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Evaluating the Impacts of Universal Two-Child Policy on Beijing’s Population

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Journal of Systems Science & Complexity 2020年第4期33卷 1126-1143页

作者： liu qing liu Xiuli High School Affiliated to Southwest University Chongqing 400700China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China Center for Forecasting Science Chinese Academy of SciencesBeijing 100190 China University of Chinese Academy of Sciences Beijing 100049China

This paper explores the impacts of the universal two-child policy on Beijing’s population in the long *** gives a detail estimation of Beijing population considering the latest fertility and immigration policy and can help related government department management *** cohortcomponent method based on a net migration was applied to project population by age for Beijing from2020 to 2050 in four fertility *** innovation is the estimation method of the mortality rate with the life table linked with life *** results show that,though the basic development trend of Beijing’s population will not change essentially under the universal two-child policy,low birth rate and aging problems will be *** with the partial policy relaxation,the total population will be 876,478 persons more than that in 2050,the share of population aged 0–14 will increase 1.1 percentage points,and the aged dependency ratio will decrease 1.96 percentage *** measures should be taken to encourage more couples to have a second child and introduce more young talents to promote Beijing’s prosperity.

关键词： Population policy fertility

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-qing liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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基于特征间几何约束的指针仪表读数识别方法

沈阳理工大学学报 2025年第1期44卷 1-8页

作者：刘昶卢景峰刘青沈阳理工大学信息科学与工程学院沈阳110159 闪捷信息科技有限公司杭州311121

在指针式仪表示值监控系统中,倾斜拍摄仪表图像时会导致识别结果出现偏差,为此提出一种基于仪表特征间几何约束的识别方法。首先利用一幅平铺于仪表上表面的平面标定板图像实现相机参数标定,生成仪表在标定平面上的虚拟图像;然后利用表... 详细信息

在指针式仪表示值监控系统中,倾斜拍摄仪表图像时会导致识别结果出现偏差,为此提出一种基于仪表特征间几何约束的识别方法。首先利用一幅平铺于仪表上表面的平面标定板图像实现相机参数标定,生成仪表在标定平面上的虚拟图像;然后利用表壳上表面、刻度平面、指针平面与虚拟像平面间的平行关系,确定表壳圆的圆心、仪表刻度圆心、指针转轴中心特征间的透视投影约束关系,利用图像的极坐标变换和离散傅里叶变换提取仪表刻度圆心的最优位置及起始刻度线的角度,利用Hough变换的投票原理估计指针的转动角度;最后利用角度法实现仪表读数的解算。以某型号指针式温度计为测试对象进行实验验证,识别结果的平均误差为0.23℃,最大误差为0.7℃,本文方法能够准确识别仪表读数且识别精度优于人工读数。

关键词：指针式仪表透视投影约束相机标定离散傅里叶变换

电刺激诱导miR-741-3p调控Radil促进施万细胞的迁移

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中国组织工程研究 2025年第19期29卷 4038-4043页

作者：刘庆高博杨霄姜宇王培承德医学院附属医院河北省承德市067000 承德医学院河北省承德市067000

背景:越来越多的动物实验和临床研究证实电刺激可以促进周围神经损伤修复,具体的机制尚未完全明确。目的:探讨电刺激诱导miR-741-3p调控Radil对施万细胞迁移的影响。方法:①12只雄性SD大鼠,随机分为电刺激组和对照组,电刺激组在坐骨神... 详细信息

背景:越来越多的动物实验和临床研究证实电刺激可以促进周围神经损伤修复,具体的机制尚未完全明确。目的:探讨电刺激诱导miR-741-3p调控Radil对施万细胞迁移的影响。方法:①12只雄性SD大鼠,随机分为电刺激组和对照组,电刺激组在坐骨神经挤压伤后连续电刺激7 d,对照组在坐骨神经挤压后不做任何处理。术后第7天取损伤处神经,利用荧光原位杂交技术检测两组miR-741-3p的表达差异。②通过miRDB、TargetScan和miRWalk数据库预测miR-741-3p靶基因。③将miR-741-3p模拟物及其对照、miR-741-3p抑制物及其对照、Radil siRNA及其对照、miR-741-3p抑制物+Radil siRNA及miR-741-3p抑制物+siRNA对照对施万细胞进行转染,采用RT-PCR检测转染效率,Transwell小室检测施万细胞的迁移能力。结果与结论:①电刺激组神经残端miR-741-3p荧光强度低于对照组;②数据库预测结果显示有69个基因可能是miR-741-3p靶基因,Radil是预测靶基因之一,主要参与细胞黏附和迁移;③与miR-741-3p抑制物对照组相比,miR-741-3p抑制物组施万细胞迁移数增多(P<0.05);与miR-741-3p模拟物对照组相比,miR-741-3p模拟物组施万细胞迁移数减少(P<0.05);与siRNA对照组相比,Radil siRNA组施万细胞迁移数减少(P<0.05);④与miR-741-3p抑制物对照组相比,miR-741-3p抑制物组Radil的表达水平升高;与miR-741-3p模拟物对照组相比,miR-741-3p模拟物组Radil的表达水平降低;⑤与miR-741-3p抑制物+siRNA对照组相比,miR-741-3p抑制物+Radil siRNA组施万细胞迁移数减少(P<0.05)。结果表明,电刺激通过下调miR-741-3p调控Radi的表达来促进施万细胞迁移。

关键词：施万细胞电刺激 miR-741-3p Radil 细胞迁移神经再生

Detoxification and concentration of corn stover hydrolysate and its fermentation for ethanol production

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 140-151页

作者： qing Li Yingjie Qin Yunfei liu Jianjun liu qing liu Pingli Li Liqiang liu School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China Chembrane Engineering & Technology Inc. Tianjin 300308 China

Environmental and energy concerns have increased interest in renewable energy sources, particularly biofuels. Thus the fermentation of glucose from sulfuric acid-hydrolyzed corn stover for the production of bioethanol has been explored using a combined acid retardation and continuous-effect membrane distillation treatment process. This process resulted in the separation of the sugars and acids from the acid-catalyzed hydrolysate, the removal of most of the fermentation inhibitors from the hydrolysate and the concentration of the detoxified hydrolysate. The recovery rate of glucose from the sugar-acid mixture using acid retardation was greater than 99.12% and the sulfuric acid was completely recovered from the hydrolysate. When the treated com stover hydrolysate, containing 100 g/L glucose, was used as a carbon source, 43.06 g/L of ethanol was produced with a productivity of 1.79 g/(L· h) and a yield of 86.31 %, In the control experiment, where glucose was used as the carbon source these values were 1.97 g/(L·h) and 93.10% respectively. Thus the integration of acid retardation and a continuous-effect membrane distillation process are effective for the production of fuel ethanol from com stover.

关键词： com stover hydrolysate acid retardation continuous-effect membrane distillation ethanol fermentation

Automatic pattern acquisition from game records in GO

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The Journal of China Universities of Posts and Telecommunications 2007年第1期14卷 100-105页

作者： liu Zhi-qing DOU qing School of Software Engineering Beijing University of Posts and Telecommunications Beijing 100876 China

Computer programs of GO are typically constructed using a knowledge-based approach with heuristics and pattern matching because of enormous complexities of the game. In this approach, quantity, quality, and consistency of patterns used in computer programs of GO to a large extent determine the strengths of the programs. This study presents an effective method to acquire automatically comprehensive GO patterns from large collections of game records. Statistical usages of the patterns ensure consistency and quality of the patterns, which in turn can help improve the strengths of computer GO programs. Additionally, statistical usages of patterns from different sources of game records clearly show subtle and significant discrepancies among various types of GO players, and clarify certain myths in the playing of GO.

关键词： computer games automatic knowledge acquisition,spatial patterns recognition

An Embedded Feature Selection Method for Imbalanced Data Classification

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IEEE/CAA Journal of Automatica Sinica 2019年第3期6卷 703-715页

作者： Haoyue liu MengChu Zhou qing liu IEEE the Department of Electrical and Computer Engineering New Jersey Institute of Technology Institute of Systems Engineering Macao University of Science and Technology

Imbalanced data is one type of datasets that are frequently found in real-world applications, e.g., fraud detection and cancer diagnosis. For this type of datasets, improving the accuracy to identify their minority class is a critically important *** selection is one method to address this issue. An effective feature selection method can choose a subset of features that favor in the accurate determination of the minority class. A decision tree is a classifier that can be built up by using different splitting criteria. Its advantage is the ease of detecting which feature is used as a splitting node. Thus, it is possible to use a decision tree splitting criterion as a feature selection method. In this paper, an embedded feature selection method using our proposed weighted Gini index(WGI) is proposed. Its comparison results with Chi2, F-statistic and Gini index feature selection methods show that F-statistic and Chi2 reach the best performance when only a few features are selected. As the number of selected features increases, our proposed method has the highest probability of achieving the best performance. The area under a receiver operating characteristic curve(ROC AUC) and F-measure are used as evaluation criteria. Experimental results with two datasets show that ROC AUC performance can be high, even if only a few features are selected and used, and only changes slightly as more and more features are selected. However, the performance of Fmeasure achieves excellent performance only if 20% or more of features are chosen. The results are helpful for practitioners to select a proper feature selection method when facing a practical problem.

关键词： Classification and regression tree feature selection imbalanced data weighted Gini index (WGI)

On the calibration of feedback broadband seismometer FBS-3A with current signal

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Acta Seismologica Sinica(English Edition) 2001年第2期14卷 203-215页

作者： liu qing-wei 1. Center for Analysis and Prediction China Seismological Bureau 100036 Beijing China

With the time passing by and the environmental changing, the characteristics of the components in a seismometer may change a little to some extent. To realize this kind of change and take steps to control or adjust it is helpful to improve the reliability of the sensor's output. Therefore, every seismometer must be calibrated, either before leaving factory or in use. Up to now, there are two kinds of calibrations used frequently with current signals, namely using square-wave signal and sine-wave signal. From the view point of systematic analysis, after getting the transfer function of the seismometer and simplifying the process of calibration with current signal, research has been done, in complex frequency domain, to the process of calibration with simulation method. On the basis of this, the relationship between the output figure of square-wave calibration and the intrinsic parameters of a sensor is discussed in this paper. The relationship between the steady output of sine-wave calibration and the calibration current, as well as the relationship of the calibration outputs caused by two sine waves with specific frequencies is presented. As the result of the theoretical analysis, two applications of the calibration with current signal are provided. The aim of this paper is to clarify the meanings of these two commonly used calibration methods, which would be fairly positive and helpful to the adjustment and the practical application of the seismometers.

关键词： calibration with current signal FBS-3A broadband seismometer P631.4+32

Existence,Multiplicity and Infinite Solvability of Positive Solutions for One-Dimensional p-Laplacian

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Acta Mathematica Sinica,English Series 2005年第4期21卷 691-698页

作者： qing liu YAO Department of Applied Mathematics Nanjing University of Finance and Economics Nanjing 210003 P. R. China

The existence, multiplicity and infinite solvability of positive solutions are established for some two-point boundary value problems of one-dimensional p-Laplacian. In this paper, by multiplicity we mean the existenc... 详细信息

关键词： One-dimensional p-Laplacian Positive solution Existence Multiplicity Infinite solvability