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Effect of spinal hyperpolarization-activated,cyclic nucleotide-gated cation channel subunit 1 and 2 ion channels on rats with chronic viseral hypersensitivity

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Effect of spinal hyperpolarization-activated,cyclic nucleoti...

使用多管双线阻力探管压力计对三维流体进行测量

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： DL LU,cy liu,C LIN~* Fujian Medical University,Fuzhou 350004,China

＜正＞Objective Previous work done has shown that colorectal distensions（CRD） in neonates can engender chronic visceral hypersensitivity in adult *** studies have shown that acute visceral hyperalgesia produced by colon inflammation is attenuated by hyperpolarization-activated cyclic nucleotide gated cation（HCN） channel blocker-ZD7288. The present study is to assess the contribution of spinal HCN1 and HCN2 to chronic visceral hypersensitivity. Methods Experiments were done on 48 male adult Sprague-Dawley rats:24 neonates received CRD as models and the others served as *** rats received 60 mmHg CRD once daily on post neonatal days *** withdrawal reflex and spikes of external oblique muscle of abdomen were tested to assess the visceral sensitivity of ***7288 at the dose of 25-100 nM was given to the control and model rats by intrathecal application;The expression and distribution of HCN1 and HCN2 channel protein in thoracolumbar and lunbosacral spinal cord were detected by immunohistochemical techniques in control and model ***（1）The reaction to pain in rats with chronic visceral pain can be inhibited and the pain threshold can be increased by intrathecal application of ZD7288 in a dose-dependent manner.（2） The expression of HCN1 and HCN2 channel protein are significantly increased on thoracolumbar and lunbosacral spinal cord in chronic model rats than in control *** In summary,the results indicate that spinal HCN1 and HCN2 subunits could be involved in central mechanism of chronic visceral sensitization in model rats.

关键词： chronic visceral hypersensitivity HCNl HCN2 spinal ZD7288

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国外计量 1991年第2期 45-47,16页

作者： liu,cy 许庆

单向凝固AL—45Wt%Cu合金的内部及外产中缩孔

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舞钢译丛 1990年第3期 18-24页

作者： liu.,cy 杜游

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测量液体差压的双线电阻探测器

国外计量 1990年第6期 27-29页

作者： liu.,cy 贾铭

一种基于新型计算机流体力学算法的血流储备分数在诊断缺血特异性冠状动脉疾病中的应用

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中华医学杂志 2021年第39期101卷 3252-3252页

作者：刘通源(编译) Tang CX liu cy Lu MJ 东部战区总医院放射诊断科不详

基于冠状动脉计算机断层血管造影(CTA)的血流储备分数(CT-FFR)是一种评估冠状动脉疾病(CAD)生理意义的新技术。CT-FFR是一种强大的无创诊断工具,在评估心肌缺血、指导治疗策略以及提供预后信息方面都具有显著的潜力。其中HeartFlow的CT-... 详细信息

基于冠状动脉计算机断层血管造影(CTA)的血流储备分数(CT-FFR)是一种评估冠状动脉疾病(CAD)生理意义的新技术。CT-FFR是一种强大的无创诊断工具,在评估心肌缺血、指导治疗策略以及提供预后信息方面都具有显著的潜力。其中HeartFlow的CT-FFR算法(美国,HeartFlow公司)已经在3个多中心临床试验中得到验证。然而,HeartFlow的CT-FFR算法需要使用非现场的超级计算机进行计算。

关键词：血流储备分数多中心临床试验冠状动脉疾病无创诊断计算机断层计算机流体力学生理意义治疗策略

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测量甚低差压用双线电阻探头压力计

国外计量 1992年第1期 22-24页

作者：傅烈堂 liu,cy

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双金属丝电阻变换转子流量计

国外计量 1991年第1期 42-45页

作者： liu,cy 付烈堂

Continuous epidermal growth factor receptor-tyrosine kinase inhibitor administration in primary lung adenocarcinoma patients harboring favorable mutations with controlled target lung tumors dose not hinder survival benefit despite small new lesions

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Continuous epidermal growth factor receptor-tyrosine kinase ...

Experimental Research on a Feasible Building Insulation Material Based Reed in China

第九届中国肿瘤学术大会暨第十五届海峡两岸肿瘤学术大会

作者： Hsu PC Chiu LC Li SH Chen CH Wang CL Kao KC Chang JW Wang CW Yu CT Chung FT Yang CT liu cy 陳志弘 Department of Thoracic Medicine Chang Gung Memorial Hospital at LinkouChang Gung University College of Medicine Department of Oncology Chang Gung Memorial Hospital at LinkouChang Gung University College of Medicine Department of Pathology Chang Gung Memorial Hospital at LinkouChang Gung University College of Medicine 長庚醫院

BACKGROUND:In this study,we investigated the efficacy of continuous epidermal growth factor receptor（EGFR）tyrosine kinase inhibitors（TKIs）administration in lung adenocarcinoma patients harboring favorable mutations regarding the progressive disease（PD）status with appearance of indolent new ***:From June 2010 to October 2012,102 patients with lung adenocarcinoma,harboring favorable EGFR mutations and treated with EGFR-TKI were *** new lesions were detected during EGFR-TKI therapy,even though the primary target tumors were ***:Of the 102 patients,57 continued and 45 discontinued EGFR-TKI *** median overall survival was 529 days for the discontinuation group and 791 days for the continuation group（p=0.0197）.Median survival time after the discontinuation of EGFR-TKI was 181 days and115 days in the discontinuation and continuation groups,respectively（p=0.1776）,whereas median survival time after the appearance of indolent new lesions was 204 days and 262days,respectively（p=0.0237）.CONCLUSION:Continuous EGFR-TKI administration in favorable EGFR-mutative lung adenocarcinoma patients with controlled primary tumors did not hinder the survival benefit,despite the appearance of new lesions.

关键词： Epidermal growth factor receptor-tyrosine kinase inhibitor Overall survival Progression-tree survival Progressive disease Response Evaluation Criteria in Solid Tumors

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Journal of Thermal Science 2025年第1期34卷 176-187页

作者： liu Tiantian PENG Yizhe liu Lifang CAI Chenghan WANG Shuang LI Hongqiang College of Civil Engineering Hunan University College of Civil Engineering Hunan University of Science and Technology School of Energy and Power Jiangsu University of Science and Technology National Center for International Research Collaboration in Building Safety and Environment (NCIRCBSE) Hunan University Key Laboratory of Building Safety and Energy Efficiency of the Ministry of Education Hunan University

The seemingly useless reeds are prepared as thermal insulation materials,which not only meet the requirements of environmental sustainability but also enhance the added value of reeds,creating new economic *** hydrophobicity of raw biomass surfaces leads to problems such as weak bonding strength and non-dense structure in the formed materials,as well as issues related to the residual insect infestations on the *** this study,reed straw was used as the raw material,and foamed geopolymer was used as the binder to prepare building insulation materials based *** improve the interfacial adhesion performance between reed straw and foamed geopolymer,a thermochemical modification method-thermal carbonization,was *** this study,the mechanical properties and hydraulic properties of the studied materials with different degrees of surface thermal modification were tested,especially the fire resistance performance,and weathering resistance performance rarely found in published *** the surface thermal modification condition of reed straw was 250℃（30 min）,the comprehensive performance of reed-based building insulation materials was the best,when the studied material density was 321.3 kg/m3;the compressive strength was 0.59 MPa;the thermal conductivity was 0.101 W/（m·K）;the pH was 11.27;the moisture absorption rate was 25.1%,and the compressive strength loss rate in wet-dry cycles was 18.5%.In addition,it had excellent fire resistance performance and weathering resistance *** new material can be widely used to improve the thermal insulation of traditional buildings and as sandwich filler in prefabricated buildings,such as preparing insulating walls.

关键词： building insulation material based reed fire resistance performance interface adhesion properties pre-treatment of reeds weathering resistance performance