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Journal of Energy Chemistry 2023年第11期86卷 16-22,I0002页

作者： liting huang Yongfeng Lun Yuping Liu Liming Chen Bowen Li Shuqin Song Yi Wang The Key Lab of Low-carbon Chemistry&Energy Conservation of Guangdong Province PCFM LabSchool of Chemical Engineering and TechnologySchool of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275GuangdongChina

Colloidal synthesis of metal nanoclusters will inevitably lead to the blockage of catalytically active sites by organic ligands.Here,taking[Au_(25)(PET)_(18)]-(PET=2-phenylethanethiol)nanocluster as a model catalyst,this work reports a feasible procedure to achieve the controllably partial removal of thiolate ligands from unsupported[Au_(25)(PET)_(18)]-nanoclusters with the preservation of the core structure.This procedure shortens the processing duration by rapid heating and cooling on the basis of traditional annealing treatment,avoiding the reconfiguration or agglomeration of Au_(25)nanoclusters,where the degree of dethiolation can be regulated by the control of duration.This work finds that a moderate degree of dethiolation can expose the Au active sites while maintaining the suppression of the competing hydrogen evolution reaction.Consequently,the activity and selectivity towards CO formation in electrochemical CO_(2)reduction reaction of Au_(25)nanoclusters can be promoted.This work provides a new approach for the removal of thiolate ligands from atomically precise gold nanoclusters.

关键词： Gold nanoclusters Thiolates Ligand removal Electrochemically active surface area Electrochemical CO_(2)reduction

Optogenetic activation of intracellular signaling based on light-inducible protein-protein homo-interactions

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Neural Regeneration Research 2022年第1期17卷 25-30页

作者： Peiyuan huang Zhihao Zhao liting Duan Department of Biomedical Engineering The Chinese University of Hong KongSha TinHong Kong Special Administrative RegionChina Shun Hing Institute of Advanced Engineering(SHIAE) The Chinese University of Hong KongSha TinHong Kong Special Administrative RegionChina

Dynamic protein-protein interactions are essential for proper cell functioning.Homointeraction events—physical interactions between the same type of proteins—represent a pivotal subset of protein-protein interactions that are widely exploited in activating intracellular signaling pathways.Capacities of modulating protein-protein interactions with spatial and temporal resolution are greatly desired to decipher the dynamic nature of signal transduction mechanisms.The emerging optogenetic technology,based on genetically encoded light-sensitive proteins,provides promising opportunities to dissect the highly complex signaling networks with unmatched specificity and spatiotemporal precision.Here we review recent achievements in the development of optogenetic tools enabling light-inducible protein-protein homo-interactions and their applications in optical activation of signaling pathways.

关键词： cryptochrome 2 homo-interaction intracellular signaling light light-induced protein-protein interaction light-oxygen-voltage-sensing domain light-sensitive proteins optogenetics phytochrome signal transduction

Photodynamic Therapy Activities of 10-（4-Formylphenyl）-5,15-bis（pentafluorophenyl）corrole and Its Gallium Complex

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Chinese Journal of Chemistry 2017年第1期35卷 86-92页

作者： Fan Cheng liting huang Huahua Wang Yunjun Liu Jaipal Kandhadi Hui Wang Liangnian Ji Haiyang Liu Department of Chemistry Key Laboratory of Functional Molecular Engineering of Guangdong Provinee South China University of Technology Guangzhou Guangdong 510641 China School of Pharmacy Guangdong Pharmaceutical University Guangzhou Guangdong 510006 China State Key Laboratory of Optoelectronics Materials and Technologies Sun-Yat Sen University Guangzhou Guangdong 510275 China

10-（4-Formylphenyl）-5,15-bis（pentafluorophenyl）corrole 1 and its gallium complex 1-Ga were used to investigate their photocytotoxicity in liver cancer （BEL-7402）, lung cancer （A549） and cervical cancer （Siha, Hela） cell lines. Among all the tested tumor cells, Siha tumor cells were the most sensitive to photodynamic therapy （PDT） treatment by 1 and 1-Ga. PDT IC50 of 1 and 1-Ga toward Siha tumor cell reaches 1.3 and 0.8 gmol/L respectively, which is 10-fold higher than that of cisplatin. 1 and 1-Ga might pass across the tumor cell membrane smoothly without the help of carrier protein, and mainly localized in the cytoplasm of tumor cell. After PDT treatment, the intracellular reactive oxygen species （ROS） level increased and the mitochondrial membrane potential decreased significantly, which would finally result in the apoptosis of tumor cells.

关键词： corrole gallium photodynamic therapy tumor cell

Unintentional modulation microstructure enlargement

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Journal of Systems Engineering and Electronics 2022年第3期33卷 522-533页

作者： SUN liting WANG Xiang huang Zhitao Department of Electronic Science National University of Defense TechnologyChangsha 410073China

Radio frequency fingerprinting(RFF)is a technology that identifies the specific emitter of a received electromagnetic signal by external measurement of the minuscule hardware-level,device-specific imperfections.The RFF-related information is mainly in the form of unintentional modulation(UIM),which is subtle enough to be effectively imperceptible and is submerged in the intentional modulation(IM).It is necessary to minimize the influence of the IM and expand the slight differences between emitters for successful RFF.This paper proposes a UIM microstructure enlargement(UMME)method based on feature-level adaptive signal decomposition(ASD),accompanied by autocorrelation and cross-correlation analysis.The common IM part is evaluated by analyzing a newly-defined benchmark feature.Three different indexes are used to quantify the similarity,distance,and dependency of the RFF features from different devices.Experiments are conducted based on the real-world signals transmitted from 20 of the same type of radar in the same working mode.The visual image qualitatively shows the magnification of feature differences;different indicators quantitatively describe the changes in features.Compared with the original RFF feature,recognition results based on the Gaussian mixture model(GMM)classifier further validate the effectiveness of the proposed algorithm.

关键词： radio frequency fingerprinting(RFF) unintentional modulation(UIM) adaptive signal decomposition(ASD) variational mode decomposition(VMD) similarity measurement

Good综合征合并新型冠状病毒感染4例并文献复习

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中华结核和呼吸杂志 2024年第5期47卷 430-436页

作者：杨露露黄丽婷任思颖欧阳若芸中南大学湘雅二医院呼吸与危重症学科、中南大学呼吸疾病研究所、湖南省呼吸与危重症疾病临床医学研究中心、中南大学呼吸疾病诊疗中心长沙410011

目的总结和分析Good综合征合并2019冠状病毒病(COVID-19)患者的临床特点。方法回顾性分析2023年1月1日至8月31日中南大学湘雅二医院诊治的4例Good综合征合并COVID-19患者的临床资料,并以“Good综合征”“新型冠状病毒”为关键词,检索万... 详细信息

目的总结和分析Good综合征合并2019冠状病毒病(COVID-19)患者的临床特点。方法回顾性分析2023年1月1日至8月31日中南大学湘雅二医院诊治的4例Good综合征合并COVID-19患者的临床资料,并以“Good综合征”“新型冠状病毒”为关键词,检索万方数据库和PubMed数据库相关文献,对患者的临床特征、治疗与转归进行归纳分析。结果本院4例Good综合征合并COVID-19患者均为男性,住院天数分别为17、23、7、13 d。数据库共检索到6例Good综合征合并COVID-19病例,均为国外患者,其中女性3例,男性3例,住院天数分别为12、22、13、25、21、34 d,10例患者均达到重症或危重症新冠肺炎诊断标准,其中3例患者死亡(2例患者死于脓毒血症,1例患者死于呼吸衰竭),均为中年男性患者。结论Good综合征患者合并COVID-19易发展为重症或危重症新冠肺炎,且更易合并多种病原体混合感染,及时补充免疫球蛋白是治疗的关键。

关键词：胸腺瘤新型冠状病毒感染感染丙种球蛋白缺乏血症

Unintentional modulation evaluation in time domain and frequency domain

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Chinese Journal of Aeronautics 2022年第4期35卷 376-389页

作者： liting SUN Xiang WANG Zhitao huang Department of Electronic Science National University of Defense Technology410073 ChangshaChina

With the development of wireless communication technology, the electromagnetic environment has become more and more complex. Conventional signal identification methods are difficult to accurately identify illegal devices. However, electromagnetic signals have an unavoidable device-specific characteristic unintentionally generated by a transmitter, appearing in the form of an Un Intentional Modulation(UIM), namely Radio Frequency Fingerprint(RFF). RFFs can be used to uniquely identify an emitter to match a received signal with its source. In this paper, the authors propose a novel RFF scheme to separate UIM part from the original signals from the time and frequency domain, and then utilize non-Gaussian measuring tools to extract a set of dimensionreduced secondary features. Additionally, Singular Value Reconstruction(SVR) is developed to extract UIM in the frequency spectrum. In time domain, a curve-fitting residual method is proposed to extract the UIM on the estimated instantaneous phase based on Maximum Likelihood Estimator(MLE). Various aspects of the proposed method are evaluated, including identification accuracy under various Signal-to-Noise Ratio(SNR) conditions, energy relationships between the UIM and the whole signal, and sensitivity to training set size. Compared with other methods, experimental results based on real-world signals prove that the proposed method has remarkable performance and high practicability.

关键词： Instantaneous phase estimation Pattern recognition Radio Frequency Fingerprint(RFF) Singular Value Decomposition(SVD) Un Intentional Modulation(UIM)

化妆品中托萘酯、利拉萘酯的高效液相色谱定量及高效液相色谱-串联质谱确证

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日用化学工业（中英文） 2024年第2期54卷 231-238页

作者：鲁毅翔伍丽婷蒋济民陈海露黄璇广西壮族自治区药品检验研究院广西南宁530022 桂林医学院药学院广西桂林541004

建立了化妆品中托萘酯、利拉萘酯的高效液相色谱法(HPLC)和高效液相色谱-串联质谱(HPLC-MS/MS)确证方法。以乙腈为提取溶剂,经涡旋、超声制成样品溶液。在HPLC方法中,采用5μm粒径的常规C18色谱柱,以乙腈和0.1%甲酸水为流动相,在258和28... 详细信息

建立了化妆品中托萘酯、利拉萘酯的高效液相色谱法(HPLC)和高效液相色谱-串联质谱(HPLC-MS/MS)确证方法。以乙腈为提取溶剂,经涡旋、超声制成样品溶液。在HPLC方法中,采用5μm粒径的常规C18色谱柱,以乙腈和0.1%甲酸水为流动相,在258和283 nm波长下进行定量测定,同时结合200~400 nm范围光谱进行定性。HPLC-MS/MS方法所用流动相与HPLC法相同,经粒径为1.8μm的高效C18柱分离,用ESI源在MRM模式下对目标物进行确证。在HPLC方法中,托萘酯和利拉萘酯的线性范围分别为0.1~10.0 mg/L和0.2~20.0 mg/L(R^(2)>0.99),检出限为3.0和6.0 mg/kg,定量限为10和20 mg/kg,加标回收率为93.3%~107.9%(RSD0.99),检出限均为0.002 mg/kg,定量限均为0.005 mg/kg,加标回收率为84.0%~112.8%(RSD<5%)。本研究建立的方法简便、快速、专属性强、准确度高,适用于化妆品中托萘酯和利拉萘酯的测定。

关键词：高效液相色谱高效液相色谱-串联质谱托萘酯利拉萘酯化妆品

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小学教师数字素养水平体系的建构与实证检验

教师发展研究 2024年第1期8卷 94-99页

作者：黄晓婷郭丽婷北京大学教育学院北京100871

提升教师数字素养是推进教育数字化转型的重要环节。基于教育部颁布的《教师数字素养》教育行业标准,借鉴国际经验,建构了小学教师数字素养水平体系,并应用该水平体系对225位小学教师进行了实证检验。结果表明:小学教师数字素养处于中... 详细信息

提升教师数字素养是推进教育数字化转型的重要环节。基于教育部颁布的《教师数字素养》教育行业标准,借鉴国际经验,建构了小学教师数字素养水平体系,并应用该水平体系对225位小学教师进行了实证检验。结果表明:小学教师数字素养处于中等水平,具备基本的数字化工具使用技能,年龄较轻、职称较低、学历较高的小学教师数字素养水平相对更高,教龄、培训时长是影响小学教师数字素养水平的主要因素。建议培养教师综合、创造性应用数字技术的能力,建立“反向传帮带”机制以及充分发挥教师数字技术共同体的效应,以有效提升小学教师的数字素养水平。

关键词：数字素养小学教师教育数字化教育现代化

迎接“AI+设计”:以彩色化技术研究进展为例

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包装工程 2024年第6期45卷 177-187页

作者：夏天琳李宇航黄丽婷丁友东姜佳琦黄文宣上海大学上海电影学院上海200072 上海电影特效工程技术研究中心上海200072 东华大学机械工程学院上海201600

目的以彩色化技术为主要研究内容,从人工智能结合设计的角度重点阐述了彩色化研究的技术特点及适用场景,结合人工智能背景对智能设计发展趋势进行思考和总结。方法首先,对人工智能彩色化研究的技术需求、应用场景进行融合分析,推导人工... 详细信息

目的以彩色化技术为主要研究内容,从人工智能结合设计的角度重点阐述了彩色化研究的技术特点及适用场景,结合人工智能背景对智能设计发展趋势进行思考和总结。方法首先,对人工智能彩色化研究的技术需求、应用场景进行融合分析,推导人工智能与设计创作结合的可能性;其次,对彩色化传统方法与人工智能基础技术进行调研,以交互设计的理念为灵感启发,将人工智能的彩色化方法分为显式交互彩色化和隐式交互彩色化并进行归纳和总结;最后讨论研究彩色化技术的应用对象、预处理步骤和实践体验。结果总结概括彩色化技术结合人工智能设计的发展趋势与未来技术重点。结论“AI+设计”的趋势背景下,以彩色化为代表的人工智能数字图像处理技术正成为设计师的辅助工具,在科技、艺术、影视、人文等领域展现出交叉融合的大趋势。

关键词：彩色化人工智能设计深度学习图像处理

Notoginsenoside R1 Protects against Diabetic Nephropathy through TXNIP-NLRP3 Signaling Pathway

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Clinical Complementary Medicine and Pharmacology 2023年第4期3卷 34-48页

作者： Chunting Zhang Renyikun Yuan Siyuan Li Guodong huang Kaili Sun Jiaping Pan Qiuxia Liu Xiang Gao Zhijing Wang Tongyu Li Shilong Lu Jianzhen Lv liting huang Hongwei Gao College of Pharmacy Guangxi University of Chinese MedicineNanning 530200GuangxiChina Guangxi Engineering Technology Research Center of Advantage Chinese Development Nanning 530200GuangxiChina Guangxi International Zhuang Medicine Hospital Nanning 530200GuangxiChina The First Affiliated Hospital of Guangxi University of Chinese Medicine Nanning 530200GuangxiChina Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine Nanning 530001GuangxiChina

Background:Diabetic nephropathy(DN)is a microvascular complication of diabetes mellitus(DM).DN results from many factors,including changes in glomerular hemodynamics,oxidative stress and inflammation,and in-terstitial fibrosis and tubular atrophy.Panax notoginseng,a commonly used Chinese medicine,has been used in the treatment of kidney disease.Notoginsenoside R1(NGR1),the main compound isolated from P.notoginseng,has been reported to have a renoprotective role in DN.However,the therapeutic effect and mechanism of NGR1 in DN remain unclear.Objective:The present study aimed to investigate the therapeutic effect and mechanism of NGR1 in DN.Methods:In this study,mouse podocytes(MPC-5 cells)and db/db mice were used to investigate the effect of NGR1 on DN in vitro and in vivo,respectively.Blood glucose,renal function,inflammatory factors,and PI3K/AKT-Nrf2-NLRP3 signaling pathway proteins were assessed.Results:The study results indicated that NGR1 reversed cell viability induced by high glucose(HG,30 mM).The related mechanism results showed that NGR1 decreased oxidative stress by inhibiting reactive oxygen species(ROS)level and upregulating the expression of Nrf2,NQO1,and HO-1 via TXNIP targeting.In addition,NLRP3 inflammasome and PI3K/AKT were engaged in NGR1-based protection against HG-stimulated podocytes.In db/db mice,NGR1 significantly decreased blood glucose,urine protein,urine output,blood urea nitrogen,and other parameters as well as reversed kidney injury by inhibiting oxidative stress and proinflammatory response.Conclusion:Taken together,this study revealed that NGR1 exerted a significant therapeutic effect on DN both in vitro and in vivo via a mechanism related to the TXNIP-Nrf2 pathway and NLRP3 inflammasome,suggesting that NGR1 is a potential therapeutic option for DN.

关键词： Diabetic nephropathy NGR1 PI3K/AKT NRF2 TXNIP NLRP3 inflammasome