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Alpha-fetoprotein,protein induced by vitamin K absence or antagonist-Ⅱ,lens culinaris agglutinin-reactive fraction of alpha-fetoprotein alone and in combination for early detection of hepatocellular carcinoma from nonalcoholic fatty liver disease:A multicenter analysis

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 559-568页

作者： Ming-Cheng Guan Wei Ouyang Si-Yu Liu Li-Yang sun Wei-Yue Chen Xiang-Min Tong Hong Zhu Tian Yang Department of Medical Oncology the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Laboratory Zhejiang University Lishui HospitalLishui 323000China Department of Hepatobiliary Pancreatic and Minimal Invasive SurgeryZhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014China The Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province Department of Interventional RadiologyZhejiang University Lishui HospitalLishui 323000China School of Clinical Medicine Hangzhou Medical CollegeHangzhou 310059China Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical University(Navy Medical University)Shanghai 200438China

Background:Current surveillance strategies for hepatocellular carcinoma(HCC)among patients with non-alcoholic fatty liver disease(NAFLD)are *** study aimed to investigate the diagnostic perfor-mance of alpha-fetoprotein(AFP),protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ),lens culinaris agglutinin-reactive fraction of AFP(AFP-L3),and their combinations in HCC underlying NAFLD ***:Serologic AFP,AFP-L3,and PIVKA-Ⅱ levels in NAFLD patients with and without HCC were *** receiver operating characteristic(ROC)analyses,the area under the curve(AUC),sensitivity,and specificity were obtained to evaluate the diagnostic accuracy of each biomarker and their ***:This study was conducted on 139 patients with NAFLD-HCC and 345 NAFLD *** eleva-tion of these three biomarkers was observed in patients with NAFLD-HCC compared to those in NAFLD controls(all P<0.001).When they were analyzed individually,PIVKA-Ⅱ showed the best performance in diagnosing any-stage HCC with an AUC of 0.869,followed by AFP(0.763;***-Ⅱ,P<0.001)and AFP-L3(0.689;***-II,P<0.001).When they were analyzed in combination,AFP+PIVKA-Ⅱ yielded the highest AUC(0.906),followed by AFP+PIVKA-II+AFP-L3(0.904;***+PIVKA-Ⅱ,P=0.086),PIVKA-Ⅱ+AFP-L3(0.881;***+PIVKA-II,P<0.001),and AFP+AFP-L3(0.759;***+PIVKA-II,P<0.001).Similar findings were obtained in the subgroup with early-stage NAFLD-HCC,as well as the non-cirrhotic ***:These data validated the better diagnostic ability of PIVKA-II than AFP or AFP-L3 alone for diagnosing any-stage HCC among patients with NAFLD,and the combination of AFP+PIVKA-II signifi-cantly improved the diagnostic accuracy of NAFLD-HCC.

关键词： Hepatocellular carcinoma Nonalcoholic fatty liver disease Alpha-fetoprotein Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein Protein induced by vitamin K absence or antagonist-Ⅱ

Zwitterionic ring-opening polymerization of macrocyclic ethyleneoxy-substituted carbonate:Access to cyclic PEG-like polycarbonate

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Chinese Chemical Letters 2024年第3期35卷 282-286页

作者： Jin Huang Jinwen Li Rui Yan Yuanyuan Qu Fengzhen Guo Lei Shen Can-liang Ma Jie sun Zhenjiang Li Kai Guo State Key Laboratory of Materials-Oriented Chemical Engineering College of Biotechnology and Pharmaceutical EngineeringNanjing Tech UniversityNanjing 211816China Institute of Nanjing Advanced Biomaterials&Processing Equipment Lishui Economic Development ZoneNanjing 211299China

The innovation in polymer design to rival conventional polyethylene glycol(PEG)is an important approach to achieving a more sustainable ***,cyclic PEG-like polycarbonates having high molecular weight(4.4–49.5 kg/mol)were enabled through zwitterionic ring-opening polymerization(ZROP)of macrocyclic carbonates(MCs)mediated by N-heterocyclic carbene(NHC).The thermodynamic behavior of polymerization depends on the ring size of *** this process,the ZROP of 11-membered MC was driven by the change of enthalpy(ΔH_(p))which differed from the ZROP of 14-membered MC driven by the entropic change(ΔS_(p)).Cyclic polycarbonates depicted improved thermostability(T_(d5%)≥204℃)and higher glass transition temperatures(T_(g)>–40℃)in comparison to their linear analogues(T_(d5%)≤185℃,T_(g)~–50℃).In addition,the mechanism of ZROP of MC was addressed through computational study.A distinct mechanism of polymerization distinguishable from the well-known NHC-mediated ZROP of cyclic esters was revealed,where the zwitterion from nucleophilic addition to MC,*** intermediate,cannot be ring-opened probably due to the delocalization of negative charge on the carbonate group,but serves as an active center for the *** comparison to PEG,the attained polymer demonstrated comparable hydrophilic and biocompatible properties,as revealed by the results of contact angle and in vitro cytotoxicity studies,suggesting that cyclic polycarbonate hold the promise as the alternative of PEG.

关键词： Zwitterionic ring-opening polymerization Cyclic polycarbonate Macrocycles Tetrahedral intermediate NHC carbene

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北京市松山天然油松林生态系统的碳储量

水土保持通报 2016年第5期36卷 320-325页

作者：朱嘉磊田菊孙宾金星李璇聂立水吴记贵北京林业大学林学院北京100083 北京松山国家级自然保护区管理处北京102115

[目的] 分析北京市松山地区天然油松林生态系统碳储量，为研究区天然油松林的碳固定和碳储量管理研究提供理论依据。[方法] 以北京市松山天然油松林生态系统为研对象，设置标准样地进行乔木。灌木。草本。凋落物调查，采集并分析0-100 c... 详细信息

[目的] 分析北京市松山地区天然油松林生态系统碳储量，为研究区天然油松林的碳固定和碳储量管理研究提供理论依据。[方法] 以北京市松山天然油松林生态系统为研对象，设置标准样地进行乔木。灌木。草本。凋落物调查，采集并分析0-100 cm土层土样，根据相关方程计算出生态系统以及各个层次的碳储量。[结果] 植物体含碳率变化在42.39%～49.95%，0-100 cm土壤含碳率变化在0.26%～1.31%。天然油松生态系统碳储量为147.24 Mg/hm^2，其中植被碳储量为57.14 Mg/hm^2，占生态系统碳储量的36.7%，植被各层碳储量的顺序为乔木（54.93 Mg/hm^2）〉灌木（0.45 Mg/hm^2）〉草本（0.29 Mg/hm^2）；土壤碳储量为66.35 Mg/hm^2，占生态系统碳储量的46.30%，分别是植被碳储量的1.16倍和凋落物碳储量的2.79倍，且随着土层深度的增加而递减；凋落物碳储量为23.75 Mg/hm^2，占生态系统碳储量17%。[结论] 松山地区天然乔木对植被碳储量的贡献率最大，松山地区天然油松林植被含碳率表现为：乔木〉灌木〉草本〉凋落物。

关键词：森林生态系统碳储量天然油松林松山

Gut microbiota dysbiosis in Chinese children with type 1 diabetes mellitus:An observational study

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World Journal of Gastroenterology 2021年第19期27卷 2394-2414页

作者： Xia Liu Yi-Wen Cheng Li Shao Shu-Hong sun Jian Wu Qing-Hai Song Hong-Sheng Zou Zong-Xin Ling Department of Intensive Care Unit Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases State Key Laboratory for Diagnosis and Treatment of Infectious DiseasesNational Clinical Research Center for Infectious DiseasesThe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Institute of Hepatology and Metabolic Diseases Hangzhou Normal UniversityHangzhou 310000Zhejiang ProvinceChina Institute of Translational Medicine The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310000Zhejiang ProvinceChina Department of Laboratory Medicine Linyi People’s HospitalLinyi 276000Shandong ProvinceChina Department of Geriatrics Lishui Second People's HospitalLishui 323000Zhejiang ProvinceChina Department of Intensive Care Unit People’s Hospital of RongchengRongcheng 264300Shandong ProvinceChina

BACKGROUND Gut microbiota dysbiosis is reportedly actively involved in autoimmune diseases such as type 1 diabetes mellitus(T1DM).However,the alterations in the gut microbiota and their correlation with fasting blood glucose(FBG)in Chinese children with T1DM remain *** To investigate alterations in the gut microbiota in Chinese children with T1DM and their associations with clinical *** Samples from 51 children with T1DM and 47 age-matched and gender-matched healthy controls were obtained,to explore the structural and functional alterations in the fecal *** V3-V4 regions of the 16S rRNA gene were sequenced on a MiSeq instrument,and the association with FBG were *** We found that the bacterial diversity was significantly increased in the T1DMassociated fecal microbiota,and changes in the microbial composition were observed at different taxonomic *** T1DM-reduced differential taxa,such as Bacteroides vulgatus ATCC8482,Bacteroides ovatus,Bacteroides xylanisolvens,and Flavonifractor plautii,were negatively correlated with FBG,while the T1DMenriched taxa,such as Blautia,Eubacterium hallii group,Anaerostipes hadrus,and Dorea longicatena,were positively correlated with *** vulgatus ATCC8482,Bacteroides ovatus,the Eubacterium hallii group,and Anaerostipes hadrus,either alone or in combination,could be used as noninvasive diagnostic biomarkers to discriminate children with T1DM from healthy *** addition,the functional changes in the T1DM-associated fecal microbiota also suggest that these fecal microbes were associated with altered functions and metabolic activities,such as glycan biosynthesis and metabolism and lipid metabolism,which might play vital roles in the pathogenesis and development of *** Our present comprehensive investigation of the T1DM-associated fecal microbiota provides novel insights into the pathogenesis of the disease and sheds light on the diagnosis and treatment of T1D

关键词： Dysbiosis Fasting blood glucose Sequencing Metabolism Type 1 diabetes mellitus

Hydrological response characteristics of landslides under typhoon-triggered rainstorm conditions

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China Geology 2020年第3期3卷 455-461页

作者： Tai-li Zhang Ai-guo Zhou Qiang sun He-sheng Wang Jian-bo Wu Zheng-hua Liu Nanjing Center China Geological SurveyMinistry of Natural ResourcesNanjing 210016China China University of Geosciences Wuhan 430074China Geological Environment Monitoring Institute of Zhejiang Province Hangzhou 310007China

Many landslide disasters,which tend to result in significant damage,are caused by typhoon-triggered *** this case,it is very important to study the dynamic characteristics of the hydrological response of landslide bodies since it enables the early warning and prediction of landslide disasters in typhoon *** investigate the dynamic mechanisms of groundwater in a landslide body under typhoon-triggered rainstorm conditions,the authors selected the landslide occurring in Zhonglin Village,Wencheng County,China(also referred to as Zhonglin Village landslide)as a case *** transient seepage field characteristics of groundwater in the landslide body were simulated with two different rainfall models by using the finite element method(FEM).The research results show that the impact of typhoon-triggered rainstorms on landslides can be divided into three stages:(i)Rapid rise of groundwater level;(ii)infiltration of groundwater from the surface to deeper level,and(iii)surface runoff ***,the infiltration rate of groundwater in the landslide body is mainly affected by the intensity of typhoon-induced *** can be deduced that higher rainfall intensity leads to a greater potential difference and a higher infiltration *** rainfall intensity also determines the development mode of landslide deformation and destruction.

关键词： Typhoon-triggered rainstorm Landslide Seepage Hydrological response Hydrogeological survey engineering Geological disaster survey engineering Zhejiang Province China

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混凝土跨线桥快速安装技术

桥梁建设 2024年第2期54卷 145-151页

作者：孙博文朱世峰中交特种工程有限公司湖北武汉430071 公路与桥梁高效养护及安全耐久国家工程研究中心(武汉) 湖北武汉430071

佛山里水大道跨线桥分西、中、东三幅上跨广佛高速,为消除安全隐患、提升道路使用空间,需拆除并重建里水大道广佛跨线桥。针对西幅跨线桥改造所采用的架桥机法对交通影响大、安全风险高、效率低等问题,提出采用整体移运法快速改造中、... 详细信息

佛山里水大道跨线桥分西、中、东三幅上跨广佛高速,为消除安全隐患、提升道路使用空间,需拆除并重建里水大道广佛跨线桥。针对西幅跨线桥改造所采用的架桥机法对交通影响大、安全风险高、效率低等问题,提出采用整体移运法快速改造中、东幅跨线桥。为提高施工的安全性,降低对交通的影响,采用分批次架设,梁体、墩柱首先在路外封闭区域预制,然后封闭交通,利用驮运子系统将梁体及墩柱快速移运至桥位,墩柱通过快速连接子系统与承台临时固定后移除驮运子系统,随后恢复原交通,最后进行墩柱永久固结施工。通过预制墩柱快速连接子系统和驮运子系统实现了墩、梁同步快速安装,解决了整体移运法在混凝土小箱梁安装过程中梁体易开裂的问题。实践证明,整体移运法具有施工效率高、交通影响低、安全性高、适应性强的优点。

关键词：跨线桥混凝土桥整体移运法预制墩柱墩、梁同步快速安装驮运子系统桥梁改建

PT菌剂对陕北黄土区土壤性质和油松苗木的影响

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水土保持通报 2016年第5期36卷 46-50,57页

作者：于海艳张国全孙宾聂立水朱清科北京林业大学林学院北京100083 北京林业大学水土保持学院北京100083

[目的]分析PT菌剂对陕北黄土区土壤性质和油松苗木的影响,为干旱和半干旱黄土高原植被恢复提供科学依据。[方法]在陕西黄土高原丘陵区采用完全随机区组试验(2013年3—10月),以常规施肥为对照,以上、中、下3个坡位为区组,研究施用PT菌剂... 详细信息

[目的]分析PT菌剂对陕北黄土区土壤性质和油松苗木的影响,为干旱和半干旱黄土高原植被恢复提供科学依据。[方法]在陕西黄土高原丘陵区采用完全随机区组试验(2013年3—10月),以常规施肥为对照,以上、中、下3个坡位为区组,研究施用PT菌剂对6年生油松苗木地径、树高、成活状况以及0—60cm这3个不同层次土壤主要养分含量的影响。[结果]施用PT菌剂油松地径平均生长量为4.5mm,是对照的2倍;树高总生长量达10cm,比对照高54%;油松死亡率比对照低9%。施用PT菌剂后土壤有机质含量平均达到7.8g/kg,是对照的2倍多;土壤全氮的含量平均为0.41g/kg,比对照高52%;速效钾的含量平均达到42.4mg/kg,比对照增加了26%;PT菌剂对有效磷提高不明显;坡位对油松地径和树高影响不显著,对各层次土壤养分性质有显著影响。[结论]PT菌剂能改善造林地土壤性质,促进油松成活和生长,建议在黄土高原地区油松造林实践中施用PT菌剂。

关键词：植被恢复造林土壤养分土壤肥力 PT菌剂

BGB微生物菌剂对黄土高原区域土壤与油松的影响

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水土保持通报 2015年第5期35卷 211-216页

作者：金星朱清科聂立水张国全孙宾朱嘉磊北京林业大学林学院北京100083

[目的]研究黄土高原区域油松造林中施用BGB微生物菌剂对油松造林成活率、树高、地径生长的影响,以及土壤养分与水分的变化,为BGB微生物菌剂在黄土丘陵地区的植被恢复应用提供理论依据和技术支持。[方法]在不同坡面处施用3种量的BGB微生... 详细信息

[目的]研究黄土高原区域油松造林中施用BGB微生物菌剂对油松造林成活率、树高、地径生长的影响,以及土壤养分与水分的变化,为BGB微生物菌剂在黄土丘陵地区的植被恢复应用提供理论依据和技术支持。[方法]在不同坡面处施用3种量的BGB微生物菌剂,观察不同量的处理对油松及土壤养分的影响。[结果]BGB微生物菌剂能够显著提高苗木的成活率,促进苗木树高、地径的增长;可以显著地提高土壤中各养分的含量,增加土壤含水量,且影响随着土壤深度的增加而减小,随坡度的降低而变大。其中对土壤中速效磷和有机质的影响最显著;BGB微生物菌剂能够明显改善土壤的含水量,并且在土壤20—40cm处作用较明显。[结论]BGB微生物菌剂对油松造林成活率、生长量与土壤养分有显著的影响。

关键词：油松黄土高原 BGB微生物菌剂成活率土壤养分土壤含水量

Causal inference with marginal structural modeling for longitudinal data in laparoscopic surgery: A technical note

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Laparoscopic, Endoscopic and Robotic Surgery 2022年第4期5卷 146-152页

作者： Zhongheng Zhang Peng Jin Menglin Feng Jie Yang Jiajie Huang Lin Chen Ping Xu Jian sun Caibao Hu Yucai Hong Department of Emergency Medicine Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Key Laboratory of Digital Technology in Medical Diagnostics of Zhejiang Province Hangzhou 310016China Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province Hangzhou 310016China Division of Biostatistics Department of Population HealthNew York University School of MedicineNew YorkNY 10023USA Saw Swee Hock School of Public Health and Institute of Data Science National University of Singapore119077Singapore Department of Critical Care Medicine Jinhua Hospital Affiliated Zhejiang University School of MedicineJinhua 321000China Emergency Department Zigong Fourth People's HospitalZigong 643000China Institute of Medical Big Data Zigong Academy of Artificial Intelligence and Big Data for Medical Science Artificial IntelligenceZigong 643000China Key Laboratory of Sichuan Province Zigong 643000China Department of Critical Care Medicine Lishui Center HospitalLishui 323000China Department of Intensive Care Medicine Zhejiang HospitalHangzhou 310013China

Causal inference prevails in the field of laparoscopic *** the causality between an intervention and outcome is established,the intervention can be applied to a target population to improve clinical *** many clinical scenarios,interventions are applied longitudinally in response to patients’*** longitudinal data comprise static variables,such as age,gender,and comorbidities;and dynamic variables,such as the treatment regime,laboratory variables,and vital *** dynamic variables can act as both the confounder and mediator for the effect of an intervention on the outcome;in such cases,simple adjustment with a conventional regression model will bias the effect *** address this,numerous statistical methods are being developed for causal inference;these include,but are not limited to,the structural marginal Cox regression model,dynamic treatment regime,and Cox regression model with time-varying *** technical note provides a gentle introduction to such models and illustrates their use with an example in the field of laparoscopic surgery.

关键词： Causal inference Laparoscopic surgery Machine learning Marginal structural modeling