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Quantitative trait loci identification reveals zinc finger protein CONSTANS-LIKE 4 as the key candidate gene of stigma color in watermelon(Citrullus lanatus)

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Journal of Integrative Agriculture 2024年第7期23卷 2292-2305页

作者： Shuang Pei Zexu Wu Ziqiao Ji Zheng liu Zicheng Zhu Feishi Luan Shi liu Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(Northeast Region) Ministry of Agriculture and RuralAffairs/College of Horticulture and Landscape ArchitectureNortheast Agricultural UniversityHarbin 150030China Institute of Rural Revitalization Science and Technology Heilongjiang Academy of Agricultural SciencesHarbin 150028China

Stigma color is a critical agronomic trait in watermelon that plays an important role in ***,there are few reports on the regulation of stigma color in *** this study,a genetic analysis of the F2 population derived from ZXG1553(P1,with orange stigma)and W1-17(P2,with yellow stigma)indicated that stigma color is a quantitative trait and the orange stigma is recessive compared with the yellow *** segregant analysis sequencing(BSA-seq)revealed a 3.75 Mb segment on chromosome 6 that is related to stigma ***,a major stable effective QTL Clqsc6.1(QTL stigma color)was detected in two years between cleaved amplified polymorphic sequencing(CAPS)markers Chr06_8338913 and Chr06_9344593 spanning a~1.01 Mb interval that harbors 51 annotated ***97C06G117020(annotated as zinc finger protein CONSTANS-LIKE 4)was identified as the best candidate gene for the stigma color trait through RNA-seq,quantitative real-time PCR(qRT-PCR),and gene structure alignment analysis among the natural watermelon *** expression level of Cla97C06G117020 in the orange stigma accession was lower than in the yellow stigma accessions with a significant difference.A nonsynonymous SNP site of the Cla97C06G117020 coding region that causes amino acid variation was related to the stigma color variation among nine watermelon accessions according to their re-sequencing *** color formation is often related to carotenoids,and we also found that the expression trend of ClCHYB(annotated asβ-carotene hydroxylase)in the carotenoid metabolic pathway was consistent with Cla97C06G117020,and it was expressed in low amounts in the orange stigma *** data indicated that Cla97C06G117020 and ClCHYB may interact to form the stigma *** study provides a theoretical basis for gene fine mapping and mechanisms for the regulation of stigma color in watermelon.

关键词： watermelon stigma color gene mapping zinc finger protein CONSTANS-LIKE 4

Rapid and sensitive detection of urinary KIM-1 using fully printed photonic crystal microarrays

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Nano Research 2024年第5期17卷 4329-4337页

作者： Yang liu Xuwei He Zewei Lian Qian Guo Jimei Chi Xiaoxue Lin Liyue Zhang Zheng liu Yingyuan liu Meng Su Keyu Wang Qiangguo Ao Qingli Cheng Department of Nephrology The Second Medical Center of Chinese PLA General HospitalNational Clinical Research Centre for Geriatric DiseasesBeijing 100853China Chinese PLA Medical School Beijing 100853China Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesBeijing Engineering Research Center of Nanomaterials for Green Printing TechnologyBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(ICCAS)Beijing 100190China Department of Rheumatology and Immunology Peking University International HospitalBeijing 102206China Department of Clinical Laboratory The Second Medical Center of Chinese PLA General HospitalNational Clinical Research Centre for Geriatric DiseasesBeijing 100853China

Urinary kidney injury molecule 1(uKIM-1)serves as a reliable marker for the early diagnosis of acute kidney injury(AKI).The rapid and facile detection of changes in uKIM-1 is essential for early AKI diagnosis,ultimately improving the prognosis of *** this study,we developed a fully printed photonic crystal-integrated microarray with photonic crystal-enhanced fluorescence properties,which can detect uKIM-1 levels at the *** confirmed its efficacy in the early diagnosis of AKI using clinical urine *** quantitative detection of uKIM-1 was achieved within 10 *** lowest limit of detection is 8.75 pg·mL^(-1) with an accuracy of 94.2%.The diagnostic efficacy was validated using 86 clinical urine samples,highlighting the high sensitivity and stability of the photonic crystal ***,a facile and reliable immunoassay was designed and prepared for the rapid quantitative detection of uKIM-1,which is crucial for the early identification and convenient detection of AKI in hospital or community ***,convenient,cost-effective,and long-term monitoring of changes in uKIM-1 levels can assist clinicians in making timely adjustments to treatment regimens,preventing the transition from AKI to chronic kidney disease(CKD),improving the quality of life of patients with AKI,and reducing healthcare *** highlights the advantages of utilizing urine samples as a noninvasive and easily accessible medium for early detection and monitoring of kidney-related conditions.

关键词： photonic crystal point-of-care testing urine kidney injury molecule-1(KIM-1) acute kidney injury

疾病特异诱导多能干细胞距离神经退行性疾病的临床治疗还有多远

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中国组织工程研究与临床康复 2011年第1期15卷 126-129页

作者：罗虎刘渔凯李泽桂解放军第三军医大学学员旅17队重庆市400038 解放军第三军医大学药学院生药学教研室重庆市400038

背景:各种神经退行性疾病传统的内外科治疗只能缓解症状而不能阻止疾病的进一步发展,细胞替代治疗近年进展迅速,但是干细胞存在的伦理问题及免疫排斥等问题不容忽视,而诱导多能干细胞的产生为这些问题提供了新的解决途径。目的:综述神... 详细信息

背景:各种神经退行性疾病传统的内外科治疗只能缓解症状而不能阻止疾病的进一步发展,细胞替代治疗近年进展迅速,但是干细胞存在的伦理问题及免疫排斥等问题不容忽视,而诱导多能干细胞的产生为这些问题提供了新的解决途径。目的:综述神经退行性疾病的治疗现状以及诱导多能干细胞作为新的细胞来源治疗神经退行性疾病的可能性。方法:应用计算机检索1995/2010PubMed数据库(http://***/PubMed)及万方数据库(http://***),英文检索词为"induced pluripotent stem cell,PD,ALS,SMA,degenerative disease",中文检索词为"干细胞,帕金森病"。初检得到文献374篇,根据纳入标准选择29篇文章进行综述。结果与结论:疾病特异诱导多潜能干细胞可保持疾病特异的基因型,有利于疾病分子机制的进一步阐明,且其拥有与胚胎干细胞类似的多向分化能力;在体外动物模型中可分化为多巴胺能神经元,缓解帕金森病的临床症状,在神经退行性疾病的临床治疗方面具有广泛的应用前景。

关键词：诱导多能干细胞帕金森病脊髓侧索硬化脊髓性肌萎缩神经退行性疾病

Multi-Objective Optimization Based on Life Cycle Assessment for Hybrid Solar and Biomass Combined Cooling,Heating and Power System

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Journal of Thermal Science 2024年第3期33卷 931-950页

作者： liu Jiejie LI Yao MENG Xianyang WU Jiangtao Key Laboratory of Thermo-Fluid Science and Engineering Ministry of EducationXi’an Jiaotong UniversityXi’an710049China

The complementary of biomass and solar energy in combined cooling,heating and power(CCHP)system provides an efficient solution to address the energy crisis and environmental *** work aims to propose a multi-objective optimization model based on the life cycle assessment(LCA)method for the optimal design of hybrid solar and biomass *** life-cycle process of the poly-generation system is divided into six phases to analyze energy consumption and greenhouse gas *** comprehensive performances of the hybrid system are optimized by incorporating the evaluation criteria,including environmental impact in the whole life cycle,renewable energy contribution and economic *** non-dominated sorting genetic algorithmⅡ(NSGA-Ⅱ)with the technique for order preference by similarity to ideal solution(TOPSIS)method is employed to search the Pareto frontier result and thereby achieve optimal *** developed optimization methodology is used for a case study in an industrial *** results indicate that the best performance from the optimized hybrid system is reached with the environmental impact load reduction rate(EILRR)of 46.03%,renewable energy contribution proportion(RECP)of 92.73%and annual total cost saving rate(ATCSR)of35.75%,*** comparing pollutant-eq emissions of different stages,the operation phase emits the largest pollutant followed by the phase of raw material ***,this study reveals that the proposed multi-objective optimization model integrated with LCA method delivers an alternative path for the design and optimization of more sustainable CCHP system.

关键词： combined cooling heating and power system solar-biomass multi-objective optimization life cycle assessment optimal design

Scattering-based hybrid network for facial attribute classification

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Frontiers of Computer Science 2024年第3期18卷 105-116页

作者： Na liu Fan ZHANG Liang CHANG Fuqing DUAN School of Artificial Intelligence Beijing Normal UniversityBeijing 100875China

Face attribute classification(FAC)is a high-profile problem in biometric verification and face *** recent research has been devoted to extracting more delicate image attribute features and exploiting the inter-attribute correlations,significant challenges still *** scattering transform(WST)is a promising non-learned feature *** has been shown to yield more discriminative representations and outperforms the learned representations in certain *** to the image classification task,WST can enhance subtle image texture information and create local deformation *** paper designs a scattering-based hybrid block,to incorporate frequency-domain(WST)and image-domain features in a channel attention manner(Squeezeand-Excitation,SE),termed WS-SE *** with CNN,WS-SE achieves a more efficient FAC performance and compensates for the model sensitivity of the small-scale affine *** addition,to further exploit the relationships among the attribute labels,we propose a learning strategy from a causal *** cause attributes defined using the causalityrelated information can be utilized to infer the effect attributes with a high confidence *** analysis experiments demonstrate the effectiveness of our model,and our hybrid model obtains state-of-the-art results in two public datasets.

关键词： wavelet scattering transform causality-related learning facial attribute classification

Research on concrete structure defect repair based on three-dimensional printing

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Frontiers of Structural and Civil Engineering 2024年第5期18卷 731-742页

作者： Yang GU Wei LI Xupeng YAO Guangjun liu School of Mechanical Engineering Tongji UniversityShanghai 201804China College of Civil Engineering Tongji UniversityShanghai 200092China Shanghai Engineering Research Center for Safety Intelligent Control of Building Machinery Shanghai 200032China

Quality assurance and maintenance play a crucial role in engineering construction,as they have a significant impact on project *** common issue in concrete structures is the presence of *** enhance the automation level of concrete defect repairs,this study proposes a computer vision-based robotic system,which is based on three-dimensional(3D)printing technology to repair *** system integrates multiple sensors such as light detection and ranging(LiDAR)and *** is utilized to model concrete pipelines and obtain geometric parameters regarding their ***,a convolutional neural network(CNN)is employed with a depth camera to locate defects in concrete ***,a method for coordinate transformation is presented to convert the obtained coordinates into executable ones for a robotic ***,the feasibility of this concrete defect repair method is validated through simulation and experiments.

关键词： concrete defect detection 3D printing deep learning point cloud data

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优化物流中心配送方案的遗传算法

系统工程理论与实践 2003年第4期23卷 76-81页

作者：贺国先刘凯北方交通大学交通运输学院北京100044

提出了一种配送方案模型 ,该模型在满足车辆满载约束的同时充分考虑货物的运到期限 ,通过实例计算表明。

关键词：遗传算法物流中心配送

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朝鲜蓟叶中的酚性糖苷化合物(英文)

云南植物研究 2009年第1期31卷 89-92页

作者：刘荣蒋孟圆周忠玉刘吉开中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室云南昆明650204 中国科学院研究生院北京100049

从朝鲜蓟(Cynara scolymus)叶中分离得到2个酚性糖苷化合物,其中一个是新化合物,通过波谱学方法确定其结构为2-甲氧基-4-(2,3-二羟基-丙酰基)-苯基-1-O-(6′-O-没食子酰基)-β-D-吡喃葡萄糖苷(1)。

关键词：朝鲜蓟菊科酚性糖苷

弯曲变形工况下板状燃料堆芯三维热工水力特性分析

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原子能科学技术 2023年第S1期57卷 67-78页

作者：刘奚彤刘凯王明军王啸宇田文喜秋穗正苏光辉西安交通大学核科学与技术学院动力工程多相流国家重点实验室陕西省先进核能技术重点实验室陕西西安710049 中国核动力研究设计院四川成都610065

板状燃料因其功率密度高、燃耗较深的特点,在诸多测试堆与实验堆中得到广泛应用。受堆内辐照、流致振动等常见预期瞬态影响,其狭长的冷却剂流道极易受压而发生弯曲变形,进一步影响堆芯换热并对反应堆安全造成威胁。本文依托OpenFOAM平... 详细信息

板状燃料因其功率密度高、燃耗较深的特点,在诸多测试堆与实验堆中得到广泛应用。受堆内辐照、流致振动等常见预期瞬态影响,其狭长的冷却剂流道极易受压而发生弯曲变形,进一步影响堆芯换热并对反应堆安全造成威胁。本文依托OpenFOAM平台开发了板状燃料堆芯三维通道级热工水力分析程序CorTAF-PT,在数组矩形窄缝通道流动换热实验对比验证的基础上,针对IAEA 10 MW材料测试堆开展了弯曲变形工况下三维数值模拟,获得了全堆芯关键热工水力参数的多尺度分布特性,并对堆芯出口处热点偏移现象进行了分析。本研究对自主可控堆芯级高精度三维热工水力分析技术开发具有参考价值,同时也可为后续板状燃料堆芯事故安全分析的开展提供了基础。

关键词：板状燃料 OpenFOAM 耦合换热弯曲变形