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Manipulation of photosensory and circadian signaling restricts phenotypic plasticity in response to changing environmental conditions in Arabidopsis

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Molecular Plant 2024年第9期17卷 1458-1471页

作者： Martin William Battle Scott fraser Ewing Cathryn Dickson Joseph Obaje Kristen N.Edgeworth Rebecca Bindbeutel Rea LAntoniou-Kourounioti Dmitri A.Nusinow Matthew Alan Jones Plant Science Group School of Molecular BiosciencesUniversity of GlasgowGlasgow G128QQUK Danforth Plant Science Center St.LouisMO 63132USA Department of Biological and Biomedical Sciences Washington University in St.LouisSt.LouisMO 63130USA Present address:School of Biological and Environmental Sciences Liverpool John Moores UniversityLiverpool L22QPUK

Plants exploit phenotypic plasticity to adapt their growth and development to prevailing environmental *** of light and temperature signals is aided by the circadian system,which provides a temporal *** plasticity provides a selective and competitive advantage in nature but is obstructive during large-scale,intensive agricultural practices since economically important traits(including vegetative growth and flowering time)can vary widely depending on local environmental *** prevents accurate prediction of harvesting times and produces a variable *** this study,we sought to restrict phenotypic plasticity and circadian regulation by manipulating signaling systems that govern plants'responses to environmental *** modeling of plant growth and develop-ment predicted reduced plant responses to changing environments when circadian and light signaling pathways were *** tested this prediction by utilizing a constitutively active allele of the plant photoreceptor phytochrome B,along with disruption of the circadian systemvia mutation of *** found that these manipulations produced plants that are less responsive to light and temper-ature cues and thus fail to anticipate *** engineered plants have uniform vegetative growth and flowering time,demonstrating how phenotypic plasticity can be limited while maintaining plant *** has significant implications for future agriculture in both open fields and controlled environments.

关键词： circadian developmental plasticity phenotypic plasticity external coincidence light temperature

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Risk factors for fracture in adult kidney transplant recipients

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World Journal of Transplantation 2016年第2期6卷 370-379页

作者： Kyla L Naylor Guangyong Zou William D Leslie Anthony B Hodsman Ngan N Lam Eric McArthur lisa-ann fraser Gregory A Knoll Jonathan D Adachi S Joseph Kim Amit X Garg Institute for Clinical Evaluative Sciences 2nd Institute of Health Policy Management and EvaluationUniversity of Toronto Department of Epidemiology and Biostatistics Western University Department of Medicine University of Manitoba Division of Nephrology Western University Division of Nephrology University of Alberta Division of Endocrinology Western University Division of Nephrology Kidney Research CentreOttawa Hospital Research InstituteUniversity of Ottawa Division of Rheumatology McMaster University Division of Nephrology University Health NetworkUniversity of Toronto

AIM: To determine the general and transplant-specific risk factors for fractures in kidney transplant ***: We conducted a cohort study of all adults who received a kidney-only transplant(n = 2723) in Ontario, Canada between 2002 and 2009. We used multivariable Cox proportional hazards regression to determine general and transplant-specific risk factors for major fractures(proximal humerus, forearm, hip, and clinical vertebral). The final model was established using the backward elimination strategy, selecting risk factors with a P-value ≤ 0.2 and forcing recipient age and sex into the model. We also assessed risk factors for other fracture locations(excluding major fractures, and fractures involving the skull, hands or feet). RESULTS: There were 132 major fractures in the follow-up(8.1 fractures per 1000 person-years). General risk factors associated with a greater risk of major fracture were older recipient age [adjusted hazard ratio(a HR) per 5-year increase 1.11, 95%CI: 1.03-1.19] and female sex(a HR = 1.81, 95%CI: 1.28-2.57). Transplant-specific risk factors associated with a greater risk of fracture included older donor age(5-year increase)(a HR = 1.09, 95%CI: 1.02-1.17) and end-stage renal disease(ESRD) caused by diabetes(a HR = 1.72, 95%CI: 1.09-2.72) or cystic kidney disease(a HR = 1.73, 95%CI: 1.08-2.78)(compared to glomerulonephritis as the reference cause). Risk factors across the two fracture locations were not consistent(major fracture locations vs other). Specifically, general risk factors associated with an increased risk of other fractures were diabetes and a fall with hospitalization prior to transplantation, while length of time on dialysis, and renal vascular disease and other causes of ESRD were the transplant-specific risk factors associated with a greater risk of other ***: Both general and transplant-specific risk factors were associated with a higher risk of fractures in kidney transplant recipients. Results ca

关键词： Fracture Risk factors Kidney transplant recipient Prognostication Cohort study

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Modelling the development of biological structures displaying longitudinal geometries in vitro:culturing pluripotent stem cells on plasma-treated,growth factor-coupled polycaprolactone fibres

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Engineered Regeneration 2024年第1期5卷 124-138页

作者： Badwi B.Boumelhem Stuart T.fraser Syamak Farajikhah Rachel A.Shparberg Michael B.Morris Marcela M.M.Bilek Anyu Zhang Behnam Akhavan Simon Fleming Maryanne Large School of Physics Faculty of ScienceUniversity of SydneyAustralia Sydney Nano Institute University of SydneyAustralia School of Chemical and Biomolecular Engineering University of SydneyAustralia School of Medical Sciences Faculty of Medicine and HealthUniversity of SydneyAustralia School of Biomedical Engineering Faculty of EngineeringUniversity of SydneyAustralia School of Engineering University of NewcastleCallaghanNSW 2308Australia Hunter Medical Research Institute(HMRI) Precision Medicine ProgramNew Lambton Heights NSW 2305Australia

Many biological structures such as nerves,blood and lymphatic vessels,and muscle fibres exhibit longitudinal ge-ometries with distinct cell types extending along both the length and width of internal linear *** these three-dimensional structures in vitro is challenging:the best-defined stem-cell differentiation systems are mono-layer cultures or organoids using pluripotent stem *** stem cells can differentiate into functionally mature cells depending on the signals received,holding great promise for regenerative ***,the integration of in vitro differentiated cell types into diseased tissue remains a *** scaffolds can bridge this gap if the appropriate signalling systems are incorporated into the ***,we have taken a biomimicry approach to generate longitudinal structures in *** this approach,mouse embryonic stem cells are directed to differentiate to specific cell types on the surface of polycaprolactone(PCL)fibres treated by plasma-immersion ion implantation and to which with lineage-specifying molecules have been covalently *** demonstrate the simplicity and utility of our method for efficiently generating high yields of the following cell types from these pluripotent stem cells:neurons,vascular endothelial cells,osteoclasts,adipocytes,and cells of the erythroid,myeloid,and lymphoid *** arranged plasma-treated scaffolds with differentiated cell types could ultimately serve as a means for the repair or treatment of diseased or damaged tissue.

关键词： Pluripotent stem cells Lineage commitment Growth factors Biomaterial engineering Plasma-immersion ion implantation Covalent biomolecule attachment Polycaprolactone

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单分子结中的有机自由基

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Science China Materials 2024年第3期67卷 709-728页

作者：张雅琦邱仁慧屈恺张成 J.fraser Stoddart 陈洪亮 Stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310021China Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation CentreZhejiang UniversityHangzhou 311215China Department of Chemistry and Innovation Center of Pesticide Research China Agricultural UniversityBeijing 100193China Department of Chemistry The University of Hong KongHong Kong SAR 999077China School of Chemistry University of New South WalesSydneyNSW 2052Australia Beijing National Laboratory for Molecular Sciences Beijing 100871China

空气稳定有机自由基的发现引起了人们对探究其在分子电子学和自旋电子学中应用的兴趣.这些自由基具有独特的开壳层电子结构,因而表现出特殊的电学特性.由于其较弱的旋轨耦合特性,也使得其成为自旋电子学的重要研究对象.此外,自由基还可... 详细信息

空气稳定有机自由基的发现引起了人们对探究其在分子电子学和自旋电子学中应用的兴趣.这些自由基具有独特的开壳层电子结构,因而表现出特殊的电学特性.由于其较弱的旋轨耦合特性,也使得其成为自旋电子学的重要研究对象.此外,自由基还可以通过二聚、分子识别和机械互锁等分子间相互作用来构筑超分子器件.本文综述了空气稳定有机自由基在电子学及自旋电子学中的应用,通过详述其卓越的电磁性能来拓展启发分子设计的多样性.本综述还概述了超分子自由基的制备方法和相关性质的研究进展,拓宽了单分子研究的范围.此外,自由基介导的单分子反应是一个新兴的研究方向,本文也对该领域的未来发展方向进行了展望.通过阐明空气稳定有机自由基的应用潜力,本文将有望对分子电子学和自旋电子学的研究产生一定的指导意义.

关键词： air-stable radicals molecular electronics spintronics supramolecular devices

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Adsorption of As on hydroxy-Fe-montmorillonite complexes

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Science China Earth Sciences 2005年第12期48卷 2155-2165页

作者： Donald G. fraser Department of Earth Sciences Oxford University Parks Road Oxford OX1 3PR UK

Arsenate has high affinity for soluble hydroxy-Fe species and Fe-oxyhydroxide pre-cipitates. In addition, the hydrolysis of Fe(III) and the growth of the initially precipitated Fe(III) phases are strongly influenced by the presence of montmorillonite. In this paper, the adsorption of As onto various hydroxy-Fe-montmorillonite (H-F-M) complexes was studied. Three systems of samples were prepared by mixing montmorillonite, hydroxy-Fe and arsenate in different se-quences: (1) Prior mixing of montmorillonite and hydroxy-Fe before the addition of arsenate; (2) prior mixing of hydroxy-Fe and arsenate before the addition of montmorillonite; and (3) prior mixing of montmorillonite and arsenate before the addition of hydroxy-Fe. For each system, the effects of pH, ionic strength, temperature, initial Fe and As concentrations and adsorption dura-tion on the overall uptake of As by H-F-M complexes were studied. Results showed that the up-take of As increased with increasing pH, temperature, initial Fe concentration and adsorption duration, and decreased with increasing ionic strength and initial As concentration to different extents for the three systems. The variation of the As uptake of H-F-M complexes with pH in the range of study is opposite to that reported previously for Fe-O-H systems in the absence of montmorillonite and similar to that reported for montmorillonite in the absence of hydroxy-Fe. The marked influence of ionic strength on the As uptake of H-F-M complexes indicates that outer-sphere complexation plays an important role. This is quite different from the adsorption of As on the surface of either Fe-oxyhydroxides or montmorillonite alone in which inner-sphere complexation dominates. Under all experimental conditions, the H-F-M complexes studied dis-played a very strong affinity for As, among which system 2 had the highest As adsorption capac-ity and system 1 the lowest. The authors attribute this to the differences in mixing sequence which resulted in more hy

关键词： hydroxy-Fe, montmorillonite, complex, arsenate adsorption.

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Mapping frontier molecular orbitals using photocurrents

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Science China Materials 2023年第9期66卷 3761-3762页

作者： Ping Zhou J.fraser Stoddart Hongliang Chen Stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310027China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311215China Department of Chemistry Northwestern University2145 Sheridan RoadEvanstonIllinois 60208USA School of Chemistry University of New South WalesSydneyNSW 2052Australia

In the regime of coherent transport, the conductance of a molecular junction is governed(Fig. 1a) by the probability of electron transmission between the metal electrodes, a physica property which is affected significantly by the hybridization of frontier molecular orbitals(FMOs) with the continuous band of energy levels on the electrodes.

关键词： frontier molecular orbitals

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Endoscopic ultrasound-guided elastography in the nodal staging of oesophageal cancer

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World Journal of Gastroenterology 2012年第9期18卷 889-895页

作者： Stuart Paterson fraser Duthie Adrian J Stanley Department of Gastroenterology Forth Valley Royal Hospital Department of Pathology Glasgow Royal Infirmary Department of Gastroenterology Glasgow Royal Infirmary

AIM： To assess quantitative endoscopic ultrasound （EUS）- guided elastography in the nodal staging of oesophago- gastric cancers.METHODS： This was a single tertiary centre study as- sessing 50 patients with established oesophago-gastric cancer undergoing EUS-guided fine needle aspiration biopsy （FNAB） of lymph nodes between July 2007 and July 2009. EUS-guided elastography of lymph nodes was performed before EUS-FNAB. Standard EUS charac- teristics were also described. Cytological determination of whether a lymph node was malignant or benign was used as the gold standard for this study. Comparisons of elastography and standard EUS characteristics were made between the cytologically benign and malignant nodes. The main outcome measure was the accuracy of elastography in differentiating between benign and malignant lymph nodes in oesophageal cancers.

关键词： Endoscopic ultrasound Oesophageal cancerLymph nodes Elastography Tumour staging

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Nutritional support teams increase percutaneous endoscopic gastrostomy uptake in motor neuron disease

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World Journal of Gastroenterology 2012年第44期18卷 6461-6467页

作者： Lin Zhang Leanne Sanders Robert JL fraser Nutrition and Dietetic Department Flinders Uni- versity of South Australia Bedford Park 5042 South Australia Australia Department of Nutrition and Dietetics Repa- triation General Hospital Daw Park 5041 South Australia Aus- tralia School of Medicine Flinders University of South Australia Bedford Park 5042 South Australia Australia

AIM:To examine factors influencing percutaneous endoscopic gastrostomy(PEG) uptake and outcomes in motor neuron disease(MND) in a tertiary care ***:Case notes from all patients with a confirmed diagnosis of MND who had attended the clinic at the Repatriation General Hospital between January 2007 and January 2011 and who had since died,were *** were extracted for demographics(age and gender),disease characteristics(date of onset,bulbar or peripheral predominance,complications),date and nature of discussion of gastrostomy insertion,nutritional status [weight measurements,body mass index(BMI)],date of gastrostomy insertion and subsequent progress(duration of survival) and quality of life(QoL) [Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised(ALSFRS-R)].In addition,the type of clinician initiating the discussion regarding gastrostomy was recorded as Nutritional Support Team(involved in providing nutrition input viz Gastroenterologist,Speech Pathologist,Dietitian) and other(involved in non-nutritional aspects of patient care).Factors affecting placement and outcomes including length of survival,change in weight and QoL were ***:Case records were available for all 86 patients(49 men,mean age at diagnosis 66.4 years).Thirty-eight patients had bulbar symptoms and 48 had peripheral disease as their presenting ***-six patients reported ***-one patients had undergone gastrostomy *** major indications for PEG placement were dysphagia and weight *** patients required immediate full feeding,whereas 17 patients initially used the gastrostomy to supplement oral intake,4 for medication administration and 1 for *** the PEG regime met 73% ± 31% of the estimated total energy requirements,increasing to 87% ± 32% prior to *** was stabilization of weight in patients undergoing gastrostomy [BMI at 3 mo(22.6 ± 2.2 kg/m 2) and 6 mo(22.5 ± 2.0 kg/m 2) after PEG placement compared to

关键词： Motor neuron disease Multidisciplinary ma-nagement Nutrition support team Percutaneous endo-scopic gastrostomy Survival

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The history and development of the theory and practice of cybercartography

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International Journal of Digital Earth 2010年第1期3卷 2-15页

作者： D.R.fraser Taylor Stephanie Pyne Department of Geography and Environmental Studies Geomatics and Cartographic Research CentreCarleton UniversityOttawaONCanada

This paper describes the development of cybercartography since the introduction of the term in *** the origins of cybercartography were largely conceptual in nature,the evolution of cybercartography to date has been an iterative process reflecting the creative interplay between theory and practice.A major step forward was made in 2002 when the Geomatics and Cartographic Research Centre at Carleton University received a$2.5 million grant from the Social Sciences and Humanities Research Council of Canada to explore the utility of cybercartography to what was described as the New *** 2006,the interaction between theory and practice had led to considerable advances in cybercartography as a holistic,location-based concept and two new cybercartographic products,the Cybercartographic Atlas of Antarctica and the Cybercartographic Atlas of Canada’s Trade with the World,were *** 2006 and 2009,cybercartography was further developed as a result of interaction with indigenous communities,especially in Canada’s north and new interactive atlases such as the Kitikmeot Place Names Atlas and the Community Atlas of Arctic Bay were created in cooperation with the communities *** Nunaliit Cybercartographic Atlas Framework,built using open source software and open specifications and standards,was developed to facilitate direct input to these *** is now entering a new phase in both theory and practice building on a recently completed prototype atlas of Indigenous Perspectives and Knowledge.

关键词： cybercartography cybercartographic atlases indigenous mapping cybercartographic atlas framework iteration theory and practice

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fraser Syndrome: Two millennia of cryptophthalmos from Pliny the Elder to FRAS, FREM and GRIP: A historical perspective

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Open Journal of Genetics 2013年第2期3卷 1-7页

作者： George R. fraser Green Templeton College Oxford UK

From its first description in antiquity, the place of cryptophthalmos in the history of medical genetics is briefly set out until, in the twentieth century, this rare constellation of multiple congenital malformations of which cryptophthalmos is the most striking, even though not obligatory, component, was identified as an inherited autosomal recessive condition. It was given the name of fraser syndrome and mutant alleles of the genes FRAS1, FREM2 and GRIP1 were identified as being responsible for a proportion of cases. In the remainder of cases, it may be supposed that mutant alleles of other genes, as yet unidentified, are responsible. In general, this association of multiple disparate malformations in an autosomal recessive condition may be expected to throw light on important aspects of gene action in embryogenesis. An aspect of medical genetics, which has become important with respect to the condition, is antenatal diagnosis with the prospect of abortion of affected fetuses.

关键词： Cryptophthalmos fraser Syndrome Blindness Deafness Sublethal Genes Autosomal Recessive Inheritance

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