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瓷厂与锡矿及钨矿石英粉尘表面铝硅酸盐包裹的测定和分析

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中华劳动卫生职业病杂志 2006年第9期24卷 537-539页

作者： William e.wallace 陈镜琼王海椒陈卫红美国国家职业安全卫生研究所美国摩根镇26505 华中科技大学同济医学院公共卫生学院劳动卫生与环境卫生学系环境与健康教育部重点实验室

目的探讨石英粉尘表面铝硅酸盐包裹的测定方法和包裹对粉尘致病作用的影响。方法应用呼吸性粉尘采样器以2L/min采集江西钨矿、瓷厂和广西锡矿粉尘,用扫描电镜-能散X线分光计(SeM-eDS)以5keV和20keV电压照射测定呼吸性粉尘颗粒中各元素... 详细信息

目的探讨石英粉尘表面铝硅酸盐包裹的测定方法和包裹对粉尘致病作用的影响。方法应用呼吸性粉尘采样器以2L/min采集江西钨矿、瓷厂和广西锡矿粉尘,用扫描电镜-能散X线分光计(SeM-eDS)以5keV和20keV电压照射测定呼吸性粉尘颗粒中各元素成分的含量,计算不同电子伏特照射下粉尘颗粒中硅与铝的比值。结果7个瓷厂、3个锡矿和3个钨矿的47个粉尘样本共计3982个粉尘颗粒,瓷厂样本的89%(24/27)与锡矿样本的27%(3/11)和钨矿样本的56%(5/9)存在明确的铝硅酸盐包裹,与对照样本比较,差异有统计学意义(P＜0．01)。瓷厂粉尘颗粒的45%、锡矿的18%和钨矿的13%存在表面铝硅酸盐包裹。瓷厂粉尘与钨矿和锡矿粉尘表面铝硅酸盐含量的差异有统计学意义(P＜0．01),高铝硅酸盐含量的粉尘颗粒在瓷厂、锡矿和钨矿样本中的比率分别为22%、7%和10%。结论瓷厂工作场所粉尘颗粒表面夹杂铝硅酸盐含量高于钨矿和锡矿的粉尘,粉尘颗粒表面成分的分析对解释不同厂矿尘肺发病的差异有一定作用。

关键词：二氧化硅铝硅酸盐粉尘矽肺

Amount of polyhydramnios attributable to diabetes may be less than previously reported

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World Journal of Diabetes 2017年第1期8卷 7-10页

作者： lisa e Moore Department of Obstetrics and Gynecology Texas Tech Health Sciences CenterEl PasoTX 79905United States

AIM To evaluate the frequency and the quantity of polyhydramnios attributable to diabetes in *** The charts of patients with a four-quadrant amniotic fluid index(AFI) ≥ 20 cm and either a diagnosis of diabetes or a diabetes screening test during the index pregnancy were retrospectively reviewed. AFI was stratified into 5 categories and the frequency of diabetes was evaluated for each group. The frequency of polyhydramnios attributable to diabetes was compared to the frequency of polyhydramnios in the setting of fetal anomalies or no known cause. ReSULTS One thousand five hundred and forty-five patients were included in the study. eight point five percent(n = 131) had diabetes and no other cause for polyhydramnios. eleven point two percent(173) had antenatally diagnosed anomalies. For all categories of AFI except the largest(> 40.9 cm) the most common cause of polyhydramnios was idiopathic. In patients with diabetes the AFI was most likely to be between 26 cm and 35.9 *** The rate of polyhydramnios in this study is 8.5%. Patients with diabetes most commonly have mild polyhydramnios between 26 and 35.9 cm of fluid on a four-quadrant AFI.

关键词： Gestational diabetes Amniotic fluid index Diabetes in pregnancy Polyhydramnios

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粉尘致病性科研成果急需与粉尘防治相结合

中华劳动卫生职业病杂志 2008年第1期26卷 1-2页

作者：刘秉慈陈卫红 William e. wallace 中国疾病预防控制中心职业卫生与中毒控制所北京100050 华中科技大学同济医学院公共卫生学院环境与健康教育部重点实验室 National Institute for Occupational Safety and Health USA

生产性粉尘是严重的职业有害因素，矽尘与石棉尘是两种主要的、危害性很强的生产性粉尘。结晶型二氧化硅不仅可导致肺纤维化，还可导致癌症。中国是世界上接触粉尘和患尘肺病人数最多的国家。至2006年底，中国尘肺病累计病例数为616442... 详细信息

生产性粉尘是严重的职业有害因素，矽尘与石棉尘是两种主要的、危害性很强的生产性粉尘。结晶型二氧化硅不仅可导致肺纤维化，还可导致癌症。中国是世界上接触粉尘和患尘肺病人数最多的国家。至2006年底，中国尘肺病累计病例数为616442例，死亡146195例。在过去5年（2001至2006年）中，每年新病例数为8000～10000例，其中主要为矽肺和煤工尘肺。中国政府高度重视粉尘控制、粉尘毒性及粉尘致病机制的研究，并在这些方面取得了巨大成绩。

关键词：粉尘防治致病性生产性粉尘累计病例数科研职业有害因素中国政府尘肺病人

NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

大盆地地区晚第四纪断层作用的型式、年代及其与区域构造特征的关系

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地震地质译丛

地震地质译丛 1985年第4期 51-55页

作者： Robert e.wallace 张忠连

晚第四纪期间大盆地地区发生了大规模的地表断层事件,断层长数十公里,包括一米多的位移,并且可能是地震断层(图1,2)。整个区域的断层分布很不均匀:各地方的断层形式既不相同,而且断层的发生在时间上的分布也不均匀。鉴别断层作用的型式... 详细信息

晚第四纪期间大盆地地区发生了大规模的地表断层事件,断层长数十公里,包括一米多的位移,并且可能是地震断层(图1,2)。整个区域的断层分布很不均匀:各地方的断层形式既不相同,而且断层的发生在时间上的分布也不均匀。鉴别断层作用的型式,发生地点及大规模断层的重复率或重复率的变化,对于评价地震危险和为预报区内未来地震提供构造背景方面是极端重要的。正如岩石类型的分布以及重力和地磁资料所表明的那样,断层的某些型式看来与一些更为宽阔或更为综合的构造分区有关(图3)。

关键词：断层作用构造特征断层带地堑断层槽盆地地区晚第四纪型式

Recent Advancements in the Optimization Capacity Configuration and Coordination Operation Strategy of Wind-Solar Hybrid Storage System

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energy engineering 2025年第1期122卷 285-306页

作者： Hongliang Hao Caifeng Wen Feifei Xue HaoQiu Ning Yang Yuwen Zhang Chaoyu Wang edwin e.Nyakilla Department of New energy Storage Peking University Ordos Research Institute of EnergyOrdos017010China School of energy and Power engineering Inner Mongolia University of TechnologyHohhot010080China Key Laboratory of Wind energy and Solar energy Utilization Technology Inner Mongolia University of TechnologyHohhot010051China

Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy *** paper proposes a wind-solar hybrid energy storage system(HeSS)to ensure a stable supply grid for a longer period.A multi-objective genetic algorithm(MOGA)and state of charge(SOC)region division for the batteries are introduced to solve the objective function and configuration of the system capacity,***/Simulink was used for simulation *** optimization results show that for a 0.5 MW wind power and 0.5 MW photovoltaic system,with a combination of a 300 Ah lithium battery,a 200 Ah lead-acid battery,and a water storage tank,the proposed strategy reduces the system construction cost by approximately 18,000 ***,the cycle count of the electrochemical energy storage systemincreases from4515 to 4660,while the depth of discharge decreases from 55.37%to 53.65%,achieving shallow charging and discharging,thereby extending battery life and reducing grid voltage fluctuations *** proposed strategy is a guide for stabilizing the grid connection of wind and solar power generation,capability allocation,and energy management of energy conservation systems.

关键词： electric-thermal hybrid storage modal decomposition multi-objective genetic algorithm capacity optimization allocation operation strategy

Identification of factors predicting scar outcome after burn injury in children:a prospective case-control study

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Burns & Trauma 2017年第3期5卷 186-198页

作者： Hilary J. wallace Mark W. Fear Margaret M. Crowe lisa J. Martin Fiona M. Wood Burn Injury Research Unit Faculty of Health and Medical Sciences University of Western Australia Perth WA Australia Burn Injury Research Unit Faculty of Health and Medical Sciences University of Western Australia M318 35 Stirling Highway Crawley 6009 WA Australia Burn Injury Research Unit Faculty of Health and Medical Sciences University of Western Australia Perth WA Australia Burns Service of Western Australia Princess Margaret Hospital for Children and Fiona Stanley Hospital Perth WA Australia Burn Injury Research Unit Faculty of Health and Medical Sciences University of Western Australia Perth WA Australia Burns Service of Western Australia Princess Margaret Hospital for Children and Fiona Stanley Hospital Perth WA Australia

Background:There is a lack of rigorous research investigating the factors that influence scar outcome in children. Improved clinical decision-making to reduce the health burden due to post-burn scarring in children will be guided by evidence on risk factors and risk stratification. This study aimed to examine the association between selected patient, injury and clinical factors and the development of raised scar after burn injury. Novel patient factors were investigated including selected immunological co-morbidities (asthma, eczema and diabetes type 1 and type 2) and skin pigmentation (Fitzpatrick skin type). Methods:A prospective case-control study was conducted among 186 children who sustained a burn injury in Western Australia. Logistic regression was used to explore the relationship between explanatory variables and a defined outcome measure:scar height measured by a modified Vancouver Scar Scale (mVSS). Results:The overall correct prediction rate of the model was 80.6%;80.9%for children with raised scars (>1 mm) and 80.4%for children without raised scars (≤1 mm). After adjustment for other variables, each 1%increase in%total body surface area (%TBSA) of burn increased the odds of raised scar by 15.8%(95%CI=4.4-28.5%). Raised scar was also predicted by time to healing of longer than 14 days (OR=11.621;95%CI=3.727-36.234) and multiple surgical procedures (OR=11.521;1.994-66.566). Conclusions:Greater burn surface area, time to healing of longer than 14 days, and multiple operations are independently associated with raised scar in children after burn injury. Scar prevention strategies should be targeted to children with these risk factors.

关键词： Burns Wound healing Hypertrophic scar Risk factors Children

Seismic Hazard Assessment of District Mansehra,Khyber Pakhtoonkhawa,Pakistan

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Acta Geologica Sinica(english edition) 2014年第4期88卷 1157-1168页

作者： MONA lisa COMSATS Institute of Information Technology(CIIT) Islamabad PakistanDepartment of Earth SciencesQuaid-i-Azam University

The site of Mansehra is located seismically in an active regime, known as the Crystalline Nappe Zone and Hazara-Kashmir Syntaxis in NW Himalayas, Pakistan. Seismic Hazard Assessment （SHA） for the site has been carried out by considering the earthquake source zones, selection of appropriate attenuation equations, near fault effects and maximum potential magnitude estimation. The Mansehra Thrust, Oghi Fault, Banna Thrust, Balakot Shear Zone, Main Boundary Thrust, Panjal Thrust, Jhelum Fault and Muzaffarabad Fault and, further to the south, the Sanghargali, Nathiagali, and Thandiani Thrusts are the most critical tectonic features within the 50 km radius of Mansehra. Using the available instrumental seismological data from 1904 to 2007, SHA has been carried out. Other reactivated critical tectonic features in the area have been investigated. Among them the Balakot-Bagh fault, with the fault length of 120 km from Balakot to Poonch, has been considered as the most critical tectonic feature on the basis of geological/structural/seismological data. The potential earthquake of maximum magnitude 7.8 has been assigned to the Balakot-Bagh fault using four regression relations. The peak ground acceleration value of 0.25 g （10% probability of exceedance for 50 years） and 0.5 g has been calculated with the help of the attenuation equation using probabilistic and deterministic approaches.

关键词： Seismic Hazard Assessment Mansehra District NW Himalayas Pakistan Probabilistic and Deterministic Approaches Balakot-Bagh Fault

Mechanisms, prevention and clinical implications of nonsteroidal anti-inflammatory drug-enteropathy

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World Journal of Gastroenterology 2013年第12期19卷 1861-1876页

作者： John L wallace Farncombe Family Digestive Health Research Institute McMaster University Inflammation Research Network University of Calgary

This article reviews the latest developments in understanding the pathogenesis, detection and treatment of small intestinal damage and bleeding caused by nonsteroidal anti-inflammatory drugs (NSAIDs). With improvements in the detection of NSAID-induced damage in the small intestine, it is now clear that this injury and the associated bleeding occurs more frequently than that occurring in the stomach and duodenum, and can also be regarded as more dangerous. However, there are no proven-effective therapies for NSAID-enteropathy, and detection remains a challenge, particularly because of the poor correlation between tissue injury and symptoms. Moreover, recent studies suggest that commonly used drugs for protecting the upper gastrointestinal tract (i.e., proton pump inhibitors) can significantly worsen NSAID-induced damage in the small intestine. The pathogenesis of NSAID-enteropathy is complex, but studies in animal models are shedding light on the key factors that contribute to ulceration and bleeding, and are providing clues to the development of effective therapies and prevention strategies. Novel NSAIDs that do not cause small intestinal damage in animal models offer hope for a solution to this serious adverse effect of one of the most widely used classes of drugs.

关键词： Anti-inflammatory Ulcer Prostaglandin Non-steroidal Bleeding Intestinal Bile enterohepatic Bacteria Hydrogen sulfide Aspirin Hemorrhage