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世界建筑 1995年第2期 40-41页

作者： Cuningham hamilton QuiterArchitects 段峰 CHQ事务所

近年来的美国建筑业处于萧条时期,设计市场竞争白热化,许多大公司都被迫缩减。但有一些公司却因一套独特的经营系统不但没有被吞并,而且因时得利在萧条阶段扩大了业务。这里介绍的CHQ事务所及其采用的“团体系统”

关键词：娱乐中心格兰特体系统建设项目建筑师事务所设计市场竞争技术问题业主密西西比州

Effects of lysophosphatidic acid antagonists on mitogenic responses in human breast cancer cell lines

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Effects of lysophosphatidic acid antagonists on mitogenic re...

对近期提出的太阳-QBO-天气之间关系的看法

第十五届国际药理学大会

作者： hamilton Renae Meier Kathryn Department of Biochemistry. Washington State University.Pullman. Washington. USA 99164. Department of Pharmaceutical Sciences. Washington State University. Pullman. Washington. USA 99163- 6534.

＜正＞ Lysophosphatidic acid （LPA） refers to a family of phospholipid mediators that bind to G- protein- coupled receptors （LPA1. LPA2. LPA3）. This study evaluated the role of LPA in human breast cancer cells. Specifically, the effects of LPA antagonists on pro - mitogenic actions of epidermal growth factor （EOF） were investigated. Two human breast cancer cell lines were used. MCF - 7 and MDA - MB - 231. Both cell lines express mRNA for LPA1, LPA2, and LPA3. At 10mM. 18: 1 LPA enhances both directed （ chemotactic） and random （chemokinetic） migration of MDA - MB - 231 cells. Both MCF - 7 and MDA - MB - 231 cells generate LPA;LPA levels in medium are increased by exogenous 18:1 LPA and by EGF. MCF - 7 and MDA - MB - 231 cells proliferate in response to EGF and LPA. LPA and EGF also stimulate activation of Erk and Akt kinases in both cell lines. LPA- induced activations of Erk and Akt kinases. as well as proliferation, are inhibited by Ki16425 and VPC32183, antagonists for LPA1/LPA3. Kil6425 and VPC32183 also inhibit EGF- induced activation of Akt （MDA-MB-231 andMCF-7） and Erk （MCF-7）. These studies suggest a potential role for LPA as an autocrine mediator of mitogenic signaling in breast cancer cells.

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气象科技 1993年第2期21卷 69-76页

作者： Kevin hamilton 杨义文 GFDL普林斯顿大学

联系太阳活动,考察了1875—1936年期间若干测站的地面气象资料,特别是想看一看这些历史资料是否与 van Loon 和 Labitzke(vLL)最近根据现代资料(1950年以后)所找出的太阳-QBO-天气之间的关系相一致。在把 vLL 的分析往前延伸时,主要问... 详细信息

联系太阳活动,考察了1875—1936年期间若干测站的地面气象资料,特别是想看一看这些历史资料是否与 van Loon 和 Labitzke(vLL)最近根据现代资料(1950年以后)所找出的太阳-QBO-天气之间的关系相一致。在把 vLL 的分析往前延伸时,主要问题是不知道 QBO 的位相。在该研究中,对 QBO 位相的数百万种可能的序列重复了 vLL 的计算。其结果揭示出在早期资料中再现 vLL 的结果时存在的一些问题。这表明,或者是 QBO 活动在过去是不同的,或者是vLL关于太阳-天气关系的研究结果对长序列资料是不稳定的。

关键词：太阳天气平流层准两年振荡

Make the univent tube more effective in one lung ventilation

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Make the univent tube more effective in one lung ventilation

2006年中华医学会全国麻醉学术年会

作者： hamilton Shay Alexandra Bastien Department of Anesthesiology Montefiore Medical Center111 E 210th streetBronxNew York 10467 U．S．A．

This brief report describes a simple way to improve the Univent tube in one lung ventilation. Modified connection tubing is applied, which make effective suction possible through the bronchial block port and deliberately collapses the non -dependent lung faster. It may help to shunt the blood to the dependent lung within a shorter period of time. This type of suction may also make it easier to remove blood or secretion within the bronchus of the nondependent lung.

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人与机器人的未来方程式

疯狂英语（初中天地） 2007年第9期 16-19页

作者： Linda.hamilton 小狐

刚过去的暑假,大家有没有进电影院感受《变形金刚》超炫的视觉效果?这部电影再次将我们的目光聚集在机器人身上。从小说到电影,凡是涉及未来的主题总少不了这种机械生命体的身影。过去的作家认为它们会让人类从此衣食无忧,现在的导演则... 详细信息

刚过去的暑假,大家有没有进电影院感受《变形金刚》超炫的视觉效果?这部电影再次将我们的目光聚集在机器人身上。从小说到电影,凡是涉及未来的主题总少不了这种机械生命体的身影。过去的作家认为它们会让人类从此衣食无忧,现在的导演则担心机器终有一天反客为主——其实像《变形金刚》这样,交个机器人朋友可能也是一个不错的未来哦!

关键词：机器人方程式创造物好莱坞《变形金刚》

Modeling the impact of changing sexual behaviors with opposite-sex partners and STI testing among women and men ages 15-44 on STI diagnosis rates in the United States 2012-2019

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Infectious Disease Modelling 2023年第4期8卷 1169-1176页

作者： Deven T.hamilton David A.Katz Laura T.Haderxhanaj Casey E.Copen Ian H.Spicknall Matthew Hogben Center for Studies in Demography and Ecology University of WashingtonSeattleWAUSA Department of Global Health University of WashingtonSeattleWAUSA Division of STD Prevention National Center for HIV/AIDSHepatitisSexually Transmitted DiseaseTuberculosis PreventionCenters for Disease Control and PreventionAtlantaGAUSA

Objective:To estimate the potential contributions of reported changes in frequency of penile-vaginal sex(PVS),condom use and STI screening to changes in gonorrhea and chlamydial diagnoses from 2012 to ***:An agent-based model of the heterosexual population in the *** the STI *** was calibrated to 2012 diagnosis rates,testing,condom use,and frequency of *** used behaviors from the 2017-2019 NSFG,and we evaluated changes in diagnosis and incidence rates in ***:Higher testing rates increased gonorrhea and chlamydia diagnosis by 14%and 13%,respectively,but did not reduce *** frequency of PVS reduced the diagnosis rate for gonorrhea and chlamydia 6%and 3%respectively while reducing incidence by 10%and 9%*** condom use had negligible impact on diagnosis and ***:Understanding how changing behavior drives STI incidence is essential to addressing the growing *** in testing and frequency of PVS likely contributed to some,but not all,of the changes in *** research is needed to understand the context within which changing sexual behavior and testing are occurring.

关键词： Gonorrhea Chlamydia Agent-based modeling Simulation

Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease

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World Journal of Gastroenterology 2009年第10期15卷 1209-1218页

作者： Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele Department of Internal Medicine University of Nebraska Medical Center 986350 Nebraska Medical Center Omaha NE 68198-6350 United States Veterans Administration Alcohol Research Center Omaha Veterans Administration Medical Center 4101 Woolworth Avenue Omaha NE 68105 United States Department of Pathology and Microbiology University of Nebraska Medical Center 986495 Nebraska Medical Center Omaha NE 68198-6495 United States

The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD.

关键词： Alcoholic liver disease Inflammation Fibrosis Sinusoidal liver endothelial cells Kupffer cells Hepatocyte Stellate cells Precision cut liver slices

Reduction of mitomycin C resistance in human bladder cancer T24 cells by knocking-down ras oncogene

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Cancer Drug Resistance 2018年第1期1卷 59-71页

作者： Osama Sharaf Eldin Abdel-Motaal Fouda Amany R.Youssef Peter hamilton Perry Maxwell Kate E.Williamson Weston General Hospital Weston-super-Mare BS234TQUK Faculty of Medicine Mansoura UniversityMansoura 35516Egypt Centre for Cancer Research and Cell Biology Queen's UniversityBelfast BT97AEUK

Aim:Mitomycin C(MMC)is a commonly used as intravesical treatment for superficial bladder ***,its role in combination with ras inhibition has not been *** aim of this study was to explore the role of ras in MMC-induced apoptosis in T24 bladder cancer cells and to determine the efficacy of combination therapy in ***:We measured the effects of various doses of MMC on apoptosis induction as well as on ras,ERK and Ki-67 protein expression by T24 cell line using immunocytochemistry,flow cytometry and Western *** also tested the effect of siRNA on ras employed singly or in combination with ***:T24 cells expressed high level of ras *** treatment increased the level of ras and ERK protein expression after 24 h,and decreased these levels after 72 *** siRNA(100 nmol/L)caused massive apoptosis associated with a marked decrease in ras expression in T24 *** combined with low doses of MMC,ras siRNA(50 nmol/L)sensitized T24 cells to apoptosis and decreased their expression of *** effect of combined therapy was higher than that of either compound used *** levels of ERK,a downstream target of ras,declined following combination ***:Ras siRNA in combination with low dose MMC is a possible treatment strategy for patients with ras-positive bladder tumors.

关键词： Mitomycin C ras oncogene T24 cells bladder cancer siRNA

糖皮质激素与炎症因子对应急时相反应蛋白SIP24/24p3的协同调控作用及其意义(英文)

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生理学报 2003年第5期55卷 525-529页

作者：刘全胜 Marit Nilsen-hamilton 熊思东复旦大学上海医学院免疫学系教育部分子医学重点实验室上海基因免疫与疫苗研究中心上海200032 Biochemistry Biophysics and Molecular Biology Iowa State University Ames IA 5001 I USA

小鼠应急时相反应蛋白SIP24/24p3有抗炎症和特异性诱导白细胞凋亡的功能,其在体内的表达是高度特异性的。为研究 SIP24/24p3的调控因子及机制,我们在小鼠 Balb/cT3和 BNL细胞培养中通过灵敏的^(35)S代谢标记方法检测SIP24/24p3蛋白的表... 详细信息

小鼠应急时相反应蛋白SIP24/24p3有抗炎症和特异性诱导白细胞凋亡的功能,其在体内的表达是高度特异性的。为研究 SIP24/24p3的调控因子及机制,我们在小鼠 Balb/cT3和 BNL细胞培养中通过灵敏的^(35)S代谢标记方法检测SIP24/24p3蛋白的表达水平,定量观测分析了糖皮质激素化合物dexamethasone对SIP24/24p3的诱导作用及其与炎症因子白介素6(IL-6)和肿瘤坏死因子α(TNF-α)的协同调控作用。结果显示:(1)在Balb/c 3T3和BNL细胞中,dexamethasone对SIP24/24p3都有明显诱导作用,这种诱导作用在BNL细胞中尤其显著;(2)在Balb/c3T3和BNL细胞中dexamethasone与IL-6协同诱导SIP24/24p3;(3)在Balb/c 3T3细胞中dexamethasone与TNF-α对SIP24/24p3有协同诱导效应,而在 BNL细胞中 dexamethasone与 TNF-α对 SIP24/24p3的诱导表现为相加效应;(4)在 Balb/c 3T3和BNL细胞中 dexamethasone与IL-6/TNF-α对SIP24/24p3的诱导分别表现出协同和相加效应。多种因子对SIP24/24p3的协同诱导调控有助于阐明其在体内的高度特异表达及机制,SIP24/24p3在不同细胞中的不同表达格局也对体内应急时相反应蛋白在肝脏外和肝脏内的表达方式及诱导机制有提示作用。SIP24/24p3能同时被炎症因子和抗炎症因子诱导的事实显示了其在炎症全过程中的重?

关键词：应急时相反应蛋白SIP24/24p3 ^35S代谢标记糖皮质激素白介素6 肿瘤坏死因子α

Comparative Evaluation of Peptidases Produced by Penicillium corylophilum and Penicillium waksmanii in Solid State Fermentation Using Agro-industrial Residues

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Journal of Agricultural Science and Technology(B) 2013年第3期3卷 230-237页

作者： Ronivaldo Rodrigues da Silva Tamara Angelo hamilton Cabral Institute of Biosciences Letters and Exact Sciences Sao Paulo State University UNESP SSo Josd do Rio Preto Sao Paulo Brazil Department Pharmaceutical Sciences School of Pharmaceutical Sciences ofRibeirao Preto University ofSao Paulo RibeiraoPreto Sao Paulo CEP 14040-903 Brazil

In this present work, the best conditions for production of peptidases under solid state fermentation by the fungi Penicillium corylophilum and Penicillium waksmanii, partial purification using Sephadex G-75 gel filtration column, as well as the biochemical characterization of the partial purified enzymes were investigated. P. corylophilum showed the best production in medium containing wheat bran, agro-industrial residue, without additives （egg albumin or casein）, in which peptidase activity reached 520 U mL^-1 and the enzyme displayed the optimum activity between pH range from 7 to 8 and 60 ℃. It also showed high stability in wide pH range and temperature until 45 ℃ for 60 min of incubation. On the other hand, P. waksmanii, the best production was noted in a medium containing wheat bran （95%） and casein （5%）, reaching 545 U mL^-1, with proteolytic optimum activity at pH 7.5 and 55 ℃. The enzyme was mainly stable in pH range from 8 to 9 and at temperatures until 45 ℃ for 60 rain of incubation. The peptidases secreted by both fungi were inhibited in the presence of phenylmethane sulfonyl fluoride, showing that they belong to the subclass of serine peptidases.

关键词： Serine peptidase biochemical characterization enzymatic extract fungi.