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Oncology and Translational Medicine 2024年第3期10卷 143-150页

作者： wenzhen liu Macao Wan Department of The SecondClinic The 940 Hospital of Joint Logistics Support Force of Chinese PLALanzhou 730050China

Background:Previous studies have established the role of 2-oxoglutarate and Fe(II)-dependent oxygenase domain–containing protein 1(OGFOD1)in *** objective of this investigation was to discern the diagnostic and prognostic relevance of OGFOD1 within the context of bladder cancer(BLCA)using bioinformatics ***:We collected RNA sequencing data from The Cancer Genome Atlas database and verified it using the GSE13507 *** analysis was based on data from the human protein atlas,and the protein-protein interaction network was constructed using the STRING *** analysis was performed using the R application,analyzing the correlation between clinical characteristics and OGFOD1 expression,exploring the potential mechanisms of OGFOD1 in BLCA through Kyoto Encyclopedia of Genes and Genomes analysis,and evaluating the diagnostic and prognostic value of OGFOD1 expression in BLCA through receiver operating characteristic curve analysis,Kaplan-Meier analysis,and multivariate Cox ***,a BLCA prognostic nomogram was ***:We report higher expression levels of OGFOD1 in BLCA specimens compared with those in noncancerous tissues;this can be used to predict the outcome of the ***,results suggest that OGFOD1 is implicated in the activation of the peroxisome proliferator-activated receptor signaling cascade,potentially interacting with other genes linked to expression in promoting the onset and progression of ***:OGFOD1 is a promising candidate as a prognostic indicator in BLCA.

关键词： OGFOD1 bladder cancer bioinformatics function diagnosis prognosis

Unified analysis of pressure melting of ice around horizontal columns

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Progress in Natural Science:Materials International 2007年第3期17卷 371-374页

作者： liu Feng, CHEN wenzhen, MENG Bin and GONG Miao (College of Power and Shipping, Naval University of Engineering, Wuhan 430033, China) [a]College of Power and Shipping Naval University of Engineering Wuhan China

The contact melting processes of ice, caused by pressure under the two-dimension axisymmetric horizontal columns, are generally studied. The unified mathematical expressions of the characteristic parameters for the pressure contact melting processes are obtained. Applying these expressions to the analysis of the pressure contact melting of ice around the horizontal cylinder, elliptical cylinder and flat plate, the related results in the published literatures are obtained, which prove the correctness and validity of the expressions. In addition, the expressions for the pressure contact melting of ice around the wedge-shaped object are also derived.

关键词： pressure melting contact melting horizontal columns flat plate wedge-shaped object

Characterization and Fine Mapping of a Novel Rice Narrow Leaf Mutant nal9

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Journal of Integrative Plant Biology 2013年第11期55卷 1016-1025页

作者： Wei Li Chao Wu Guocheng Hu Li Xing Wenjing Qian Huamin Si Zongxiu Sun Xingchun Wang Yaping Fu wenzhen liu State Key Laboratory of Rice Biology China National Rice Research Institute College of Life Sciences Shanxi Agricultural University Institute of Horticulture Zhejiang Academy of Agricultural Sciences Biotechnology Research Center China Three Gorges University

A narrow leaf mutant was isolated from transgenic rice （Oryza sativa L.） lines carrying a T-DNA insertion. The mutant is characterized by narrow leaves during its whole growth period, and was named nal9 （narrow leaf 9）. The mutant also has other phenotypes, such as light green leaves at the seedling stage, reduced plant height, a small panicle and increased tillering. Genetic analysis revealed that the mutation is controlled by a single recessive gene. A hygromycin resistance assay showed that the mutation was not caused by T-DNA insertion, so a map-based cloning strategy was employed to isolate the nal9 gene. The mutant individuals from the F2 generations of a cross between the nal9mutant and Longtepu were used for mapping. With 24 F2 mutants, the nal9 gene was preliminarily mapped near the marker RM156 on the chromosome 3. New INDEL markers were then designed based on the sequence differences between japonica and indica at the region near RM156. The nal9 gene was finally located in a 69.3 kb region between the markers V239B and V239G within BAC OJ1212_C05 by chromosome walking. Sequence and expression analysis showed that an ATP-dependent CIp protease proteolytic subunit gene （CIpP） was most likely to be the nal9 gene. Furthermore, the nal9 mutation was rescued by transformation of the CIpP cDNA driven by the 35S promoter. Accordingly, the CIpP gene was identified as the NAL9 gene. Our results provide a basis for functional studies of NAL9 in future work.

关键词： ice narrow leaf mutant nal9 fine mapping.

Increasing the Genetic Recombination Frequency by Partial Loss of Function of the Synaptonemal Complex in Rice

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Molecular Plant 2015年第8期8卷 1295-1298页

作者： Wang, Kejian Wang, Chun liu, Qing liu, wenzhen Fu, Yaping Chinese Acad Agr Sci China Natl Rice Res Inst State Key Lab Rice Biol Hangzhou 310006 Zhejiang Peoples R China

Dear Editor Genetic recombination results in novel allele combinations and is the most important genetic phenomenon for generating variation in breeding populations. However, in most organisms, the number of genetic recombinations is tightly constrained, which hampers the introgression of new genetic traits and limits genetic variation during agricultural breeding （Barakate et al., 2014）. Therefore, the possibility of increasing genetic recombination frequency has attracted much interest from crop breeders because of the obvious practical applications in traditional breeding （Leflon et al., 2010; Crismani et al., 2012）. However, to date, the goal of increasing the genetic recombination frequency has not been achieved in crop plants.

关键词：繁殖联会复合体内皮缩血管肽类稻属遗传现象胰岛素植物重组遗传

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传统健身功法对银发族功能性体适能之效益

武汉体育学院学报 2012年第3期46卷 66-69页

作者：刘文祯正修科技大学运动健康与休闲系

研究目的:以传统健身功法易筋经为训练内容,期望提升银发族功能性体适能指针,进而提升日常生活中所需的基本能力以安享老年生活。研究方法:以高雄市华美、文英、协和及乌材林4个小区关怀据点银发族为研究对象,男性25名平均年龄75.32±5... 详细信息

研究目的:以传统健身功法易筋经为训练内容,期望提升银发族功能性体适能指针,进而提升日常生活中所需的基本能力以安享老年生活。研究方法:以高雄市华美、文英、协和及乌材林4个小区关怀据点银发族为研究对象,男性25名平均年龄75.32±5.61岁,女性45名平均年龄为73.71±5.99岁,每周2次,每次60 min(热身运动10 min:主要运动——易筋经40 min:缓和运动10 min),共接受20周的易筋经训练。统计方法包括叙述性统计、独立样本t检定分析。结果发现:易筋经对男性银发族之影响,在体重、身体质量指数及坐姿前弯方面,虽有进步但皆未达显著差异水平;在抓背、2.44 m绕物测验、二头肌内卷、30 s起坐及2 min原地踏步,皆有进步且达显著差异水平。对女性银发族之影响,在身高、体重、身体质量指数方面,虽有进步但未达显著差异水平;在坐姿前弯、抓背、2.44 m绕物测验、二头肌内卷、30 s起坐及2 min原地踏步,皆有进步且达显著差异水平。结论:易筋经对银发族是有帮助的,是值得推展的传统健身运动;有些检测结果变化虽未达显著差异水平,原因可能是活动量不足或训练时间太短所致;合适的运动项目对银发族是相当重要的,运动量不足则无法达到既定的成效,而太强又容易导致运动伤害,如何选择适当运动项目及强度,是值得相关单位重视的议题。

关键词：传统健身功法易筋经银发族功能性体适能

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西藏基层党建与乡村振兴耦合机制研究

西藏研究 2022年第5期196卷 76-82页

作者：刘文珍西藏自治区党委党校政法教研部西藏拉萨850000

基层党建与乡村振兴的关系是当前学术界研究的一大热点。从理论和实际两方面分析,二者是互相促进、联动式前进的耦合发展关系。从当前的情况来看,西藏的农牧区基层党建与乡村振兴的耦合效应还未完全显现。因此,通过党建治理资源与乡村... 详细信息

基层党建与乡村振兴的关系是当前学术界研究的一大热点。从理论和实际两方面分析,二者是互相促进、联动式前进的耦合发展关系。从当前的情况来看,西藏的农牧区基层党建与乡村振兴的耦合效应还未完全显现。因此,通过党建治理资源与乡村产业和生态振兴耦合,促进乡村资源内生;通过党建组织与乡村组织和人才振兴耦合,发挥农牧民的主体性;通过党建价值与乡村文化振兴耦合,促进乡村文化认同,实现西藏基层党建与乡村振兴的全面耦合发展。

关键词：基层党建乡村振兴耦合机制

信用评级对我国资产证券化产品发行定价的影响机理

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财经科学 2019年第9期 14-25页

作者：朱波刘文震西南财经大学金融学院

本文基于2016-2018年中国交易所市场和银行间市场发行的企业ABS与信贷CLO数据,以评级机构的竞争程度作为债券评级的工具变量,就信用评级对资产证券化产品发行定价的影响机理问题进行了考察。研究发现:我国资产证券化产品的信用评级显著... 详细信息

本文基于2016-2018年中国交易所市场和银行间市场发行的企业ABS与信贷CLO数据,以评级机构的竞争程度作为债券评级的工具变量,就信用评级对资产证券化产品发行定价的影响机理问题进行了考察。研究发现:我国资产证券化产品的信用评级显著地降低了发行人的融资成本,但不同发行市场的具体效应之间存在较大的差异,交易所市场呈现出显著为负的效应,而银行间市场的信用评级效应却不显著。发行人分层数目越多,信用评级质量越高,资产证券化产品的违约风险越低,发行利差越小,因此我国资产证券化产品分层结构设计较好地规避了逆向选择行为,提升了信用评级在资产证券化市场上的公信力。发行人规模、债券特征和增信措施等对资产证券化产品的发行定价也有显著影响,但主体评级对信用利差的效应却不显著。本文研究为我国资产证券化产品的优化设计、信用评级市场的不断完善和资产证券化市场的大力发展提供了参考。

关键词：资产证券化信用利差信用评级分层结构

股权关联关系对资产证券化产品定价存在影响吗——基于隶属关联和声誉机制视角的分析

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财经科学 2020年第7期 27-40页

作者：朱波刘文震西南财经大学金融学院

本文基于2014—2018年中国银行间市场发行的信贷CLO产品数据,以平均关联率作为发起人和发行人股权关联关系的工具变量,就发起人与发行人隶属关联关系对信贷资产证券化产品发行价差的影响问题进行了考察。研究结果表明,发起人与发行人隶... 详细信息

本文基于2014—2018年中国银行间市场发行的信贷CLO产品数据,以平均关联率作为发起人和发行人股权关联关系的工具变量,就发起人与发行人隶属关联关系对信贷资产证券化产品发行价差的影响问题进行了考察。研究结果表明,发起人与发行人隶属关联关系对信贷资产证券化产品发行价差有显著的负向效应,隶属关联关系显著地降低了发起人的融资成本。就声誉调节机制而言,发行人和承销商声誉提升有助于降低信贷资产证券化产品的融资成本,高声誉发行人和承销商在一定程度上缓解了债券发行中的信息不对称,具体效应与产品的分层设计、次级分券占比、发起人的所有制结构紧密相关。论文结论为我国资产证券化产品创新机制设计和监管政策科学制定提供了参考。

关键词：资产证券化信用利差隶属关系声誉机制分层结构

带扰动的两类相关索赔风险模型的折现罚金函数

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中国科学技术大学学报 2013年第6期43卷 444-454页

作者：刘文震王传玉安徽工程大学金融工程系安徽芜湖241000

考虑带扰动的两类相关索赔风险过程.把相关的两类索赔计数过程通过模型转换为独立的Poisson-Geometric和广义Erlang(n)计数过程.得到了此模型的折现罚金函数的积分微分方程和该模型的折现罚金函数的Laplace变换,并且当相关两类索赔的密... 详细信息

考虑带扰动的两类相关索赔风险过程.把相关的两类索赔计数过程通过模型转换为独立的Poisson-Geometric和广义Erlang(n)计数过程.得到了此模型的折现罚金函数的积分微分方程和该模型的折现罚金函数的Laplace变换,并且当相关两类索赔的密度函数的Laplace变换为有理函数时,给出了折现罚金函数的具体表达式.

关键词：破产概率 Poisson-Geometric过程广义Erlang(n)过程折现罚金函数 Laplace变换

A new class of nitrobenzoic acid-based AIE photosensitizers for highly efficient photodynamic antibacterial therapy

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Science China Materials 2021年第10期64卷 2601-2612页

作者： Huanhuan Wang Xiaohong Pan Yaqi Wang wenzhen liu Tao Dai Binbin Yuan Xueyuan Chen Zhuo Chen State Key Laboratory of Structural Chemistry CAS Key Laboratory of Design and Assembly of Functional NanostructuresFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China

hotodynamic therapy(PDT)has been drawing more and more attention in the antibacterial *** photosensitizers(PSs)tend to aggregate in aqueous media,which reduces the generation of reactive oxygen species(ROS)and seriously affects the photodynamic *** efforts have been made to prevent aggregation of traditional *** contrast,aggregation-induced emission PSs(AIE-PSs)take advantage of aggregation to boost ROS generation and fluorescence ***,the efficacies of the reported antibacterial AIE-PSs are ***,we report a new class of highly effective antibacterial AIE-PSs based on nitrobenzoic acid ***,a negatively charged AIE-PS,can not only selectively kill spherical bacteria(Staphylococcus aureus(***))rather than rod-shaped bacteria(Escherichia coli(***)),but also be easily extended to several AIE-PSs(TTVBP1–3)with positive charges and broad-spectrum antibacterial *** demonstrate that TTVBP2 can kill3.0 log_(10)of *** at very low concentration(125 nmol L^(-1)),TTVBP3 can kill 4.7 log_(10)of Staphylococcus epidermidis(***)at a concentration of 1μmol L^(-1)and 3.8 log_(10)of *** at 5μmol L^(-1),thus enabling them among the most effective antibacterial AIE-PSs reported so ***,these AIE-PSs exhibit excellent wash-free imaging ability for bacteria by simple mixing with *** thus envision that TTVBA,a nitrobenzoic acid-based extendable AIE-PS,provides a new route for the design of AIE-PSs in antibacterial treatment.

关键词： photodynamic antibacterial therapy photosensitizer aggregation-induced emission reactive oxygen species imaging