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Hillslope coupled stream morphology, flow conditions, and their effects on detrital sedimentology in Garnet Canyon, Teton Range,Wyoming

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Geoscience Frontiers 2018年第4期9卷 1193-1202页

作者： lisa m.Tranel Department of Geography Geology and the Environment Illinois State University

Characterizing stream erosion in any steep mountain landscape is arduous, but the challenge level increases when the stream flows through a glaciated catchment frequently modified by hillslope *** landforms and stochastic mass wasting in alpine systems may interfere with sediment delivery to downstream sites where detrital sediments are often collected to represent upstream bedrock *** use detrital sediments as indicators of erosion, we need to understand potential sediment accumulation in flat glaciated reaches or behind rockfall barriers. This study investigates the stream channel in Garnet Canyon, a glaciated catchment located in the central Teton Range, to describe hillslope coupled channel morphology and the subsequent effects on sediment transport throughout the *** cross-section surveys and sediment size measurements of the surface bedload were collected in the field within a glacially flattened segment of Garnet Canyon. Calculations of shear stress conditions allowed evaluation of the importance of mineral densities on potential grain entrainment. The length of the Garnet Canyon stream observed in this study was coupled with hillslope deposits. Critical shear stresses were sufficient to move gravel-sized sediments through all sections when calculated with quartz mineral density and through most sections when applying apatite mineral density. These results verify the application of detrital sediments to evaluate erosion rates or spatial bedrock sources because snowmelt stream flow efficiently moves entrained sediment past glacially reduced slopes and potential talus barriers.

关键词： Stream morphology Garnet Canyon Sediment Talus

Phylogeny and taxonomy of Ophiognomonia(Gnomoniaceae,Diaporthales),including twenty-five new species in this highly diverse genus

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Fungal Diversity 2012年第6期57卷 84-146页

作者： Donald m.Walker lisa A.Castlebury Amy Y.Rossman Luis C.mejía James F.white Department of Natural Sciences The University of FindlayFindlayOH 45840USA Systematic mycology&microbiology Laboratory USDA Agricultural Research ServiceBeltsvilleMD 20705USA Smithsonian Tropical Research Institute Apartado0843-03092BalboaAnconRepublic of Panama Department of Plant Biology and Pathology Rutgers UniversityNew BrunswickNJ 08901USA

Species of Ophiognomonia are leaf-inhabiting endophytes,pathogens,and saprobes that infect plants in the families Betulaceae,Fagaceae,Juglandaceae,Lauraceae,malvaceae,Platanaceae,Rosaceae,Salicaceae,and *** on extensive collecting,this speciesrich genus is now known to have a world wide distribution in primarily temperate areas,although some species are known from the *** of DNA sequences from three markers including guanine nucleotide-binding protein subunit beta-like protein(mS204),translation elongation factor 1α(tef-1α),and the ITS region including ITS1,5.8 S rDNA and ITS2 regions(ITS)were used to define phylogenetic species in *** plant association correlated with these ***-five new species of Ophiognomonia and two new combinations are proposed with descriptions and *** addition,descriptions and illustrations are provided for 12 other species of Ophiognomonia.A key is provided to the 45 currently accepted species of *** disposition of additional names in Ophiognomonia is also discussed.

关键词： Birch foliar pathogen Butternut canker GCPSR Genealogical sorting index Host associations mS204 multilocus phylogeny Walnut anthracnose and leaf blotch

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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Targeted protein delivery:carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds

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Regenerative Biomaterials 2019年第5期6卷 279-287页

作者： Constantin Edi Tanase Omar Qutachi lisa J.white Kevin m.Shakesheff Andrew W.mcCaskie Serena m.Best Ruth E.Cameron Department of materials Science and metallurgy University of CambridgeCambridge Centre for Medical MaterialsCambridge27Charles Babbage RoadCB30FSUK Centre for Biomolecular Sciences School of PharmacyUniversity of NottinghamUniversity ParkNottingham NG72RDUK Division of Trauma&Orthopaedic Surgery Department of SurgeryUniversity of CambridgeBox 180Addenbrooke’s HospitalHills RoadCambridge CB20QQUK Present address:School of Pharmacy De Montforte UniversityLeicester LE19BHUK

Tissue engineering response may be tailored via controlled,sustained release of active agents from protein-loaded degradable microparticles incorporated directly within three-dimensional(3D)ice-templated collagen ***,the effects of covalent crosslinking during scaffold preparation on the availability and release of protein from the incorporated microparticles have not been ***,we load 3D ice-templated collagen scaffolds with controlled additions of poly-(DL-lactide-co-glycolide)*** probe the effects of subsequent N-(3-dimethylaminopropyl)-N0-ethylcarbodiimide hydrochloride crosslinking on protein release,using microparticles with different internal protein *** isothiocyanate labelled bovine serum albumin is used as a model protein *** scaffolds display a homogeneous microparticle distribution,and a reduction in pore size and percolation diameter with increased microparticle addition,although these values did not fall below those reported as necessary for cell *** protein distribution within the microparticles,near the surface or more deeply located within the microparticles,was important in determining the release profile and effect of crosslinking,as the surface was affected by the carbodiimide crosslinking reaction applied to the *** of microparticles with a high proportion of protein at the surface caused both a reduction and delay in protein *** located within the bulk of the microparticles,was protected from the crosslinking reaction and no delay in the overall release profile was seen.

关键词： collagen scaffolds PLGA microparticles FITC-BSA EDC crosslinking pore size percolation diameter

POLYmERIC SURFACTANT STRUCTURE

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Chinese Journal of Polymer Science 2001年第2期19卷 135-145页

作者： P.m.Saville J.W.white Research School of Chemistry The Australian National University Canberra ACT 0200 AustraliaResearch School of Chemistry The Australian National University Canberra ACT 0200 Australia

Polymeric surfactants are amongst the most widespread of all polymers. In nature, proteins and polysaccharidescause self organization as a result of this surfactancy; in industry, polymeric surfactants play key roles in the food, explosivesand surface coatings sectors. The generation of useful nano- and micro-structures in films and emulsions as a result ofpolymer amphiphilicity and the application of mechanical stress is discussed. The use of X-ray and neutron small anglescattering and reflectivity to measure these structures and their dynamic properties will be described. New results on linear and dendritic polymer surfactants are presented.

关键词： Polymeric Surfactant Structure X-ray Neutron Reflectivity Film

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

Perspectives on the clinical development of mmunotherapy in prostate cancer

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Asian Journal of Andrology 2018年第3期20卷 253-259页

作者： lisa m Cordes James L Gulley Ravi A madan Clinical Center National Institutes of Health Bethesda MD 20892 USA Genitourinary malignancies Branch Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD 20892 USA

Despite impressive survival benefits with immunotherapy in patients with various solid tumors, the full potential of these agents in prostate cancer has yet to be realized. SipuleuceI-T demonstrated a survival benefit in this population, indicating that prostate cancer is an immunoresponsive disease; however, these results have not been matched by other agents. A large trial with ipilimumab in prostate cancer failed to meet its primary objective, and small trials with PD-1/PD-L1 inhibitors did not yield a significant improvement in overall response. However, several late-stage clinical trials are underway with other vaccines in prostate cancer. Reports of clinical benefit with immunotherapies, particularly when used in combination or a select population, have provided the framework to develop sound clinical trials. Understanding immunogenic modulation, antigen spread, biomarkers, and DNA-repair defects will also help mold future strategies. Through rational patient selection and evidence-based combination approaches, patients with prostate cancer may soon derive durable survival benefits with immunotherapies.

关键词： checkpoint inhibitor immunotherapy prostate cancer therapeutic vaccine

ESTImATION OF TImE DEPENDENT CARBON TRANSFER COEFFICIENTS USING NET ECOSYSTEm EXCHANGE DATA

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Journal of Systems Science & Complexity 2010年第3期23卷 640-664页

作者： Luther white Department of mathematics University of Oklahoma Norman

Time dependent carbon transfer coefficients are estimated using ecosystem exchange databy minimizing over variable observational intervals,Kalman filter,and variational minimization *** coefficients are determined by application of estimation procedures to subintervalsfrom a partition of the observational time period,minimizing the variance of analyzed errors withoutthe imposition of a priori transfer coefficient models in Kalman filters,and minimization with respectto transfer coefficients in variational fit-to-data *** are compared between methodsand seasonal variability is observed in the transfer coefficients.

关键词： Inverse problems kalman filter stochastic differential equations variance minimization.

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting