检索结果-南通市图书馆

Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning chang liu Yu-Chi liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

工作面过空巷基本顶超前破断压架机理及控制技术研究

在线全文

学校读者我要写书评

暂无评论

煤炭学报 2017年第8期42卷 1932-1940页

作者：刘畅杨增强弓培林王开张俊文李玉琳张小强中国矿业大学(北京)资源与安全工程学院北京100083 太原理工大学矿业工程学院山西太原030024 黑龙江科技大学矿业工程学院黑龙江哈尔滨150022

基本顶超前破断及压架研究对工作面过空巷、进入回撤通道安全保障有重要意义。通过相似模拟得到了工作面过大断面空巷基本顶超前破断前后覆岩破断特征、围岩应力及支架载荷。研究表明:在基于圣华煤业复采工作面围岩条件的相似模拟实验中... 详细信息

基本顶超前破断及压架研究对工作面过空巷、进入回撤通道安全保障有重要意义。通过相似模拟得到了工作面过大断面空巷基本顶超前破断前后覆岩破断特征、围岩应力及支架载荷。研究表明:在基于圣华煤业复采工作面围岩条件的相似模拟实验中,工作面通过12 m宽不支护空巷时,基本顶会发生超前破断。导致基本顶上方亚关键层随基本顶破断、滑落,支架上载荷由4 000 kN激增到12 500 kN再到16 200 kN,支承应力升高并前移。从理论上研究了超前程度、围岩条件、开采技术对破断后基本顶稳定性的影响,结果表明:随超前破断距离增大,阻止关键块所需阻力成倍增加;随自由空间高度的增加、块度的增加,基本顶结构稳定性降低;亚关键层破断会导致所需支架阻力激增,单从提高支架阻力来维持超前破断后基本顶结构稳定性不可行,应当从防止基本顶超前破断来预防切顶压架事故。提出了针对此类工作面的控制技术,现场应用效果明显。

关键词：过空巷超前破断压架

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin liu Jian Zhang Ya Gao Shuyue Li Cui chang Xiang liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

Hierarchical hollow microspheres assembled from carbon nanosheets integrated with molybdenum carbide nanoparticles for boosting microwave absorption properties

在线全文

学校读者我要写书评

暂无评论

Nano Research 2025年第1期18卷 10-20页

作者： Zongsheng Chen Yahui Wang Yi liu Zhigang Li Xiangyin Lv Liping liu Yajing chang Jiaming Shi Xiao Zhang State Key Laboratory of Pulsed Power Laser Technology School of Electronic EngineeringNational University of Defense TechnologyHefei 230037China Anhui Provincial Laboratory of Advanced Laser Technology School of Electronic EngineeringNational University of Defense TechnologyHefei 230037China Centre for Environmental and Energy Nanomaterials Anhui Key Laboratory of Nanomaterials and NanotechnologyCAS Centre for Excellence in NanoscienceInstitute of Solid State PhysicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China

Hierarchical hollow structure has demonstrated potential for enhancing electromagnetic(EM)attenuation and improving impedance matching,garnering significant attention for ***,we have successfully implemented compositional and structural engineering to fabricate hollow Mo2C/C microspheres with controllable composition by coupling interaction between dopamine hydrochloride and ammonium *** the synergistic effect of composition and hollow structure,the strongest reflection loss intensity and broadest effective absorption of the optimized sample reach-70.2 dB and 6.2 GHz,*** formation of hollow heterogeneous structures not only favors impedance matching feature,but also generates considerable contribution to EM attenuation ***,radar cross-section simulation data indicate that hollow Mo2C/C microspheres with compositional optimization and heterogeneous structures have broad prospects for practical applications.

关键词： electromagnetic absorption Mo2C/C microwave absorption hollow structure

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

鹿茸不同炮制品化学成分的对比分析

中国中药杂志 2018年第6期43卷 1145-1155页

作者：王燕华孙印石张磊刘畅宫瑞泽中国农业科学院特产研究所吉林长春130112 吉林农业大学中药材学院吉林长春130118

研究药典规定的鹿茸2种炮制品“鹿茸粉”和“鹿茸片”中化学成分的差异。以多糖、粗蛋白、氨基酸、脂肪酸、矿质元素、生物胺、核苷类成分为评价指标，对参照药典方法炮制而成的鹿茸粉与鹿茸片进行对比分析。结果表明，与直接“劈成碎... 详细信息

研究药典规定的鹿茸2种炮制品“鹿茸粉”和“鹿茸片”中化学成分的差异。以多糖、粗蛋白、氨基酸、脂肪酸、矿质元素、生物胺、核苷类成分为评价指标，对参照药典方法炮制而成的鹿茸粉与鹿茸片进行对比分析。结果表明，与直接“劈成碎块，研成细粉”的鹿茸粉相比，40％乙醇炮制的鹿茸片中粗蛋白、氨基酸、生物胺、核苷类成分依次减少5．0l％，4．35％，5．90％，27．62％；50％乙醇炮制的鹿茸片中多糖，核苷类成分分别减少24．53％，21．07％；60％乙醇炮制的鹿茸片中粗蛋白，核苷类成分各减少1．65％，20．52％。3种方式炮制而成的鹿茸片中脂肪酸、矿质元素的含量未见减少。“鹿茸片”中的多糖、粗蛋白、氨基酸、核苷类成分比“鹿茸粉”有所减少，尤以多糖、核苷类成分最为显著；根据主成分综合评分，50％乙醇炮制的鹿茸片所测有效成分减少量最小。

关键词：鹿茸粉鹿茸片中国药典化学成分比较

利用北斗观测数据实时监测中国区域电离层变化

在线全文

学校读者我要写书评

暂无评论

空间科学学报 2017年第1期37卷 67-74页

作者：董恩强曹月玲宫磊刘晓萍常志巧吴晓莉北京卫星导航中心北京100094 上海市空间导航与定位技术重点实验室上海200030

北斗卫星导航信号采用三个频点工作,可以利用伪距双频组差方法解算电离层电子含量,为实时监视中国区域电离层变化提供新的技术手段.中国中低纬度处于电离层赤道异常变化区,在北纬20°±5°区域时常发生较大梯度的电离层变化.利用北斗实... 详细信息

北斗卫星导航信号采用三个频点工作,可以利用伪距双频组差方法解算电离层电子含量,为实时监视中国区域电离层变化提供新的技术手段.中国中低纬度处于电离层赤道异常变化区,在北纬20°±5°区域时常发生较大梯度的电离层变化.利用北斗实时多频伪距和相位观测数据,采用相位平滑伪距方法计算电离层穿刺点电子含量,分析通过北斗系统GEO卫星监测的电离层周日变化特性;采用多面函数方法拟合中国区域1°×1°分辨率的电离层延迟量,每5 min绘制一幅中国区域电离层图,观测区域所有电离层穿刺点拟合残差RMS为2.778TECU;分析北斗系统实时监测中国区域电离层异常情况,当发生电离层异常变化时,相邻两天的VTEC(Vertical Total Electronic Content)峰值相差约60 TECU.

关键词：北斗系统电离层延迟多面函数区域电离层图电离层异常

High‑Entropy Electrode Materials:Synthesis,Properties and Outlook

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 472-506页

作者： Dongxiao Li chang liu Shusheng Tao Jieming Cai Biao Zhong Jie Li Wentao Deng Hongshuai Hou Guoqiang Zou Xiaobo Ji College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083People’s Republic of China School of Chemistry and Chemical Engineering Hunan Institute of EngineeringXiangtan 411104People’s Republic of China

High-entropy materials represent a new category of high-performance materials,first proposed in 2004 and extensively investigated by researchers over the past two *** definition of high-entropy materials has continuously *** the last ten years,the discovery of an increasing number of high-entropy materials has led to significant advancements in their utilization in energy storage,electrocatalysis,and related domains,accompanied by a rise in techniques for fabricating high-entropy electrode ***,the research emphasis has shifted from solely improving the performance of high-entropy materials toward exploring their reaction mechanisms and adopting cleaner preparation ***,the current definition of high-entropy materials remains relatively vague,and the preparation method of high-entropy materials is based on the preparation method of single metal/low-or medium-entropy *** should be noted that not all methods applicable to single metal/low-or medium-entropy materials can be directly applied to high-entropy *** this review,the definition and development of high-entropy materials are briefly ***,the classification of high-entropy electrode materials is presented,followed by a discussion of their applications in energy storage and catalysis from the perspective of synthesis ***,an evaluation of the advantages and disadvantages of various synthesis methods in the production process of different high-entropy materials is provided,along with a proposal for potential future development directions for high-entropy materials.

关键词： High-entropy Energy storage Electrode materials

经肺热稀释法评估重度急性敌敌畏中毒猪呼吸功能变化

在线全文

学校读者我要写书评

暂无评论

中华急诊医学杂志 2012年第4期21卷 381-386页

作者：何新华李春盛武军元刘长弓宿志宇韩奕首都医科大学附属北京朝阳医院急诊科北京100020 辽宁省本溪市中心医院急诊科北京大学人民医院急诊科复旦大学附属中山医院急诊科

目的有机磷农药中毒早期即可出现急性呼吸衰竭，能反映呼吸功能早期变化的指标不多。为此，制作重度急性敌敌畏中毒猪模型，利用PiCCO监测仪，评估敌敌畏中毒早期呼吸功能变化。方法20只雌性家猪随机（随机数字法）分成敌敌畏组（7只）... 详细信息

目的有机磷农药中毒早期即可出现急性呼吸衰竭，能反映呼吸功能早期变化的指标不多。为此，制作重度急性敌敌畏中毒猪模型，利用PiCCO监测仪，评估敌敌畏中毒早期呼吸功能变化。方法20只雌性家猪随机（随机数字法）分成敌敌畏组（7只）、阿托品组（7只），对照组（6只）。敌敌畏组胃管注入80％乳油敌敌畏（100mg／kg），复制重度敌敌畏中毒猪模型，阿托品组注入敌敌畏半小时后静脉推注阿托品至阿托品化并维持，对照组除不使用敌敌畏和阿托品以外，其他均相同。所有动物均在0、0．5、1、2、4、6h6个时点采集动、静脉血进行血气分析以及胆碱酯酶水平，记录EVLWI和PVPI值，6h后活杀动物，取肺组织行肺湿质量／干质量比及组织学观察。结果从0．5h时点开始，敌敌畏组SaO2、PO2／FiO2出现明显下降，第1小时时点下降幅度最为明显，而PaCO2经历了先下降（1h前）而后上升的过程；阿托品组SaO2、PaCO2、PO2／FiO2先下降，但从第1小时时点开始逐渐回升。敌敌畏组EVLWI和PVPI变化过程相似，表现为逐渐升高；经过阿托品治疗后，二者上升趋势从第1小时时点开始明显减缓；对照组上述指标与基础时点比较无明显变化。相关关系分析，敌敌畏组和阿托品组，EVLWI与PO2／FiO2呈负相关关系；与PVPI变化呈正相关关系。与对照组比较，敌敌畏组肺湿质量／干质量明显增加，而阿托品组轻度增加。与此同时，敌敌畏组肺组织病理和超微病理变化显著，而阿托品组变化较轻。结论重度急性敌敌畏中毒猪呼吸功能变化显著，EVLWI是早期评估中毒猪呼吸功能变化的有效指标。

关键词：敌敌畏肺血管外水指数肺血管通透指数呼吸功能经肺热稀释 PiCCO 急性有机磷农药中毒模型

Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing Qiu Mengting Yang Danfeng gong Haiying Liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

Rational modulation of fluorophosphate cathode by anionic groups to reduce the polarization behavior for fast-charging sodium-ion batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 509-521页

作者： Xinyuan Wang Fan Zhang Xingyu Zhou Qian Wang changyu liu Yangyang liu Hui Wang Xiaojie liu Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry & Materials Science Northwest University

Na3V2（PO4）2O2F （VP） is recognized as a promising cathode material for sodium-ion batteries due to its stable structural framework and high specific *** functional theory （DFT） and finite element simulations show that incorporating SO42-into VP decreases its band gap,lowers the migration energy barrier,and ensures a uniform Na+concentration gradient and stress distribution during charge and discharge ***,the average Na+diffusion coefficient of Na3V2（PO4）1.95（SO4）0.05O2F（VPS-1） is roughly double that of VP,leading to enhanced rate capability (80 C,75.5 mAh g-1) and cycling stability (111.0 mAh g-1capacity after 1000 cycles at 10 C current density) for ***-1 exhibits outstanding fast-charging capabilities,achieving an 80%state of charge in just 8.1 *** assembled VPS-1//SbSn/NPC full cell demonstrated stable cycling over 200 cycles at a high 5 C current,maintaining an average coulombic efficiency of 95.35%.

关键词： Anionic group modulation Polarization behavior Fast-charging Sodium-ion battery Fluorophosphate Cathode