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Antimicrobial roles of phagocytosis in teleost fish:Phagocytic B cells vs professional phagocytes

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Aquaculture and Fisheries 2024年第2期9卷 105-114页

作者： liting wu Lan Li Along Gao Jianmin Ye Jun Li Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture Institute of Modern Aquaculture Science and EngineeringSchool of Life SciencesSouth China Normal UniversityGuangzhou510631China Guangdong Province Key Laboratory of Waterfowl Healthy Breeding Zhongkai University of Agriculture and EngineeringGuangzhou510225China School of Science and Medicine Lake Superior State UniversitySault Ste.MarieMI49783USA

The defense system of teleost fish organized on innate and adaptive immunity protects them against a wide variety of pathogenic microorganisms in the aquatic *** is one of the most effective defense strategies against microbial challenge mainly performed by classical‘professional’phagocytes(including monocytes,macrophages and granulocytes).They contain,kill and process the internalized pathogens for antigen presentation by providing antigenic ligands to initiate activation and clonal expansion of T and B cells,which bridge the innate and adaptive *** discovery of phagocytic B cells in teleost fish has broken the paradigm that primary vertebrate B cells are lack of phagocytosis of particulates,as well as led to the investigation of phagocytic activity of mammalian B-1 B *** active phagocytic,microbicidal capabilities and antigen presentation in teleost phagocytic B cell have demonstrated to be similar as professional phagocytes,providing a potential impact on development of new vaccination strategies to prevent and control infectious *** this review,we aim to address current progress on the antimicrobial role of phagocytic B cells in teleost fish by comparing it with other professional phagocytes and mammalian B-1 B cells,and provide the application prospect of phagocytic B cells in developing vaccines as well as the prevention of fish diseases.

关键词： Teleost fish Phagocytic B cell Phagocytosis Antimicrobial role Vaccine design

Cell Membrane-camouflaged Multi-functional Dendritic Large Pore Mesoporous Silica Nanoparticles for Combined Photothermal Therapy and Radiotherapy of Cancer

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Chemical Research in Chinese Universities 2022年第2期38卷 562-571页

作者： wu liting XIN Yujia GUO Zhaoyang GAO Wei ZHU Yanpeng WANG Yinsong RAN Ruixue YANG Xiaoying Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics(Theranostics) School of PharmacyTianjin Medical UniversityTianjin 300070P.R.China

Combining photothermal therapy and radiotherapy(PTT-RT) with reducing tumor hypoxia acts as an important antitumor modality. However, it is a great challenge to realize photothermal therapy, radiotherapy and exogenous oxygen supply in one nanosystem. To realize a combination of the three functions, we fabricated a red blood cell membrane(RBCm)-camouflaged, red blood cell content(RBCc) and the copper sulfide(CuS) co-loaded dendritic large pore mesoporous silica nanoparticle(DLMSN/CuS/RBCc/ RBCm). The cell membrane coating endowed the nanoparticles with good stability in the physiological environment, and CuS allowed the nanoparticle exhibiting good photothermal and radiosensitization properties. RBCc loaded nanoparticle DLMSN/CuS/RBCc enhanced superior anti-tumor effect than DLMSN/CuS during combined PTT-RT therapy because the introduction of RBCc increased the exogenous oxygen supply. The in vitro study further demonstrated that the combination of photothermal therapy and radiotherapy induced superior antitumor efficacy than single therapy. Our work thus presents a unique multifunctional nanoscale platform favorable for combined PTT and RT.

关键词： Dendritic large pore mesoporous silica nanoparticle Photothermal therapy Radiosensitization Red blood cell membrane Oxygen carrying

Constructing metal-free heterophotocatalyst using two-dimensional carbon nitride sheets and violet phosphorene for highly efficient visible-light photocatalysis

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Journal of Materials Science & Technology 2023年第15期146卷 113-120页

作者： Yong Wang Chengxin Zeng liting wu Yalin Dong Yu Zhang Dingyi Yang Wen Hu Jian Hao Hongzhe Pan Rusen Yang Academy of Advanced Interdisciplinary Research School of Advanced Materials and NanotechnologyXidian UniversityXi’an 710126China Department of Physics Shaanxi University of Science and TechnologyXi’an 710021China State Key Laboratory of High-Efficiency Utilization of Coal and Green Chemical Engineering Ningxia UniversityYinchuan 750021China School of Physics and Electronic Engineering Linyi UniversityLinyi 276005China

Two-dimensional(2D)carbon nitride sheets(CNs)with nanoscale thickness have great potential in solar energy conversion owing to their intrinsic ***,their photocatalytic efficiency falls far below the practical requirements because the generated electron-hole pairs rapidly *** construct a metal-free 2D p–n junction heterophotocatalyst from CNs and violet phosphorene(VP)using a simple electrostatic self-assembly *** experimental results and density functional theory calculations show that the built-in electric field of the p–n junction promotes photogenerated carrier transport at the heterojunction interface,thereby promoting the separation of photogenerated electron-hole *** visible-light illumination,the visible-light photocatalytic hydrogen and CO production rates of the CNs/VP heterojunction were increased by 5.85 and 1.51 times,respectively,when compared to that of *** study provides new insights into the design of metal-free heterogeneous photocatalysts with high catalytic activity。

关键词： Heterostructures DFT calculations Visible-light photocatalysis

Enhanced visible-light photocatalytic hydrogen evolution using two-dimensional carbon nitride sheets with the removal of amine groups

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Chinese Chemical Letters 2024年第2期35卷 446-450页

作者： Yu Zhang liting wu Shaopeng Wang Dingyi Yang Huan Liang Yizhang wu Jian Hao Youqing Wang Jianke Liu Yong Wang Department of Physics Shaanxi University of Science and TechnologyXi'an 710021China School of Advanced Materials and Nanotechnology Academy of Advanced Interdisciplinary ResearchXidian UniversityXi'an 710126China The State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology Xidian UniversityXi'an 710126China Collaborative Innovation Center of Advanced Microstructures National Laboratory of Solid State MicrostructuresNanjing UniversityNanjing 210093China State Key Laboratory of High-Efficiency Utilization of Coal and Green Chemical Engineering Ningxia UniversityYinchuan 750021China

Two-dimensional(2D)carbon nitride sheets(CNs)with atomically thin structures are regarded as one of the most promising materials for solar energy ***,due to their substantially enlarged bandgap caused by the strong quantum size effect and their incomplete polymerisation with a large number of non-condensed surface amino groups,the practical applicability of CNs in photocatalysis is *** this study,CNs with broad visible-light absorption were synthesised using a 5-min fast thermal *** removal of uncondensed amine groups reduces the bandgap of CNs from 3.06 eV to 2.60 eV,increasing their absorption of visible ***,the CNs were distorted after annealing,which can differentiate the spatial positions of electrons and holes,enhancing the visible-light absorption *** a result,when exposed to visible light,the photocatalytic hydrogen production activity of atomically thin 2D CNs rose by 8.38 *** research presents a dependable and speedy method for creating highly effective visible-light photocatalysts with narrowed bandgaps and improved visible-light absorption.

关键词： 2D carbon nitride sheets Rapid thermal annealing DFT calculations Visible-light absorption visible-light photocatalysis

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Classic analogue of Autler–Townes-splitting transparency using a single magneto-optical ring resonator

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Chinese Physics B 2023年第10期32卷 420-427页

作者：吴利婷曹文康蒋昊林 School of Information and Communication Engineering Nanjing Institute of TechnologyNanjing 211167China School of Mechanical Engineering Guizhou UniversityGuiyang 550025China School of Electronics and Information Engineering Nanjing University of Information Science and TechnologyNanjing 210044China

We show that an optical transparency can be obtained by using only one single magneto-optical ring resonator. This effect is based on the splitting of counterclockwise and clockwise modes in the ring resonator. Within a proposed resonator-waveguide configuration the superposition between the two degeneracy broken modes produces a transparency window,which can be closed, open, and modified by tuning the applied magnetic field. This phenomenon is an analogue of Autler–Townes splitting, and the magnetic field is equivalent to the strong external pump field. We provide a theoretic analysis on the induced transparency, and numerically demonstrate the effect using full-wave simulation. Feasible implication of this effect and its potential applications are also discussed.

关键词： magneto-optic effect dynamic tunable single optical ring resonator

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Flexible Strain Sensors with Ultra-High Sensitivity and Wide Range Enabled by Crack-Modulated Electrical Pathways

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NANO-MICRO LETTERS 2025年第1期17卷 1-19页

作者： Bai, Yunzhao Zhou, Yunlei wu, Xuanyu Yin, Mengfei Yin, liting Qu, Shiyuan Zhang, Fan Li, Kan Huang, Yongan Huazhong Univ Sci & Technol State Key Lab Intelligent Mfg Equipment & Technol Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Flexible Elect Res Ctr Wuhan 430074 Peoples R China Xidian Univ Hangzhou Inst Technol Hangzhou 311200 Peoples R China Xidian Univ Sch Mechanoelect Engn Xian 710071 Peoples R China Univ Southern Calif Dept Aerosp & Mech Engn Los Angeles CA 90089 USA

This study presents a breakthrough in flexible strain sensor technology with the development of an ultra-high sensitivity and wide-range sensor, addressing the critical challenge of reconciling sensitivity with measurement range. Inspired by the structure of bamboo slips, we introduce a novel approach that utilises liquid metal to modulate the electrical pathways within a cracked platinum fabric electrode. The resulting sensor demonstrates a gauge factor greater than 108 and a strain measurement capability exceeding 100%. The integration of patterned liquid metal enables customisable tuning of the sensor's response, while the porous fabric structure ensures superior comfort and air permeability for the wearer. Our design not only optimises the sensor's performance but also enhances the electrical stability that is essential for practical applications. Through systematic investigation, we reveal the intrinsic mechanisms governing the sensor's response, offering valuable insights for the design of wearable strain sensors. The sensor's exceptional performance across a spectrum of applications, from micro-strain to large-strain detection, highlights its potential for a wide range of real-world uses, demonstrating a significant advancement in the field of flexible electronics.

关键词： Flexible strain sensor Fabric Crack Response regulation Epidermal device

Based on network pharmacology to explore the mechanism of hepatotoxicity of Fructus Meliae Toosendan

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Asian Toxicology Research 2021年第4期3卷 27-35页

作者： liting wu Tengda Li Yu Zhang Lihui Yang Rongjin Yang Handong Liu Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital.Tianjin 300120China Tianjin University of Traditional Chinese Medicine Tianjin301617China

Objective:To explore the potential mechanism of hepatotoxicity induced by Fructus Meliae Toosendan(FMT)through network ***:The active components and targets of FMT were identified and screened by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform Database,PubChem Database and Swiss Target Prediction database,***,pharmGKB,and OMIM databases were used to collect relevant targets of hepatotoxicity,and intersect them with the targets of active ingredients to obtain the potential targets of hepatotoxicity caused by FMT.A compound-target network was constructed with Cytoscape 3.8.0 *** String 11.0 database was used to construct the protein-protein interaction(PPI)network of the targets and to screen out the core *** addition,Gene Ontology(GO)terms and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were conducted by R software,and then the pathways directly related to hepatotoxicity were ***:In this study,9 active ingredients of FMT and 265 targets were *** are 533 hepatotoxicity-related targets,and 76 potential targets for hepatotoxicity caused by FMT,among which quercetin,melianone,and nimbolin A are the key active components for hepatotoxicity caused by FMT,and MYC,STAT3,JUN,and RELA were the core target proteins of FMT’s *** were 2353 GO entries(P<0.05),including 2181 Biological Process(BP),41 Cellular Component(CC)and 131 Molecular Function(MF).KEGG enrichment analysis revealed 165 pathways(P<0.05),of which Th17 cell differentiation,HIF-1 signaling pathway,PI3K-Akt signaling pathway were strongly correlated with the hepatotoxicity of ***:Through network pharmacology,it was found that many potential components in azadirachia chinaberry may be involved in the regulation of apoptosis,excessive inflammatory response and mitochondrial dynamics through multi-target and multi-pathway,resulting in the generation of hepatotoxi

关键词： Fructus Meliae Toosendan Hepatotoxicity Network pharmacology Mechanisms of toxicity

CBCR:CBC MAC with rotating transformations

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Science China(Information Sciences) 2011年第11期54卷 2247-2255页

作者： ZHANG liting 1,2,wu WenLing 1,ZHANG Lei 1 & WANG Peng 21 State Key Laboratory of Information Security,Institute of Software,Chinese Academy of Sciences,Beijing 100190,China 2 Graduate University of Chinese Academy of Sciences,Beijing 100049,China 1. State Key Laboratory of Information Security Institute of Software Chinese Academy of Sciences Beijing 100190 China2. Graduate University of Chinese Academy of Sciences Beijing 100049 China

Message authentication codes (MACs) are widely used to protect data integrity and data origin authentication in *** this paper,we propose a new block-cipher-based MAC algorithm,CBCR,with provable security for arbitrary-length *** adopts rotating operations in the end of cipherblock-chaining structure,and it appends fixed-length prefixes to all messages,which implies flexible usages in *** example,these fixed-length prefixes can be filled with some security parameters,message redundancies,*** also propose CBCR0,a special case of CBCR that sets its prefix to be an all-zero *** with CMAC,a recommended standard by the US National Institute of Standards and Technology (NIST),CBCR0 enjoys all the advantages that CMAC has,but requires less memory;so,in practical applications,CBCR0 behaves as well as CMAC does,and it is even more suitable for environments with limited memory resources,*** cards.

关键词： message authentication code cipher block chaining block cipher provable security

城市轨道交通主用与备用车载控制器冗余切换方案研究

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城市轨道交通研究 2017年第B08期20卷 66-67,76页

作者：邬利挺上海自仪泰雷兹交通自动化系统有限公司上海工程师201206

主用与备用车载控制器(VOBC)的冗余是保证城市轨道交通信号系统可用性的重要技术措施,而实现冗余的方案各不相同。分析了一种主用与备用VOBC冗余方案的切换过程、实现原理、实现电路、安全分析以及应用案例。该解决方案从市场需求出发,... 详细信息

主用与备用车载控制器(VOBC)的冗余是保证城市轨道交通信号系统可用性的重要技术措施,而实现冗余的方案各不相同。分析了一种主用与备用VOBC冗余方案的切换过程、实现原理、实现电路、安全分析以及应用案例。该解决方案从市场需求出发,实现了VOBC所有设备包括外部设备等的完全冗余,解决了无扰切换等技术难题。

关键词：城市轨道交通车载控制器冗余无扰切换

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