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The commercial antibiotics with inherent AIE feature: In situ visualization of antibiotic metabolism and specifically differentiation of bacterial species and broad-spectrum therapy

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Bioactive Materials 2023年第5期23卷 223-233页

作者： Bingnan Wang lirong Wang Haozhong Wu Xiaolin Liu Jiamiao Zhu Rong hu Dan Ding Anjun Qin Ben Zhong Tang State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesSouth China University of TechnologyGuangzhou510640China Center for Aggregation-Induced Emission AIE InstituteSouth China University of TechnologyGuangzhou510640China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenGuangdong518172China Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction The Hong Kong University of Science&TechnologyClear Water BayKowloonHong KongChina State Key Laboratory of Medicinal Chemical Biology Frontiers Science Center for Cell ResponsesKey Laboratory of Bioactive MaterialsMinistry of EducationCollege of Life SciencesNankai UniversityTianjin300071China

The research on pharmacology usually focuses on the structure-activity relationships of drugs,such as antibiotics,to enhance their activity,but often ignores their optical ***,investigating the photophysical properties of drugs is of great significance because they could be used to in situ visualize their positions and help us to understand their working *** this work,we identified a class of commercialized antibiotics,such as levofloxacin,norfloxacin,and moxifloxacin(MXF)hydrochloride,featuring the unique aggregation-induced emission(AIE)*** taking advantage of their AIE feature,antibiotic metabolism in cells could be in situ visualized,which clearly shows that the luminescent aggregates accumulate in the ***,after a structure-activity relationship study,we found an ideal site of MXF to be modified with a triphenylphosphonium and an antibiotic derivative MXF-P was prepared,which is able to specifically differentiate bacterial species after only 10 min of ***,MXF-P shows highly effective broad-spectrum antibacterial activity,excellent therapeutic effects and biosafety for ***-infected wound ***,this work not only discovers the multifunctionalities of the antibiotics but also provides a feasible strategy to make the commercialized drugs more powerful.

关键词： Aggregation-induced emission Antibiotics Antibacterial activity In situ visualization

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Assessment of different mcy genes for detecting the toxic to non-toxic Microcystis ratio in the field by multiplex qPCR

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Journal of Oceanology and Limnology 2018年第4期36卷 1132-1144页

作者： ZUO Jun CHEN Liting SHAN Kun hu Lili SONG lirong GAN Nanqin State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China University of Chinese Academy of Sciences Beijing 100049 China Institute of Electronic Information Technology Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences Chongqing 400714 China

Harmful cyanobacterial blooms, especially Microcystis blooms, occur worldwide and draw widespread attention. The dynamics of microcystin-producing Microcystis and competition between microcystin-producing Microcystis and non-microcystin-producing Microcystis are key to predicting and treating Microcystis blooms. Multiplex qPCR is a useful tool to assess such issues. In this study, we developed multiplex qPCR methods with newly-designed probes and primers for the microcystin-synthesis related genes mcyA and mcyE. We used seven toxic Microcystis strains and four non-toxic Microcystis strains to compare the differences in the ratios of toxic and non-toxic Microcystis in mixed cultures, which were calculated using abundances of the genes mcyA, mcyB, mcyD, mcy E and phycocyanin( PC). We also compared traditional cell counting and multiplex qPCR. Hierarchical clustering and principal component analysis indicated that mcyD was the most suitable mcy gene for quantification in laboratory experiments. mcyB abundances were always higher; we suggest that the amount of toxic Microcystis measured using mcyB might overestimate the actual percentages.

关键词： Microcystis bloom toxic Microcystis multiplex qPCR mcyA mcyB mcyD meTE PCA

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Improving photosynthesis of microalgae by changing the ratio of light-harvesting pigments

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Chinese Science Bulletin 2005年第15期50卷 1622-1626页

作者： WANG Gaohong CHEN Lanzhou LI Genbao LI Dunhai hu Chunxiang CHEN Haofeng LIU Yongding SONG lirong State Key Laboratory of Fresh Water Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China School of Resource and Environment Sciences Wuhan UniversityWuhan 430072 China

Changing the ratio of light-harvesting pigments was regarded as an efficient way to improve the photosyn-thesis rate in microalgae, but the underlying mechanism is still unclear. In the present study, a mutant of Anabeana simensis (called SP) was selected from retrieved satellite cul-tures. Several parameters related with photosynthesis, such as the growth, photosynthesis rate, the content of photosyn-thetic pigment, low temperature fluorescence spectrum (77K) and electron transport rate, were compared with those of the wild type. It was found that the change in the ratio of light-harvesting pigments in the mutant led to more efficient light energy transfer and usage in mutant than in the wild type. This may be the reason why the mutant had higher photosynthesis and growth rates.

关键词：微藻类光合作用色素荧光性散射电子传送

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Effects of inorganic arsenic on growth and microcystin production of a Microcystis strain isolated from an algal bloom in Dianchi Lake,China

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Chinese Science Bulletin 2011年第22期56卷 2337-2342页

作者： GONG Yan AO HongYi LIU BiBo WEN Sheng WANG Zhi hu DingJing ZHANG XingZhong SONG lirong LIU JianTong Institute of Agricultural Quality Standards & Testing Technology Hubei Academy of Agriculture Sciences Wuhan 430064 China Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China Department of Resourses and Environment Engineering Henan Institute of Engineering Zhengzhou 451191 China National Institute of Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beifing 100050 China Institute of Agricultural Resource and Environmental Sciences Jiangsu Academy of Agricultural Sciences Nanjing 210014 China

Our previous data have shown that inorganic arsenic concentrations were high in Dianchi Lake,China,where Microcystis blooms often *** explore the relationship between arsenic and the growth of Microcystis,the effects of arsenite[As(III)]and arsenate[As(V)]on the growth and toxin production of *** strain FACHB 905 were *** showed that *** FACHB 905 was tolerant to inorganic arsenic and its growth was not inhibited when the concentration of As(III)was below 10-5 mol L-1 or that of As(V)below 10-3 mol *** microcystin production was stimulated in the presence of 10-7 mol L-1 As(III)and the response of this *** strain to As(III)seemed to be a typical inverted U-shaped *** content increase of microcystin-LR per cell indicated that the toxicity was enhanced as *** FACHB 905 was exposed to As(V).Considering the relatively high concentration of inorganic arsenic in Dianchi Lake(139μg L-1 in epilimnetic water),the origin of the *** strain,inorganic arsenic favors survival of *** FACHB 905 and may stimulate its microcystin production and cellular toxicity.

关键词：微囊藻毒素无机砷生产滇池中国假单胞菌分离藻华

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Controlling N-doping type in carbon to boost single-atom site Cu catalyzed transfer hydrogenation of quinoline

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Nano Research 2020年第11期13卷 3082-3087页

作者： Jian Zhang Caiyan Zheng Maolin Zhang Yajun Qiu Qi Xu Weng-Chon Cheong Wenxing Chen lirong Zheng Lin Gu Zhengpeng hu Dingsheng Wang Yadong Li Department of Chemistry Tsinghua UniversityBeijing100084China School of Physics Nankai UniversityTianjin300071China KAUST Catalysis Center(KCC) King Abdullah University of Science and TechnologyThuwal23955-6900Saudi Arabia Department of Physics and Chemistry Faculty of Science and TechnologyUniversity of MacaoTaipaMacao SARChina School of Materials Science and Engineering Beijing Institute of TechnologyBeijing100081China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing100190China

Single-atom site(SA)catalysts on N-doped carbon(CN)materials exhibit prominent performance for their active sites being *** to the commonly random doping behaviors of N species in these CN,it is a tough issue to finely regulate their doping types and clarify their effect on the catalytic property of such ***,we report that the N-doping type in CN can be dominated as pyrrolic-N and pyridinic-N respectively through compounding with different metal *** is found that the proportion of distinct doped N species in CN depends on the acidity and basicity of compounded metal oxide *** to the coordination by pyrrolic-N,the SA Cu catalyst displays an enhanced activity(two-fold)for transfer hydrogenation of quinoline to access the valuable molecule tetrahydroquinoline with a good selectivity(99%)under mild *** higher electron density of SA Cu species induced by the predominate pyrrolic-N coordination benefits the hydrogen transfer process and reduces the energy barrier of the hydrogenation pathway,which accounts for the improved catalytic effeciency.

关键词： nitrogen-doping type metal oxide nitrogen-doped carbon single-atom site catalyst transfer hydrogenation

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Environmental Benefits for Phase-Out HCFC-22 in the Residential Air-Conditioner Sector in China

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Advances in Climate Change Research 2011年第2期2卷 86-92页

作者： Tingting Wan Yanwei Dou Lei Wang lirong Yang Xiaofang Zhou Dan Wan Jianxin hu College of Environmental Science ＆ Engineering Peking University Beijing 100871 China China National Environmental Monitoring Centre Beijing 100012 China China Household Electrical Appliances Association Beijing 100062 China Foreign Economic Cooperation Office Ministry of Environmental Protection Beijing 100035 China

China is the largest producer and consumer of hydrochlorofluorocarbons （HCFCs）, and the production of HCFC-22 accounts for more than 80% of all HCFCs. This paper concentrates on the residential air-conditioner industry and analyzes the environmental benefits of accelerating the phase-out of HCFC-22 in China. According to the comparison of the baseline and phase-out scenarios of HCFC-22, the findings show that using HC-290 （propane） as a refrigerant alternative will directly reduce the greenhouse effect, and indirectly reduce the emission of greenhouse gases due to a reduction in the electricity consumption. The comparison of two scenarios of HC-290 and HFC-410A refrigerant alternatives shows that the use of HC-290 refrigerant will produce significantly higher environmental benefits than the HFC-410A refrigerant.

关键词： HCFC-22 HFC-410A HC-290 residential air-conditioner GWP ODP

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Study of the Satellite Ephemeris and Clock Error Corrections in CAPS Wide Area Differential System

Study of the Satellite Ephemeris and Clock Error Corrections...

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第四届中国卫星导航学术年会

作者： lirong Zhang Zhengqun hu National Astronomical Observatories Chinese Academy of Sciences Graduate University of Chinese Academy of Sciences

According to the characteristics of satellite distribution of CAPS positioning system, we do some research of the satellite ephemeris and clock error corrections in CAPS wide area differential system. The method in CAPS wide Area Differential system changes the order of calculation usually using in the traditional WAAS. By reducing dimensionalities to reduce DOP value can achieve more accuracy of CAPS wide area differential system. Not even the time synchronization of differential stations is needed.

关键词： CAPS communication satellites wide area differential method

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Performance Analysis of Different Pressure Sensor in Differential Barometric Altimeter System

Performance Analysis of Different Pressure Sensor in Differe...

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第四届中国卫星导航学术年会

作者： Zhengqun hu lirong Zhang National Astronomical Observatories Chinese Academy of Sciences Graduate University of Chinese Academy of Sciences

Two classic atmospheric pressure sensors MS5534C and BP5607 were introduced, due to the measurement sensitivity and resolution is different, performance in differential barometric altimeter system may be different. The experiments show that the two sensors both can distinguish be-tween floors in the differential barometric altimeter system and have a good measured highprecision. Yet, for BP5607 the elevation resolution is better than the MS5534C, the use of BP5607 is more flexible and so on. High-sensitivity, high-resolution pressure sensor in the field of location information services will have greater application space.

关键词： height measurement MEMS Sensor barometric altimetry

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微波消解—原子荧光光谱法测定平菇和小棕蘑菇中总砷

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食用菌学报 2008年第2期15卷 75-78页

作者：韩丽荣胡清秀杨小红李力湖南农业大学园艺园林学院湖南长沙410128 中国农业科学院农业资源与农业区划研究所北京100081

采用微波消解—原子荧光光谱法,优化了微波消解—原子荧光光谱法测定食用菌中总砷的各种条件：前处理选用3.00 mL HNO3＋1.50 mL30%H2O2作消解剂,采用方案3（步骤1维持时间5 min,步骤2维持时间12 min,其它参数参考MARS5微波消解植物样... 详细信息

采用微波消解—原子荧光光谱法,优化了微波消解—原子荧光光谱法测定食用菌中总砷的各种条件：前处理选用3.00 mL HNO3＋1.50 mL30%H2O2作消解剂,采用方案3（步骤1维持时间5 min,步骤2维持时间12 min,其它参数参考MARS5微波消解植物样品推荐方案）消解样品,在400 mL/min载气流量,15 g/L硼氢化钾溶液还原条件下测定了平菇和小棕蘑菇中砷的含量,测定结果准确可靠,此方法的检出限为0.1μg/L,标准偏差4.26%,试验回收率在86.4%～108.6%之间。该方法适用于原子荧光光谱法测定食用菌中的总砷。

关键词：微波消解原子荧光光谱法食用菌砷

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Design of compensation pixel circuit with In-Zn-O thin film transistor for active-matrix organic light-emitting diode 3D display

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Frontiers of Optoelectronics 2017年第1期10卷 45-50页

作者： Xiao hu Xingheng XIA Lei ZHOU lirong ZHANG Weijing WU State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 China Guangzhou New Vision Opto-Electronic Technology Co. Ltd. Guangzhou 510530 China

This paper presents a new compensation pixe] circuit suitable for active-matrix organic light-emitting diode （AMOLED） stereoscopic three dimensional （3D~ displays with shutter glasses. The simultaneous emissio~ method was used to solve the crosstalk problem, in which the periods of initialization and threshold voltage detectio11 occur for each pixel of whole panel simultaneously. Furthermore, there was no need of the periods of initialization and threshold voltage detection from the second frame beginning by one-time detection method. employing threshold voltage The non-uniformity of the proposed pixel circuit was considerably low with an average value of 8.6% measured from 20 discrete proposed pixel circuits integrated by In-Zn-O thin film transistors （IZO TFTs）. It was shown that the OLED current almost remains constant for the number of frames up to 70 even the threshold voltage detection period only exists in the first frame.

关键词： active-matrix organic light-emitting diode(AMOLED) compensation pixel circuit three dimensional(3D) display simultaneous emission

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