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Genome-wide association studies for inflorescence type and remontancy in Hydrangea macrophylla

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Horticulture Research 2020年第1期7卷 2477-2485页

作者： Xingbo Wu lisa W.Alexander Oak Ridge Institute of Science and Technology Otis L.Floyd Nursery Research Center472 Cadillac LaneMcMinnvilleTNUSA U.S.Department of Agriculture Agricultural Research ServiceU.S.National ArboretumFloral and Nursery Plants Research UnitOtis L.Floyd Nursery Research Center472 Cadillac LaneMcMinnvilleTNUSA

Inflorescence type and remontancy are two valuable traits in bigleaf hydrangea(Hydrangea macrophylla L.)and both are recessively *** marker-assisted selection(MAS)can greatly reduce the time necessary to breed cultivars with desired *** this study,a genome-wide association study(GWAS)using 5803 single-nucleotide polymorphisms(SNPs)was performed using a panel of 82 bigleaf hydrangea *** SNP locus(Hy_CAPS_Inflo)associated with inflorescence type was identified with general linear model(GLM)and mixed linear model(MLM)methods that explained 65.5%and 36.1%of the phenotypic variations,***-three SNPs associated with remontancy were detected in GLM whereas no SNP was detected in *** SNP locus(Hy_CAPS_Inflo)was converted to a cleaved amplified polymorphic sequence(CAPS)marker that showed absolute identification accuracy(100%)of inflorescence type in a validation panel consisting of eighteen *** *** SNP was investigated in 341 F1 progenies using genotyping by sequencing(GBS)and co-segregated with inflorescence type(χ^(2)=0.12;P=0.73).The SNP was subsequently used for breeding selection using kompetitive allele specific PCR(KASP)*** directions for the use of genomics and MAS in hydrangea breeding improvement are *** results presented in this study provide insights for further research on understanding genetic mechanisms behind inflorescence type and remontancy in *** CAPS and KASP markers developed here will be immediately useful for applying MAS to accelerate breeding improvement in hydrangea.

关键词： breeding cultivar CAPS

Eating as a motivated behavior:modulatory effect of high fat diets on energy homeostasis,reward processing and neuroinflammation

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Integrative Zoology 2018年第6期13卷 673-686页

作者： Michael J.BUTLER lisa A.ECKEL Department of Psychology and Program in Neuroscience Florida State UniversityTallahasseeFloridaUSA

Eating is a basic motivated behavior that provides fuel for the body and supports brain *** ensure survival,the brain’s feeding circuits are tuned to monitor peripheral energy balance and promote food-seeking behavior when energy stores are *** brain’s bias toward a positive energy state,which is necessary to ensure adequate nutrition during times of food scarcity,is evolutionarily conserved across mammalian species and is likely to drive overeating in the presence of a palatable,energy-dense *** models of diet-induced overeating have played a vital role in investigating how the drive to consume palatable food may override the homeostatic processes that serve to maintain energy *** animal models have provided valuable insights into the neurobiological mechanisms underlying homeostatic and non-homeostatic eating,motivation and food reward,and the development of obesity and related ***,we provide a brief review of this literature and discuss how diet-induced inflammation in the central nervous system impacts the neural control of food intake and regulation of body *** connection between diet and the immune system provides an exciting new direction for the study of ingestive behavior and the pathophysiology of obesity.

关键词： high fat diet inflammation obesity

Amount of polyhydramnios attributable to diabetes may be less than previously reported

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World Journal of Diabetes 2017年第1期8卷 7-10页

作者： lisa E Moore Department of Obstetrics and Gynecology Texas Tech Health Sciences CenterEl PasoTX 79905United States

AIM To evaluate the frequency and the quantity of polyhydramnios attributable to diabetes in *** The charts of patients with a four-quadrant amniotic fluid index(AFI) ≥ 20 cm and either a diagnosis of diabetes or a diabetes screening test during the index pregnancy were retrospectively reviewed. AFI was stratified into 5 categories and the frequency of diabetes was evaluated for each group. The frequency of polyhydramnios attributable to diabetes was compared to the frequency of polyhydramnios in the setting of fetal anomalies or no known cause. RESULTS One thousand five hundred and forty-five patients were included in the study. Eight point five percent(n = 131) had diabetes and no other cause for polyhydramnios. Eleven point two percent(173) had antenatally diagnosed anomalies. For all categories of AFI except the largest(> 40.9 cm) the most common cause of polyhydramnios was idiopathic. In patients with diabetes the AFI was most likely to be between 26 cm and 35.9 *** The rate of polyhydramnios in this study is 8.5%. Patients with diabetes most commonly have mild polyhydramnios between 26 and 35.9 cm of fluid on a four-quadrant AFI.

关键词： Gestational diabetes Amniotic fluid index Diabetes in pregnancy Polyhydramnios

Exploring innovative synthetic solutions for advanced polymer-based electrochromic energy storage devices:Phenoxazine as a promising chromophore

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Journal of Energy Chemistry 2024年第4期91卷 433-452页

作者： Catalin-Paul Constantin Mihaela Balan-Porcarasu Gabriela lisa “Petru Poni”Institute of Macromolecular Chemistry Electroactive Polymers&Plasmochemistry Laboratory41A Grigore Ghica Voda AlleyIasi 700487Romania “Gh.Asachi”Technical University Iasi Faculty of Chemical EngineeringBd.Mangeron 71Iasi 700050Romania

The current investigation offers an innovative synthetic solution regarding electrochromic(EC)and energy storage applications by exploring phenoxazine(POZ)***,three POZ-based polymers(polyimide,polyazomethine,and polyamide)were synthesized to ascertain the superior *** polyamide exhibited remarkable attributes,including high redox stability during 500 repetitive CVs,optical contrast of 61.98%,rapid response times of 1.02 and 1.38 s for coloring and bleaching,EC efficiency of 280 cm^(2)C^(-1).and decays of the optical density and EC efficiency of only 12.18%and 6.23%after 1000 ***,the energy storage performance of polyamide PA was tested,for which the following parameters were obtained:74.7 F g^(-1)(CV,scan rate of 10 mV s^(-1))and 118 F g^(-1)(GCD,charging current of 0.1 A g^(-1)).Then,the polyamide was tested in EES devices,which yielded the following EC parameters:an optical contrast of 62.15%,response times of 9.24 and 5.01 s for coloring and bleaching,EC efficiency of 178 cm^(2)C^(-1),and moderate decays of 20.25%and 23.24%for the optical density and EC efficiency after 500 *** energy storage performance included a capacitance of 106 F g^(-1)(CV,scan rate of 0.1 mV s^(-1))and 9.23 F g^(-1)(GCD,charging current of 0.1 A g^(-1)),capacitance decay of 11.9%after500 cycles,and 1.7 V retention after 2 ***,two EES devices connected in series powered a 3 V LED for almost 30 s.

关键词： Polymers Phenoxazine Electrochromic Energy storage Electrochromi cenergy storage devices

When Virtues, Roles and Duties Fail: Early Greek and Chinese Accounts & Akrasia

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Frontiers of Philosophy in China 2019年第1期14卷 29-46页

作者： lisa Raphals Department of Comparative Literature and Languages University of California Riverside CA 92521-0321 USA

Both the Mohist canon and the works of Aristotle recognize that people sometimes fail to act according to virtues, roles and duties, what in a Western context is called akrasia or ''weakness of will," an important topic in both Greek and contemporary philosophy. I argue that questions of akrasia are treated different in the early Chinese and ancient Greek philosophy. Greek accounts focus on issues of will and control, while some Chinese thinkers treat akrasia as a lack of a skill, and the failure to act in the right way is less lack of will than lack of skill. I begin with a brief account of the problem of akrasia as first presented by Plato in the "Protagoras" and Republic, and developed by Aristotle in the Nicomachean Ethics. I then turn to akrasia in an early Chinese context, focusing on a very different Mohist view of akrasia as lack of a skill. Finally, I contrast the "skill" the Mohists find lacking with a very different account of skill in the Zhuangzi.

关键词： akrasia Aristotle Mozi "Protagoras "skill Zhuangzi

Approximation of the Mean Escape Time for a Tilted Periodic Potential

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Communications in Computational Physics 2019年第1期25卷 1-40页

作者： Tamra Heberling lisa Davis Tomas Gedeon Los Alamos National Laboratory XTD-SSLos AlamosNM87545USA Department of Mathematical Sciences Montana State UniversityBozemanMT59717-2400USA

We present a formula approximating the mean escape time(MST)of a particle from a tilted multi-periodic potential *** potential function consists of a weighted sum of a finite number of component functions,each of which is *** this particular case,the least period of the potential function is a common period amongst all of its component *** approximation of the MST for the potential function is derived,and this approximation takes the form of a product of the MSTs for each of the individual periodic component *** first example illustrates the computational advantages of using the approximation for model validation and parameter tuning in the context of the biological application of DNA *** also use this formula to approximate the MST for an arbitrary tilted periodic potential by the product of MSTs of a finite number of its Fourier *** examples using truncated Fourier series are presented and analyzed.

关键词： Brownian Ratchet multi-periodic potential tilted periodic potential Fokker-Plank equation

Disease monitoring in inflammatory bowel disease

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World Journal of Gastroenterology 2015年第40期21卷 11246-11259页

作者： Shannon Chang lisa Malter David Hudesman Division of Gastroenterology New York University

The optimal method for monitoring quiescent disease in patients with Crohn's disease(CD) and ulcerative colitis is yet to be determined. Endoscopic evaluation with ileocolonoscopy is the gold standard but is invasive,costly,and time-consuming. There are many commercially available biomarkers that may be used in clinical practice to evaluate disease status in patients with inflammatory bowel disease(IBD),but the most widely adopted biomarkers are C-reactive protein(CRP) and fecal calprotectin(FC). This review summarizes the evidence for utilizing CRP and FC for monitoring IBD during clinical remission and after surgical resection. Endoscopic correlation with CRP and FC is evaluated in each disease state. Advantages and drawbacks of each biomarker are discussed with special consideration of isolated ileal CD. Fecal immunochemical testing,traditionally used for colorectal cancer screening,is mentioned as a potential new alternative assay in the evaluation of IBD. Based on a mixture of information gleaned from biomarkers,clinical status,and endoscopic evaluation,the best treatment decisions can be made for the patient with IBD.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerat

Hunting down the dominating subclone of cancer stem cells as a potential new therapeutic target in multiple myeloma: An artificial intelligence perspective

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World Journal of Stem Cells 2020年第8期12卷 706-720页

作者： lisa X Lee Shengwen Calvin Li Division of Hematology/Oncology Department of MedicineChao Family Comprehensive Cancer CenterUCI HealthOrangeCA 92868United States Neuro-oncology and Stem Cell Research Laboratory CHOC Children's Research InstituteChildren's Hospital of Orange CountyOrangeCA 92868United States Department of Neurology University of California-Irvine School of MedicineOrangeCA 92868United States

The development of single-cell subclones,which can rapidly switch from dormant to dominant subclones,occur in the natural pathophysiology of multiple myeloma(MM)but is often"pressed"by the standard treatment of *** emerging subclones present a challenge,providing reservoirs for chemoresistant *** advancement is required to track MM subclonal changes,as understanding MM's mechanism of evolution at the cellular level can prompt the development of new targeted ways of treating this *** methods to study the evolution of subclones in MM rely on technologies capable of phenotypically and genotypically characterizing plasma cells,which include immunohistochemistry,flow cytometry,or ***,all of these technologies may be limited by the sensitivity for picking up rare *** contrast,more incisive methods such as RNA sequencing,comparative genomic hybridization,or whole-genome sequencing are not yet commonly used in clinical *** we introduce the epidemiological diagnosis and prognosis of MM and review current methods for evaluating MM subclone evolution,such as minimal residual disease/multiparametric flow cytometry/next-generation sequencing,and their respective advantages and *** addition,we propose our new single-cell method of evaluation to understand MM's mechanism of evolution at the molecular and cellular level and to prompt the development of new targeted ways of treating this disease,which has a broad prospect.

关键词： Multiple myeloma Single cells Single-cell transcriptome Subclonal evolution Cancer stem cells Systemic tracking of single-cell landscape Artificial intelligence medicine

Complex pathologies of angiotensin Ⅱ-induced abdominal aortic aneurysms

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第8期12卷 624-628页

作者： Alan DAUGHERTY lisa A. CASSIS Hong LU Saha Cardiovascular Research Center University of KentuckyLexington KY40536-0509 USA Graduate Center for Nutritional Sciences University of KentuckyLexington KY40536-0200 USA

Angiotensin II （Angll） is the primary bioactive peptide of the renin angiotensin system that plays a critical role in many cardiovascular diseases. Subcutaneous infusion of Angll into mice induces the development of abdominal aortic aneurysms （AAAs）. Like human AAAs, Angll-induced AAA tissues exhibit progressive changes and considerable heterogeneity. This complex pathology provides an impediment to the quantification of aneurysmal tissue composition by biochemical and immunostaining techniques. Therefore, while the mouse model of Angll-induced AAAs provides a salutary approach to studying the mechanisms of the evolution of AAAs in humans, meaningful interpretation of mechanisms requires consideration of the heterogeneous nature of the diseased tissue.

关键词： Abdominal aortic aneurysms Angiotensin II,Pathologies Mouse