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Protective effect of inducible nitric oxide synthase inhibitor on pancreas transplantation in rats

World Journal of Gastroenterology 2007年第45期13卷 6066-6071页

作者： Bai-Feng Li Yong-Feng liu ying Cheng Ke-zhong Zhang Tie-Min Li Ning Zhao Department of Surgery and OrganTransplant Unit The First Affiliated Hospital China MedicalUniversity Shenyang 110001 Liaoning Province China

AIM: To investigate the effect of inducible nitric oxide synthase inhibitor, aminoguanidine, on pancreas transplantation in rats. METHODS: A model of pancreas transplantation was established in rats. Streptozotocin-induced diabetic male Wistar rats were randomly assigned to sham-operation control group (n= 6), transplant control group (n= 6), and aminoguanidine (AG) treatment group (n=18). In the AG group, aminoguanidine was added to intravascular infusion as the onset of reperfusion at the dose of 60 mg/kg, 80 mg/kg, 100 mg/kg body weight, respectively. Serum nitric oxide (NO) level, blood sugar and amylase activity were detected. Nitric oxide synthase (NOS) test kit was used to detect the pancreas cNOS and inducible NOS (iNOS) activity. Pancreas sections stained with HE and immunohistochemistry were evaluated under a light microscope. RESULTS: As compared with the transplant control group, the serum NO level and amylase activity decreased obviously and the evidence for pancreas injury was much less in the AG group. The AG (80 mg/kg body weight) group showed the most signifi cant difference in NO and amylase (NO: 66.0 ± 16.6 vs 192.3 ± 60.0, P < 0.01 and amylase: 1426 ± 177 vs 4477 ± 630, P < 0.01). The expression and activity of tissue iNOS, and blood sugar in the AG (80 mg/kg body weight) group were much lower than those in the transplant control group (iNOS: 2.01 ± 0.23 vs 26.59 ± 5.78, P < 0.01 and blood sugar: 14.2 ± 0.9 vs 16.8 ± 1.1, P < 0.01). CONCLUSION: Selective iNOS inhibitor, aminoguanidine as a free radical, has a protective effect on pancreas transplantation in rats by inhibiting NO and reducing its toxicity.

关键词： Pancreas Transplantation Inducible nitricoxide synthase Aminoguanidine Rat

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Robust-augmentation nonlinear dynamic inversion control of over-actuated coaxial high-speed helicopter in transition mode

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Chinese Journal of Aeronautics 2024年第8期37卷 404-420页

作者： Yuqing QIU Yan LI Jinxi LANG Yuxian liu zhong WANG School of Automation Northwestern Polytechnical UniversityXi’an 710129China

As the elevator and rudder can be used actively for control,in addition to the rotors,Coaxial High-speed Helicopters(CHHs)have the problems of control redundancy and changing control authority in the transition *** paper presents a robust-augmentation transitioning flight control design for a CHH under the adverse conditions of parametric uncertainties and external ***,based on control characteristic analysis,an Adaptive Filtered Nonlinear Dynamic Inversion(AFNDI)controller is proposed for the angular rate to handle the effect of unknown unstructured uncertainties and external *** analysis proves that the presented angular rate controller can guarantee steady-state and transient ***,the attitude angle and velocity controllers are also ***,an Incremental-based Nonlinear Prioritizing Control Allocation(INPCA)method is designed to take into account control surface transition and changing control authority,which efficiently distributes the required moments between coaxial rotors and aero-surfaces,and avoids the control reversal problem of the yaw *** the proposed control architecture,the low-pass filter is introduced to alleviate the adverse influence of time delay and measurement ***,the effectiveness of the proposed controller is demonstrated through nonlinear numerical simulations,and is compared with existing *** results show that the proposed control law can improve both capabilities of disturbance rejection and fast response,and works satisfactorily for the CHH transitioning control characteristic.

关键词： Coaxial high-speed helicopter Transition mode Attitude control Control allocation Robust adaptive control

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Dendritic Learning and Miss Region Detection-Based Deep Network for Multi-scale Medical Segmentation

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Journal of Bionic Engineering 2024年第4期21卷 2073-2085页

作者： Lin zhong Zhipeng liu Houtian He Zhenyu Lei Shangce Gao Faculty of Engineering University of ToyamaToyama9300887Japan

Automatic identification and segmentation of lesions in medical images has become a focus area for *** for medical image provides professionals with a clearer and more detailed view by accurately identifying and isolating specific tissues,organs,or lesions from complex medical images,which is crucial for early diagnosis of diseases,treatment planning,and efficacy *** paper introduces a deep network based on dendritic learning and missing region detection(DMNet),a new approach to medical image *** combines a dendritic neuron model(DNM)with an improved SegNet framework to improve segmentation accuracy,especially in challenging tasks such as breast lesion and COVID-19 CT scan *** work provides a new approach to medical image segmentation and confirms its *** have demonstrated that DMNet outperforms classic and latest methods in various performance metrics,proving its effectiveness and stability in medical image segmentation tasks.

关键词： Medical image segmentation Dendritic learning Deep supervision Dynamic focal loss

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Research Progress in the Fabrication of Covalent Organic Framework Membranes for Chemical Separations

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Chinese Journal of Polymer Science 2024年第2期42卷 141-158,I0005页

作者： Cui-Ting Ding Jin-Qiu Yuan Meng-ying Xie Qing-Yuan liu Zeng-Guang Yao Shi-Yu Zhang Run-Nan Zhang Hong Wu zhong-Yi Jiang Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China Zhejiang Institute of Tianjin University NingboZhejiang315201China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China Tianjin Key Laboratory of Membrane Science and Desalination Technology Tianjin UniversityTianjin300072China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou350207China

Membrane technology has become one of the most promising separation technologies for its energy saving, high separation efficiency, environmental friendliness, and economic feasibility. Covalent organic frameworks(COFs) with intrinsically high porosity, controllable pore size, uniform pore size distribution and long-range ordered channel structure, have emerged as next-generation materials to fabricate advanced separation membranes. This feature article summarizes some latest studies in the development of pure COF membranes in our lab, including their fabrication and applications in chemical separations. Finally, current challenges facing high-performance COF separation membranes are discussed.

关键词： Covalent organic frameworks Covalent organic framework membranes Water treatment Organic solvent nanofiltration Gas separation

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Process design and intensification of multicomponent azeotropes special distillation separation via molecular simulation and system optimization

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Chinese Journal of Chemical Engineering 2024年第7期71卷 24-44页

作者： Chunliang liu Jianhui zhong Ranran Wei Jiuxu Ruan Kaicong Wang Zhaoyou Zhu yinglong Wang Limei zhong College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042China

This work provides an overview of distillation processes,including process design for different distillation processes,selection of entrainers for special distillation processes,system integration and intensification of distillation processes,optimization of process parameters for distillation processes and recent research progress in dynamic control ***,the feasibility of using thermodynamic topological theories such as residual curve,phase equilibrium line and distillation boundary line to analyze different separation regions is discussed,and the rationality of distillation process design is discussed by using its ***,the application of molecular simulation methods such as molecular dynamics simulation and quantum chemical calculation in the screening of entrainer is discussed for the extractive distillation *** thermal coupling mechanism of different distillation processes is used to explore the process of different process ***,a mixed integer nonlinear optimization strategy for the distillation process based on different algorithms is ***,the improvement of dynamic control strategies for different distillation processes in recent years is *** work focuses on the application of process intensification and system optimization in the design of distillation process,and analyzes the challenges,prospects,and development trends of distillation technology in the separation of multicomponent azeotropes.

关键词： Azeotrope separation Process design Optimization algorithm Process integration Dynamic control Entrainer selection

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Computer-aided molecular design and optimization of potent inhibitors disrupting APC-Asef interaction

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2631-2645页

作者： Xuefei Wang Zeqian Du Yuegui Guo Jie zhong Kun Song Junyuan Wang Jianqiang Yu Xiuyan Yang Chen-ying liu Ting Shi Jian Zhang Department of Pathophysiology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationShanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China Key Laboratory of Protection Development and Utilization of Medicinal Resources in Liupanshan AreaMinistry of EducationPeptide&Protein Drug Research CenterSchool of PharmacyNingxia Medical UniversityYinchuan 750004China State Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental SciencesSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Department of Colorectal and Anal Surgery Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Basic Science Research Center Base(Pharmaceutical Science) Yantai UniversityYantai 264005China Medicinal Chemistry and Bioinformatics Center Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Colorectal cancer(CRC)is the second leading cause of cancer mortality *** initial diagnosis,approximately 20%of patients are diagnosed with metastatic CRC(mCRC).Although the APC-Asef interaction is a well-established target for mCRC therapy,the discovery and development of effective and safe drugs for mCRC patients remains an urgent and challenging *** this study,we identified a novel structural scaffold based on MAI inhibitors,the first-in-class APC-Asef inhibitors we reported *** model-driven optimizations of the N-terminal cap and experimental evaluations of inhibitory activity were performed,and 24-fold greater potency was obtained with the best inhibitor compared to the parental *** addition,the cocrystal structure validated that the two-layerπ-πstacking interactions were essential for inhibitor stabilization in the bound ***,in vitro and in vivo studies have demonstrated that novel inhibitors suppressed lung metastasis in CRC by disrupting the APC-Asef *** results provide an intrinsic structural basis to further explore drug-like molecules for APC-Asef-mediated CRC therapy.

关键词： APC-Asef Peptidomimetic Computer-aided molecular design ONIOM model π-πstacking Metastatic colorectal cancer

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Super-high bed sintering for iron ores:behaviors,causes and solutions of horizontal segregation on strand

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Journal of Iron and Steel Research International 2024年第7期31卷 1590-1596页

作者： Liang-ping Xu Hui-bo liu zhong-lin Dong Qiang zhong Yu-chao Zhao Guang-hui Li School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina

Horizontal segregation has been a constraint to the development and application of super-high bed *** eliminate the horizontal segregation of super-high bed sintering,several typical sintering machines were sampled and analyzed,and theoretical calculation was made to compare the bed depth and their differences in different areas within the mixture ***,solutions were proposed and applied to a 265 m^(2) sintering *** results showed that the horizontal seg-regation of the 265 m^(2) sintering machine was dominated by particles larger than 8 mm with horizontal segregation degree of 0.48,while 360 and 550 m^(2) sintering machines were affected by 5-8 mm and 1-3 mm particles with horizontal segregation degree of 0.27 and 0.31,*** analysis indicated the different segregation distribution results from the matching of the bed depth of each area within the mixture ***,the horizontal segregation degree not larger than 0.06 was achieved by optimizing the time parameters and the division of three zones on the 265 m^(2) sintering machine.

关键词： Super-high bed sintering Horizontal segregation Feeder Particle distribution Agglomeration

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Investigations on High-Speed Flash Boiling Atomization of Fuel Based on Numerical Simulations

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1427-1453页

作者： Wei zhong Zhenfang Xin Lihua Wang Haiping liu School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai200092China Beijing Mechanical Equipment Research Institute Beijing100854China

Flash boiling atomization(FBA)is a promising approach for enhancing spray atomization,which can generate a fine and more evenly distributed spray by increasing the fuel injection temperature or reducing the ambient ***,when the outlet speed of the nozzle exceeds 400 m/s,investigating high-speed flash boiling atomization(HFBA)becomes quite *** difficulty arises fromthe involvement ofmany complex physical processes and the requirement for a very fine mesh in numerical *** this study,an HFBA model for gasoline direct injection(GDI)is *** model incorporates primary and secondary atomization,as well as vaporization and boilingmodels,to describe the development process of the flash boiling *** to lowspeed FBA,these physical processes significantly impact *** this model,the Eulerian description is utilized for modeling the gas,and the Lagrangian description is applied to model the droplets,which effectively captures the movement of the droplets and avoids excessive mesh in the Eulerian *** various conditions,numerical solutions of the Sauter mean diameter(SMD)for GDI show good agreement with experimental data,validating the proposed model’s *** based on this HFBA model investigate the influences of fuel injection temperature and ambient pressure on the atomization *** analyses of the velocity field,temperature field,vapor mass fraction distribution,particle size distribution,and spray penetration length under different superheat degrees reveal that high injection temperature or low ambient pressure significantly affects the formation of small and dispersed droplet *** effect is conducive to the refinement of spray particles and enhances atomization.

关键词： High-speed flash boiling atomization numerical simulations Eulerian description Lagrangian description gasoline direct injection

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Understanding the Activity Performance of Comets 38P/Stephan-Oterma,64P/Swift-Gehrels and C/2017 M4(ATLAS)through Broadband Photometric Observations

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Research in Astronomy and Astrophysics 2024年第8期24卷 147-156页

作者： Xuan Zhang Jin-zhong liu Le-Tian Wang Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China

In this work,we report observations of three comets:38P/Stephan-Oterma,64P/Swift-Gehrels,and C/2017 M4(ATLAS),conducted with the Nanshan one-meter wide-field telescope in 2018 August and November,and *** extracted morphological features through image enhancement techniques and calculated the dust activity parameter,Afρ,along with dust mass loss rates and coma color indices using broadband photometric *** morphological analysis uncovered a spectrum of dust characteristics among the observed comets,ranging from a significant twisted structure in comet 38P/Stephan-Oterma’s coma to the regular coma envelope surrounding comet 64P/*** Afρvalues varied between 148.8±0.3 cm for 64P/Swift-Gehrels and1118.5±6.2 cm for C/2017 M4(ATLAS)(measured within a reference aperture radius ofρ=6″),indicating a range from moderate to high activity *** mass loss rates were estimated from 328.1 kg s^(-1)for comet 64P/Swift-Gehrels to 1395.5 kg s^(-1)for comet C/2017 M4(ATLAS).The color indices of comets 38P/Stephan-Oterma and C/2017 M4(ATLAS)closely resemble the average colors of active short-period comets and active longperiod comets,*** contrast,64P/Swift-Gehrels exhibits a significantly bluer hue than typical Jupiter family comets.

关键词： comets general-comets individual(38P/Stephan-Oterma,64P/Swift-Gehrels,C/2017 M4(ATLAS))-techniques photometric

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Super-high bed sintering for iron ores: inhomogeneous phenomena and its mechanism during mineralizing

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Journal of Iron and Steel Research International 2024年第8期31卷 1850-1860页

作者： Hui-bo liu Liang-ping Xu Xi-duan Yang zhong-lin Dong Qiang zhong Guang-hui Li School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina

The inhomogeneous sinter properties in super-high bed sintering have been reported in our previous *** inves-tigate the reasons for the inhomogeneous phenomena,detailed sampling and analysis of mixed material bed and sintered bed in super-high bed sintering plant were *** results indicated that the higher porosity and thinner dendrite of silico-ferrite of calcium and aluminum in the upper layer as well as dense structure and higher secondary hematite content in the lower layer led to the heterogeneities of mechanical strength and reduction properties exceeding 20%and 10%,*** the bed top downward,the basicity of mixed material decreased from 2.13 to 1.68 because the average particle size increased from 2.65 to 4.56 *** and fuels gathered in finer particles(-3 mm)of mixed material,and the-3 mm particles of mixed material generated more liquid phase than+3 mm *** heat input of super-high sintering bed was inhomogeneous due to the heat accumulation effect and unreasonable fuel *** inhomo-geneous sintering heat condition in sintering bed resulted in the different quantities and properties of liquid *** inhomogeneous quantities and properties of liquid phase that were influenced by inhomogeneous distribution of chemical composition,particle size,and heat input led to inhomogeneous mineralizing *** mineralizing condition is the key for homogeneous super-high bed sintering.

关键词： Iron ore Super-high bed sintering Mineralization Material segregation Heat accumulation

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