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Variation characteristics of acid rain in zhuzhou,Central China over the period 2011-2020

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Journal of Environmental Sciences 2024年第4期138卷 496-505页

作者： Jiahao Ren liquan zhu Xi Zhang Yuqian Luo Xuecai Zhong Bowen Li Yuwen Wang Kai Zhang State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China zhuzhou Environment Monitoring Center Zhuzhou 412000China Faculty of Environmental Engineering The University of Kitakyushu1–1 HibikinoWakamatsuKitakyushuFukuoka 808-0135Japan College of Natural Resources and Environment South China Agricultural UniversityGuangzhou 510642China

zhuzhou was one of the most polluted cities in China with the serious acid *** to the implementation of air pollution control measures from 2016 to 2018,the acid rain pollution in this city has *** order to understand the recent situation,a comprehensive study on the acid rain was carried out from January 2011 to December *** pH values during the study period varied from 3.3 to 7.5,with a volume-weighted mean value of *** predominant acidic components of the precipitation were SO_(4)^(2-)and NO_(3)^(-),accounting for 89.3% of the total *** ratio of non-sea-salt SO_(4)^(2-)to NO_(3)^(-)showed a decreasing trend,revealing that the pollution type of acid rain changed from sulfuric acid type to sulfuric acid and nitric acid compound *** correlation analysis(p<0.05)showed that SO_(4)^(2-)was positively correlated with NH_(4)^(+),Ca^(2+),and Mg^(2+);hence,it predominated in precipitation as(NH_(4))_(2)SO_(4),NH_(4)HSO_(4),CaSO_(4),and MgSO_(4).Significant positive correlation of Ca^(2+)with Mg^(2+)shows that they may originated mainly from *** positive correlation between SO_(4)^(2-)and F^(-)and Cl^(-)indicate that their source may be related to the non-ferrous metal smelting industry in *** correlation analysis shows that emissions from the non-ferrous metal smelting industry in the area have a large significant on SO_(4)^(2-)and F^(-)in precipitation,while Cl^(-)may still be emitted from other anthropogenic sources.

关键词： Acid rain pH Chemical composition Neutralization factor Correlation analysis

Recent advances in construction of small molecule-based fluorophoredrug conjugates

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Journal of Pharmaceutical Analysis 2020年第5期10卷 434-443页

作者： Wenjie Lang Chaonan Yuan liquan zhu Shubo Du Linghui Qian Jingyan Ge Shao Q Yao Key Laboratory of Bioorganic Synthesis of Zhejiang Province College of Biotechnology and BioengineeringZhejiang University of TechnologyHangzhou310014PR China Department of Chemistry National University of Singapore3 Science Drive 3Singapore117543Singapore Institute of Drug Metabolism and Pharmaceutical Analysis College of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China

As a powerful tool to advance drug discovery,molecular imaging may provide new insights into the process of drug effect and therapy at cellular and molecular *** compared with other detection methods,fluorescence-based strategies are highly attractive and can be used to illuminate pathways of drugs’transport,with multi-color capacity,high specificity and good *** conjugates of fluorescent molecules and therapeutic agents create exciting avenues for real-time monitoring of drug delivery and distribution,both in vitro and in *** this short review,we discuss recent developments of small molecule-based fluorophore-drug conjugates,including non-cleavable and cleavable ones,that are capable of visualizing drug delivery.

关键词： Drug delivery Fluorescent monitoring Prodrug Cleavable linker

Expression and Interaction Analysis of FAZ1 Protein in Brassica oleracea

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Phyton-International Journal of Experimental Botany 2021年第6期90卷 1599-1612页

作者： Hecui Zhang Xiaoping Lian Yizhong Zhang Tonghong Zuo Chongmo Yuan Qinqin Xie liquan zhu College of Agronomy and Biotechnology Southwest UniversityChongqing400715China State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan School of AgricultureYunnan UniversityKunming650091China

To identify and characterize genes involved in reproductive tissue abscission in Brassica oleracea,the transcript data of pollinated pistil was analyzed.A differentially expressed gene,named BoFAZ1(FLOWER ABSCISSION ZONE1)was identified,which contains one exon and encompass a ***,a T-DNA insertion mutant(SALK_302_G01)(faz1 mutant)was obtained from Arabidopsis thaliana mutant *** organ shedding from mutants was delayed and a V-shaped structure in the boundary region between the stalk and torus of the sepal abscission zone was obtained in faz1 *** cell density of this structure was lower than that of the corresponding region in the wild-type *** the transgenic plants,the normal development of the stalk zone of faz1 was recovered completely by transforming a 1919-bp DNA fragment of BoFAZ1 into the faz1 *** Addition,our data showed that BoFAZ1 was expressed in mature pollen grains,but not in the bracts,roots,stems,leaves,and *** expression in the filaments,stigma,and pistil exfoliation layer gradually increased after *** localization experiments showed that BoFAZ1 was located in the cell membrane.A myristoylation site was found at the N-terminus of *** of this site resulted in protein dislocation in the cytoplasm,cell membrane and ***,a yeast two-hybrid test indicated that BoH3.2(histone H3.2),a protein involved in abscission zone development,interacted with *** interaction was verified by a GST pull-down *** summary,our data indicated that BoFAZ1 was involved in the formation of the pistil abscission zone in ***.

关键词： Abscission AZ B.oleracea flower development organ boundary

Genome-Wide Identification and Expression Analysis of the Phytocyanin Gene Family in Nicotiana tabacum

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Phyton-International Journal of Experimental Botany 2023年第5期92卷 1469-1492页

作者： Peiling Wang Xiaohong Xu Yong Li Hecui Zhang Xuejie Zhang Siru Zhou Yimei Liu Yunyan Feng Tonghong Zuo liquan zhu School of Agronomy and Biotechnology Engineering Research Center of South Upland AgricultureMinistry of EducationSouthwest UniversityChongqing400715China Tobacco Science Research Institute of Chongqing Tobacco Company Chongqing400715China Chongqing Qianjiang Tobacco Branch Company Chongqing Institute of Tobacco Science Chongqing400715China

Phytocyanin(PC)is a class of plant-specific blue copper proteins involved in electron transport,plant growth,development,and stress ***,PC proteins have not been systematically evaluated in tobacco *** determined the whole-genome sequences of the PC family in the tobacco cultivar‘K326.’The transcriptome data were used to analyze the expression of the NtPC family at different development stages and tissue-specific ***-time fluorescence quantitative analysis was used to analyze the expression of the NtPC gene family under low temperature and methyl jasmonate *** tobacco NtPC family contained 110 members and was divided into four subfamilies:early nodulin-like protein(NtENODL),uclacyanin-like protein,stellacyanin1-like protein,and plantacyanin-like *** to phylogenetic and structural analyses,the NtPC family could be divided into eight structural ***-three NtPCs were randomly distributed on 22 of 24 tobacco *** analysis revealed 33 pairs of genes belonging to the NtPC *** ontology analysis showed that the PC genes are components of the plasma membrane and may participate in plasma membrane-related *** NtPC family contained numerous elements related to hormonal and abiotic stress responses and was specifically expressed in the tobacco prosperous,maturation,and budding ***-specific expression analysis showed that some genes were tissue *** expression of NtENODL58 and other genes was significantly induced by low-temperature and methyl jasmonate ***,the NtPC gene family plays an important role in plant stress response.

关键词： Tobacco phytocyanin gene family bioinformatics gene expression

Progress on Integrated Control of Tobacco Black Shank

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Agricultural Biotechnology 2015年第4期4卷 37-41页

作者： Yonghui XIE Yonggui ZHANG liquan zhu Daogui YOU Yao LU Luquan Branch Kunming Tobacco Company Institute of Agricultural Environment& Resources Yunnan Academy of Agricultural Sciences

Tobacco black shank is one of the devastating diseases of tobacco. In recent years, this disease widely occurred in most tobacco-growing areas, which caused disastrous losses and has severely threatened the sustainable development of flue-cured tobacco. In order to lay a theoretical foundation for the better control of tobacco black shank, the occurrence characteristics and integrated control strategis of this disease were systematically discussed according to the aspects of agricultural control, chemical control, biological control, etc.

关键词： Tobacco Black shank Integrated control Research progress

高亲和性铁离子渗透酶Ftr1和Ftr2调控白念珠菌生长和形态

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微生物学报 2015年第5期55卷 579-586页

作者：杜浛朱利泉西南大学农学与生物科技学院重庆400715

【目的】通过分析FTR1、FTR2基因缺失株在不同培养条件下的生长情况以及菌丝生长能力,明确高亲和性铁离子渗透酶在白念珠菌生长和形态发生中的功能。【方法】将不同基因型的菌株分别置于不同的培养基和培养温度下进行培养,对其生长速度... 详细信息

【目的】通过分析FTR1、FTR2基因缺失株在不同培养条件下的生长情况以及菌丝生长能力,明确高亲和性铁离子渗透酶在白念珠菌生长和形态发生中的功能。【方法】将不同基因型的菌株分别置于不同的培养基和培养温度下进行培养,对其生长速度以及菌丝的生长状态进行观察,获取相应的实验结果。【结果】FTR1或FTR2单基因缺失对于白念珠菌的生长没有显著的影响,但是FTR1、FTR2双基因缺失使白念珠菌在Spider培养基中不能生长,铁离子的增加能够恢复该双基因缺失株的生长能力。FTR1、FTR2双基因缺失株在营养贫瘠的合成培养基上生长速度也较慢。此外,ftr1/frt1菌株的菌丝生长能力增强,而ftr2/ftr2菌株的菌丝生长能力减弱。双突变株ftr1/ftr1 ftr2/ftr2的菌丝生长能力能够恢复到野生对照株的水平。【结论】Ftr1与Ftr2对白念珠菌在微量铁元素环境中的生存有着重要的作用,还参与了白念珠菌对碳源N-乙酰葡萄糖胺、乙醇和甘油等的利用。此外,Ftr1对白念珠菌菌丝生长起负调控作用,Ftr2对菌丝生长起正调控作用。因此,ftr1/ftr1 ftr2/ftr2双基因突变株的菌丝生长能力能够恢复到野生对照株的水平。

关键词：白念珠菌菌丝生长高亲和性铁离子渗透酶 Ftr1 Ftr2

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中国兰花资源分子标记鉴定研究进展

生物技术通报 2010年第9期26卷 56-60页

作者：武海蹇黎朱利泉西南大学农学与生物科技学院重庆400716

系统阐述了RAPD、SSR、RFLP、AFLP和其它几类分子标记在中国兰花种质资源鉴定及遗传多样性研究中的应用进展。同时指出,应用分子标记研究兰属植物的遗传多样性对兰属的科学分类及新品种选育等具有指导意义,并提出展望。

关键词： RAPD SSR RFLP AFLP 分子标记中国兰花

SDT联用安罗替尼对非小细胞肺癌的协同杀伤作用

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中国肿瘤临床 2024年第20期51卷 1027-1033页

作者：雷月朱丽全刘鹏王浩强谢波广州中医药大学研究生院广州市510006 中国人民解放军南部战区总医院肿瘤科

目的:探究声动力疗法(sonodynamic therapy,SDT)联合安罗替尼对非小细胞肺癌(non-small cell lung cancer,NSCLC)的协同杀伤效果及作用机制。方法:本研究选取A549和H1299肺癌细胞作为研究对象,设置空白对照组、单药安罗替尼组、单纯SDT... 详细信息

目的:探究声动力疗法(sonodynamic therapy,SDT)联合安罗替尼对非小细胞肺癌(non-small cell lung cancer,NSCLC)的协同杀伤效果及作用机制。方法:本研究选取A549和H1299肺癌细胞作为研究对象,设置空白对照组、单药安罗替尼组、单纯SDT组及SDT联合安罗替尼治疗组。通过CCK-8和细胞划痕实验检测细胞活性与细胞迁移能力;流式细胞术检测活性氧(reactive oxygen species,ROS)水平、凋亡状态和细胞周期;蛋白质印迹法(Western blot)检测凋亡蛋白Caspase-3和周期蛋白Cyclin D1的表达;ROS清除实验等探讨SDT联合安罗替尼协同作用机制。结果:与单纯使用安罗替尼相比,SDT联合安罗替尼可显著抑制肺癌细胞的增殖[细胞存活率:A549:(49.96±4.82)%vs.(86.79±2.64)%,P<0.01;H1299:(31.91±4.87)%vs.(88.04±2.16)%,P<0.001]与迁移[愈合率:A549:(4.23±0.17)%vs.(14.28±0.05)%,P<0.05;H1299:(13.68±2.16)%vs.(42.81±8.11)%,P<0.001]。联合治疗组可明显诱导A549细胞凋亡[凋亡率:(12.58±0.815)%vs.(8.43±0.56)%,P<0.05]。机制研究发现,安罗替尼耐药与ROS水平相关,经活性氧清除剂N-乙酰半胱氨酸(NAC)作用后,细胞内ROS含量减少,安罗替尼IC50增大,敏感性下降。SDT联合安罗替尼后,肿瘤细胞内的ROS水平显著高于单药安罗替尼组(934.14±2.01 vs.166.75±1.45,P<0.001),并激活Caspase-3,下调Cyclin D1的表达。结论:SDT联合安罗替尼具有明显的协同抗肿瘤作用,其机制与ROS通路激活下游凋亡蛋白Caspase-3及下调Cyclin D1,抑制肺癌细胞增殖,诱导细胞凋亡相关。

关键词：非小细胞肺癌声动力疗法安罗替尼 ROS

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甘蓝自交不亲和性的测定方法(综述)

农业生物技术学报 1998年第2期6卷 95-99页

作者：王晓佳朱利泉西南农业大学南方蔬菜遗传育种与栽培重点开放实验室

论述了从常规育种学逐步深入到分子生物学水平的５种关于甘蓝及其相关物种孢子体型自交不亲和性的测定方法，及其在测定ＳＣ系、ＳＩ系和各种Ｓ－单倍型中的应用。对未来自交不亲和性测定方法的发展方向进行了探讨。

关键词：甘蓝自交不亲和性 S-单倍型测定方法