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Jianpi-Huatan-Huoxue-Anshen formula ameliorates gastrointestinal inflammation and microecological imbalance in chemotherapytreated mice transplanted with H22 hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4209-4231页

作者： Ya-Nan Wang xiang-Yang Zhai Zheng Wang Chun-Ling Gao Sui-cai Mi Wen-Li Tang Xue-Min Fu Huai-Bang Li Li-Feng Yue Peng-Fei Li Sheng-Yan xi Department of TCM Xiang’an HospitalSchool of MedicineXiamen UniversityXiamen 361102Fujian ProvinceChina Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao 999078China Department of Radiotherapy Chenggong Hospital of Xiamen UniversityPLA 73rd Army HospitalXiamen 361003Fujian ProvinceChina Department of Oncology Xiamen Hospital of Traditional Chinese MedicineXiamen 361015Fujian ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China

BACKGROUND Jianpi-Huatan-Huoxue-Anshen formula[Tzu-Chi cancer-antagonizing&lifeprotecting II decoction(TCCL)]is a Chinese medical formula that has been clinically shown to reduce the gastrointestinal side effects of chemotherapy in cancer patients and improve their quality of ***,its effect and mechanism on the intestinal microecology after chemotherapy are not yet *** To discover the potential mechanisms of TCCL on gastrointestinal inflammation and microecological imbalance in chemotherapy-treated mice transplanted with hepatocellular carcinoma(HCC).METHODS Ninety-six mice were inoculated subcutaneously with HCC *** week later,the mice received a large dose of 5-fluorouracil by intraperitoneal injection to establish a HCC chemotherapy ***-six mice were randomly selected before administration,and feces,ileal tissue,and ileal contents were collected from each *** remaining mice were randomized into normal saline,continuous chemotherapy,Yangzheng xiaoji capsulestreated,and three TCCL-treated *** treatment,feces,tumors,liver,spleen,thymus,stomach,jejunum,ileum,and colon tissues,and ileal contents were *** changes,serum levels of IL-1β,IL-6,IL-8,IL-10,IL-22,TNF-α,and TGF-β,intestinal SIgA,and protein and mRNA expression of ZO-1,NF-κB,Occludin,MUC-2,Claudin-1,and IκB-αin colon tissues were *** effect of TCCL on the abundance and diversity of intestinal flora was analyzed using 16S rDNA *** TCCL treatment improved thymus and spleen weight,thymus and spleen indexes,and body weight,decreased tumor volumes and tumor tissue cell density,and alleviated injury to gastric,ileal,and colonic mucosal *** proteins and genes associated with inflammation,IL-10,TGF-β,SIgA,ZO-1,MUC-2,and Occludin were upregulated,whereas NF-κB,IL-1β,IL-6,TNF-α,IL-22,IL-8,and IκB-αwere ***,TCCL increased the proportions of fecal Actinobacteria,AF12,Adlercreutzia,Clostridium,Coriobac

关键词： Chinese medicine Chemotherapy H22 hepatocellular carcinoma Intestinal barrier function Intestinal microecological balance

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一个数据要素的经济学新理论框架

Simultaneously enhancing the strength and ductility of as-extruded AlN/AZ91 composites via nano-precipitation and pyramidal slip

财经问题研究 2024年第5期 33-48页

作者：蔡思航翁翕北京大学光华管理学院北京 100871

本文基于一个数据要素的经济学新理论框架,围绕平台、流量和数据等数字经济新元素,研究了数据要素市场发展中的经济规律和关键问题.该框架主要基于博弈论与信息经济学,强调数据要素的非竞争性和副产品特性是其区别于其他传统生产要素的... 详细信息

本文基于一个数据要素的经济学新理论框架,围绕平台、流量和数据等数字经济新元素,研究了数据要素市场发展中的经济规律和关键问题.该框架主要基于博弈论与信息经济学,强调数据要素的非竞争性和副产品特性是其区别于其他传统生产要素的核心特点和优势,规模收益递增和网络效应意味着数据要素在价值创造和分配中可以实现"1+1＞2"的效果,通过放大、叠加、倍增作用提高其他要素的全要素生产率.本文认为,当前数据要素市场的发展仍需解决如何合理衡量数据要素收益和贡献,以及构建初次分配、再分配和第三次分配机制等关键问题,应鼓励市场主体逐步探索和完善数据交易模式和定价体系,并通过税收设计和共享开放实现数据红利的再分配,从而更充分地提升数据要素价值.

关键词：数据要素数据要素市场信息经济学价值创造与分配

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Journal of Materials Science & Technology 2024年第5期172卷 240-254页

作者： Bin Zhang Yunxia Sun Tuo Liang Yunzhen Li Tian Li Jingchao Wang Ruiru cai Changlin Yang State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China

Age hardening is often used to optimize the mechanical properties of as-deformed Mg-based materials in industry,whereas the improvement of strength is usually accompanied by the significant loss of ductility,which hinders the application of Mg-based materials in structural *** the present work,high strength-ductility synergy(the yield strength of 263±9 MPa,ultimate tensile strength of 398±7 MPa and elongation to fracture of 34%±1%)was realized in as-extruded AlN/AZ91 composites after optimiz-ing aging *** characterization shows that AlN particles induced a large number of geometrically necessary dislocations around the AlN/Mg interface during extrusion,which decreased the nucleation barrier and provided more heterogeneous nucleation sites forγ-Mg 17 Al 12 continuous ***,95%of residual dislocations in as-extruded AlN/AZ91 composites were annihilated dur-ing peak-aging,suppressing the growth and coarsening of continuous ***,high density of nano-sizedγ-Mg 17 Al 12 continuous precipitates was produced in as-extruded AlN/AZ91 composites af-ter *** tension,gliding dislocations bypassed sphericalγ-Mg 17 Al 12 nano-precipitates by Orowan looping rather than cutting mechanism,which induced a strong block on dislocation *** high yield strength was mainly attributed to the high density of non-shearableγ-Mg 17 Al 12 nano-precipitates with spherical morphology,which was different from other Mg-Al-based *** results of texture evolution and slip trace analysis demonstrated that the suppression of extension twinning and less basal slip was due to the enhanced activity of pyramidalc+aslip in as-extruded AlN/AZ91 com-posites after peak-aging during the room temperature tension,meanwhile,the dislocation density of as-extruded AlN/AZ91 composites was significantly decreased during peak-aging,then higher elongation to fracture was achieved.

关键词： Magnesium matrix composites Mechanical properties Precipitation Deformation mechanisms Non-basal slip

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空间目标探测多传感器协同规划

国防科技大学学报 2024年第4期46卷 37-44页

作者：龙洗蔡伟伟杨乐平国防科技大学空天科学学院湖南长沙410073

以多个地基雷达协同探测空间目标为背景,针对传统以整个可探测弧段为决策变量的协同规划方法存在的探测效率不高问题,建立了多传感器协同探测调度模型,提出了一种能够同时确定探测弧段和探测起始时间的自适应免疫遗传算法。考虑空间目... 详细信息

以多个地基雷达协同探测空间目标为背景,针对传统以整个可探测弧段为决策变量的协同规划方法存在的探测效率不高问题,建立了多传感器协同探测调度模型,提出了一种能够同时确定探测弧段和探测起始时间的自适应免疫遗传算法。考虑空间目标属性、类型、发射时间、雷达散射面积等级、用途等多种因素,构建了多层次模糊综合评价模型,并运用1-9标度法得到空间目标的优先级。以优先级最大化为目标,考虑探测时长、传感器容量等约束条件,采用自适应免疫遗传算法求解,并从探测资源消耗率和任务完成率两方面对规划方法性能进行评价。与改进的启发式算法以及传统进化算法的对比仿真表明,所提算法能够在提高任务完成率的同时降低资源消耗率。

关键词：空间态势感知资源调度模糊综合评价自适应免疫遗传算法

瑞马唑仑在气管插管全身麻醉老年患者中的临床效果及对血流动力学的影响

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首都食品与医药 2024年第20期31卷 63-65页

作者：蔡茜四川省南充市中心医院四川南充637003

目的分析瑞马唑仑在气管插管全身麻醉老年患者中的临床效果及对血流动力学的影响.方法选择南充市中心医院2021年1月-2023年12月收治的94例行全身麻醉腹部手术患者作为研究对象,随机分为瑞马唑仑组(R组)和丙泊酚组(B组),每组47例,R组采... 详细信息

目的分析瑞马唑仑在气管插管全身麻醉老年患者中的临床效果及对血流动力学的影响.方法选择南充市中心医院2021年1月-2023年12月收治的94例行全身麻醉腹部手术患者作为研究对象,随机分为瑞马唑仑组(R组)和丙泊酚组(B组),每组47例,R组采用瑞马唑仑进行麻醉诱导,B组采用丙泊酚进行麻醉诱导;比较两组不同时间段心率(HR)、平均动脉压(MAP)及麻醉诱导后相关指标变化和不良反应发生情况.结果麻醉诱导前,两组HR、MAP比较,无统计学差异(P>0.05);麻醉后1min、气管插管后、气管插管后10min,两组HR、MAP显著降低(P0.05);R组麻醉起效时间、睁眼时间、拔管时间显著短于B组(P0.05).结论与丙泊酚麻醉诱导相比较,瑞马唑仑的麻醉诱导对气管插管全身麻醉老年患者血流动力学的影响更小,取得的麻醉效果更为理想,且具有较高的安全性.

关键词：瑞马唑仑气管插管全身麻醉老年患者

35 kV及以下输电线路的故障检测与智能化维护

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通信电源技术 2024年第6期41卷 213-215页

作者：蔡希智方设计股份有限公司湖北武汉430000

35 kV及以下输电线路在社会经济发展中扮演着至关重要的角色。随着电力系统的不断进步,对其安全稳定性的需求日益突出。文章深入探讨了35 kV及以下输电线路的故障检测与智能化维护,详细介绍了不同类型故障的特点,分析了传统方法的局限性... 详细信息

35 kV及以下输电线路在社会经济发展中扮演着至关重要的角色。随着电力系统的不断进步,对其安全稳定性的需求日益突出。文章深入探讨了35 kV及以下输电线路的故障检测与智能化维护,详细介绍了不同类型故障的特点,分析了传统方法的局限性,探讨了智能故障检测技术的未来趋势。此外,还深入讨论了关键技术细节,包括传感器与监测设备、数据采集与分析技术以及故障检测算法和相应模型,剖析了大数据分析、物联网以及人工智能技术在智能化输电线路维护领域的应用,并展望了未来发展。

关键词： 35 kV输电线路故障检测智能化维护大数据分析人工智能

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Q235钢真实应力-应变曲线研究

中南林业科技大学学报 2011年第4期31卷 182-186页

作者：田芳刘财喜刘芳罗武邓瑞基陈胜铭罗迎社中南林业科技大学流变力学与材料工程研究所湖南长沙410004

通常所说的应力-应变曲线为名义应力-应变曲线,它只是一种近似曲线,对实际工程问题起到一个参考作用。对工程中常用的Q235金属材料,通过单轴压缩实验并结合A/H外推法获得其真实应力-应变曲线。通过此方法可以有效的消除试件端面与压力... 详细信息

通常所说的应力-应变曲线为名义应力-应变曲线,它只是一种近似曲线,对实际工程问题起到一个参考作用。对工程中常用的Q235金属材料,通过单轴压缩实验并结合A/H外推法获得其真实应力-应变曲线。通过此方法可以有效的消除试件端面与压力机滑块和工作台之间的摩擦力对实验结果的影响,使之成为理想的单轴压缩状态。该方法不但简单易行,普适性强,而且具有重要的理论意义和工程应用价值。

关键词：真实应力-应变曲线 Q235钢摩擦力 A/H外推法

隧道施工人员安全风险双网耦合模型设计及应用

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铁道科学与工程学报 2024年第7期21卷 2917-2931页

作者：黄健陵蔡茜李瑚均蔡超勋陈辉华中南大学湖南长沙410075 河南理工大学河南焦作454003 中国铁道科学研究院集团有限公司北京100081

施工人员作为施工活动的执行主体,他们之间会因为作业活动的合作产生风险共担关系,又因工序衔接产生风险传导关系,然而尚未出现一种有效合理的方式对施工人员之间安全风险关系进行研究。本文引入双网耦合原理,运用社会网络分析(SNA)构... 详细信息

施工人员作为施工活动的执行主体,他们之间会因为作业活动的合作产生风险共担关系,又因工序衔接产生风险传导关系,然而尚未出现一种有效合理的方式对施工人员之间安全风险关系进行研究。本文引入双网耦合原理,运用社会网络分析(SNA)构建隧道施工人员安全风险关系模型,用于显性化施工人员之间的风险关系,为研究隧道施工安全风险提供新视角和预防隧道安全风险发生提供新工具。首先通过WBS(Work Breakdown Structure,即工作分解结构)-RBS(Risk Breakdown Structure,即风险分解结构)法识别隧道施工安全风险因素并确定施工活动与风险因素之间的耦合关系,通过OBS(Organization Breakdown Structure,即组织分解结构)-WBS法确定隧道施工人员集并确定施工人员与施工活动之间的耦合关系;依据施工进度网络计划图显性化施工活动之间的依赖关系;依据施工人员、施工活动和安全风险因素三者之间的耦合关系和施工活动之间的依赖关系,将施工活动网络转换为施工人员风险关系网络;采取中心度分析,对施工人员在风险关系网络中的角色定位进行探讨;最后以广东密州隧道作为典型案例,验证该模型对研究施工人员之间风险关系的有效性。结果表明:不同施工人员在风险关系网络中扮演的角色不同,其中施工项目管理人员承担影响者角色,施工现场管理人员承担中介风险传导角色以及施工现场作业人员承担受影响者角色居多。基于双网耦合铁路施工人员安全风险关系模型可帮助施工管理者了解不同施工人员在安全管理中的角色定位与任务分工,从而提出针对性安全管控建议,提高人员安全管理效率。

关键词：隧道工程施工人员风险关系双网耦合角色定位社会网络分析

Microstructural evolution and deformation behavior of friction stir welded twin-induced plasticity steel

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Journal of Materials Science & Technology 2024年第2期169卷 68-81页

作者： Ke Qiao Kuaishe Wang Jia Wang Zhengyang Hao Yating xiang Peng Han Jun cai Qi Yang Wen Wang School of Metallurgical Engineering National and Local Joint Engineering Research Center for Functional Materials ProcessingXi’an University of Architecture and TechnologyXi’an 710055China Shanghai Research Institute of Materials Shanghai 200437China

The weldability of twin-induced plasticity(TWIP)steel with ultra-high strength via friction stir welding(FSW)technique was investigated,and microstructural evolution and deformation behavior of whole and micro-zones of FSW TWIP joint were studied for the first *** results showed that the content of recrystallized grains in the stir zone(SZ)increased from 10.5%of basal material(BM)to 14.2%,and that of heat affected zone(HAZ)increased to 78.6%.The percentage of annealing twins decreased from 26.8%in BM to 11%in SZ,while increased to 35%in *** with the BM,the ultimate tensile strength and yield strength of the FSW joint increased to 1036 and 550 MPa,respectively,reaching 106.7%and 110.9%of BM,*** elongation of the entire joint was 50.5%,which was lower than that of BM due to the nonuniform deformation during the tensile *** engineering strain was mainly concentrated in BM and SZ and transferred to each other during the tensile test,while the engineering strain in HAZ was always the ***,the tensile fracture occurred in the *** order of ultimate tensile strength of micro-zones in the FSW joint was as follows:HAZ>BM≈*** order of yield strength was as follows:HAZ>BM>SZ.

关键词： Twin-induced plasticity steel Friction stir welding Microstructure Mechanical property Deformation behavior