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RCAN family member 3 deficiency contributes to noncompaction of the ventricular myocardium

Journal of Genetics and Genomics 2024年第5期51卷 543-553页

作者： Ting Hu Lan liu He Wang Mei Yang Bocheng Xu Hanbing Xie ziyuan Lin Xiaolei Jin Ping Wang Yanyan liu Huaqin Sun Shanling liu Department of Medical Genetics West China Second University HospitalSichuan UniversityChengduSichuan 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengduSichuan 610041China Medical College Tibet UniversityLhasaTibet 850000China SCU-CUHK Joint Laboratory for Reproductive Medicine West China Second University HospitalSichuan UniversityChengduSichuan 610041China West China School of Medicine Sichuan UniversityChengduSichuan 610041China

Noncompaction of the ventricular myocardium(NVM),the third most diagnosed cardiomyopathy,is characterized by prominent trabeculae and intratrabecular ***,the genetic etiology of 40%–60%of NVM cases remains ***,we identify two infants with NVM,in a nonconsanguineous family,with a typical clinical presentation of persistent bradycardia since the prenatal period.A homozygous missense variant(R223L)of RCAN family member 3(RCAN3)is detected in both infants using whole-exome *** the zebrafish model,marked cardiac dysfunction is detected in rcan3 deficiency(MO-rcan3^(ATG)-injected)and rcan^(−/−) *** dysplasia of both endocardial and myocardial layers is also detected in rcan3-deficient ***3 R223L variant mRNAs can not rescue heart defects caused by rcan3 knockdown or knockout;however,hRCAN3 mRNAs rescue these ***-seq experiments show that several genes involved in cardiomyopathies are significantly regulated through multiple signaling pathways in the rcan3-knockdown zebrafish *** human cardiomyocytes,RCAN3 deficiency results in reduced proliferation and increased apoptosis,together with an abnormal mitochondrial ***,we suggest that RCAN3 is a susceptibility gene for cardiomyopathies,especially NVM and that the R223L mutation is a potential loss-of-function variant.

关键词： Cardiomyopathy NVM RCAN3 Mitochondrial structure Heartdefects

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加强森林资源管理巩固发展木片产业

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林业经济 2001年第3期 58-59页

作者：刘自远中国林产品经销公司，北京市100013

为加强木片生产管理,林业部于1990年筹建了木片领导小组,1992年根据国务院办公厅的批复意见,林业部党组作出了把小木片办成大产业的决定,同时提出了木片生产经营按照'四统一'原则进行,正式组建了木片生产领导小组,下设木片生产管理办公... 详细信息

为加强木片生产管理,林业部于1990年筹建了木片领导小组,1992年根据国务院办公厅的批复意见,林业部党组作出了把小木片办成大产业的决定,同时提出了木片生产经营按照'四统一'原则进行,正式组建了木片生产领导小组,下设木片生产管理办公室,主要负责全国木片生产的规划、组织、协调、指导和服务,制订林业产业政策和木片生产标准.

关键词：中国木片产业森林资源管理木片生产森林合理利用

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A lunar time scale from the perspective of the Moon’s dynamic evolution

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Science China Earth Sciences 2024年第1期67卷 234-251页

作者： Dijun GUO Jianzhong liu James WHEAD Fuqin ZHANG Zongcheng LING Shengbo CHEN Jianping CHEN Xiaozhong DING Jinzhu JI ziyuan OUYANG State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Center for Lunar and Planetary Sciences Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Department of Earth Environmental and Planetary SciencesBrown UniversityProvidence RI 02912USA Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029China Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space SciencesShandong UniversityWeihai 264209China College of Geoexploration Science and Technology Jilin UniversityChangchun 130026China School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China School of Resources and Environmental Engineering Inner Mongolia University of TechnologyHohhot 010051China Center for Excellence in Comparative Planetology Chinese Academy of SciencesHefei 230026China

A geologic time scale is a chronological system that separates the geological strata of a planetary body into different units in temporal sequence and shows its progressive *** time scale of the Moon was established a half-century ago during the telescopic-early Apollo exploration era,using data with limited spatial coverage and *** past decades have seen a wide array of studies,which have significantly extended our understanding of global lunar geologic *** on a comprehensive review of lunar evolution with respect to the dynamical changes,we propose two major updates to the current lunar time scale paradigm to include the evolution of both endogenic and exogenic dynamic forces now known to have influenced early lunar ***,based on the temporal interplay of exogenic and endogenic processes in altering the Moon,we defined three Eon/Eonothem-level units to represent three dynamical evolutionary ***,the pre-Nectarian System is redefined and divided as the magma ocean-era Magma-oceanian System and the following Aitkenian System beginning with the South Pole-Aitken *** ejecta of this basin,Das Formation,was deposited on the primordial lunar crust as the oldest stratum produced from exogenic *** updated lunar time scale,facilitated by the post-Apollo exploration and research advances,provides an integrated framework to depict the evolution of the Moon and has important implications for the geologic study of other terrestrial planets.

关键词： The Moon Geologic time scale Evolution history Endogenic process Exogenic process

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Probabilistic Automata-Based Method for Enhancing Performance of Deep Reinforcement Learning Systems

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IEEE/CAA Journal of Automatica Sinica 2024年第11期11卷 2327-2339页

作者： Min Yang Guanjun liu ziyuan Zhou Jiacun Wang the Department of Computer Science Tongji University IEEE the Computer Science and Software Engineering Department Monmouth University West Long Branch

Deep reinforcement learning(DRL) has demonstrated significant potential in industrial manufacturing domains such as workshop scheduling and energy system ***, due to the model's inherent uncertainty, rigorous validation is requisite for its application in real-world tasks. Specific tests may reveal inadequacies in the performance of pre-trained DRL models, while the “black-box” nature of DRL poses a challenge for testing model behavior. We propose a novel performance improvement framework based on probabilistic automata,which aims to proactively identify and correct critical vulnerabilities of DRL systems, so that the performance of DRL models in real tasks can be improved with minimal model ***, a probabilistic automaton is constructed from the historical trajectory of the DRL system by abstracting the state to generate probabilistic decision-making units(PDMUs), and a reverse breadth-first search(BFS) method is used to identify the key PDMU-action pairs that have the greatest impact on adverse outcomes. This process relies only on the state-action sequence and final result of each trajectory. Then, under the key PDMU, we search for the new action that has the greatest impact on favorable results. Finally, the key PDMU, undesirable action and new action are encapsulated as monitors to guide the DRL system to obtain more favorable results through real-time monitoring and correction mechanisms. Evaluations in two standard reinforcement learning environments and three actual job scheduling scenarios confirmed the effectiveness of the method, providing certain guarantees for the deployment of DRL models in real-world applications.

关键词： Job shop scheduling Decision making Automata Probabilistic logic Deep reinforcement learning Real-time systems Trajectory Manufacturing Standards Monitoring Deep reinforcement learning (DRL) performance improvement framework probabilistic automata real-time monitoring the key probabilistic decision-making units (PDMU)-action pair

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教育结果公平追求的问题研究——基于双因素理论

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江苏高教 2023年第12期 58-63页

作者：刘梓远江苏开放大学纪委南京210036

随着中国高等教育步入普及化阶段,学生对优质的教育结果公平愈发重视。中国学术界主要从教育机会公平和过程公平出发,探究如何实现教育结果公平。教育结果公平与工作世界密切相关,单纯依靠教育领域的发展来实现教育结果公平困难重重。... 详细信息

随着中国高等教育步入普及化阶段,学生对优质的教育结果公平愈发重视。中国学术界主要从教育机会公平和过程公平出发,探究如何实现教育结果公平。教育结果公平与工作世界密切相关,单纯依靠教育领域的发展来实现教育结果公平困难重重。社会和政府在实现教育结果公平上扮演着举足轻重的角色。文章借鉴双因素理论,从工作世界的角度出发进行深入思考,剖析学生对现有教育结果公平不满的深层次原因,并据此提出相应的改进建议,以期在促进中国社会稳定与创新发展的进程中作出贡献。

关键词：教育结果公平双因素理论保健因素激励因素

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Study on 5G Application Scenarios in Intelligent High-Speed Railway

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Chinese Railways 2023年第1期 45-53页

作者： LI Ping LUAN Zhong liu ziyuan CHENG Zhibo XIE Chenhui ZHANG Yiran China Academy of Railway Sciences Corporation Limited Institute of Computing Technology China Academy of Railway Sciences Corporation Limited 不详

5G technology is indispensable for developing comprehensive perception and ubiquitous interconnection of intelligent high-speed railways(HSRs),and can be applied to many scenarios in intelligent construction,intelligent equipment,intelligent operation and in other *** order to promote the standardized application of 5G technology in intelligent HSRs in a scientific and orderly manner and to avoid redundant construction and wasteful investment,it is imperative to carry out a systematical top-level design of the application scenarios at the initial *** this end,after investigating and analyzing the 5G application demands in different aspects of HSRs and the general structure of the railway 5G network,this paper formulates an overall planning of 5G technology application scenarios and proposes solutions to some typical application scenarios in the intelligent HSR system,based on the architecture and requirements of the intelligent HSR system.

关键词： intelligent high-speed railway 5G technology communication application scenarios

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MXene@c-MWCNT Adhesive Silica Nanofiber Membranes Enhancing Electromagnetic Interference Shielding and Thermal Insulation Performance in Extreme Environments

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Nano-Micro Letters 2024年第10期16卷 82-98页

作者： ziyuan Han Yutao Niu Xuetao Shi Duo Pan Hu liu Hua Qiu Weihua Chen Ben Bin Xu Zeinhom MEl-Bahy Hua Hou Eman Ramadan Elsharkawy Mohammed AAmin Chuntai liu Zhanhu Guo Key Laboratory of Materials Processing and Mold(Zhengzhou University) Ministry of EducationNational Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450002People's Republic of China School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026People's Republic of China Key Laboratory of Multifunctional Nanomaterials and Smart Systems Advanced Materials DivisionSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123People's Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi'an 710072People's Republic of China College of Chemistry&Green Catalysis Center Zhengzhou UniversityZhengzhou 450001People's Republic of China Mechanical and Construction Engineering Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle Upon Tyne NE18UK Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr City 11884CairoEgypt Department of Chemistry Faculty of ScienceNorthern Border UniversityArarSaudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 1109921944 TaifSaudi Arabia

A lightweight flexible thermally stable composite is fabricated by com-bining silica nanofiber membranes(SNM)with MXene@c-MWCNT hybrid *** flexible SNM with outstanding thermal insulation are prepared from tetraethyl orthosilicate hydrolysis and condensation by electrospinning and high-temperature calcination;the MXene@c-MWCNT_(x:y)films are prepared by vacuum filtration *** particular,the SNM and MXene@c-MWCNT_(6:4)as one unit layer(SMC_(1))are bonded together with 5 wt%polyvinyl alcohol(PVA)solution,which exhibits low thermal conductivity(0.066 W m^(-1)K^(-1))and good electromagnetic interference(EMI)shielding performance(average EMI SE_(T),37.8 dB).With the increase in func-tional unit layer,the overall thermal insulation performance of the whole composite film(SMC_(x))remains stable,and EMI shielding performance is greatly improved,especially for SMC_(3)with three unit layers,the average EMI SET is as high as 55.4 *** addition,the organic combination of rigid SNM and tough MXene@c-MWCNT_(6:4)makes SMC_(x)exhibit good mechanical tensile ***,SMC_(x)exhibit stable EMI shielding and excellent thermal insulation even in extreme heat and cold ***,this work provides a novel design idea and important reference value for EMI shielding and thermal insulation components used in extreme environmental protection equipment in the future.

关键词： SiO_(2)nanofiber membranes MXene@c-MWCNT Composite film Thermal insulation Electromagnetic interference shielding

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人类疱疹病毒4型相关胆管细胞癌影像及临床分析

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中华实验外科杂志 2024年第5期41卷 916-916页

作者：刘健刘子源段小辉陈志鸿毛志群湖南师范大学附属第一医院(湖南省人民医院)放射科长沙410005 湖南师范大学附属第一医院(湖南省人民医院)肝胆外科长沙410005 湖南师范大学附属第一医院(湖南省人民医院)病理科长沙410005

人类疱疹病毒4型相关胆管细胞癌(EBVaICC)是肝内胆管细胞癌(ICC)的一种少见类型,约占ICC的6.6%,其预后在ICC中较良好。本研究旨在进一步探讨该疾病的临床及影像表现。

关键词：胆管细胞癌影像表现人类疱疹病毒4型临床分析 ICC 少见类型 BV

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舰用燃气轮机寿命周期费用分析

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中国舰船研究 2022年第S1期17卷 109-115页

作者：刘子源姜刚中国人民解放军92228部队北京100072

[目的]作为重要的舰用动力装备,舰用燃气轮机的研制具有难度大、周期长、费用高的特点,其经济性是十分重要的评价指标。因此,有必要在立项阶段通过主要指标和参数对其主要寿命周期费用进行估算,开展寿命周期的经济性评估。[方法]首先,... 详细信息

[目的]作为重要的舰用动力装备,舰用燃气轮机的研制具有难度大、周期长、费用高的特点,其经济性是十分重要的评价指标。因此,有必要在立项阶段通过主要指标和参数对其主要寿命周期费用进行估算,开展寿命周期的经济性评估。[方法]首先,收集整理典型舰用燃气轮机的技术指标、物理参数、费用等数据,建立研制费、订购价格的参数法估算模型,并进行验证。同时,结合运行、维护维修等阶段费用发生特点,建立主要寿命周期费用分析框架与估算模型。[结果]结果显示,建立的研制费、订购价格模型估算误差在5%以内;建立的运行费、维护维修费估算方法贴合实际,易于使用。[结论]研究表明,建立的寿命周期费用分析框架与估算模型具有适用性与可行性,可为舰用燃气轮机立项阶段的经济性分析工作提供有效支撑。

关键词：舰用燃气轮机寿命周期费用研制费订购价格费用估算

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Over-expression of small ubiquitin-like modifier proteases 1 predicts chemo-sensitivity and poor survival in non-small cell lung cancer

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Chinese Medical Journal 2014年第23期127卷 4060-4065页

作者： Mu Juwei Zuo Yong Yang Wenjing Chen Zhaoli liu ziyuan Tu Jun Li Yan Yuan Zuyang Cheng Jinke He Jie Department of Thoracic Surgical Oncology Cancer Institute & Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China Department of Biochemistry and Molecular Cell Biology Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Background Non-small cell lung cancer （NSCLC） is one of the most common malignant *** the advances in therapy over the years,its mortality remains *** aim of this study was to evaluate the expression of small ubiquitin-like modifier （SUMO） proteases 1 （SENP1） in NSCLC tissues and its role in the regulation of vascular endothelial growth factor （VEGF） *** also investigated the association between the expression level of SENP1 and the clinicopathological features and survival of the *** A SENP1 small interfering RNA （siRNA） was constructed and transfected into the NSCLC *** gene expression was analyzed by real-time polymerase chain reaction （RT-PCR）.Immunohistochemistry staining was used to assess the expression of SENP1 in 100 NSCLC patients and its association with the clinicopathological features and survival was *** VEGF expression was significantly higher in NSCLC tissues than in normal lung *** of SENP1 by siRNA was associated with decreased VEGF ***1 was over-expressed in 55 of the 100 NSCLC samples （55％） and was associated with a moderate and low histological tumor grade （3.6％,38.2％,and 58.2％ in high,moderate and low differentiated tumors,respectively,P=0.046）,higher T stage （10.9％ in T1,and 89.1％ in T2 and T3 tumor samples,P ＜0.001）and TNM stage （10.9％ in stage Ⅰ,and 89.1％ in stages Ⅱ and Ⅲ tumor samples,P ＜0.001）.The rate of lymph node metastasis was significantly higher in the SENP1 over-expression group （76.4％） than that in the SENP1 low expression group （33.3％,P ＜0.001）.Sixty three patients received postoperative chemotherapy,including 34 with SENP1 over-expression and 29 with SENP1 low *** the 34 patients with SENP1 over-expression,22 （64.7％） patients developed recurrence or metastasis,significantly higher than those in the low expression group 27.6％（8/29）（P=0.005）.Multivariate Cox regression analysis showed that lymph node metastasis （P=0.015）,TNM stage

关键词： small ubiquitin-like modifier proteases 1 (SENP1) non-small cell lung cancer prognosis neoplasm recurrence

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