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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui liu Xingxing Fang Liangming Zhang bin liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang bin liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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Weak feedback self-mixing interference fringe slope discrimination method based on deep learning

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Optoelectronics Letters 2025年

作者： ZHAO Yan LIN Maohua DU Shengzhi TONG Jigang liu bin HAN Fangfang School of Electrical Engineering and Automation， Tianjin University of Technology Tianjin Key Laboratory for Control Theory and Applications in Complicated Systems Department of Electrical Engineering， Tshwane University of Technology

In order to identify the tilt direction of the self-mixing interference (SMI) signals under weak feedback regime interfered by noise， a deep learning method is proposed. The one-dimensional U-Net (1D U-Net) neural network can discriminate the direction of self-mixing fringes accurately and quickly. For experimental SMI signals， the 1D U-Net can be used for discriminant direction after a one-step normalization. Simulation and experimental results show that the proposed method is suitable for SMI signals with noise within the whole weak feedback regime， and can maintain a high discrimination accuracy for signals interfered by 5dB noise. Combined with fringe counting method， accurate and rapid SMI signal displacement reconstruction can be realized.

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知识生产模式转型视域下国家卓越工程师学院创建的动因、机制与进路

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黑龙江高教研究 2025年第1期43卷 1-8页

作者：刘涵滨天津大学天津300000

国家卓越工程师学院是知识生产模式转型趋势下大学组织变革的时代产物。“科技自立自强”的迫切需求与“回归工程范式”的变革趋势相交叠,构成我国大学创建国家卓越工程师学院的时代动因。探其机制,国家卓越工程师学院形成以服务应用为... 详细信息

国家卓越工程师学院是知识生产模式转型趋势下大学组织变革的时代产物。“科技自立自强”的迫切需求与“回归工程范式”的变革趋势相交叠,构成我国大学创建国家卓越工程师学院的时代动因。探其机制,国家卓越工程师学院形成以服务应用为导向的组织理念、多元主体异质共在的成员构成、持续适应的柔性组织架构、多维综合的质量控制机制。以知识生产模式转型趋势为参照,未来,国家卓越工程师学院应持守育人价值本位,形塑主动适应的组织理念;优化创新制度环境,赋能组织成员的知识协同;提升卓越项目的治理能力,着力构建水样组织;引入公众参与的评价机制,加强知识生产的社会问责。

关键词：知识生产模式转型国家卓越工程师学院组织变革交叉学科组织

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Solar trough receiver with V-grooved light traps for efficiency improvement

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Science China Technological Sciences 2025年第1期 146-156页

作者： bin liu Qing LI Yu QIU School of Energy Science and Engineering Central South University

Parabolic trough collector is a promising technology for both domestic and industrial heat supplies. To enhance the collector efficiency, a modified trough receiver with dozens of V-grooved light traps incorporated into its lower-half absorber was introduced. For assessing the performance of this receiver, a solar-thermal-stress coupled model was established. Using this model, firstly, the effects of the V-grooved light traps were investigated. The results reveal that, compared to the conventional trough receiver, the modified trough receivers equipped with different traps can reduce their optical losses by 81.9–138.0 Wm-1（i.e., 15.0%–25.2%）, improving their optical efficiencies by 1.60%–2.69%. However, these traps also result in increased thermal loss from the receiver. Therefore, there is no single optimal modified trough receiver that consistently outperforms all other receivers across all possible conditions. Nonetheless, the MTR30-3 and MTR60-3 receivers emerge as the optimized choices due to their better solar-thermal performance. Subsequently, performance evaluation reveals that the two optimized receivers can enhance the receiver efficiencies within the typical solar irradiance range by 0.02%–2.65% and 0.05%–1.70% when the inlet fluid temperatures are below 488 and 523 K, respectively. Consequently, the collector efficiencies can be improved by 0.02%–2.49% and 0.05%–1.60%, respectively. Additionally, thermal stress analysis verifies that the two optimized receivers remain within safe limits under all typical conditions. Given that the heating temperature of a typical solar collector for domestic or industrial heat supply is typically below 523 K, the integration of the two optimized receivers has the capability to effectively enhance the overall collector efficiency.

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嵌入式系统的需求描述综述

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软件学报 2025年第1期36卷 27-46页

作者：陈小红刘少彬金芝上海市高可信计算重点实验室(华东师范大学) 高可信软件技术教育部重点实验室(北京大学) 北京大学计算机学院

随着嵌入式系统的广泛应用,其需求正变得越来越复杂,需求分析成为嵌入式系统开发的关键阶段,如何准确地建模和描述需求成为首要问题.系统地调研嵌入式系统的需求描述,并进行全面的比较分析,以便更深入地理解嵌入式系统需求的核心关注点... 详细信息

随着嵌入式系统的广泛应用,其需求正变得越来越复杂,需求分析成为嵌入式系统开发的关键阶段,如何准确地建模和描述需求成为首要问题.系统地调研嵌入式系统的需求描述,并进行全面的比较分析,以便更深入地理解嵌入式系统需求的核心关注点.首先采用系统化文献综述方法,对1979年1月–2023年11月间发表的相关文献进行识别、筛选、汇总和分析.通过自动检索和滚雪球等检索过程,筛选出150篇与主题密切相关的文献,力求文献综述的全面性.其次,从需求描述关注点、需求描述维度、需求分析要素等方面,分析现有嵌入式需求描述语言的表达能力.最后,总结现有嵌入式系统软件需求描述所面临的挑战,并针对嵌入式软件智能合成任务,提出对嵌入式系统需求描述方法表达能力的要求.

关键词：嵌入式系统需求描述需求描述语言需求分析系统需求

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基于合成生物学微生物底盘细胞构建与优化的研究进展

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食品工业科技 2025年第1期46卷 394-402页

作者：孙天丽黄明珠刘斌陈雪岚江西师范大学生命科学学院江西南昌330022 国家淡水鱼加工技术研发专业中心江西南昌330022

微生物菌株的改造优化是现代工业生物技术的核心,其中工业微生物底盘细胞的构建已成为合成生物学的研究热点之一。基于合成生物学“设计-构建-测试-学习”策略,对微生物底盘细胞理想设计和改造是优良细胞工厂构建的重要手段,本文对合成... 详细信息

微生物菌株的改造优化是现代工业生物技术的核心,其中工业微生物底盘细胞的构建已成为合成生物学的研究热点之一。基于合成生物学“设计-构建-测试-学习”策略,对微生物底盘细胞理想设计和改造是优良细胞工厂构建的重要手段,本文对合成生物学和微生物底盘细胞的改造优化策略进行了相关概述,同时总结了基于合成生物学各工业微生物底盘细胞的构建及应用,最后对在构建底盘细胞时所遇到的障碍及未来的前景进行了展望,以推动具有优良性状的微生物细胞工厂的构建。

关键词：合成生物学底盘细胞基因组精简工业微生物微生物细胞工厂

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mFAST:A MATLAB toolbox for ocean bottom seismometer refraction first-arrival traveltime tomography

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Earth and Planetary Physics 2022年第5期6卷 487-494页

作者： bin liu Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China Guangzhou Marine Geological Survey Guangzhou 511458China

First-arrival seismic traveltime tomography(FAST)is a well-established technique to estimate subsurface velocity *** several existing open-source packages are available for first-arrival traveltime tomography,most were written in compiled languages and lack sufficient extendibility for new algorithms and *** this work,we develop an open-source,selfcontained FAST package based on MATLAB,one of the most popular interpreted scientific programming languages,with a focus on ocean bottom seismometer refraction traveltime *** package contains a complete traveltime tomography workflow,including ray-tracing-based first-arrival traveltime computation,linearized inversion,quality control,and high-quality *** design the package as a modular toolbox,making it convenient to integrate new algorithms and functionalities as *** the current stage,our package is most efficient for performing FAST for two-dimensional ocean bottom seismometer *** demonstrate the efficacy and accuracy of our package by using a synthetic data example based on a modified Marmousi model.

关键词： ocean bottom seismometer(OBS) first-arrival traveltime tomography open source MATLAB

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Layered Double Hydroxide Derived Triple-phase Interfaces for Efficient Acetylene Electroreduction

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Chemical Research in Chinese Universities 2021年第6期37卷 1350-1351页

作者： liu bin School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingapore637459Singapore

*** Tierui and *** Haotian recently demonstrated a room temperature electrochemical acetylene reduction strategy at the copper-based triple-phase interfaces[***.,2021,4(7),565-574].The conversion rate of acetylene reached 99.9%with over 90%ethylene selectivity,outperforming most of thermal hydrogenation *** water as the clean proton source and discharging oxygen on the counter electrode as the only by-product,the concentration of acetylene was successfully reduced from 5000 ppm(parts per million)to less than 1 ppm in ethylene abundant gas flow.

关键词： flow. acetylene phase

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Dual single-site catalyst promoter boosts catalytic performance

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National Science Review 2020年第12期7卷 1841-1842页

作者： bin liu School of Chemical and Biomedical Engineering Nanyang Technological University

Single-atom catalysts(SACs) have received great research interest because of their maximum atom-utilization efficiency and unique catalytic properties[1–5].However,most of the reported SACs only focus on single-site active components,with rare reports studying catalyst promoters in their single-site forms [6–8].Because promoters are essential components in many industrial catalysts,

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