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Decorin treatment for reversing trabecular meshwork fibrosis in open-angle glaucoma

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Neural Regeneration Research 2016年第6期11卷 922-923页

作者： lisa J Hill Zubair Ahmed Ann logan Neuroscience and Ophthalmology University of Birmingham

In this perspective,we discuss the use of an anti-fibrotic agent Decorin to treat established fibrosis associated with glaucoma originally published by Hill et al.（2015）.Glaucoma describes a group of progressive opt... 详细信息

关键词： glaucoma trabecular originally irreversible progressive optic outflow ganglion progression elevated

Pseudogenization of the Humanin gene is common in the mitochondrial DNA of many vertebrates

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Zoological Research 2017年第4期38卷 198-202页

作者： lan S. logan 22 Parkside Drive Exmouth Devon UK

In the human the peptide Humanin is produced from the small Humanin gene which is embedded as a gene-within-a-gene in the 16S ribosomal molecule of the mitochondrial DNA （mtDNA）. The peptide itself appears to be significant in the prevention of cell death in many tissues and improve cognition in animal models. By using simple data mining techniques, it is possible to show that 99.4% of the human Humanin sequences in the GenBank database are unaffected by mutations. However, in other vertebrates, pseudogenization of the Humanin gene is a common feature; occurring apparently randomly in some species and not others. The persistence, or loss, of a functional Humanin gene may be an important factor in laboratory animals, especially if they are being used as animal models in studies of Alzheimer＇s disease （AD）. The exact reason why Humanin underwent pseudogenization in some vertebrate species during their evolution remains to be determined. This study was originally planned to review the available information about Humanin and it was a surprise to be able to show that pseudogenization has occurred in a gene in the mtDNA and is not restricted solely to chromosomal genes.

关键词： mtDNA Humanin Pseudogenization NUMT

Resilience:Lessons to be learned from safety and acceptable risk

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Journal of Safety Science and Resilience 2021年第4期2卷 253-257页

作者： Kosovac Anna Tom McLeod logan Faculty of Engineering and Information Technology The University of MelbourneAustralia Civil and Natural Resources Engineering The University of CanterburyNew Zealand

It is not unusual to see the concept of resilience housed in binary terms:Your city is either‘resilient’or *** contrast,being‘safe’is widely recognized as a statement based on‘acceptable risk’where absolute safety is *** why do we treat resilience and,as an example,the idea of“Resilient Cities”as a distinct endpoint?In this paper,we argue that this mindset is not only incongruent with current understandings of safety and risk but could create a false sense of security for systems that otherwise have been judged‘resilient’.An alternative is that we can and should consider framing resilience in the same manner as we do to *** benefit of doing this is that we can learn from the safety literature and appreciate that,like for safety,there is no such thing as absolute ***,we should be striving to constantly identify and reduce the risks to our systems and society.

关键词： Risk analysis Safety Risk assessment Resilient Resilience Urban Cities Disaster management

Amalgamated gold-nanoalloys with enhanced catalytic activity for the detection of mercury ions(Hg^2+)in seawater samples

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Nano Research 2020年第4期13卷 989-998页

作者： Natasha logan Claire McVey Christopher Elliott Cuong Cao Institute for Global Food Security School of Biological SciencesQueens University Belfast19 Chlorine GardensBelfastBT95DLUK Material and Advanced Technologies for Healthcare Queens University Belfast18-30 Malone RoadBelfastBT95BNUK

Mercury(Hg)is extremely toxic,and continues to cause major threats to aquatic life,human health and the ***^2+mainly derives from seawater as a product of atmospheric deposition,therefore there is great demand for sensing approaches that can detect Hg^2+in seawater ***,we demonstrate that the peroxidase-mimicking activity of gold nanoparticles(AuNPs)or so-called nanozymes,can be exploited for the detection of Hg^2+ions in various water *** a high electrolyte environment,the catalytic activity for the oxidation of 3,3’,5,5’-tetramethylbenzidine(TMB)was significantly diminished due to poor stability of the *** activity was reduced by-73.7%when the NaCl concentration was higher than 1.168%,which is much lower than that of seawater(-3.5%),thus presenting its unsuitability for detecting Hg^2+in harsh water *** overcome this limitation,AuNPs were first functionalized with oligo-ethylene glycol(OEG),of which their colloidal form presented high stability in NaCl concentrations up to 20%and across a wide range of pHs from ***,the catalytic activity of OEG-AuNPs for the oxidation of TMB was strongly suppressed by the coating,but enhanced upon formation of Au-Hg *** novel finding underlies a straightforward,sensitive,and highly selective detection platform for Hg^2+in water *** approach could detect the exposure limit level for Hg^2+in drinking water(i.e.,2 ppb for tap and bottled water)as set by the United States Environmental Protection Agency(EPA)and the World Health Organization(WHO).When Hg^2+was spiked into a 3.5%saline solution and a coastal seawater certified reference material(CRM),the detection limits were found to be 10 ancM 3 ppb,respectively,which exceed the Hg^2+concentrations commonly found within seawater(-60-80 ppb).The whole procedure takes less than 45 min to conduct,providing a highly innovative,rapid and low-cost approach for detecting Hg^2+in complex water matrices.

关键词： gold nanoparticles nanozyme peroxidase-like mercury detection w ater samples seawater

Your personal choices in transportation and food are important for lowering carbon emissions

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 27-32页

作者： Bruce logan Fang Zhang Wulin Yang Le Shi Institute of Energy and the Environment The Pennsylvania State UniversityUniversity ParkPA 16802USA School of Environment Tsinghua UniversityBeijing 100084China College of Environmental Sciences and Engineering Peking UniversityBeijing 100871China College of Environmental and Resource Sciences Zhejiang UniversityHangzhou 310058China

There is a global need to reduce greenhouse gas emissions to limit the extent of climate change.A better understanding of how our own activities and lifestyle influence our energy use and carbon emissions can help us enable changes in activities that can lead to reductions in carbon *** we discuss an approach based on examining carbon emissions from the perspective of the unit C,where 1 C is the CO_(2)from food a person would on average eat every *** approach shows that total CO_(2)emissions in China,normalized by the population,is 22.5 C while carbon emissions for a person in the US is 43.9 C.A better appreciation of our own energy use can be obtained by calculating carbon emissions from our own activities in units of C,for example for driving a car gasoline or electric vehicle a certain number of kilometers,using electricity for our homes,and eating different *** this information,we can see how our carbon emissions compare to national averages in different countries and make decisions that could lower our personal CO_(2)emissions.

关键词： Carbon dioxide Climate change Daily energy Greenhouse gas

Aerosol Properties and Their Impacts on Surface CCN at the ARM Southern Great Plains Site during the 2011 Midlatitude Continental Convective Clouds Experiment

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Advances in Atmospheric Sciences 2018年第2期35卷 224-233页

作者： Timothy logan Xiquan DONG Baike XI Department of Atmospheric Sciences Texas A&M University College Station TX 77843-3150 USA Department of Hydrology andAtmospheric Sciences University of Arizona Tucson AZ 85721-0081 USA

Aerosol particles are of particular importance because of their impacts on cloud development and precipitation processes over land and ocean. Aerosol properties as well as meteorological observations from the Department of Energy Atmospheric Radiation Measurement （ARM） platform situated in the Southern Great Plains （SGP） are utilized in this study to illustrate the dependence of continental cloud condensation nuclei （CCN） number concentration （NccN） on aerosol type and transport pathways. ARM-SGP observations from the 2011 Midlatitude Continental Convective Clouds Experiment field campaign are presented in this study and compared with our previous work during the 2009-10 Clouds, Aerosol, and Precipitation in the Marine Boundary Layer field campaign over the current ARM Eastern North Atlantic site. Northerly winds over the SGP reflect clean, continental conditions with aerosol scattering coefficient （~rsp） values less than 20 Mm-1 and Ncct~ values less than 100 cm .3. However, southerly winds over the SGP are responsible for the observed moderate to high correlation （R） among aerosol loading （Crsp 〉 60 Mm 1） and NCCN, carbonaceous chemical species （biomass burning smoke）, and precip- itable water vapor. This suggests a common transport mechanism for smoke aerosols and moisture via the Gull＇ of Mexico, indicating a strong dependence on air mass type. NASA MERRA-2 reanalysis aerosol and chemical data are moderately to highly correlated with surface ARM-SGP data, suggesting that this facility can represent surface aerosol conditions in the SGE especially during strong aerosol loading events that transport via the Gulf of Mexico. Future long-term investigations will help to understand the seasonal influences of air masses on aerosol, CCN, and cloud properties over land in comparison to over ocean.

关键词： aerosol indirect effect aerosol transport biomass burning smoke

Seismic Hazard Assessment of District Mansehra,Khyber Pakhtoonkhawa,Pakistan

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Acta Geologica Sinica(English Edition) 2014年第4期88卷 1157-1168页

作者： MONA lisa COMSATS Institute of Information Technology(CIIT) Islamabad PakistanDepartment of Earth SciencesQuaid-i-Azam University

The site of Mansehra is located seismically in an active regime, known as the Crystalline Nappe Zone and Hazara-Kashmir Syntaxis in NW Himalayas, Pakistan. Seismic Hazard Assessment （SHA） for the site has been carried out by considering the earthquake source zones, selection of appropriate attenuation equations, near fault effects and maximum potential magnitude estimation. The Mansehra Thrust, Oghi Fault, Banna Thrust, Balakot Shear Zone, Main Boundary Thrust, Panjal Thrust, Jhelum Fault and Muzaffarabad Fault and, further to the south, the Sanghargali, Nathiagali, and Thandiani Thrusts are the most critical tectonic features within the 50 km radius of Mansehra. Using the available instrumental seismological data from 1904 to 2007, SHA has been carried out. Other reactivated critical tectonic features in the area have been investigated. Among them the Balakot-Bagh fault, with the fault length of 120 km from Balakot to Poonch, has been considered as the most critical tectonic feature on the basis of geological/structural/seismological data. The potential earthquake of maximum magnitude 7.8 has been assigned to the Balakot-Bagh fault using four regression relations. The peak ground acceleration value of 0.25 g （10% probability of exceedance for 50 years） and 0.5 g has been calculated with the help of the attenuation equation using probabilistic and deterministic approaches.

关键词： Seismic Hazard Assessment Mansehra District NW Himalayas Pakistan Probabilistic and Deterministic Approaches Balakot-Bagh Fault

MICROSTRUCTURE CHARACTERIZATION OF LiCoO_2 COATINGS FOR MOLTEN CARBONATE FUEL CELLS COMPONENTS

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Chinese Journal of Mechanical Engineering 2002年第2期15卷 182-185页

作者： Klein lisa College of Materials Science and Engineering Fuzhou University Fuzhou 350002China ***

The sol-gel process, sing aqueous solutions, is used for dip coating ontosubstrates of 316L stainless steel. A suitable coating of Li CoO_2 is achieved by varying thethickness and heat treating at 650 deg C for 3 h. Thermal analysis, X-ray diffraction analysis andSEM are carried out to characterize the microstructure of the coatings. The results show that thecoating transforms from an amorphous gel to crystalline phases above 350 deg C, and show a porousstructure. The phase transition mechanism is discussed.

关键词： Molten carbonate fuel cells Sol-gel LiCoO_2 coating Crystalline phasetransition

A general-purpose machine learning framework for predicting properties of inorganic materials

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npj Computational Materials 2016年第1期2卷 70-76页

作者： logan Ward Ankit Agrawal Alok Choudhary Christopher Wolverton Department of Materials Science and Engineering Northwestern UniversityEvanstonILUSA Department of Electrical Engineering and Computer Science Northwestern UniversityEvanstonILUSA

A very active area of materials research is to devise methods that use machine learning to automatically extract predictive models from existing materials *** prior examples have demonstrated successful models for some applications,many more applications exist where machine learning can make a strong *** enable faster development of machine-learning-based models for such applications,we have created a framework capable of being applied to a broad range of materials *** method works by using a chemically diverse list of attributes,which we demonstrate are suitable for describing a wide variety of properties,and a novel method for partitioning the data set into groups of similar materials to boost the predictive *** this manuscript,we demonstrate how this new method can be used to predict diverse properties of crystalline and amorphous materials,such as band gap energy and glass-forming ability.

关键词： method properties inorganic