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Phosphorylation of PLIN3 by AMPK promotes dispersion of lipid droplets during starvation

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Protein & Cell 2019年第5期10卷 382-387页

作者： Jianxi Zhu Mingyang Xu Yi Liu lisha zhuang Kejun Ying Feng Liu Dan Liu Wenbin Ma Zhou Songyang MOE Key Laboratory of Gene Function and Regulation State Key Laboratory for BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Guangzhou Regenerative Medicine and Health-Guangdong Laboratory(GRMH-GDL) Guangzhou 510530China Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of MedicineOne Baylor PlazaHoustonTX 77030USA

Dear Editor,Lipid droplets(LDs)are dynamic lipid-storage organelles of storage depots and sources of essential substrates for myriad cellular processes and protect cells from lipotoxicity(Ohsaki et al.,2006).Disrupted LD and fat storage homeostasis has been linked to metabolic diseases such as atherosclerosis,obesity,and type II diabetes(Levin et al.,2001).Structurally,the core of neutral lipids in LDs is surroun ded by a phospholipid mono layer and coated with specific proteins(Storey et al.,2011).Perilipin family of proteins are the predominant LD-associated proteins.

关键词： Phosphorylation PLIN3 AMPK

Simulating the development of resilient human settlement in Changsha

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Journal of Geographical Sciences 2022年第8期32卷 1513-1529页

作者： TANG lisha LONG Hualou School of Business Hunan First Normal UniversityChangsha 410205China School of Public Administration Guangxi UniversityNanning 530004China Institute of Geographic Sciences and Natural Resources Research CASBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

Using the system dynamics simulation software Vensim PLE, we built a model to simulate the development of resilient human settlement in Changsha. This model includes five subsystems: living, economy, society, ecology and engineering. The model simulates various scenarios, based on different parameter settings to predict the trend of human settlement from 2019–2040 in Changsha. It puts forward four development programs under different simulation scenarios. The results show that the current system of human settling lacks self-regulation and feedback, where simple increases in the economy and urbanization cannot drive the internal system to progress positively. In contrast, the resilient human settlement program is more reasonable and scientific, up to the year 2040, the production, living and ecological environment of residents will be markedly improved in terms of per capita disposable income, per capita floor space and medical insurance coverage;these will increase by 98.9%, 39.7%, and 170.7%, respectively. This system of developing resilient human settlement provides feedback according to the internal relation loops and thus drives itself to adjust and recover, achieving harmonious and sustainable development. In the forthcoming development, we should take the initiative to optimize economic development and upgrade industrial structures, establish emergency plans and response mechanisms to enhance human quality of life.

关键词： human settlement resilience system dynamics simulation sustainable development

Hydroxyapatite reinforced inorganic-organic hybrid nanocomposite as high-performance adsorbents for bilirubin removal in vitro and in pig models

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Bioactive Materials 2021年第12期6卷 4772-4785页

作者： Yamin Chai zhuang Liu Yunzheng Du Lichun Wang Jinyan Lu Qian Zhang a Wenyan Han Tingting Wang Yameng Yu lisha Sun Lailiang Ou Key Laboratory of Bioactive Materials Ministry of EducationCollege of Life SciencesNankai UniversityTianjin300071China General Hospital Tianjin Medical UniversityTianjin300052China

Highly efficient removal of bilirubin from whole blood directly by hemoperfusion for liver failure therapy remains a challenge in the clinical field due to the low adsorption capacity,poor mechanical strength and low biocompatibility of *** this work,a new class of nanocomposite adsorbents was constructed through an inorganic-organic co-crosslinked nanocomposite network between vinyltriethoxysilane(VTES)-functionalized hydroxyapatite nanoparticles(V-Hap)and non-ionic styrene-divinylbenzene(PS-DVB)resins(PS-DVB/V-Hap)using suspension ***,our adsorbent demonstrated substantially improved mechanical performance compared to the pure polymer,with the hardness and modulus increasing by nearly 3 and 2.5 times,***,due to the development of a mesoporous structure,the prepared PS-DVB/V-Hap3 exhibited an ideal adsorption capacity of 40.27 mg·g^(-1).More importantly,the obtained adsorbent beads showed outstanding blood compatibility and ***,in vivo extracorporeal hemoperfusion verified the efficacy and biosafety of the adsorbent for directly removing bilirubin from whole blood in pig models,and this material could potentially prevent liver damage and improve clinical *** together,the results suggest that PS-DVB/V-Hap3 beads can be used in commercial adsorption columns to threat hyperbilirubinemia patients through hemoperfusion,thus replacing the existing techniques where plasma separation is initially required.

关键词： Bilirubin Hydroxyapatite-polymer composite Adsorption Hemoperfusion Biocompatibility

Imaging changes in neural circuits in patients with depression using 1 H-magnetic resonance spectroscopy and diffusion tensor imaging

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Neural Regeneration Research 2012年第24期7卷 1881-1888页

作者： Shaoqiong Chen lisha Lai zhuang Kang Xiao Luo Jiansheng Zhang Jianfang Li Department of Radiology the Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Nuclear Medicine the Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina

1 H-magnetic resonance spectroscopy imaging and diffusion tensor imaging were performed in 19 patients with mild depression and in 13 *** mean age of the patients was 31 *** mean Hamilton depression score of the patients was 22.5±13.2.N-acetylaspartate,choline and creatine concentrations and the average diffusion coefficient and fractional anisotropy values were measured in the bilateral hippocampus,striatum,thalamus and prefrontal deep white matter. Compared with the control group,the mild depressed patients had：（1）a higher choline/creatine ratio and a negative correlation between the choline/creatine ratio and the average diffusion coefficient in the hippocampus;（2）a lower choline/creatine ratio and a higher fractional anisotropy in the striatum;（3）a lower fractional anisotropy and a positive correlation between the fractional anisotropy and the choline/creatine ratio in the prefrontal deep white matter;and（4）a higher average diffusion coefficient and a positive correlation between the choline/creatine ratio and the N-acetylaspartate/creatine ratio in the thalamus,as well as positive correlation between the choline/creatine ratio and Hamilton depression *** data suggest evidence of abnormal connectivity in neurofibrotic microstructures and abnormal metabolic alterations in the limbic-cortical-striatal-pallidal-thalamic neural circuit in patients with mild depression.

关键词： depression diffusion tensor imaging hippocampus magnetic resonance spectroscopy nerve fiber neural circuit neurotransmitter neural regeneration

New Zircon U-Pb Age of Late Devonian Tuff in Guangxi, South China and the Significance for the Paleo-Tethys Branch Ocean

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Acta Geologica Sinica(English Edition) 2018年第1期92卷 402-403页

作者： HU lisha DU Yuansheng XU Yajun WANG Zhiwen WANG Chenghao Collage of Marine Geosciences Key Laboratory of Submarine Geosciences and Prospecting Technology Ocean University of China Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and Technology (QNLM) State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences

Objective The eastern extending range of the Paleo-Tethys Ocean in southwest China has always been focused and controversial. At the beginning of this century some scholars proposed that the Paleo-Tethys Branch Ocean may extend to the Babu-Pingxiang and Cengxi areas along the stouthwestern margin of the South China Block （Cai and Zhang, 2009）. However, the pivotal proof of Late Paleozoic ophoilite and magmatic rocks was absent or sporadical in the Guangxi zhuang Autonomous Region, resulting in insufficient evidence to support this viewpoint. For the first time this work reported the Late Devonian tuff in the Qinzhou area in the south of the Guangxi zhuang Autonomous Region and conducted zircon U-Pb dating on it in order to constrain the extension of the Paleo-Tethys Ocean in the South China Block.

关键词： the Paleo-Tethys Branch Ocean New Zircon U-Pb Age of Late Devonian

Failure probability estimation of overhead transmission lines considering spatial and temporal variation in severe weather

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Journal of Modern Power Systems and Clean Energy 2019年第1期7卷 131-138页

作者： Shuai YANG Wenjun ZHOU Shiyang ZHU Le WANG lisha YE Xuezhi XIA Han LI School of Electrical Engineering Wuhan University Electric Power Research Institute Guangxi Power Grid Co.Ltd Hubei Electric Engineering Corporation

Estimation for weather-related failure probability of overhead transmission lines is essential in the reliability assessment of a power *** paper analyzes the outage and weather data of 110 kV overhead transmission lines in the Guangxi zhuang Autonomous Region of China during 2011–*** result reveals obvious uneven distributions of outage events for time and space due to the spatial and temporal variation of severe *** on the results, an estimation method is proposed in this *** and aggregation is used to smooth the outage and weather *** poisson model is adopted in our method to investigate the statistic characteristics of transmission line outage *** analysis is applied to obtain the correlation between the weather intensity and history failure *** the method proposed is validated against the empirical outage data.

关键词： Severe weather Transmission line Poisson model Failure probability Regression analysis

驱动新能源汽车产业发展的地方性政策比较分析

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科技和产业 2024年第20期24卷 7-14页

作者：罗丽莎庄越武汉理工大学安全科学与应急管理学院武汉430070

对比全国汽车工业重点城市的新能源汽车产业发展和替代状况,可以发现各地新能源汽车产业发展的发展进度和侧重点各有不同。产业政策是促进新兴产业发展的重要手段,对不同城市的新能源汽车产业政策开展研究,选取上海和武汉两个新能源汽... 详细信息

对比全国汽车工业重点城市的新能源汽车产业发展和替代状况,可以发现各地新能源汽车产业发展的发展进度和侧重点各有不同。产业政策是促进新兴产业发展的重要手段,对不同城市的新能源汽车产业政策开展研究,选取上海和武汉两个新能源汽车产业重点城市作为样本,构建政策工具和创新价值链的二维理论分析框架,运用内容分析法比较研究新能源汽车产业地方政策差异及政策效果。结果表明,在制定新兴产业政策过程中,重视战略面政策工具的运用;政策着力点必须瞄准本区域产业发展痛点;新兴产业政策的完备性与产业发展息息相关;注重与产业创新价值链的匹配;结合当地产业发展规律。

关键词：新能源汽车政策工具产业政策

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55例Ⅲ期乳癌综合治疗疗效对比分析

中华放射肿瘤学杂志 1997年第2期6卷 87-89页

作者：庄承海李丽莎郑坚廖倚萍李平广州暨南大学医学院附一院肿瘤科

对比分析Ⅲ期乳癌各种综合治疗方法的疗效。材料与方法１９８４年２月～１９９０年１０月，５５例Ⅲ期乳癌非随机分为：单纯手术（Ｓ）、手术＋化疗（Ｓ＋Ｃ）、手术＋放疗（Ｓ＋Ｒ）及手术＋放疗＋比疗（Ｓ＋Ｃ＋Ｒ）４组。手术为乳腺... 详细信息

对比分析Ⅲ期乳癌各种综合治疗方法的疗效。材料与方法１９８４年２月～１９９０年１０月，５５例Ⅲ期乳癌非随机分为：单纯手术（Ｓ）、手术＋化疗（Ｓ＋Ｃ）、手术＋放疗（Ｓ＋Ｒ）及手术＋放疗＋比疗（Ｓ＋Ｃ＋Ｒ）４组。手术为乳腺单纯切除术、乳癌根治术或改良根治术，术后放疗对胸壁及淋巴引流区照射ＤＴ４５～５５Ｇｙ／２２～３０欢／５～６周。术后化疗用ＣＭＦ或ＣＡＦ／ＣＥＦ方案４～６周期。结果全组５年生存率为４７．２％（２６／５５），Ｓ组１４．２％（１／７），Ｓ＋Ｃ组３３％（２／６）．Ｓ＋Ｒ组４７．３％（９／１９），Ｓ＋Ｒ＋ｃ组６０．８％，Ｓ组与其他几组相比差异有显著性意义（Ｐ＜０．００５）。３年复发率Ｓ组２８．５％（２／７），Ｓ＋Ｃ组６６．７％（４／６），Ｓ＋Ｒ组１５．８％（３／１９），Ｓ＋Ｒ＋Ｃ组１７．４％（４／２３），Ｓ＋Ｃ组与Ｓ＋Ｒ组或Ｓ＋Ｒ＋Ｃ组比差异有显著意义（Ｐ＜０．０５）。结论（１）Ⅲ期乳癌应作包括手术、放疗和化疗在内的综合治疗。（２）术后放疗对降低局部和区域淋巴结复发有重要作用，是其他治疗手段不能代替的。

关键词： Ⅲ期乳癌综合治疗疗效比较

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浅析分部针刺治疗麻木

光明中医 2018年第2期33卷 259-260页

作者：马壮冯丽莎天津市中医药研究院附属医院脑病二科天津300120

麻木在临床上治疗起来较为困难,历代医家的研究揭示其与气血经络密切相关,故针刺治疗有着重要的优势。针刺与病邪定位是否相应直接关系到最终的临床疗效,麻木在"五体"论治体系中位于皮部、肉部,对应《黄帝内经》"九刺"法中的毛刺、络刺... 详细信息

麻木在临床上治疗起来较为困难,历代医家的研究揭示其与气血经络密切相关,故针刺治疗有着重要的优势。针刺与病邪定位是否相应直接关系到最终的临床疗效,麻木在"五体"论治体系中位于皮部、肉部,对应《黄帝内经》"九刺"法中的毛刺、络刺等刺法,相当于"三才"理论中的天部及人部。本文通过探讨麻木病位病机与"五体""九刺""三才"等理论的联系,对麻木及刺法进行纵向及横向的分部定位,以寻求临床治疗麻木的可行方法。

关键词：针刺疗法麻木分部定位