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Effects of progesterone on glutamate transporter 2 and gamma-aminobutyric acid transporter 1 expression in the developing rat brain after recurrent seizures

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Neural Regeneration Research 2012年第26期7卷 2036-2042页

作者： Lingjuan liu Dingan Mao liqun liu Yu Huang Tao Bo Department of Pediatrics Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China

Seizures were induced by flurothyl inhalation. Rats were intramuscularly treated with progesterone after each seizure. Results demonstrated that glutamate transporter 2 and y-aminobutyric acid transporter 1 expression levels were significantly increased in the cerebral cortex and hippocampus of the developing rat brain following recurrent seizures. After progesterone treatment, glutamate transporter 2 protein expression was upregulated, but ^-aminobutyric acid transporter 1 levels decreased. These results suggest that glutamate transporter 2 and y-aminobutyric acid transporter 1 are involved in the pathological processes of epilepsy. Progesterone can help maintain a balance between excitatory and inhibitory systems by modulating the amino acid transporter system, and protect the developing brain after recurrent seizures.

关键词： progesterone seizure, transporter, glutamate, ^-aminobutyric acid

基于改进的DISK算法的农林航拍图配准研究

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软件工程 2025年第1期28卷 28-32页

作者：董一波刘立群甘肃农业大学信息科学技术学院甘肃兰州730070

针对无人机的农林航拍图像配准算法存在特征点识别较少、特征点匹配不精准等问题,提出了一种改进的离散关键点(Discrete Key point,DISK)算法。该算法首先采用梯度策略DISK算法对特征点进行有效描述;其次采用基于深度学习局部特征的匹... 详细信息

针对无人机的农林航拍图像配准算法存在特征点识别较少、特征点匹配不精准等问题,提出了一种改进的离散关键点(Discrete Key point,DISK)算法。该算法首先采用梯度策略DISK算法对特征点进行有效描述;其次采用基于深度学习局部特征的匹配方法进行预匹配;最后利用RANSAC算法去除离群点,筛选匹配结果。为验证算法的有效性,选取了几组农业航拍图像的数据集进行实验比较。实验结果显示,与经典的SIFT、Dark feat算法及原始的DISK算法相比,改进的DISK算法显著提高了匹配精度,匹配精度由41.7%提升至98.9%,充分满足农林航拍图的匹配需求。

关键词：农林航拍图梯度策率局部特征图像配准 DISK算法

Effects of Rhizoma Acori Tatarinowii extracts on gamma-aminobutyric acid type A receptor alpha 1 subunit brain expression during development in a recurrent seizure rat model

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Neural Regeneration Research 2011年第6期6卷 412-417页

作者： liqun liu Ding'an Mao Keqiang Chi Xingfang Li Tao Bo Jinming Guo Zhuwen Yi Department of Pediatrics Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China College of Pharmacy Hunan University of Traditional Chinese Medicine Changsha 410007 Hunan Province China

Extracts from Rhizoma Acori Tatarinowii （Grassleaf Sweetflag Rhizome, Shichangpu） have been shown to improve learning and memory, reduce anxiety, allay excitement, and suppress seizures. Rhizoma Acori Tatarinowii extracts interact with y-aminobutyric acid and activate the y-aminobutyric acid type A receptor, although few studies have addressed the precise effects of v-aminobutyric acid type A receptor al subunit. In the present study, y-aminobutyric acid type A receptor al subunit protein expression in the cerebral cortex and hippocampus, and pathological scores of brain injury, were significantly greater following recurrent seizures, but significantly decreased following treatment with Rhizoma Acori Tatarinowii extracts. These results indicated that Rhizoma Acori Tatarinowii extracts down-regulated y-aminobutyric acid type A receptor al subunit protein expression in the cerebral cortex and hippocampus and protected seizure-induced brain injury during development.

关键词： seizure brain injury y-aminobutyric acid A receptor cortex hippocampus extracts of Rhizoma Acori Tatarinowii

Effects of RE^(3+)(RE=La,Ce,Pr,Sm,Dy,Ho,Er,and Tm) on the luminescence of Sr_2MgSiO_5:Eu^(2+) phosphors

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Rare Metals 2011年第1期30卷 14-17页

作者： CHENG Guang WEI Xiaoyan CHENG liqun liu Quansheng WANG Xiaochun SUN Haiying ZHANG Xiyan QIU Guanming School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China

Sr2MgSiO5：Eu^2＋phosphors were synthesized through a high temperature solid state reaction *** phase and luminescence properties of the samples were characterized by X-ray diffraction（XRD） and a luminescence *** effects of RE^3＋（RE = La,Ce,Pr,Sm,Dy,Ho,Er,and Tm） on the luminescent properties of the samples were *** results show that the luminescence spectrum of Sr2MgSiO5：Eu^2＋ is a broad band composed of two emission peaks,at 460 and at 530 nm under near-ultraviolet *** earth ions Re^3＋（RE = La,Ce,Pr,Sm,Dy,Ho,Er,and Tm） have great influence on the emission of Sr2MgSiO5：Eu^2＋ *** La^3＋ ion in Sr2MgSiO5：Eu^2＋ phosphors greatly enhances the emission at 460 and 530 nm.

关键词： phosphors solid state reactions rare earths luminescence

Neuroprotection of a cocktail therapy involving anti-intercellular adhesion molecule 1 antibody and insulin-like growth factor 1 in treatment of cerebral ischemia/reperfusion injury in cats Nuclear magnetic resonance examination and pathological validatio

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Neural Regeneration Research 2008年第12期3卷 1332-1337页

作者： Huaijun liu liqun Yan Yaping Hou Shuochun Wu Dan He Linfang Li Yankai Wu BoyuanHuang Fei Yang Department of Medical Imaging Second Hospital Hebei Medical University Shijiazhuang 050000 Hebei Province China

BACKGROUND： The pathophysiological mechanisms of ischemia are extremely complicated. It is difficult to confirm and maintain the therapeutic effects if only one neuroprotective agent is used. It is hypothesized that a cocktail therapy involving a combined application of neuroprotective agents is feasible and offers excellent therapeutic potential. OBJECTIVE： To evaluate the neuroprotective effects of a cocktail therapy of insulin-like growth factor 1 （IGF1） combined with anti-intercellular adhesion molecule 1 （ICAM1） antibody in the treatment of cerebral ischemia/reperfusion injury using medical imaging, pathology, and functional neurological deficit scoring techniques. DESIGN, TIME AND SETTING： This randomized, controlled, neuroimaging analysis of function and pathological observation was performed at the Laboratory of Molecular Imaging, Second Hospital, Hebei Medical University between September 2006 and December 2007. MATERIALS： Transient middle cerebral artery occlusion （MCAO） was induced in 24 healthy adult cats. Anti-ICAM1 antibody and IGF1 were sourced from the Shanghai Kangcheng Biological Product Co., Ltd., China. Stereotaxic apparatus was purchased from the Center for Medical Apparatus and Instruments, Shandong Liaocheng People＇s Hospital, China. The in situ apoptosis kit was provided by the Beijing Zhongshan Biotechnique Co., Ltd., China. METHODS： Twenty-four cat models of MCAO were randomly divided into four groups （n = 6）： control, IGF1, anti-ICAM 1 antibody and cocktail therapy. Following a 2-hour ischemia and subsequent lateral cerebral ventricular puncture, 100 μg IGFl（cerebral ventricular）, 100 μg anti-ICAM1 antibody （i.v.）, 50 μg IGFl（lateral cerebral ventricular）＋ 50 μg anti-ICAM1 antibody （i.v.）, and 100 μg physiological saline （i.v.） were administered to the IGF1, anti-ICAM1 antibody, cocktail therapy and control groups, respectively. On the following day, the same administration was performed again. MAIN OUTCOME MEASURES： Pathological observat

关键词： neuroprotection cocktail therapy ischemia/reperfusion magnetic resonance imaging

Comparative study of video-assisted thoracoscopic surgery ablation and radiofrequency catheter ablation on treating paroxysmal atrial fibrillation： a randomized, controlled short-term trial

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Chinese Medical Journal 2014年第14期127卷 2567-2570页

作者： Wang Shizhong liu liqun Zou Chengwei Shandong Univ Dept Cardiac Surg Shandong Prov Hosp Jinan 250021 Shandong Peoples R China

Background It is unclear whether the effect of video-assisted thoracoscopic surgery ablation is better than catheter ablation on paroxysmal atrial fibrillation （PAF） or not. This study aimed to compare the effects of catheter ablation and video-assisted thoracoscopic surgery ablation on PAF. Methods From March 2008 to March 2012, 138 consecutive patients with PAF were randomly assigned to receive either video-assisted thorecoscopic surgery ablation （thoracoscopy group, n=66） or the traditional catheter ablation （catheter group, n=72）. Results No patient died during the study and all were successfully followed and included in analysis. There were no significant differences in clinical and echocardiographic characteristics between the two groups. All patients were evaluated at 1 week, 1 month, 3 months, 6 months, and 12 months after discharge by physical examination and related laboratory tests. Preoperative left atrium dimensions （LADs） of the recurrent AF were （47±4） mm in the thoracoscopy group and （46±8） mm in the catheter group, whereas the LADs were （40±5） and （39±9） mm, respectively, in non-recurrent PAF. Conclusions The short-term outcome of video-assisted thoracoscopic surgery ablation is safe and effective; and the indications are wider than those for catheter ablation. The larger left atrium diameter is related to the recurrence of atrial fibrillation. Chin Med J 2014;127 （14）： 2567-2570

关键词： atrial fibrillation catheter ablation video-assisted thoracoscopic surgery ablation

Design Bistatic Interferometric DEM Generation Algorithm and Its Theoretical Accuracy Analysis for LuTan-1 Satellites

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Journal of Geodesy and Geoinformation Science 2022年第1期5卷 25-38页

作者： Bing XU liqun liu Zhiwei LI Yan ZHU Jingxin HOU Wenxiang MAO School of Geoscience and Info-Physics Central South UniversityChangsha 410083China

LuTan-1(LT-1)is a constellation with two full-polarization L-band radar satellites designed by China,and the first satellite was scheduled to be launched in December 2021 and the second one in January *** LT-1 will be operated for deformation monitoring in repeat-pass mode,and for DEM generation in bistatic mode,improving self-sufficiency of SAR data for the field of geology,earthquake,disaster reduction,geomatics,forestry and so *** this paper,we focused on designing an algorithm for interferometric DEM generation using LT-1 bistatic *** basic principle,main error sources and errors control of the DEM generation algorithm of LT-1 were systematically *** experiment results demonstrated that:①The implemented algorithm had rigorous resolution with a theoretic accuracy better than 0.03 m for DEM generation.②The errors in satellite velocity and Doppler centroid had no obvious effect on DEM accuracy and they could be *** the errors in position,baseline,slant range and interferometric phase had a significant effect on DEM *** the DEM error caused by baseline error was dominated,followed by the slant range error,interferometric phase error and satellite position error.③To obtain an expected DEM accuracy of 2 m,the baseline error must be strictly controlled and its accuracy shall be 1.0 mm or better for Cross-Track and Normal-Direction component,*** the slant range error and interferometric phase error shall be reasonably *** research results were of great significance for accurately grasping the accuracy of LT-1 data products and their errors control,and could provide a scientific auxiliary basis for LT-1 in promoting global SAR technology progress and the generation of high-precision basic geographic data.

关键词： Synthetic Aperture Radar bistatic InSAR LuTan-1 Digital Elevation Model(DEM) baseline error

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苯磺顺阿曲库铵注射剂的质量评价

医药导报 2025年第1期44卷 31-38页

作者：房晶于新颖多凯白璧炜韩宇肖可新马欣莹刘利群朱嘉亮黑龙江省药品检验研究院化药检验研究所国家药品监督管理局中药质量研究与评价重点实验室黑龙江省中药质量研究与评价重点实验室哈尔滨150088 中国食品药品检定研究院技术监督中心北京100050

目的评价国内不同企业生产的苯磺顺阿曲库铵注射剂的质量。方法采用法定标准结合探索性研究对104批抽验样品进行综合评价,包括有关物质、1,5-戊二醇二丙烯酸酯、残留溶剂、苯磺酸酯类基因毒性杂质、红外光谱、细菌内毒素,综合评价国内... 详细信息

目的评价国内不同企业生产的苯磺顺阿曲库铵注射剂的质量。方法采用法定标准结合探索性研究对104批抽验样品进行综合评价,包括有关物质、1,5-戊二醇二丙烯酸酯、残留溶剂、苯磺酸酯类基因毒性杂质、红外光谱、细菌内毒素,综合评价国内产品质量及现行质量标准对产品质量的可控性。结果按照法定检验方法检验104批样品,合格率100.0%。探索性研究结果表明,6家药品生产企业样品杂质水平均远低于限度要求,且均未检测出苯磺酸酯类基因毒性杂质;但1,5-戊二醇二丙烯酸酯、残留溶剂等存在差异。结论目前苯磺顺阿曲库铵注射剂总体质量较好;现行标准需进一步完善,建议增/修订红外光谱鉴别项、有关物质、1,5-戊二醇二丙烯酸酯检测方法,严格控制细菌内毒素限度;建议企业关注原料药质量与注射剂生产过程控制。

关键词：苯磺顺阿曲库铵注射剂质量评价有关物质 1,5-戊二醇二丙烯酸酯残留溶剂

Optimal motion planning of an underactuated spacecraft using wavelet approximate method

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Progress in Natural Science:Materials International 2006年第8期16卷 868-873页

作者： GE Xinsheng, CHEN liqun and liu Yanzhu (Beijing Institute of Machinery, Beijing 100085, China Department of Mechanics, Shanghai University, Shanghai 200072, China Department of Engineering Mechanics, Shanghai Jiaotong University, Shanghai 200030, China) Beijing Institute of Machinery Beijing 100085 China Department of Mechanics Shanghai University Shanghai 200072 China Department ofEngineering Mechanics Shanghsi Jiaotong University Shanghsi 200030 China

An optimal motion planning scheme using wavelet approximation is proposed for an underactuated spacecraft. The motion planning of an underactuated spacecraft can be formulated as an optimal control of a drift-free system. A cost functional is used to incorporate the control energy and the final state errors. The motion planning is to determine control inputs to minimize the cost functional. Using the method of wavelet, one can transform an infinite-dimensional optimal control problem to a finite-dimensional one and use Gauss-Newton algorithm to solve it for a feasible trajectory which satisfies nonholonomic constraints. The proposed scheme has been applied to a rigid spacecraft with two momentum wheels. The numerical simulation results indicate that optimal control with wavelet approximation is an effective approach to steering an underactuated spacecraft system from the initial configuration to the final configuration.

关键词： underactuated spacecraft motion planning optimal control nonholonomic constraint wavelet analysis.