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Stroke & Vascular Neurology 2022年第2期7卷 172-175页

作者： Charlotte L Warner lisa Bunn Nehzat Koohi Gunnar Schmidtmann Jennifer Freeman Diego Kaski School of Health Professions University of PlymouthPlymouthUK Department of Clinical and Movement Neurosciences University College LondonLondonUK The Ear Institute University College LondonLondonUK Neuro-otology Department University College London HospitalsLondonUK

Background Acute vestibular syndrome(AVS)features continuous dizziness and may result from a benign inner ear disorder or *** head impulse-nystagmus-test of skew(HINTS)bedside assessment is more sensitive than brain MRI in identifying stroke as the cause of AVS within the first 24 ***’perspectives of the test in UK secondary care remains ***,we explore front-line clinicians’perspectives of use of the HINTS for the diagnosis of *** Clinicians from two large UK hospitals who assess AVS patients completed a short online survey,newly designed with closed and open *** Almost half of 73 total responders reported limited(n=33),or no experience(n=19),reflected in low rates of use of HINTS(n=31).While recognising the potential utility of HINTS,many reported concerns about subjectivity,need for specialist skills and poor patient *** clinicians reported high levels of confidence in performing HINTS,with 98%identifying training needs.A lack of formalised training was associated with onward specialist referrals and neuroimaging(p=0.044).Conclusions Although the low sample size in this study limits the generalisability of findings to wider sites,our preliminary data identified barriers to the application of the HINTS in AVS patients and training needs to improve rapid,cost-effective and accurate clinical diagnosis of stroke presenting with vertigo.

关键词： AVS diagnosis formal

Mechanisms of neratinib resistance in HER2-mutant metastatic breast cancer

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Cancer Drug Resistance 2022年第4期5卷 873-881页

作者： lisa D.Eli Shyam M.Kavuri Translational Medicine and Diagnostics Puma BiotechnologyInc.Los AngelesCA 90024USA Lester and Sue Smith Breast Center Baylor College of MedicineHoustonTX 77030USA Department of Medicine Baylor College of MedicineHoustonTX 77030USA

Human epidermal growth factor receptor 2 (HER2) is a major drug target and clinical biomarker in breast cancertreatment. Targeting HER2 gene amplification is one of the greatest successes in oncology, resulting in the use of awide array of HER2-directed agents in the clinic. The discovery of HER2-activating mutations as novel therapeutictargets in breast and other cancers marked a significant advance in the field, which led to the metastatic breast andother solid tumor trials MutHER (NCT01670877), SUMMIT (NCT01953926), and one arm of plasmaMATCH(NCT03182634). These trials reported initial clinical benefit followed by eventual relapse ascribed to eitherprimary or acquired resistance. These resistance mechanisms are mediated by additional secondary genomicalterations within HER2 itself and via hyperactivation of oncogenic signaling within the downstream signaling axis.

关键词： Neratinib HER2 ERBB2 estrogen receptor mutation

Antithrombotic therapy in patients with COVID-19:indications,pharmacotherapy and controversy

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Stroke & Vascular Neurology 2023年第4期8卷 263-265页

作者： David Wang Christopher Leo Liping Liu Li Huang lisa Huang Yun Lu Department of Neurology Petznick Stroke CenterBarrow Neurological InstitutePhoenixArizonaUSA Department of Medicine/Division of General Internal Medicine/Hospital Medicine Duke UniversityDurhamNorth CarolinaUSA Neurosurgical Intensive Care Unit(NICU) Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Doctors Medical Center ModestoCaliforniaUSA Chesapeake Regional Medical Center ChesapeakeVirginiaUSA Hennepin Healthcare System and the University of Minnesota MinneapolisMinnesotaUSA

Hypercoagulability associated with COVID-19 infection increases risks for either venous or arterial thrombotic events(ATEs)or both.1 For hospitalised patients with COVID-19,the incidence of venous thromboembolism(VTE)was 4.5%2;the rate among patients with crit-ical illness was 27.9%as compared with those not critically ill(7.1%).The exact mechanism of COVID-19-related thrombotic events is ***,it may partially be related to Virchow triad:alternation of blood flow(stasis),vascular endothelial injury by SARS-CoV 2 virus and alteration of the constituents of the blood including inherited or acquired hypercoagulable ***,it is a challenge to evaluate the thromboembolic risk,select an appropriate antithrombotic agent and decide on the doses and duration of therapy in these *** international and American societies have published clinical guidelines that reviewed evaluation of coagulation abnormalities in patients with COVID-19.3-6 To balance the risk of bleeding and preventing or treating thromboembolic events,a simplified practical summarisation is needed.

关键词： patients thrombotic doses

Seismic Hazard Assessment of District Mansehra,Khyber Pakhtoonkhawa,Pakistan

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Acta Geologica Sinica(English Edition) 2014年第4期88卷 1157-1168页

作者： MONA lisa COMSATS Institute of Information Technology(CIIT) Islamabad PakistanDepartment of Earth SciencesQuaid-i-Azam University

The site of Mansehra is located seismically in an active regime, known as the Crystalline Nappe Zone and Hazara-Kashmir Syntaxis in NW Himalayas, Pakistan. Seismic Hazard Assessment （SHA） for the site has been carried out by considering the earthquake source zones, selection of appropriate attenuation equations, near fault effects and maximum potential magnitude estimation. The Mansehra Thrust, Oghi Fault, Banna Thrust, Balakot Shear Zone, Main Boundary Thrust, Panjal Thrust, Jhelum Fault and Muzaffarabad Fault and, further to the south, the Sanghargali, Nathiagali, and Thandiani Thrusts are the most critical tectonic features within the 50 km radius of Mansehra. Using the available instrumental seismological data from 1904 to 2007, SHA has been carried out. Other reactivated critical tectonic features in the area have been investigated. Among them the Balakot-Bagh fault, with the fault length of 120 km from Balakot to Poonch, has been considered as the most critical tectonic feature on the basis of geological/structural/seismological data. The potential earthquake of maximum magnitude 7.8 has been assigned to the Balakot-Bagh fault using four regression relations. The peak ground acceleration value of 0.25 g （10% probability of exceedance for 50 years） and 0.5 g has been calculated with the help of the attenuation equation using probabilistic and deterministic approaches.

关键词： Seismic Hazard Assessment Mansehra District NW Himalayas Pakistan Probabilistic and Deterministic Approaches Balakot-Bagh Fault

Treatment of colonic varices and gastrointestinal bleeding by recanalization and stenting of splenic-vein-thrombosis:A case report and literature review

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World Journal of Gastroenterology 2023年第24期29卷 3922-3931页

作者： lisa-Michaela Füssel Rene Müller-Wille Patrick Dinkhauser Walter Schauer Harald Hofer Department of Internal Medicine Ⅰ Gastroenterology and HepatologyKlinikum Wels-GrieskirchenWels 4600Austria Department of Radiology Klinikum Wels-GrieskirchenWels 4600Austria Department of Abdominal Surgery Klinikum Wels-GrieskirchenWels 4600Austria

BACKGROUND Splenic vein thrombosis is a known complication of *** can lead to increased blood flow through mesenteric *** segmental hypertension may result in the development of colonic varices(CV)with a high risk of severe gastrointestinal *** clear guidelines for treatment are lacking,splenectomy or splenic artery embolization are often used to treat *** vein stenting has been shown to be a safe *** SUMMARY A 45-year-old female patient was admitted due to recurrent gastrointestinal *** was anemic with a hemoglobin of 8.0 g/*** a source of bleeding,CV were *** tomography scans revealed thrombotic occlusion of the splenic vein,presumably as a result of a severe acute pancreatitis 8 years *** a selective angiography,a dilated mesenterial collateral leading from the spleen to enlarged vessels in the right colonic flexure and draining into the superior mesenteric vein could be *** hepatic venous pressure gradient was within normal *** an interdisciplinary board,transhepatic recanalization of the splenic vein via balloon dilatation and consecutive stenting,as well as coiling of the aberrant veins was discussed and successfully *** evaluation revealed complete regression of CV and splenomegaly as well as normalization of the red blood cell count during *** Recanalization and stenting of splenic vein thrombosis might be considered in patients with gastrointestinal bleeding due to ***,a multidisciplinary approach with a thorough workup and discussion of individualized therapeutic strategies is crucial in these difficult to treat patients.

关键词： Pancreatitis-induced splenic vein thrombosis Gastrointestinal hemorrhage Colonic varices Splenic vein stenting Segmental/sinistral hypertension Case report

Volume and surface effects on two-photonic and three-photonic processes in dry co-doped upconversion nanocrystals

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Nano Research 2022年第3期15卷 2362-2373页

作者： Bettina Grauel Christian Würth Christian Homann lisa Krukewitt Elina Andresen Janina Roik Sebastian Recknagel Markus Haase Ute Resch-Genger Federal Institute for Materials Research and Testing(BAM) Division 1.2 BiophotonicsRichard-Willstaetter-Str.1112489 BerlinGermany Federal Institute for Materials Research and Testing(BAM) Division 1.6 Inorganic Reference MaterialsRichard-Willstaetter-Str.1112489 BerlinGermany Institute of Chemistry of New Materials Department Biology/ChemistryUniversity OsnabrueckBarbarastr.749076 OsnabrueckGermany Department of Anesthesiology and Intensive Care Medicine University Medical Center RostockSchillingallee 3518057 RostockGermany

Despite considerable advances in synthesizing high-quality core/shell upconversion(UC)nanocrystals(NC;UCNC)and UCNC photophysics,the application of near-infrared(NIR)-excitable lanthanide-doped UCNC in the life and material sciences is still hampered by the relatively low upconversion luminescence(UCL)of UCNC of small size or thin protecting *** obtain deeper insights into energy transfer and surface quenching processes involving Yb^(3+) and Er^(3+) ions,we examined energy loss processes in differently sized solid core NaYF_(4) nanocrystals doped with either Yb^(3+)(YbNC;20%Yb^(3+))or Er^(3+)(ErNC;2%Er^(3+))and co-doped with Yb^(3+) and Er^(3+)(YbErNC;20%Yb^(3+) and 2%Er^(3+))without a surface protection shell and coated with a thin and a thick NaYF_(4) shell in comparison to single and co-doped bulk *** studies at 375 nm excitation demonstrate back-energy transfer(BET)from the ^(4)G_(11/2) state of Er^(3+) to the ^(2)F_(5/2) state of Yb^(3+),through which the red Er^(3+) ^(4)F_(9/2) state is efficiently *** power density(P)-dependent steady state and time-resolved photoluminescence measurements at different excitation and emission wavelengths enable to separate surface-related and volume-related effects for two-photonic and three-photonic processes involved in UCL and indicate a different influence of surface passivation on the green and red Er3+*** intensity and lifetime of the latter respond particularly to an increase in volume of the active UCNC *** provide a three-dimensional random walk model to describe these effects that can be used in the future to predict the UCL behavior of UCNC.

关键词： upconversion luminescence core/shell nanoparticles dopant concentration lifetime volume effect surface quenching

Vascular-confined multi-passage discoidal nanoconstructs for the low-dose docetaxel inhibition of triple-negative breast cancer growth

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Nano Research 2022年第1期15卷 482-491页

作者： Alessia Felici Daniele Di Mascolo Miguel Ferreira Simone Lauciello Luca Bono Andrea Armirotti Arunkumar Pitchaimani Anna lisa Palange Paolo Decuzzi Laboratory of Nanotechnology for Precision Medicine Fondazione Istituto Italiano di TecnologiaGenoa 16163Italy Department of Informatics BioengineeringRobotics and System EngineeringUniversity of GenoaGenoa 16126Italy Nanochemistry Laboratory Fondazione Istituto Italiano di TecnologiaGenoa 16163Italy Analytical Chemistry Laboratory Fondazione Istituto Italiano di TecnologiaGenoa 16163Italy

Taxane efficacy in triple negative breast cancer(TNBC)is limited by insufficient tumor accumulation and severe off-target *** offer a unique opportunity to enhance the anti-cancer potency of this ***,1,000 nm×400 nm discoidal polymeric nanoconstructs(DPN)encapsulating docetaxel(DTXL)and the near infrared compound Iipid-Cy5 were *** were obtained by filling multiple times cylindrical wells in a poly(vinyl alcohol)template with a polymer mixture comprising poly(lactic-co-glycolic acid)(PLGA)and poly(ethylene glycol)diacrylate(PEG-DA)chains together with therapeutic and imaging *** resulting“multi-passage”DPN exhibited higher DTXL loading,Iipid-Cy5 stability,and stiffness as compared to the conventional"single-passage"*** microscopy confirmed that DTXL-DPN were not taken up by MDA-MB-231 cells but would rather sit next to the cell membrane and slowly release DTXL *** DPN had no toxicity on TNBC cells,whereas DTXL-DPN presented a cytotoxic potential comparable to free DTXL(IC_(50)=2.6 nM±1.0 nM vs.7.0 nM±1.09 nM at 72 h).In orthotopic murine models,DPN accumulated in TNBC more efficiently than *** only 2 mg/kg DTXL,intravenously administered every 2 days for a total of 13 treatments,DTXL-DPN induced tumor regression and were associated to an overall 80%survival rate as opposed to a 30%survival rate for free-DTXL,at 120 *** untreated mice succumbed before 90 ***,this data demonstrates that vascular confined multi-passage DPN,biomimicking the behavior of circulating platelets,can efficiently deliver chemotherapeutic molecules to malignant tissues and effectively treat orthotopic TNBC at minimal taxane doses.

关键词： hydrogel particles template strategy vascular targeting biomimicry cancer therapy

Sagittal crest morphology decoupled from relative bite performance in Pleistocene tapirs(Perissodactyla:Tapiridae)

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Integrative Zoology 2023年第2期18卷 254-277页

作者： lisa VAN LINDEN Kim STOOPS Larissa C.C.S.DUMBÁ Mario A.COZZUOL Jamie A.MACLAREN Functional Morphology Lab Department of BiologyCampus Drie EikenUniversiteit AntwerpenAntwerpenBelgium Departamento de Zoologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisMinas GeraisBrazil Evolution and Diversity Dynamics Lab Department of GeologyUniversitéde LiègeQuartier AgoraLiègeBelgium

Bite force is often associated with speciﬁc morphological features,such as sagittal *** presence of a pro-nounced sagittal crest in some tapirs(Perissodactyla:Tapiridae)was recently shown to be negatively correlated with hard-object feeding,in contrast with similar cranial structures in *** aim of this study was to investi-gate bite forces and sagittal crest heights across a wide range of modern and extinct tapirs and apply a comparative investigation to establish whether these features are correlated across a broad phylogenetic *** examined a sample of 71 specimens representing 15 tapir species(5 extant,10 extinct)using the dry-skull method,linear measurements of cranial features,phylogenetic reconstruction,and comparative *** were found to ex-hibit variation in bite force and sagittal crest height across their phylogeny and between different biogeographical realms,with high-crested morphologies occurring mostly in Neotropical *** highest bite forces within tapirs appear to be driven by estimates for the masseter–pterygoid muscle complex,rather than predicted forces for the temporalis *** results demonstrate that relative sagittal crest height is poorly correlated with relative cranial bite force,suggesting high force application is not a driver for pronounced sagittal crests in this *** divergent biomechanical capabilities of different contemporaneous tapirids may have allowed multiple species to occupy overlapping territories and partition resources to avoid excess *** forces in tapirs peak in Pleistocene species,independent of body size,suggesting possible dietary shifts as a potential result of climatic changes during this epoch.

关键词： biogeography dry-skull method herbivory mastication niche partitioning Pleistocene

Cervical spinal cord injury: tailoring clinical trial endpoints to reflect meaningful functional improvements

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Neural Regeneration Research 2014年第16期9卷 1493-1497页

作者： lisa M.Bond lisa McKerracher BioAxone BioSciences Inc.Cambridge MA USA McGill University Department of Neurology and NeurosurgeryMontreal Quebec Canada

Cervical spinal cord injury （SCI） results in partial to full paralysis of the upper and lower extrem- ities. Traditional primary endpoints for acute SCI clinical trials are too broad to assess functional recovery in cervical subjects, raising the possibility of false positive outcomes in trials for cervical SCI. Endpoints focused on the recovery of hand and arm control （e.g., upper extremity motor score, motor level change） show the most potential for use as primary outcomes in upcoming trials of cervical SCI. As the field moves forward, the most reliable way to ensure meaningful clinical testing in cervical subjects may be the development of a composite primary endpoint that measures both neurological recovery and functional improvement.

关键词： spinal cord injury SCI cervical clinical trial endpoint Cethrin UEMS

MICROSTRUCTURE CHARACTERIZATION OF LiCoO_2 COATINGS FOR MOLTEN CARBONATE FUEL CELLS COMPONENTS

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Chinese Journal of Mechanical Engineering 2002年第2期15卷 182-185页

作者： Klein lisa College of Materials Science and Engineering Fuzhou University Fuzhou 350002 Rutgers University 美国 Evercel Co. Connecticut 美国

The sol-gel process, sing aqueous solutions, is used for dip coating ontosubstrates of 316L stainless steel. A suitable coating of Li CoO_2 is achieved by varying thethickness and heat treating at 650 deg C for 3 h. Thermal analysis, X-ray diffraction analysis andSEM are carried out to characterize the microstructure of the coatings. The results show that thecoating transforms from an amorphous gel to crystalline phases above 350 deg C, and show a porousstructure. The phase transition mechanism is discussed.

关键词： Molten carbonate fuel cells Sol-gel LiCoO_2 coating Crystalline phasetransition