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Energy & Environmental Materials 2024年第4期7卷 28-47页

作者： Honggang He litong wang Malek Al-Abbasi Chunyan Cao Heng Li Zhu Xu Shi Chen Wei Zhang Ruiqing Li Yuekun Lai Yuxin Tang Mingzheng Ge School of Textile and Clothing Nantong University School of Science Qingdao University of Technology Department of Biomedical Sciences City University of Hong Kong Institute of Applied Physics and Materials Engineering University of Macau College of Chemical Engineering Fuzhou University

Solid-state lithium batteries (SSLBs) with high safety have emerged to meet the increasing energy density demands of electric vehicles,hybrid electric vehicles,and portable electronic ***,the dendrite formation,high interfacial resistance,and deleterious interfacial reactions caused by solid-solid contact between electrode and electrolyte have hindered the commercialization of SSLBs.

关键词： dendrite formation high energy density interface instability interfacial resistance solid-state electrolyte

柔性直流输电系统三端口混合参数建模及其稳定性分析

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电工技术学报 2024年第16期39卷 4968-4984页

作者：刘欣袁易王利桐贾焦心孙海峰华北电力大学电力工程系保定071003

模块化多电平换流器(MMC)与系统网络之间的交互是诱发振荡的主要原因,然而现有MMC单侧阻抗/导纳建模方法往往没有计及对端换流站的动态过程,因此该文重点通过建立可以考虑交直流耦合的换流器三端口混合参数模型实现整个双端柔直系统的... 详细信息

模块化多电平换流器(MMC)与系统网络之间的交互是诱发振荡的主要原因,然而现有MMC单侧阻抗/导纳建模方法往往没有计及对端换流站的动态过程,因此该文重点通过建立可以考虑交直流耦合的换流器三端口混合参数模型实现整个双端柔直系统的稳定性分析。首先,该文基于谐波状态空间法推导考虑桥臂间谐波动态交互过程的MMC换流器交直流端口功率守恒方程,并据此建立换流器的三端口混合参数模型;其次,基于所建立的三端口混合参数模型和广义奈奎斯特判据,对MMC互联系统的稳定性进行分析,因该方法可避免计算开环传递函数右半平面零极点的数量,与传统单侧阻抗稳定性分析方法相比,可实现系统稳定性的准确判断;再次,推导了特征值相位关于三端口混合参数元素的灵敏度计算公式,揭示了系统振荡的诱因,进一步结合控制参数灵敏度分析,实现了一种用于改善互联系统直流侧稳定性的直流电流前馈附加阻尼控制策略;最后,结合时域仿真算例验证了稳定性分析和改善措施的有效性。

关键词：模块化多电平换流器三端口网络混合参数模型稳定性分析谐波状态空间

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Human lactate dehydrogenase and malate dehydrogenase possess the catalytic properties to produce aromatic α‑hydroxy acid

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Systems Microbiology and Biomanufacturing 2023年第4期3卷 627-633页

作者： litong wang Tai‑Ping Fan Mei wang Yajun Bai Xiaohui Zheng Yujie Cai The Key Laboratory of Industrial Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan University1800 Lihu RoadWuxi 214122JiangsuChina Department of Pharmacology University of CambridgeCambridge CB21TUK Leiden University‑European Center for Chinese Medicine and Natural Compounds Institute of BiologyLeiden UniversitySylviusweg 722333BE LeidenThe Netherlands College of Life Sciences Northwest UniversityXi’an 710069ShanxiChina

Lactate dehydrogenase and malate dehydrogenase are the two main alpha-hydroxy acid dehydrogenases in the human *** investigated the catalytic properties of human lactate dehydrogenase LDHC,LDHL6A and malate dehydrogenase MDH1 on aromatic α-keto acids phenylpyruvic acid,p-hydroxyphenylpyruvic acid and 3,4-dihydroxyphenylpyruvic *** optimum temperatures for LDHC,LDHL6A,and MDH1 are 37℃,35℃,and 45℃,respectively;and the optimum pH is 6.5,6.5,and 5.5,*** K_(m)of LDHC for phenylpyruvic acid and 3,4-dihydroxyphenylpyruvic acid were 0.90 mM and 0.92 mM,***6A has a high affinity for phenylpyruvic acid and 3,4-dihydroxyphenylpyruvic acid with K_(m)of 0.77 mM and 0.80 mM,respectively;MDH1 has an extremely high affinity(K_(m)=0.46 mM)and catalytic efficiency(k_(cat)/K_(m)=23.87 s^(-1)·mM^(-1))for p-hydroxyphenylpyruvic *** also has a high affinity for 3,4-dihydroxyphenylpyruvic acid with a K_(m)of 0.90 mM,but with a low affinity for phenylpyruvic acid(K_(m)=3.76 mM).The catalytic properties of human LDHC,LDHL6A,and MDH1 for the abovementioned aromatic α-keto acids may be one of the sources of L-phenyllactic acid,L-p-hydroxyphenyllactic acid,and L-3,4-dihydroxyphenyllactic acid in humans.

关键词： Aromaticα-keto acids Lactate dehydrogenase Malate dehydrogenase L-phenyllactic acid Enzymatic properties

Three‑Dimensional Nano‑displacement Measurement by Four‑Beam Laser Interferometry

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Nanomanufacturing and Metrology 2024年第2期7卷 42-49页

作者： Xu Zhang Zi wang Mengnan Liu Zhengxun Song Zuobin wang litong Dong International Research Centre for Nano Handling and Manufacturing of China Changchun University of Science and TechnologyChangchun 130022China Centre for Opto/Bio‑Nano Measurement and Manufacturing Zhongshan Institute of Changchun University of Science and TechnologyZhongshan 528437China Ministry of Education Key Laboratory for Cross‑Scale Micro and Nano Manufacturing Changchun University of Science and TechnologyChangchun 130022China JR3CN&IRAC University of BedfordshireLuton LU13JUUK

A 3D nano-displacement measurement method,where the difference in phase between the beams in a four-beam laser interference is changed,is *** results demonstrate that the variation of phase difference causes the deviation of the interference pattern in the laser interference *** on this theory,we design and build a four-beam laser interference *** corner cube prism in the optical path is shifted,and the phase of the beam is changed by applying different voltages to a piezoelectric *** phase difference is obtained by analyzing the lattice pattern with subpixel precision,and then the displacement is determined by correlation *** experimental measurement results are consistent with the theoretical analysis,thereby verifying the feasibility of this measurement method.

关键词： Four-beam laser interferometry Phase difference 3D displacement Correlation operation

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急倾斜中厚矿体采矿方法与变革

科技资讯 2024年第5期22卷 92-94页

作者：李悰赟夏传祥卢宏建王利通李凤久华北理工大学矿业工程学院河北唐山063210

中深孔机械化落矿空场嗣后充填法是一种适用于急倾斜中厚矿体的地下采矿技术。随着采矿技术和产能的需求,浅孔留矿采矿法已不能适应,中深孔机械化落矿空场嗣后充填法逐渐被应用到急倾斜中厚矿体中,并取得了良好的效果。3种采矿方法经过... 详细信息

中深孔机械化落矿空场嗣后充填法是一种适用于急倾斜中厚矿体的地下采矿技术。随着采矿技术和产能的需求,浅孔留矿采矿法已不能适应,中深孔机械化落矿空场嗣后充填法逐渐被应用到急倾斜中厚矿体中,并取得了良好的效果。3种采矿方法经过迭代的更新,并获得了现代主流采矿方法,现代主流采矿方法满足当前的政策导向和现实需求,提高了类似矿体开采效率。

关键词：急倾斜矿体中厚矿体留矿采矿法采场参数

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Effects on the STAT3-shRNA in Non-Small-Cell Lung Cancer Therapy: Design, Induction of Apoptosis, and Conjugation with Chitosan-Based Gene Vectors

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Journal of Ocean University of China 2021年第5期20卷 1097-1108页

作者： ZHANG wangwang ZHANG Yan JIANG Zhiwen SUN Le wang litong GU Zhiyang LI Wenya GUO Lili CHEN Xiaotong ZHANG Haibin HAN Baoqin CHANG Jing College of Marine Life Science Ocean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266235China

STAT3 plays a particularly important role in several cancer-related signal transduction *** STAT3 via RNA interference or small molecule inhibitors induces the apoptosis of tumor cells,thereby inhibiting the growth of the *** this study,short-hairpin RNA sequences targeting the STAT3 genes were designed,synthesized,and then connected to pGPU6/GFP/Neo plasmids as the shRNA-expression *** expression of STAT3-shRNA was analyzed by real-time PCR,western blotting,and cell apoptosis assay to study the growth and apoptosis of the ***,the effect of STAT3 knockdown on the NCI-H1650 cells was studied in a tumor mouse *** results revealed that,after an in vitro transfection,the proliferation of NCI-H1650 cells was inhibited,and the cells were induced to *** mRNA and protein expression levels of STAT3 were downregulated in the STAT3-shRNA *** vivo,the tumor mass and volume in the STAT3-shRNA group were significantly lower than in the other two *** the in vivo and in vitro results demonstrated a long-period inhibiting effect on NSCLC,especially in vivo,when the tumor inhibition rate could reach 50%in the STAT3-shRNA group,which is an exciting ***,the study of the conjugation of STAT3-shRNA and chitosan-based vectors revealed that they could be combined steadily with good cytocompati-bility and transfection *** results together provide convincing evidence for the application of STAT3-shRNA used in the treatment of non-small lung cancer,which could be a promoting prospect for the development of gene therapy.

关键词： signal transducer and activator of transcription 3 short-hairpin RNA target downregulation chitosan-based vectors gene therapy

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N-carboxymethyl chitosan/sodium alginate composite hydrogel loading plasmid DNA as a promising gene activated matrix for in-situ burn wound treatment

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Bioactive Materials 2022年第9期7卷 330-342页

作者： litong wang Le Sun Zhiyang Gu Wenya Li Lili Guo Saibo Ma Lan Guo wangwang Zhang Baoqin Han Jing Chang College of Marine Life Science Ocean University of ChinaQingdao266003PR China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao266235PR China

Improving the degree of vascularization through the regulation of wound microenvironment is crucial for wound *** activated matrix(GAM)technology provides a new approach for skin *** is a local gene delivery system that can not only maintain a moist environment,but also increase the concentration of local active *** this purpose,we fabricated the mVEGF165/TGF-β1 gene-loaded N-carboxymethyl chitosan/sodium alginate hydrogel and studied its effect on promoting deep second degree burn wound *** average diameter of the hydrogel pores was 100μm and the porosity was calculated as 50.9%.SEM and CLSM images showed that the hydrogel was suitable for cell adhesion and *** NS-GAM could maintain continuous expression for at least 9 days in vitro,showing long-term gene release and expression *** second-degree burn wound model was made on the backs of Wistar rats to evaluate the healing *** wounds were healed by day 22 in NS-GAM group with the prolonged high expression of VEGF and TGF-β1 protein.A high degree of neovascularization and high expression level of CD34 were observed in NS-GAM group in 21 *** histological results showed that NS-GAM had good tissue safety and could effectively promote epithelialization and collagen *** results indicated that the NS-GAM could be applied as a promising local gene delivery system for the repair of deep second-degree burn wounds.

关键词： Gene activated matrix Hydrogel Wounds healing N-carboxymethyl chitosan Sodium alginate

Efficient drug delivery and anticancer effect of micelles based on vitamin E succinate and chitosan derivatives

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Bioactive Materials 2021年第10期6卷 3025-3035页

作者： Xiaotong Chen Junxiang Gu Le Sun Wenya Li Lili Guo Zhiyang Gu litong wang Yan Zhang wangwang Zhang Baoqin Han Jing Chang College of Marine Life Science Ocean University of ChinaQingdao266003PR China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao266235PR China

Nanocarriers have emerged as a promising cancer drug delivery ***-drug resistance caused by overexpression of multiple-drug excretion transporters in tumor cells is the major obstacle to successful *** E derivatives have many essential functions for drug delivery applications,such as biological components that are hydrophobic,stable,water-soluble enhancing compounds,and anticancer *** addition,vitamin E derivatives are also effective mitocan which can overcome multi-drug resistance by binding to P ***,we developed a carboxymethyl chitosan/vitamin E succinate nano-micellar system(O-CMCTS-VES).The synthesized polymers were characterized by Fourier Transform IR,and 1H NMR *** mean sizes of O-CMCTS-VES and DOX-loaded nanoparticles were around 177 nm and 208 *** drug loading contents were 6.1%,13.0%and 10.6%with the weight ratio of DOX to O-CMCTS-VES corresponding 1:10,2:10 and 3:10,and the corresponding EEs were 64.3%,74.5%and 39.7%.Cytotoxicity test,hemolysis test and histocompatibility test showed that it had good biocompatibility in vitro and in *** release experiments implied good pH sensitivity and sustained-release *** DOX/O-CMCTS-VES nanoparticles can be efficiently taken up by HepG2 cancer cells and the tumor inhibition rate is up to 62.57%.In the in vivo study by using H22 cells implanted Balb/C mice,DOX/O-CMCTS-VES reduced the tumor volume and weight efficiently with a TIR of 35.58%.The newly developed polymeric micelles could successfully be utilized as a nanocarrier system for hydrophobic chemotherapeutic agents for the treatment of solid tumors.

关键词： Vitamin E succinate Chitosan Multi-drug resistance Drug delivery Nanocarrier

Acyl-CoA thioesterase 7 is oncogenic in breast cancer by promoting oxidative phosphorylation via PGC1a

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Genes & Diseases 2024年第5期11卷 13-16页

作者： Xiangyu Sun Qiang Zhang Mozhi wang litong Yao Xiang Li Hongyi Cao Yingying Xu Department of Breast Surgery Liaoning Cancer Hospital&InstituteShenyangLiaoning 110000China Department of Breast Surgery The First Hospital of China Medical UniversityShenyangLiaoning 110000China Department of Ultrasound The First Hospital of China Medical UniversityShenyangLiaoning 110000China Department of Pathology The First Hospital of China Medical University and College of Basic Medical SciencesShenyangLiaoning 110000China

Metabolic reprogramming is a key feature of tumor cells and plays a key role in the adaptation of tumor cells to increased demands of biosynthesis and rapid proliferation.1 Numerous studies have shown that some key metabolic enzymes are essential for the initiation and progression of breast cancer(BC).These metabolic enzymes are involved in the regulation of many biological processes such as gene transcription,post-translational modification,and antioxidant capacity of cells,which endow tumor cells with the ability to adapt to divergent environmental stimuli.2 Therefore,it is of great significance to identify the role of important metabolic enzymes in the occurrence and development of BC to determine promising therapeutic targets.

关键词： breast cancer oxidative

ACSL3 regulates breast cancer progression via lipid metabolism reprogramming and the YES1/YAP axis

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Cancer Biology & Medicine 2024年第7期21卷 606-635页

作者： Shirong Tan Xiangyu Sun Haoran Dong Mozhi wang litong Yao Mengshen wang Ling Xu Yingying Xu Department of Breast Surgery The First Affliated Hospital of China Medical UniversityShenyang 110000China Department of Thyroid and Breast Surgery Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000China Department of Medical Oncology The First Hospital of China Medical UniversityShenyang 110000China

Objective:Mitochondrial fatty acid oxidation is a metabolic pathway whose dysregulation is recognized as a critical factor in various cancers,because it sustains cancer cell survival,proliferation,and *** acyl-Co A synthetase long-chain(ACSL)family is known to activate long-chain fatty acids,yet the specific role of ACSL3 in breast cancer has not been ***:We assessed the prognostic value of ACSL3 in breast cancer by using data from tumor ***-of-function and lossof-function assays were also conducted to determine the roles and downstream regulatory mechanisms of ACSL3 in vitro and in ***:ACSL3 expression was notably downregulated in breast cancer tissues compared with normal tissues,and this phenotype correlated with improved survival *** experiments revealed that ACSL3 knockdown in breast cancer cells promoted cell proliferation,migration,and epithelial±mesenchymal ***,ACSL3 was found to inhibitβ-oxidation and the formation of associated byproducts,thereby suppressing malignant behavior in breast ***,ACSL3 was found to interact with YES proto-oncogene 1,a member of the Src family of tyrosine kinases,and to suppress its activation through phosphorylation at *** decrease in activated YES1 consequently inhibited YAP1 nuclear colocalization and transcriptional complex formation,and the expression of its downstream genes in breast cancer cell ***:ACSL3 suppresses breast cancer progression by impeding lipid metabolism reprogramming,and inhibiting malignant behaviors through phospho-YES1 mediated inhibition of YAP1 and its downstream *** findings suggest that ACSL3 may serve as a potential biomarker and target for comprehensive therapeutic strategies for breast cancer.

关键词： Breast cancer lipid metabolism ACSL3 YAP metastasis

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