统计学分析采用t检验、方差分析、mann－whitney U检验及Spearman相关分析。结果未服药组、服药组和对照组Lp－PLA2的水平分别为（561.9±158.5）U/L，（373.2±124.7）U/L，（467.4±130.4）U/L，未服药组明显高于对照组，三组数据差异有统计学意义（F＝48.1，P〈0.001）。多支病变组Lp－PLA2的水平为（603.4±154.8）U/L ，明显高于单支病变组（521.3±192.1）U/L，差异有统计学意义（t＝－2.31，P＝0.023）。Gensini积分高分位组Lp－PLA2的水平为（618.7±165.4）U/L ，明显高于低分位组（517.3±191.7）U/L，差异有统计学意义（t＝－2.156，P＝0.035）。结论Lp－PLA2活性可以反映冠心病的严重程度。

关键词：脂蛋白相关磷脂酶A2 动脉粥样硬化冠脉造影

TAT-SOD脂质体对UC模型大鼠的口服治疗作用

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食品与生物技术学报 2020年第10期39卷 26-33页

作者：周建森周秋婷叶芬林春通刘航琪刘树滔福州大学生物工程研究所福建福州350002

氧化应激是造成溃疡性结肠炎(UC)的重要原因之一,而超氧化物歧化酶(SOD)是调控氧化应激的基本分子。为了探究TAT-SOD脂质体对UC模型大鼠的口服治疗作用,作者利用乙醇沉淀和大孔树脂分离的方法,从基因重组毕赤酵母菌发酵液中分离纯化TAT-... 详细信息

氧化应激是造成溃疡性结肠炎(UC)的重要原因之一,而超氧化物歧化酶(SOD)是调控氧化应激的基本分子。为了探究TAT-SOD脂质体对UC模型大鼠的口服治疗作用,作者利用乙醇沉淀和大孔树脂分离的方法,从基因重组毕赤酵母菌发酵液中分离纯化TAT-SOD;利用TritonX-114相分离法,去除其细菌内毒素;利用逆向蒸发法,制备TAT-SOD脂质体;利用DSS诱导构建UC模型大鼠,经灌胃给药,通过DAI评分、结肠密度、组织切片、血清SOD酶活、血清脂多糖含量,评价其治疗效果。结果表明:初步分离获得TAT-SOD,比活为11 003 U/mg;TritonX-114对内毒素的去除率为99.30%;成功制备TAT-SOD脂质体,经体外模拟消化液处理,其酶活回收率为81.80%;动物实验中,SOD给药组与模型组相比,DAI评分均显著降低(P<0.05),且TAT-SOD脂质体组的评分最好;结肠密度和组织切片观察发现,结肠组织损伤情况均明显改善,且TAT-SOD脂质体组的改善最好;血清中SOD酶活均显著提高(P<0.05),且TATSOD脂质体组的酶活最高;血清中LPS含量无显著差异。这些表明,TAT-SOD脂质体对DSS诱导UC模型大鼠有良好的口服治疗效果,有望为UC的辅助治疗提供新的选择。

关键词：超氧化物歧化酶脂质体结肠炎抗氧化

Frequency Regulation of VSC-MTDC System with Offshore Wind Farms

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 275-286页

作者： Haoyu liu Chongru liu North China Electric Power University Beijing 102206China

Frequency regulation of voltage source converter-based multi-terminal high-voltage direct current(VSC-MTDC)system with offshore wind farms enhances the frequency stability by compensating the power for a disturbed AC ***,it is difficult to reasonably allocate frequency-regulation resources due to a lack of coordination mechanisms between wind farms and the MTDC ***,it is difficult for the frequency control of the wind farms to manage changes in wind speed;and the risk of wind-turbine stalls is ***,based on the kinetic energy of wind turbines and the power margin of the converters,the frequency-regulation capability of wind turbines is evaluated,and a dynamic frequency-support scheme considering the real-time frequency-support capability of the wind turbines and system frequency evolution is proposed to improve the frequency-support performance.A power adaptation technique at variable wind speeds is developed;the active power in the frequency-support stage and restoration stage is switched according to the wind speed.A hierarchical zoning frequency-regulation scheme is designed to use the frequency-regulation resources of different links in the MTDC system with wind *** simulation results show that the novel frequency-regulation strategy maintains frequency stability with wind-speed changes and avoids multiple frequency dips.

关键词： Wind generation voltage source converter-based multi-terminal high-voltage direct current(VSC-MTDC) frequency regulation cooperative control adaptive control variable wind speed

Preliminary compact torus injection experiments on the Keda Torus eXperiment reversed field pinch

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Plasma Science and Technology 2024年第10期26卷 56-64页

作者： Tao LAN Chen CHEN Chijin XIAO Weixing DING Jie WU Wenzhe MAO Sen ZHANG Defeng KONG Shoubiao ZHANG Zhengwei WU Qilong DONG Yongkang ZHOU hangqi XU Jiaren WU Zian WEI Xiaohui WEN Hai WANG Chu ZHOU Adi liu Hong LI Jinlin XIE Wandong liu Ge ZHUANG Department of Plasma Physics and Fusion Engineering University of Science and Technology of ChinaHefei 230026People’s Republic of China Plasma Physics Laboratory University of SaskatchewanSaskatoon SK S7N 5E2Canada Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China

A new compact torus injector(KTX-CTI)has been built for injection experiments on the Keda Torus eXperiment(KTX)reversed field pinch(RFP).The aim is to study the fundamental physics governing the compact torus(CT)central fueling *** experiments conducted under the sole influence of a 0.1 T toroidal magnetic field,the injected CT successfully penetrated the entire toroidal magnetic field,reaching the inner wall of the KTX vacuum *** reaching the inner wall,the CT diffused both radially outward and toroidally within the vessel at a discernible diffusion ***,the inherent helicity within the CT induced a modest KTX plasma current of 200 A,consistent with predictions based on helicity *** injection demonstrated the capability to initiate KTX discharges at low loop voltages,suggesting its potential as a pre-ionization and current startup *** RFP discharges featuring CT injection,the central plasma density was found to exceed the Greenwald density limit,with more peaked density profiles,indicating the predominant confinement of CT plasma within the core region of the KTX bulk plasma.

关键词： compact torus fueling reversed field pinch density limit

A Novel Design of a Pre-separation Panel Structure to Protect Against the Impact of an Explosion in an Aircraft Plenum Chamber

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Acta Mechanica Solida Sinica 2024年第1期37卷 166-180页

作者： Zongxing liu Xiang Yang Jun liu School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China COMAC Shanghai Aircraft Design and Research Institute Shanghai 201210China

To reduce the damage of the pressurizing panel structure of a fuselage caused by an explosion at the“least risk bomb location”in an aircraft structure,a new pre-separation panel structure was designed to resist blast ***,the dynamic strain response and morphology of impact damage of the new pre-separation panel were measured in an impact damage ***,the commercial software LS-DYNA was used to calculate the propagation of the blast shock wave,and the results were compared with empirical equations to verify the rationality of the numerical calculation ***,the fluid–structure coupling method was used to calculate the damage process of the pre-separation panel structure under the impact of an explosion wave and an impact *** calculated results were in good agreement with the test results,which showed the rationality of the calculation method and the *** residual strength of the damaged pre-separation panel was significantly higher than that of the original damaged *** results show that the new pre-separation panel structure is reasonable and has certain significance for guiding the design of plenum chambers with strong resistance to implosion for aircraft fuselages.

关键词： Pre-separation panel structure Explosive response Residual strength Aircraft plenum chamber Least risk bomb location

Effectiveness and safety of acupuncture in treatment of pregnancyrelated symptoms:a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 16-26页

作者： liu Tingting liu Tongou liu Mingfu School of Traditional Chinese Medicine Clinical Medicine Hubei University of Traditional Chinese MedicineWuhan 430000China First Clinical College of Hubei University of Traditional Chinese Medicine Wuhan 430000China Department of Acupuncture and Tuina Affiliated Hospital of Hubei University of Traditional Chinese MedicineHubei Provincial Hospital of Traditional Chinese MedicineWuhan 430000China

OBJECTIVE:To systematically evaluate the efficacy and safety of acupuncture(AM)in the treatment of pregnancyrelated symptoms such as acute vomiting during ***:We comprehensively searched the available literature up to November 2021,including Pub Med,Embase,Cochrane Library,Chinese Biomedical Literature Database,and China National Knowledge Infrastructure Database,for randomized controlled trials(RCTs)on AM for the treatment of severe vomiting,insomnia,pharyngeal and pelvic pain,mood abnormalities,and dyspepsia during ***:Sixteen RCTs with a cumulative sample size of 1178 cases were *** these,964 patients were included in the *** Meta-analysis results showed that AM was more efficient than Western medicine in treating discomfort during pregnancy[odds ratio(OR)=1.19,95%confidence interval(CI)(1.11,1.28),P<0.01].AM was better than the control group in improving the visual analog scale scores[standard mean difference(SMD)=0.62,95%CI(0.53,0.71),P<0.01].AM was superior to the control group in improving Numerical Rating Scale(NRS)symptom scores[OR=7.31,95%CI(3.36,15.94),P<0.01].There was no significant difference in adverse effects between the AM and sham-AM groups and the analgesic drug group[OR=0.70,95%CI(0.39,1.28),P=0.25],but the treatment and control groups had mild adverse effects with a low ***:AM is more effective than other treatments or pharmacotherapy alone in the treatment of pregnancy-related symptoms,and is relatively ***,the quality of the included trials was rather poor,and high-quality studies are required to confirm our findings.

关键词： acupuncture pregnancy nausea vomiting sleep initiation and maintenance disorders low back pain pelvic pain mood abnormalities Meta-analysis systematic review

Stochastic Unit Commitment with High-Penetration Offshore Wind Power Generation in Typhoon Scenarios

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 535-546页

作者： Yanqi liu Dundun liu Hongcai Zhang State Key Laboratory of Internet of Things for Smart City and Department of Electrical and Computer Engineering University of MacaoMacao 999078China University of Macao Zhuhai UM Science and Technology Research Institute ZhuhaiChina

To tackle the energy crisis and climate change,wind farms are being heavily invested in across the *** China's coastal areas,there are abundant wind resources and numerous offshore wind farms are being *** secure operation of these wind farms may suffer from typhoons,and researchers have studied power system operation and resilience enhancement in typhoon ***,the intricate movement of a typhoon makes it challenging to evaluate its spatial-temporal *** published papers only consider predefined typhoon trajectories neglecting *** address this challenge,this study proposes a stochastic unit commitment model that incorporates high-penetration offshore wind power generation in typhoon *** adopts a data-driven method to describe the uncertainties of typhoon trajectories and considers the realistic anti-typhoon mode in offshore wind farms.A two-stage stochastic unit commitment model is designed to enhance power system resilience in typhoon *** formulate the model into a mixed-integer linear programming problem and then solve it based on the computationally-efficient progressive hedging algorithm(PHA).Finally,numerical experiments validate the effectiveness of the proposed method.

关键词： Unit commitment two-stage stochastic programming offshore wind farm typhoon