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分化型甲状腺癌围手术期循环血微转移相关因素分析

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中国普通外科杂志 2015年第9期24卷 1333-1337页

作者：刘勤江马世红田尤新甘肃省肿瘤医院头颈外科甘肃兰州730050

目的:探讨分化型甲状腺癌围手术期循环血微转移存在状况及影响因素。方法:采用流式细胞术(FCM)对327例手术治疗的分化型甲状腺癌,围手术期检测外周血微转移并对其进行相关因素分析。结果:分化型甲状腺癌术前循环血微转移阳性93例(28.4%)... 详细信息

目的:探讨分化型甲状腺癌围手术期循环血微转移存在状况及影响因素。方法:采用流式细胞术(FCM)对327例手术治疗的分化型甲状腺癌,围手术期检测外周血微转移并对其进行相关因素分析。结果:分化型甲状腺癌术前循环血微转移阳性93例(28.4%),其中74例(74/93)术后1周持续阳性、35例(35/74)术后4周仍呈阳性。循环血微转移在术前及术后1周阳性率与肿瘤大小、淋巴结分期有关(P0.05);在术后4周时微转移阳性率仅与肿瘤的病理分化程度有关(P<0.05)。在术前微转移阴性者中,有34例(17.3%)术后1周转呈阳性,其阳性率仅与肿瘤大小有关(P<0.001)。结论:分化型甲状腺癌循环血微转移与肿瘤大小、淋巴结分期及手术刺激密切相关,肿瘤分化程度是循环血微转移阳性持续存在的主要因素。

关键词：甲状腺肿瘤肿瘤转移流式细胞术循环肿瘤细胞

Engineering biomimetic nanosystem targeting multiple tumor radioresistance hallmarks for enhanced radiotherapy

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Science China(Life Sciences) 2024年第7期67卷 1398-1412页

作者： Shuxiang Wang Hongmei Cao Cui-Cui Zhao Qian Wang Dianyu Wang Jinjian liu Lijun Yang Jianfeng liu State Key Laboratory of Advanced Medical Materials and Devices Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear MedicineKey Laboratory of Radiopharmacokinetics for Innovative DrugsTianjin Institutes of Health ScienceInstitute of Radiation MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and Therapy(Tianjin)Key Laboratory of Breast Cancer Prevention and TherapyTianjin Medical UniversityMinistry of EducationTianjin 300060China

Tumor cells establish a robust self-defense system characterized by hypoxia,antioxidant overexpression,DNA damage repair,and so forth to resist *** one of these features is insufficient to overcome radioresistance due to the feedback mechanisms initiated by tumor cells under ***,we herein developed an engineering biomimetic nanosystem(M@HHPt)masked with tumor cell membranes and loaded with a hybridized protein-based nanoparticle carrying oxygens(O_(2))and cisplatin prodrugs(Pt(Ⅳ))to target multiple tumor radioresistance hallmarks for enhanced *** administration,M@HHPt actively targeted and smoothly accumulated in tumor cells by virtue of its innate homing abilities to realize efficient co-delivery of O_(2)and Pt(Ⅳ).O_(2)introduction induced hypoxia alleviation cooperated with Pt(Ⅳ)reduction caused glutathione consumption greatly amplified radiotherapy-ignited cellular oxidative ***,the released cisplatin effectively hindered DNA damage repair by crosslinking with radiotherapy-produced DNA ***,M@HHPt-sensitized radiotherapy significantly suppressed the proliferation of lung cancer H1975 cells with an extremely high sensitizer enhancement ratio of 1.91 and the progression of H1975 tumor models with an excellent tumor inhibition rate of 94.7%.Overall,this work provided a feasible strategy for tumor radiosensitization by overcoming multiple radioresistance mechanisms.

关键词： biomimetic nanosystem hypoxia alleviation glutathione consumption oxidative stress amplification DNA damage fixation radiosensitization

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昼夜制作鼠重型闭合性颅脑创伤模型的死亡率

第四军医大学学报 2005年第8期26卷 693-693页

作者：刘清军赵景霞华北煤炭医学院附属医院神经外科华北煤炭医学院基础部生理学教研室河北唐山063000

实验资料成年雄性SD大鼠160只，体质量350～375g随机分成上午、下午，前半夜及后半夜4组，每组40只，分别在08：00～11：00，15：00～18：00，20：00～23：00及03：00～06：00严格按照1994年Marmarou的方法(J Neurosurg，1994；80(2)：... 详细信息

实验资料成年雄性SD大鼠160只，体质量350～375g随机分成上午、下午，前半夜及后半夜4组，每组40只，分别在08：00～11：00，15：00～18：00，20：00～23：00及03：00～06：00严格按照1994年Marmarou的方法(J Neurosurg，1994；80(2)：291—300．)复制重型闭合性颅脑损伤模型．于致伤后24h用乙醚吸入麻醉后，以4℃40g/L多聚甲醛250mL经心灌注固定后，开颅取脑，

关键词：重型闭合性颅脑创伤模型死亡率大鼠

Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3949-3963页

作者： Bin Li Qi Xiao Hongmei Zhao Jianuo Zhang Chunyan Yang Yucen Zou Bengang Zhang Jiushi liu Haitao Sun Haitao liu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Medicinal Plant DevelopmentChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100193China Institute of Basic Medical Sciences Chinese Academy of Medical SciencesDepartment of PathophysiologyPeking Union Medical CollegeBeijing 100005China

Non-alcoholic fatty liver disease(NAFLD),characterized by hepatic steatosis,is a common metabolic liver disease ***,satisfactory drugs for NAFLD treatment remain *** and diabetes are the leading causes of NAFLD,and compounds with anti-obesity and antidiabetic activities are considered suitable candidates for treating *** this study,biochemical and histological assays revealed that a natural lignan schisanhenol(SAL)effectively decreased lipid accumulation and improved hepatic steatosis in free fatty acid(FFA)-treated HepG2 cells and high-fat diet(HFD)-induced NAFLD ***,molecular analyses,microRNA(miRNA)-seq,and bioinformatics analyses revealed that SAL may improve NAFLD by targeting the miR-802/adenosine monophosphateactivated protein kinase(AMPK)***-specific overexpression of miR-802 in NAFLD mice significantly impaired SAL-mediated liver protection and decreased the protein levels of phosphorylated(p)-AMPK and ***-luciferase assay analysis further confirmed that miR-802 inhibits hepatic AMPK expression by binding to the 3’untranslated region of mouse Prkab1 or human PRKAA1.

关键词： Schisanhenol Non-alcoholic fatty liver disease Hepatic steatosis Lipid metabolism miR-802 AMPK SREBP-1c PPARa

Hartree-Fock quantum Monte Carlo method

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Chinese Science Bulletin 1997年第13期42卷 1090-1093页

作者： Huang, HX Xie, qj Cao, ZX liu, SB Department of Chemistry Hunan Normal University Changsha 410081 China

QUANTUM Monte Carlo (QMC) approach has already been successfully utilized in quantumchemistry. However, QMC algorithm brings statistical errors that are sharply increasedas the investigated system is enlarged. We proposed in terms of correlated sampling a novel al-gorithm with a better precision and a smaller error. However, the modified QMC methodproposed has still two problems: (i) the 'random term' in the process of calculation is un-

关键词： Hartree-Fock quantum Monte Carlo method local energy statistical error.

A Time Domain Computation Method for Dynamic Behavior of Mooring System

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China Ocean Engineering 1998年第1期13卷 1-10页

作者： liu, YZ Miao, GP Li, YL liu, ZY liu, HD Huang, QY Ma, qj Shanghai Jiao Tong Univ Sch Naval Architecture & Ocean Engn Shanghai 200030 Peoples R China Univ Michigan Dept Naval Architecture & Ocean Engn Ann Arbor MI 48109 USA Chinese Acad Sci Inst Mech Beijing 100080 Peoples R China China Offshore Oil Bohai Corp Tianjin 300452 Peoples R China

A quasi-steady time domain method is developed for the prediction of dynamic behavior of a mooring system under the environmental disturbances, such as regular or irregular waves, winds and currents. The mooring forces are obtained in a static sense at each instant. The dynamic feature of the mooring cables can be obtained by incorporating the extended 3-D lumped-mass method with the known ship motion history. Some nonlinear effects, such as the influence of the instantaneous change of the wetted hull surface on the hydrostatic restoring forces and Froude-Krylov forces, are included. The computational results show a satisfactory agreement with the experimental ones.

关键词： mooring systems dynamic characteristics time domain analysis

THERMO-ELASTIC-PLASTIC RESPONSE AND OPTIMUM DESIGN OF CERAMIC-METAL FGMS-CYCLIC THERML LOADING PROBLEM

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Journal of Wuhan University of Technology(Materials Science) 1999年第2期14卷 8-17页

作者： Zhai, PC Zhang, qj Yuan, RZ Wuhan Univ Technol State Key Lab Mat Synth & Proc Wuhan 430070 Peoples R China

The materials are made with a graded composition and microstructure in the thickness direction from the ceramic side to the metal side. The cyclic thermal loading and high temperasure gradient environment are simulated by heating the ceramic surface with a cyclic hear flux input and cooling the metal surface with a flowing liquid niterogen. The thermal and themo-elastic-plastic response of the materials is calculated using the isotropic hardening model and kinetic hardening model. Emphasis is placed on the response analysis under the different graded compositional distributions. Through the response analysis, the optimum design process of the graded composition under the dynamic case is established, which is bused on a unified viewpoint of the heat insulation property, thermal stress relaxation property and stress history feature.

关键词： functionally graded materials cyclic thermal loading thermal-elastic-plastic response

Plate drag reduction with low surface energy coating in water tunnel

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Chinese Science Bulletin 1997年第4期42卷 307-310页

作者： Tian, J Xue, qj Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou China

THE response of a compliant coating to pressure fluctuations is known to modify the skin friction in a turbulent boundary layer. It was found that the addition of the dilute solution of polymer additive would reduce drag, surface pressure fluctuation, and also high frequency radiated flow noise. The results of microbubble show that the drag reduction is near 60%

关键词： low surface energy coating drag reduction boundary layer.

Structure of Second Phase Particles in As-castTi-5Al-4Sn-2Zr-1Mo-0.25Si-1Nd Alloy

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Journal of Materials Science & Technology 1998年第1期14卷 41-44页

作者： Li, GP Li, QC Li, D liu, YY Guan, SX Wang, qj Ping, DH Hu, ZQ Harbin Inst Technol Harbin 150001 Peoples R China Chinese Acad Sci Inst Met Res Shenyang 110015 Peoples R China

The microstructure of the Ti-5Al-4Sn-2Zr-1Mo-0.25Si-1Nd (Ti-55) alloy containing second phase particles was studied. The second phase particles are 1 similar to 15 mu m in size and most of them are distributed at the grain boundaries in the form of ellipsoid with a few short needle-like and blocky phases. It consists of either dark or bright amorphous 'matrix', and some small spots dispersed within the 'matrix', which match SnO (orthorhombic, a=0.500 nm, b=0.572 nm, c=1.12 nm).

关键词： Titanium alloys