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determination of Exposure to Medical and Industrial Toxic Chemicals from Beijing by Human Hair, Nail and Blood Analysis

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Forensic Medicine and Anatomy Research 2015年第1期3卷 27-31页

作者： G. Yang d. Kechkeche H. Belhadj-Tahar N. Sadeg School of Medicine Tongji University Shanghai China departement of Chemistry University of Pierre et Marie-Curie Paris France AFPreMed Toxicology Research Group Toulouse France

The aim of the present work was to investigate the exposure to the medical and industrial toxic chemicals. The research was carried out on hair, nail and blood samples in a panel of 40 healthy volunteers aged 7 to 77 with an average of 45 ± 19 years (18 women (45%) and 22 men (55%)). All of these individuals had not received medication for at least 1 year, including antibiotics and psychotropic. This study was realized from July 2013 to March 2014 in Beijing, China. The method for an accurate and reliable screening of medical and an industrial toxic chemical was based on detection and assay by ultra-high performance liquid chromatography with UV detection type of diode arrays. Also more than 10,000 toxic molecules commonly found in western industrial countries were screened by coupling gas chromatography and mass spectrometry. The main results indicate that the molecules analyzed are mainly antibiotic (Gentamycine and Tobramycine), antidepressant (Amitriptylin and its metabolites), narcotic (MdMA and Clonitazene), ingredient in cosmetics (Benzenediol and Benzoic acid), insecticide (Carbamate derivative), ketamine, chlorhexidine and phthalate derivatives. There are no detailed documented baseline data of the analysis of medical and Industrial toxic pollutants in hair, nail and blood samples in Beijing;however, this study should be completed on samples from other provinces of China. This study is the first of its kind. Therefore, further studies should be conducted in other cities and provinces of China to be compared with each other.

关键词： Pollutants Hair Nail Blood Toxicological Screening Separative Method Mass Spectrometry

Characterization of sFRP2-like in amphioxus:insights into the evolutionary conservation of Wnt antagonizing function

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Characterization of sFRP2-like in amphioxus:insights into th...

新型冠状病毒感染康复期IgG抗体水平及疫苗接种关系

2012全国发育生物学大会

作者： Weihua Kong~a,Yongjie Yang~a,Tianxiao Zhang~a,de-Li Shi~(a,b),Yanjun Zhang~a a.Institute of developmental Biology,School of Life Sciences,Shandong Provincial Key Laboratory of Animal Cells and developmental Biology,Shandong University,Jinan,250100 b.Groupe de Biologie Exp’ erimentale,Laboratoire de Biologie du d’eveloppement,CNRS UMR 7622,Universit ’e Pierre et marie Curie,9 quai Saint-Bernard,75005,Paris,France

Wnt signaling plays a key role in embryonic patterning and morphogenetic *** secreted Frizzled-related proteins(sFRPs) antagonize Wnt signaling,but their roles in development are poorly *** determine whether function of sFRPs is conserved between amphioxus and vertebrates,we characterized sFRP2-like function in the amphioxus,Branchiostoma belcheri tsingtauense(***).As in other species of Branchiostome,in B. belcheri,expression of sFRP2-like is restricted to the mesendoderm during gastrulation and to the anterior mesoderm and endoderm during *** analyses in frog(Xenopus laevis) indicate that amphioxus sFRP2-like potently inhibits a multitude of vertebrate Wnt proteins,both canonical and ***,sFRP-2 probably functions in amphioxus embryos to inhibit Wnt signaling ***,the activity of sFRP2-like on canonical Wnts is consistent with previous works showing that this pathway is involved in anteroposterior ***,dorsal overexpression of amphioxus sFRP2-like in Xenopus embryos,like inhibition of Wnt11,blocks gastrulation movements. This implies that sFRP2-like may also modulate Wnt signaling during gastrulation movements in amphioxus. Conclusions:Our functional analysis suggests an evolutionarily conserved function of sFRP in respect to their specificity and mode of operation on Wnt signaling.

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国际呼吸杂志 2024年第1期44卷 79-84页

作者：安树昌刘国田黄新 AGBO Sedine marie desiree Nina 逄晓莉李兵蔡善花顾红岩刘晓一崔蓉清华大学第一附属医院呼吸与危重症医学科北京100016 清华大学医学院北京100084 清华大学第一附属医院检验科北京100016

目的了解新型冠状病毒感染(COVId-19)康复期IgG抗体水平及其与新型冠状病毒疫苗接种的关系。方法本研究为前瞻性队列研究。采用非随机抽样的方法,选取2023年2月至5月在清华大学第一附属医院呼吸与危重症医学科门诊和病房就诊的185例COVI... 详细信息

目的了解新型冠状病毒感染(COVId-19)康复期IgG抗体水平及其与新型冠状病毒疫苗接种的关系。方法本研究为前瞻性队列研究。采用非随机抽样的方法,选取2023年2月至5月在清华大学第一附属医院呼吸与危重症医学科门诊和病房就诊的185例COVId-19康复者为研究对象。记录患者一般资料、发病时间、病情严重程度、接种新型冠状病毒疫苗情况。收集患者感染后6、8、10、12、14、16、18周不同时间点静脉血,采用半定量磁微粒化学发光法检测血清免疫球蛋白(Ig)G、IgM抗体水平。按照新型冠状病毒疫苗接种情况分为疫苗接种组(接种2剂次以上灭活疫苗,共130例)和疫苗未接种组(因各种原因未能接种疫苗,共55例)。将2组中>75岁康复者分别纳入亚组,疫苗接种亚组(18例)和疫苗未接种亚组(28例)。比较康复者整体、2组和2亚组各时间点的IgG、IgM抗体水平。结果185例COVId-19康复者中男80例,女105例;年龄62.0(40.5,75.0)岁;111例(60.00%)合并基础病。2组患者的性别比较差异无统计学意义(χ^(2)=0.03,P=0.874);疫苗未接种组年龄、合并基础病、重症或危重症比例均较疫苗接种组高,差异均有统计学意义(均P0.05);疫苗未接种亚组合并基础病比例较疫苗接种亚组高,差异有统计学意义(χ^(2)=4.30,P=0.038)。全体康复者体内IgM抗体水平均为阴性。康复者整体IgG抗体水平在感染后第10周达到峰值,之后逐渐下降,于随访期末达最低值。疫苗接种组感染后第6、8、10、12、14、16、18周的IgG抗体水平均高于疫苗未接种组,差异均有统计学意义[157.9(73.4,240.0)比4.7(1.7,17.7),Z=2.36;132.0(75.3,213.1)比2.8(0.7,52.6),Z=3.77;137.7(79.9,227.0)比1.1(0.4,15.2),Z=4.51;134.5(81.4,211.9)比1.0(0.5,2.9),Z=3.49;92.4(68.9,112.9)比1.7(1.2,2.4),Z=2.84;61.2(33.3,108.7)比2.9(1.3,12.8),Z=3.45;57.1(32.7,87.6)比1.1(0.8,8.3),Z=4.06;均Pd-19康复者体内IgG抗体水平在达峰后逐渐下降。完成全程新型冠状病毒疫苗接种人群在患COVId-19后较未接种人群体内能产生更高水平的IgG抗体。

关键词：新型冠状病毒感染新型冠状病毒 IgG抗体疫苗接种

decoding cancer's camouflage: epithelial-mesenchymal plasticity in resistance to immune checkpoint blockade

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Cancer drug Resistance 2020年第4期3卷 832-853页

作者： Maria L.Lotsberg Austin Rayford Jean Paul Thiery Giuliana Belleggia Stacey d’Mello Peters James B.Lorens Salem Chouaib Stephane Terry Agnete S.T.Engelsen Centre for Cancer Biomarkers and department of Biomedicine University of BergenBergen 5009Norway BerGenBio ASA Jonas Lies vei 91Bergen 5009Norway INSERM UMR 1186 Integrative Tumour Immunology and ImmunotherapyGustave RoussyFac.de Médecine-Univ.Paris-SudUniversitéParis-SaclayVillejuif 94805France Cancer Science Institute of Singapore National University of SingaporeSingaporeSingapore 117599Singapore department of Biochemistry Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore 119228Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnology and ResearchA-STARSingaporeSingapore 138673Singapore Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510005China School of Medicine Clinical Skills Assessment ProgramUniversity of ConnecticutFarmingtonCT 06030USA Thumbay Research Institute of Precision Medicine Gulf Medical UniversityAjman 4184United Arab Emirates UniversitéParis-Saclay INRAEAgroParisTechGABIJouy-en-Josas 78350France

Epithelial-mesenchymal plasticity(EMP)of cancer cells contributes to cancer cell heterogeneity,and it is well established that EMP is a critical determinant of acquired resistance to cancer treatment modalities including radiation therapy,chemotherapy,and targeted ***,we aimed to explore how EMP contributes to cancer cell camouflage,allowing an ever-changing population of cancer cells to pass under the radar of our immune system and consequently compromise the effect of immune checkpoint blockade *** ultimate clinical benefit of any combination regimen is evidenced by the sum of the drug-induced alterations observed in the variety of cellular populations composing the tumor immune *** finely-tuned molecular crosstalk between cancer and immune cells remains to be fully elucidated,particularly for the spectrum of malignant cells along the epithelial to mesenchymal ***-dimensional single cell analyses of specimens collected in ongoing clinical studies is becoming a key contributor to our understanding of these *** review will explore to what extent targeting EMP in combination with immune checkpoint inhibition represents a promising therapeutic avenue within the overarching strategy to reactivate a halting cancer-immunity cycle and establish a robust host immune response against cancer *** strategies currently in clinical development will be discussed.

关键词： Epithelial-to-mesenchymal transition epithelial-mesenchymal plasticity immune evasion tumor immune microenvironment intrinsic and extrinsic mechanisms of resistance to immune checkpoint blockade therapeutic opportunity

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颗粒介质弹性的弛豫

物理学报 2015年第23期64卷 221-226页

作者：孙其诚刘传奇周公旦清华大学水沙科学与水利水电工程国家重点实验室北京100084 中国科学院水利部成都山地灾害与环境研究所成都610041

颗粒介质是复杂的多体相互作用体系,其弹性源自内部的力链结构,弹性能量处在亚稳态,具有复杂的弛豫行为.在常规作用下,颗粒介质往往呈现明显的弹性弛豫.应力松弛是应变恒定时应力的衰减现象,弹性弛豫是应力松弛的主要原因.在前期工作基... 详细信息

颗粒介质是复杂的多体相互作用体系,其弹性源自内部的力链结构,弹性能量处在亚稳态,具有复杂的弛豫行为.在常规作用下,颗粒介质往往呈现明显的弹性弛豫.应力松弛是应变恒定时应力的衰减现象,弹性弛豫是应力松弛的主要原因.在前期工作基础上,从弹性势能面和双颗粒温度热力学角度分析了弹性弛豫的机理,量化了弹性应力演化不可逆过程;基于双颗粒温度热力学计算得到了弹性能、颗粒温度和应力的演化,其中应力松弛的计算结果与实验结果基本一致,讨论了颗粒温度初值和输运系数的影响.指出,开展力链结构及其动力学研究是揭示宏观弹性弛豫机理的关键.

关键词：颗粒介质弹性弛豫热力学

Global Wheat Head detection(GWHd)dataset:A Large and diverse dataset of High-Resolution RGB-Labelled Images to develop and Benchmark Wheat Head detection Methods

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Plant Phenomics 2020年第1期2卷 243-254页

作者： Etienne david Simon Madec Pouria Sadeghi-Tehran Helge Aasen Bangyou Zheng Shouyang Liu Norbert Kirchgessner Goro Ishikawa Koichi Nagasawa Minhajul A.Badhon Curtis Pozniak Benoit de Solan Andreas Hund Scott C.Chapman Frédéric Baret Ian Stavness Wei Guo Arvalis Institut du végétal3 Rue Joseph et Marie Hackin75116 ParisFrance UMR1114 EMMAH INRAECentre PACABâtiment ClimatDomaine Saint-Paul228 Route de l’AérodromeCS 4050984914 Avignon CedexFrance Plant Sciences department Rothamsted ResearchHarpendenUK Institute of Agricultural Sciences ETH ZurichUniversitätstrasse 28092 ZurichSwitzerland CSIRO Agriculture and Food Queensland Biosciences Precinct306 Carmody RoadSt Lucia4067 QLDAustralia Plant Phenomics Research Center Nanjing Agricultural UniversityNanjingChina Institute of Crop Science National Agriculture and Food Research OrganizationJapan Hokkaido Agricultural Research Center National Agriculture and Food Research OrganizationJapan department of Computer Science University of SaskatchewanCanada department of Plant Sciences University of SaskatchewanCanada School of Food and Agricultural Sciences The University of QueenslandGatton4343 QLDAustralia Graduate School of Agricultural and Life Sciences The University of Tokyo1-1-1 Midori-choNishitokyo CityTokyoJapan

The detection of wheat heads in plant images is an important task for estimating pertinent wheat traits including head population density and head characteristics such as health,size,maturity stage,and the presence of *** studies have developed methods for wheat head detection from high-resolution RGB imagery based on machine learning ***,these methods have generally been calibrated and validated on limited *** variability in observational conditions,genotypic differences,development stages,and head orientation makes wheat head detection a challenge for computer ***,possible blurring due to motion or wind and overlap between heads for dense populations make this task even more *** a joint international collaborative effort,we have built a large,diverse,and well-labelled dataset of wheat images,called the Global Wheat Head detection(GWHd)*** contains 4700 high-resolution RGB images and 190000 labelled wheat heads collected from several countries around the world at different growth stages with a wide range of *** for image acquisition,associating minimum metadata to respect FAIR principles,and consistent head labelling methods are proposed when developing new head detection *** GWHd dataset is publicly available at http://***/and aimed at developing and benchmarking methods for wheat head detection.

关键词： Wheat wheat maturity

Sodium diffuses from Glass Substrates through P1 Lines and Passivates defects in Perovskite Solar Modules

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Energy & Environmental Materials 2023年第6期6卷 393-401页

作者： Felix Utama Kosasih Francesco di Giacomo Jordi Ferrer Orri Kexue Li Elizabeth M.Tennyson Weiwei Li Fabio Matteocci Gunnar Kusch Narges Yaghoobi Nia Rachel A.Oliver Judith L.MacManus-driscoll Katie L.Moore Samuel d.Stranks Aldo di Carlo Giorgio divitini Caterina ducati department of Materials Science and Metallurgy University of Cambridge27 Charles Babbage RoadCambridge CB30FSUK Centre for Hybrid and Organic Solar Energy(CHOSE) Department of Electronic EngineeringUniversity of Rome Tor VergataRome 00133Italy Cavendish Laboratory University of CambridgeJJ Thomson AvenueCambridge CB30HEUK department of Materials and Photon Science Institute University of ManchesterOxford RoadManchester M139PLUK department of Chemical Engineering and Biotechnology University of CambridgePhilippa Fawcett DriveCambridge CB30ASUK Laboratory for Advanced Solar Energy(LASE) National University of Science and Technology MISiSLeninskiy Prospekt 4Moscow 119049Russia Energy Research Institute@NTU Nanyang Technological University50 Nanyang DriveSingapore 637553Singapore MIIT Key Laboratory of Aerospace Information Materials and Physics College of PhysicsNanjing University of Aeronautics and AstronauticsNanjing 211106China Istituto di Struttura della Materia-CNR(ISM-CNR) Via del Fosso del Cavaliere 100Rome 00133Italy Electron Spectroscopy and Nanoscopy Istituto Italiano di TecnologiaVia Morego 30Genova 16163Italy

Most thin-film photovoltaic modules are constructed on soda-lime glass(SLG)substrates containing alkali oxides,such as Na_(2)*** may diffuse from SLG into a module's active layers through P1 lines,an area between a module's constituent cells where the substrate-side charge transport layer(CTL)is in direct contact with *** diffusion from SLG is known to cause several important effects inⅡ-Ⅵand chalcogenide solar modules,but it has not been studied in perovskite solar modules(PSMs).In this work,we use complementary microscopy and spectroscopy techniques to show that Na diffusion occurs in the fabrication process of *** diffuses vertically inside P1 lines and then laterally from P1 lines into the active area for up to 360 *** propose that this process is driven by the high temperatures the devices are exposed to during CTL and perovskite *** diffused Na preferentially binds with Br,forming Br-poor,l-rich perovskite and a species rich in Na and Br(Na-Br)close to P1 ***-Br passivates defect sites,reducing non-radiative recombination in the perovskite and boosting its luminescence by up to 5×.Na-Br is observed to be stable after 12 weeks of device storage,suggesting long-lasting effects of Na *** results not only point to a potential avenue to increase PSM performance but also highlight the possibility of unabated Na diffusion throughout a module's lifetime,especially if accelerated by the electric field and elevated temperatures achievable during device operation.

关键词： defect passivation monolithic interconnection perovskite solar modules soda-lime glass sodium diffusion solar cells thin-film photovoltaics

Highlights of the 2nd International Symposium on Tribbles and diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer

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Acta Pharmaceutica Sinica B 2019年第2期9卷 443-454页

作者： Bing Cui Patrick A. Eyers Leonard L. dobens Nguan Soon Tan Peter d. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge d. Erusalimsky dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College department of Biochemistry Institute of Integrative Biology University of Liverpool division of Molecular Biology and Biochemistry School of Biological Sciences University of Missouri-Kansas City School of Biological Sciences Nanyang Technological University Lee Kong Chian School of Medicine Nanyang Technological University Institute of Molecular and Cell Biology KK Women's and Children Hospital Biochemistry department School of Biomedical Sciences University of Otago Centre for Biomedical Research (CBMR) University of Algarve Campus de Gambelas department of Biomedical Sciences and Medicine University of Algarve Algarve Biomedical Center (ABC) University of Algarve Campus de Gambelas department of Infection Immunity and Cardiovascular Disease University of Sheffield Paul O'Gorman Leukaemia Research Centre Institute of Cancer Sciences University of Glasgow division of Carcinogenesis The Cancer Institute Japanese Foundation for Cancer Research department of Pathology and Laboratory Medicine Abramson Family Cancer Research Institute Perelman School of Medicine at the University of Pennsylvania Centre de Recherche en Transplantation et Immunologie (ou CRTI) Inserm Université de Nantes Nantes France Institut de Transplantation Urologie Néphrologie (ou ITUN) CIC bioGUNE CIBERONC Ikerbasque Basque Foundation for Science Biochemistry and Molecular Biology department University of the Basque Country (UPV/EHU) Institute for diabetes and Cancer IdC Helmholtz Center Munich Joint Heidelberg-IdC Translational diabetes Program University Hospital Heidelberg Molecular Metabolic Control Medical Faculty Technical University Munich German Center for diabetes Research (dZd) division of Cardiology Department of Medicine Columbia University Irving Medical Center School of Sport and Health Sciences Cardiff Metropolitan Universit

The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases.

关键词： Tribbles Immunology Metabolism Cell biology Kinase inhibitor Tumorigenesis Metastasis TRIB1 TRIB2 TRIB3 Pseudokinase Inflammation Atomic structure Protein quality control Ubiqutin

High-Resolution Crystal Structure and Redox Properties of Chloroplastic Triosephosphate Isomerase from Chlamydomonas reinhardtii

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Molecular Plant 2014年第1期7卷 101-120页

作者： Mirko Zaffagnini Laure Michelet Chiara Sciabolini Nastasia di Giacinto Samuel Morisse Christophe H. Marchand Paolo Trost Simona Fermani Stephane d Lemaire Laboratoire de Biologie Moleculaire et Cellulaire des Eucaryotes FRE3354 Centre National de la Recherche Scientifique Universite Pierre et Marie Curie Institut de Biologie Physico-Chimique 13 rue Pierre et Marie Curie 75005 Paris France Laboratory of Plant Redox Biology Department of Pharmacy and Biotechnology (FaBiT) University of Bologna via Irnerio 42 40126 Bologna Italy department of Chemistry 'G. Ciamician' University of Bologna via Selmi 2 40126 Bologna Italy

Triosephosphate isomerase （TPI） catalyzes the interconversion of glyceraldehyde-3-phosphate to dihydroxyacetone phosphate. Photosynthetic organisms generally contain two isoforms of TPI located in both cytoplasm and chloroplasts. While the cytoplasmic TPI is involved in the glycolysis, the chloroplastic isoform participates in the Calvin-Benson cycle, a key photosynthetic process responsible for carbon fixation. Compared with its cytoplasmic counterpart, the functional features of chloroplastic TPI have been poorly investigated and its three-dimensional structure has not been solved. Recently, several studies proposed TPI as a potential target of different redox modifications including dithiol/disulfide interchanges, glutathionylation, and nitrosylation. However, neither the effects on protein activity nor the molecular mechanisms underlying these redox modifications have been investigated. Here, we have produced recombinantly and purified TPI from the unicellular green alga Chlamydomonas reinhardtii （Cr）. The biochemical properties of the enzyme were delineated and its crystallographic structure was determined at a resolution of 1.1 A. CrTPI is a homodimer with subunits containing the typical （β/α）8-barrel fold. Although no evidence for TRX regulation was obtained, CrTPI was found to undergo glutathionylation by oxidized glutathione and trans-nitrosylation by nitrosoglutathione, confirming its sensitivity to multiple redox modifications.

关键词： triosephosphate isomerase three-dimensional structure TIM-barrel thiol-based redox regulation transnitrosylation.