检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

磁光盘轴径向偏摆和加速度的测试方法与实现

小型微型计算机系统 2000年第10期21卷 1021-1024页

作者：裴先登程裕霞刘本喜华中理工大学计算机科学技术学院武汉430074

本文简述了测试磁光盘机械特性的重要性 ,论述了磁光盘轴、径向参数的测试方法 ,着重介绍了我们的测试系统采用的测试方法、原理及实现 .

关键词：磁光盘机械特性径向偏摆加速度测试方法

在线全文

学校读者我要写书评

暂无评论

一种直接测量光盘道间距的方法

激光与红外 2000年第2期30卷 115-116页

作者：王海卫裴先登刘本喜谢长生华中理工大学外存储国家专业实验室武汉430074

介绍了一种能够直接 ,精确测量光盘道间距 ( Track Pitch)的实用方法。整个测试系统的框图 ,测试结果以及结果分析也一并给出。

关键词：光盘道间距测量

皮类植物药在皮肤病中的传统应用与现代研究开发

在线全文

学校读者我要写书评

暂无评论

中华中医药杂志 2018年第12期33卷 5654-5659页

作者：刘本玺董广平刘海洋李尚雨刘本玉杨勤运云南省彝族医药研究所云南楚雄675000 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室昆明650201 韩国生命工学研究院海外生物素材研究中心韩国大田云南大学资源环境与地球科学学院昆明650500

从"中药指南"本草数据库中,查找出能够治疗皮肤疾病的皮类植物药材,进行系统整理和编目。并从临床使用、药理作用和研究开发3个方面,对皮类植物药的运用和研究现状进行分析。发掘"以皮治皮"的传统医学思想,讨论"以皮治皮"的科学内涵;建... 详细信息

从"中药指南"本草数据库中,查找出能够治疗皮肤疾病的皮类植物药材,进行系统整理和编目。并从临床使用、药理作用和研究开发3个方面,对皮类植物药的运用和研究现状进行分析。发掘"以皮治皮"的传统医学思想,讨论"以皮治皮"的科学内涵;建议从中找出活性显著的皮类植物药材,指导开发皮肤疾病的药品制剂。

关键词：皮类植物药皮肤病传统应用研究开发

Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing Chen Chao Wu xiaoling liu Biao Meng Tao Chen Yu Han Jun Wang Shibo xi Yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao Yuan Li xi liu Wenping Liang Yu Li Liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

考虑多地区互相关性的小水电群发电能力模拟预测方法

在线全文

学校读者我要写书评

暂无评论

水电能源科学 2018年第2期36卷 75-79页

作者：陈孚程春田刘本希涂启玉大连理工大学水电与水信息研究所辽宁大连116024 昆明电力交易中心有限责任公司策划部云南昆明650000

针对小水电数量多、分布广、信息采集差、不确定性强、管理区划与流域交叉重叠等特点,提出一种考虑多地区互相关性的小水电群发电能力模拟预测方法。该方法以地区小水电群整体为研究对象,分析地区间小水电群发电能力的互相关性并构建Cop... 详细信息

针对小水电数量多、分布广、信息采集差、不确定性强、管理区划与流域交叉重叠等特点,提出一种考虑多地区互相关性的小水电群发电能力模拟预测方法。该方法以地区小水电群整体为研究对象,分析地区间小水电群发电能力的互相关性并构建Copula相关性函数,在此基础上选取代表地区构建基于Copula函数的地区权重发电能力预测模型,同时结合历史出力趋势对模拟预测值进行重构,使其满足实际出力特性,并以云南省地区小水电群为例验证了该方法的有效性。结果表明,云南省15个地区的小水电发电群预测值合格率均大于70%,合格率较高。该研究方法可为小水电的后期应用提供指导。

关键词：小水电群多地区相关性 Copula理论发电能力

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： xiao Liang xingping Quan xiaorui Geng Yujing Huang Yonghua Zhao Lei xi Zhen Yuan Ping Wang Bin liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging