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Bioactive Materials 2022年第8期7卷 134-144页

作者： Xin Qin Lirong Xiao Ni Li Chen Hou Wenman Li Jiajie Li Naihong Yan Yunfeng Lin State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu610041China Research Laboratory of Ophthalmology West China HospitalSichuan UniversityChengdu610041China College of Biomedical Engineering Sichuan UniversityChengdu610041China

Choroidal neovascularization(CNV)is a common pathological feature of various eye diseases and an important cause of visual impairment in middle-aged and elderly patients.In previous studies,tetrahedral framework nucleic acids(tFNAs)showed good carrier performance.In this experiment,we developed microRNA-155-equipped tFNAs(T-155)and explored its biological effects on CNV.Based on the results of in-vitro experiments,T-155 could regulate macrophages into the antiangiogenic M1 type.Then,we injected T-155 into the vitreous of laser-induced CNV model mice and found that T-155 significantly reduced the size and area of CNV,inhibited blood vessel leakage.In summary,we prove that T-155 could regulate the inflammatory process of CNV by polarizing macrophages,thereby improving the symptoms of CNV.Thus,T-155 might become a new DNA-based drug with great potential for treating CNV.

关键词： Choroidal neovascularization Tetrahedral framework nucleic acid Macrophages MicroRNA-155 Immunity therapy

Unexpected high-temperature brittleness of a Mg-Gd-Y-Ag alloy

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Journal of Magnesium and Alloys 2022年第9期10卷 2510-2515页

作者： Lirong Xiao Xuefei Chen Huiyan Ning Ping Jiang Yi Liu Bin Chen Dongdi Yin Hao Zhou Yuntian Zhu Nano and Heterogeneous Materials Center School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Mechanical and Electrical Engineering Heilongjiang Institute of TechnologyHarbin 150050China ThermoFisher Scientific Shanghai 201210China Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuan 610031China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China

Rare earth(RE)can produce excellent precipitation hardening in Mg alloys.However,when forming a solid solution,it also deteriorates formability,a problem that can usually be overcome by raising deformation temperature.Here we report an unexpected observation of high temperature brittleness in a Mg-Gd-Y-Ag alloy.As the temperature reached 500℃,the formability decreased drastically,leading to severe intergranular fracture under only 0.5% strain.This was caused by failure of grain boundaries,which are weakened by segregated interfacial compounds.

关键词： Interfacial compounds Formability High temperature brittleness Grain boundary sliding

Photonic graphene with reconfigurable geometric structures in coherent atomic ensembles

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Frontiers of physics 2023年第5期18卷 217-225页

作者： Fuqiang Niu Hengfei Zhang Jinpeng Yuan Liantuan xiao Suotang Jia lirong Wang State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyShanxi UniversityTaiyuan 030006China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Photonic graphene,possesses a honeycomb-like geometric structure,provides a superior platform for simulating photonic bandgap,Dirac physics,and topological photonics.Here,the photonic graphene with reconfigurable geometric structures is demonstrated in a 5S_(1/2)–5P_(3/2)–5D_(5/2) cascade-type 85Rb atomic ensembles.A strong hexagonal-coupling field,formed by the interference of three identical coupling beams,is responsible for optically inducing photonic graphene in atomic vapor.The incident weak probe beam experiences discrete diffraction,and the observed pattern at the output plane of vapor cell exhibits a clear hexagonal intensity distribution.The complete photonic graphene geometries from transversely stretched to longitudinally stretched are conveniently constructed by varying the spatial arrangement of three coupling beams,and the corresponding diffraction patterns are implemented theoretically and experimentally to map these distorted geometric structures.Moreover,the distribution of lattice sites intensity in photonic graphene is further dynamically adjusted by two-photon detuning and the coupling beams power.This work paves the way for further investigation of light transport and graphene dynamics.

关键词： atomic ensembles photonic graphene geometric structures discrete diffraction

Formation mechanism of co-axial grain boundaries in a Mg alloy

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Journal of Magnesium and Alloys 2023年第3期11卷 1094-1101页

作者： Zhen Peng Yi Liu Lirong Xiao Yue Yang Bo Gao Mengning Xu Zhaohua Hu Yandong Yu Xuefei Chen Hao Zhou School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China Nano and Heterogeneous Materials Center School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China Association for Science and Technology Nanjing University of Science and TechnologyNanjing 210094China Ansteel Beijing Research Institute Co. Ltd.Beijing 102209China Key Laboratory of Advanced Manufacturing and Intelligent Technology Ministry of EducationHarbin University of Science and TechnologyHarbin 150080China

Due to the insufficient slip systems in hexagonal close-packed structure,twinning is frequently activated to support stable plastic deformation of Mg alloy.In this work,we found four typical twin-like interfaces with misorientations of 102°,109°,142°and 149°,respectively,which had not only a shared[1120]zone axis of neighboring grains,but also overlapped diffraction spots similar to twins.However,highresolution transmission electron microscope(HRTEM)analysis revealed that the interfaces in real space deviated from the supposed twinning planes in reciprocal space,i.***.their overlapped diffraction spots.We clarified that the incoherent interfaces were co-axial grain boundaries(CGBs).Additionally,a special angle ofθ,close to 90°,between the interface and one side of basal plane,was frequently formed in CGBs.We proposed that interaction of multiple twinning contributes to the formation of CGBs,and theθis formed due to alternative tensile and compression twinning under a uniaxial loading.

关键词： Interface Twinning Tilt boundaries TEM Formation mechanism

Hibernation with rhythmicity:the circadian clock and hormonal adaptations of the hibernating Asiatic toads(Bufo gargarizans)

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Integrative Zoology 2022年第4期17卷 656-669页

作者： Zhigang XIE Ibrahim M.AHMAD lirong ZUO Feng xiao Yongpeng WANG Dongming LI Zhejiang Academy of Agricultural Sciences HangzhouChina College of Chemistry and Life Science Zhejiang Normal UniversityJinhuaChina Ministry of Education Key Laboratory of Molecular and Cellular Biology Key Laboratory of Animal PhysiologyBiochemistry and Molecular Biology of Hebei ProvinceCollege of Life SciencesHebei Normal UniversityShijiazhuangChina

Hibernation is one of the fundamental strategies in response to cold environmental temperatures.During hibernation,the endocrine and circadian systems ensure minimal expenditure of energy for survival.The circadian rhythms of key hormones,melatonin(MT),corticosterone(CORT),triiodothyronine(T3),and thyroxine(T4),and the underlying molecular regulatory mechanisms of hibernation have been well determined in mammals but not in ectotherms.Here,a terrestrial hibernating species,Asiatic toad(Bufo gargarizans),was employed to investigate the plasma CORT,MT,T3,and T4;and the retina,brain,and liver mRNA expression of the core clock genes,including circadian locomotor output cycles kaput(Clock),brain and muscle ARNT-like 1(Bmal1),cryptochrome(Cry)1 and 2,and period(Per)1 and 2,at 7-time points over a 24-h period under acute cold(1 day at 4℃),and hibernation(45 days at 4℃).Our results showed that the circadian rhythms of the core clock genes were rather unaffected by acute cold exposure in the retina,unlike the brain and liver.In contrast,during hibernation,the liver clock genes displayed significant circadian oscillations,while those in the retina and brain stopped ticking.Furthermore,plasma CORT expressed circadian oscillations in both groups,and T3 in acute cold exposure group,whereas T4 and MT did not.Our results reveal that the plasma CORT and the liver sustain rhythmicity when the brain was not,indicating that the liver clock along with the adrenal clock synergistically maintains the metabolic requirements to ensure basic survival in hibernating Asiatic toads.

关键词： Asiatic toad circadian rhythm clock genes cold exposure hibernation metabolic hormones

Exploration discovery and hydrocarbon accumulation characteristics of the Doseo strike-slip and inverted basin, Chad

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Petroleum Exploration and Development 2022年第2期49卷 247-256页

作者： DOU lirong xiao Kunye DU Yebo WANG Li ZHANG Xinshun CHENG Dingsheng HU Ying Research Institute of Petroleum Exploration and Development PetroChinaBeijing 100083China China National Oil and Gas Exploration and Development Corporation Beijing 100034China

Several international oil companies had conducted petroleum exploration, but failed to make any commercially viable discoveries in the Doseo Basin for over 30 years. In this article, an integrated analysis, based on the latest seismic and drilling data combined with exploration practice and tectonic, sedimentary as well as petroleum-geological characteristics of the basin, has been conducted with the aim to disclose the key factors of hydrocarbon accumulation and enrichment and then to find the potential petroleum plays. The Doseo Basin in Chad is a Meso-Cenozoic lacustrine rift basin developed on the Precambrian crystalline basement in the Central African Shear Zone. It is a half graben rift controlled by the strike-slip fault at the northern boundary, and can be divided into two sub-basins, an uplift and a slope. The basin experienced two rifting periods in the Cretaceous and was strongly inverted with the erosion thickness of 800–1000 m during the Eocene, and then entered the depression and extinction period. Structurally, a large number of normal faults and strike-slip faults are identified in the basin, and the boundary faults are inverted faults with normal at first. The main structural styles include inverted anticlines, fault noses, complex fault-blocks and flower structures. The Lower Cretaceous is the main sedimentary strata, which are divided into the Mangara Group, Kedeni, Doba and Koumra Formations from bottom to up. Two transgressive-regressive cycles developed in the Lower Cretaceous indicates with mainly lacustrine, fluvial, delta, braided-delta, fan-delta sandstone and mudstone. The effective source rock in the basin is the deep-lacustrine mudstone of the Lower Cretaceous containing the type Ⅰ and type Ⅱ;organic matters. Furthermore, Inverted anticlines and fault-complicated blocks comprise the main trap types and the Kedeni Uplift is the most favorable play, followed by the Northern Steep Slope and Southern Gentle Slope. Lateral sealing capacity of faults controls the hydrocarbon abundance.

关键词： Doseo Basin rift basin strike-slip inverted structure petroleum system hydrocarbon accumulation characteristics exploration discovery

Effectiveness and Acceptability of a Comprehensive Mobile Health-Based Modality for Smoking Cessation-Beijing Municipality,China,2022

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China CDC weekly 2023年第21期5卷 464-468页

作者： Shuilian Chu Hang Jing Di Zhang Yuan Cao Yunliang Qian Xiurong Liu Lin xiao Zhaohui Tong lirong Liang Department of Research on Tobacco Dependence Therapies Beijing Institute of Respiratory Medicine and Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina Beijing Center for Disease Prevention and Control BeijingChina Tobacco Control Office Chinese Center for Disease Control and PreventionBeijingChina Department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory Medicine and Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina

Summary What is already known on this topic?Mobile health interventions have been demonstrated to be effective in aiding smoking cessation among smokers.Nevertheless,research on this topic remains limited in China.What is added by this report?Following two months of utilizing the services of a comprehensive mobile health(mHealth)-based modality(“Way to Quit”modality)which integrated three online interventions through the WeChat application,29.1%of participating smokers successfully quit smoking.Participants who used a greater number of online services were more likely to cease smoking.All services were scored highly for satisfaction among smokers.What are the implications for public health practice?This study presents a practical and feasible method to assist Chinese smokers in quitting smoking.The results of this research suggest a promising direction for enhancing the accessibility and utilization of smoking cessation services.Additionally,these findings serve as a critical reference for addressing the obstacles faced by smoking cessation services in China.

关键词： smoke services utilizing

Design of compensation pixel circuit with In-Zn-O thin film transistor for active-matrix organic light-emitting diode 3D display

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Frontiers of Optoelectronics 2017年第1期10卷 45-50页

作者： xiao HU Xingheng XIA Lei ZHOU lirong ZHANG Weijing WU State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 China Guangzhou New Vision Opto-Electronic Technology Co. Ltd. Guangzhou 510530 China

This paper presents a new compensation pixe] circuit suitable for active-matrix organic light-emitting diode （AMOLED） stereoscopic three dimensional （3D~ displays with shutter glasses. The simultaneous emissio~ method was used to solve the crosstalk problem, in which the periods of initialization and threshold voltage detectio11 occur for each pixel of whole panel simultaneously. Furthermore, there was no need of the periods of initialization and threshold voltage detection from the second frame beginning by one-time detection method. employing threshold voltage The non-uniformity of the proposed pixel circuit was considerably low with an average value of 8.6% measured from 20 discrete proposed pixel circuits integrated by In-Zn-O thin film transistors （IZO TFTs）. It was shown that the OLED current almost remains constant for the number of frames up to 70 even the threshold voltage detection period only exists in the first frame.

关键词： active-matrix organic light-emitting diode（AMOLED） compensation pixel circuit three dimensional（3D） display simultaneous emission

Enhancing the strain hardening and ductility of Mg-Y alloy by introducing stacking faults

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Journal of Magnesium and Alloys 2020年第4期8卷 1221-1227页

作者： Kang Wei Lirong Xiao Bo Gao Lei Li Yi Liu Zhigang Ding Wei Liu Hao Zhou Yonghao Zhao Nano and Heterogeneous Materials Center School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China

Due to the insufficient slip systems,Mg and its alloys exhibit poor ductility during plastic deformation at room temperature.To solve this problem,alloying is considered as a most effective method to improve the ductility of Mg alloys,which attracts wide attentions of industries.However,it is still a challenge to understand the ductilization mechanism,because of the complicated alloying elements and their interactions with Mg matrix.In this work,pure Mg and Mg-Y alloys were comparatively studied to investigate the effect of Y addition on microstructure evolution and mechanical properties.A huge increase of uniform elongation,from 5.3%to 20.7%,was achieved via only 3 wt%addition of yttrium.TEM results revealed that the only activated slip system in pure Mg was basalslip,led to its poor ductility at room temperature.In contrast,a large number of stacking faults and non-basal dislocations withcomponent were observed in the deformed Mg-Y alloy,which was proposed as the main reason for significant improvement of strain hardening and ductility.High resolution TEM indicated that most of the stacking faults were II and 12 intrinsic faults,which played a critical role in improving the ductility of Mg-Y alloy.Addition of Y into Mg alloy decreased the stacking fault energy,which induced high density stacking faults in the grain interior.

关键词： Magnesium alloys Ductility Stacking faults Non-basal slip Transmission electron microscopy

Strengthening and ductilization of laminate dual-phase steels with high martensite content

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Journal of Materials Science & Technology 2021年第6期65卷 29-37页

作者： Bo Gao Rong Hu Zhiyi Pan Xuefei Chen Yi Liu Lirong Xiao Yang Cao Yusheng Li Qingquan Lai Hao Zhou Nano and Heterogeneous Materials Center School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China Herbert Gleiter Institute of Nanoscience Nanjing University of Science and TechnologyNanjing 210094China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

The steels with excellent strength and ductility are expected to be achieved by tailoring the microstructural features.In this work,laminate dual-phase(DP)steels with high martensite content(laminate HMDP steels)were produced by a combination of warm rolling and intercritical annealing.Influence of rolling strain and annealing temperature on the microstructural evolution and mechanical properties of laminate HMDP steels were systematically studied.The strength of HMDP steels was significantly improved to~1.6 GPa associated with a high uniform elongation of 7%,as long as the laminate structure is maintained.The strengthening and ductilizing mechanisms of laminate HMDP steels are discussed based on the influence of laminate structure and the high martensite content,which promote the development of internal stresses and can be correlated to the Bauschinger effect as measured by the cyclic loadingunloading-reloading experiments.Detailed transmission electron microscopy(TEM)observation was applied to characterize the dislocation structure in the deformed ferrite.

关键词： Dual phase steel Warm rolling Laminate structure Bauschinger effect HDI stress