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Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

A LOCKING-FREE SCHEME OF NONCONFORMING RECTANGULAR FINITE ELEMENT FOR THE PLANAR ELASTICITY

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Journal of Computational Mathematics 2004年第5期22卷 641-650页

作者： lie-hengwang HeQi LSEC ICMSECAcademyofMathematicsandSystemSciencesChineseAcademyofSciencesBeijing100080China BureauofBasicResearchofChineseAcademyofSciences Beijing100864China

In this paper, the authors present a locking-free scheme of the lowest order nonconforming rectangle finite element method for the planar elasticity with the pure displacement boundary condition. Optimal order error e... 详细信息

关键词： Locking-free Planar elasticity Nonconforming finite element method

wATER BREAKTHROUGH SIMULATION IN NATURALLY FRACTURED GAS RESERVOIRS wITH wATER DRIVE

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Journal of Hydrodynamics 2005年第4期17卷 466-472页

作者： ZHANG lie-hui State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum Institute Chengdu 610500 China

In the fractured water drive reservoirs of China, because of the complex geological conditions, almost all the active water invasions appear to be water breakthrough along fractures, especially along macrofraetures. These seal the path of gas flow, thus the remaining gas in the pores mixes into water, and leads to gas-water interactive distribution in the fractured gas reservoir. These complicated fraetured systems usually generate some abnormal flowing phenomena such as the crestal well produces water while the downdip well in the same gas reservoir produces gas, or the same gas well produces water intermittently. It is very difficult to explain these phenomena using existing fracture models because of their simple handling macrofractures without considering nonlinear flowing in the macrofractures and the low permeability matrix. Therefore, a nonlinear combined-flowing multimedia simulation model was successfully developed in this paper by introducing the equations of macrofractures and considering nonlinear flow in the macrofractures and the matrix. This model was then applied to actual fractured bottom water gas fields. Sensitivity studies of gas produetion by water drainage in fractured gas reservoirs were completed and the effect of different water drainage intensity and ways on actual gas production using this model were calculated. This model has been extensively used to predict the production performance in various fractured gas fields and proven to be reliable.

关键词： fractured gas reservoir water breakthrough water invasion numerical simulation implicit treatmcnt

Genome-wide association studies for inflorescence type and remontancy in Hydrangea macrophylla

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Horticulture Research 2020年第1期7卷 2477-2485页

作者： Xingbo wu lisa w.Alexander Oak Ridge Institute of Science and Technology Otis L.Floyd Nursery Research Center472 Cadillac LaneMcMinnvilleTNUSA U.S.Department of Agriculture Agricultural Research ServiceU.S.National ArboretumFloral and Nursery Plants Research UnitOtis L.Floyd Nursery Research Center472 Cadillac LaneMcMinnvilleTNUSA

Inflorescence type and remontancy are two valuable traits in bigleaf hydrangea(Hydrangea macrophylla L.)and both are recessively *** marker-assisted selection(MAS)can greatly reduce the time necessary to breed cultivars with desired *** this study,a genome-wide association study(GwAS)using 5803 single-nucleotide polymorphisms(SNPs)was performed using a panel of 82 bigleaf hydrangea *** SNP locus(Hy_CAPS_Inflo)associated with inflorescence type was identified with general linear model(GLM)and mixed linear model(MLM)methods that explained 65.5%and 36.1%of the phenotypic variations,***-three SNPs associated with remontancy were detected in GLM whereas no SNP was detected in *** SNP locus(Hy_CAPS_Inflo)was converted to a cleaved amplified polymorphic sequence(CAPS)marker that showed absolute identification accuracy(100%)of inflorescence type in a validation panel consisting of eighteen *** *** SNP was investigated in 341 F1 progenies using genotyping by sequencing(GBS)and co-segregated with inflorescence type(χ^(2)=0.12;P=0.73).The SNP was subsequently used for breeding selection using kompetitive allele specific PCR(KASP)*** directions for the use of genomics and MAS in hydrangea breeding improvement are *** results presented in this study provide insights for further research on understanding genetic mechanisms behind inflorescence type and remontancy in *** CAPS and KASP markers developed here will be immediately useful for applying MAS to accelerate breeding improvement in hydrangea.

关键词： breeding cultivar CAPS

Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

Limitations of teleporting a qubit via a two-mode squeezed state

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Photonics Research 2019年第5期7卷 I0001-I0007页

作者： SEOK HYUNG lie HYUNSEOK JEONG Center for Macroscopic Quantum Control Department of Physics and Astronomy Seoul National University

Recently, a teleportation scheme using a two-mode squeezed state to teleport a photonic qubit, so called a“hybrid” approach, has been suggested and experimentally demonstrated as a candidate to overcome the limitations of all-optical quantum information processing. we find, however, that there exists the upper bound of fidelity when teleporting a photonic qubit via a two-mode squeezed channel under a lossy *** increase of photon loss decreases this bound, and teleportation better than this limit is impossible even when the squeezing degree of the teleportation channel becomes infinity. Our result indicates that the hybrid scheme can be valid for fault-tolerant quantum computing only when the photon loss rate can be suppressed under a certain limit.

关键词： teleport a photonic qubit experimentally demonstrated photon loss decreases

New insights into the interplay between intestinal flora and bile acids in inflammatory bowel disease

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world Journal of Clinical Cases 2022年第30期10卷 10823-10839页

作者： lie Zheng Department of Gastroenterology Shaanxi Hospital of Traditional Chinese MedicineXi’an 710003Shaanxi ProvinceChina

Intestinal flora plays a key role in nutrient absorption,metabolism and immune defense,and is considered to be the cornerstone of maintaining the health of human *** acids synthesized in the liver can not only promote the absorption of fat-soluble substances in the intestine,but also directly or indirectly affect the structure and function of intestinal *** the action of intestinal flora,bile acids can be converted into secondary bile acids,which can be reabsorbed back to the liver through the enterohepatic *** complex dialogue mechanism between intestinal flora and bile acids is involved in the development of intestinal inflammation such as inflammatory bowel disease(IBD).In this review,the effects of intestinal flora,bile acids and their interactions on IBD and the progress of treatment were reviewed.

关键词： Intestinal flora Bile acids Inflammatory bowel disease Fecal microbiota transplantation Prebiotics

Qualitative analysis of a predator-prey model with rapid evolution and piecewise constant arguments

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International Journal of Biomathematics 2017年第7期10卷 175-189页

作者： lie wang School of Mathematics and Information Science Shaanxi Normal University Xi'an 710062 P. R. China

The qualitative analysis of a predator-prey model with rapid evolution and piecewise constant arguments is investigated in this work. The discrete model, which determines the dynamical behavior of the corresponding differential model, is achieved by calcula- tion. First, the sufficient conditions for the existence and local stability of the equilib- riums are concluded from the lineaxized stability theorem and latent root method. Second, the global stability of the equilibriums is discussed through the Poincarb- Bendixson theorem. Furthermore, it is proved that the system has at most one limit cycle. Third, by using the bifurcation theory it is found that the model can undergo the saddle-node bifurcation; the flip bifurcation; and the Neimark-Sacker bifurcation. From the qualitative analysis it can be found that the exponential growth rate and the ratio between the fast and slow timescales have profound influence on the dynamic behavior of the model. Finally, numerical examples carry out to justify the main results in this work.

关键词： Predator-prey model evolution functional response piecewise constantarguments.

ON LOCKING-FREE FINITE ELEMENT SCHEMES FOR THREE-DIMENSIONAL ELASTICITY

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Journal of Computational Mathematics 2005年第1期23卷 101-112页

作者： HeQi lie-hengwang wei-yingZheng LSEC ICMSECAcademyofMathematicsandSystemSciencesChineseAcademyofSciencesBeijing100080China

In the present paper, the authors discuss the locking phenomenon oI the lmlte element method for three-dimensional elasticity as the Lamé constant λ→∞. Three kinds of finite elements are proposed and analyzed to approximate the three-dimensional elasticity with pure displacement boundary condition. Optimal order error estimates which are uniform with respect to λ ∈(0,∞) are obtained for three schemes. Furthermore, numerical results are presented to show that, our schemes are locking-free and and the trilinear conforming finite element scheme is locking.

关键词： three-dimensional elasticity locking-free nonconforming finite element