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Taking advantage of drug resistance, a new approach in the war on cancer

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Frontiers of Medicine 2018年第4期12卷 490-495页

作者： liqin wang Rene Bernards Division of Molecular Carcinogenesis Oncode Institute The Netherlands Cancer Institute Plesmanlaan 121 1066 CX Amsterdam The Netherlands

Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies are given in combinations that are designed to avoid drug resistance, we discuss here therapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drug resistance. This approach is based on notion that drug resistance comes at a fitness cost to the cancer cell that can be exploited for therapeutic benefit. We discuss the development of sequential drug therapies in which the first therapy is not given with curative intent, but to induce a major new sensitivity that can be targeted with a second drug that selectively targets the acquired vulnerability. This concept of collateral sensitivity has hitherto not been used on a large scale in the clinic and holds great promise for future cancer therapy.

关键词： cancer drug resistance genetic screens senescence targeted therapy

Modeling the frictional torque of a dry-lubricated tapered roller bearing considering the roller skewing

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Friction 2019年第6期7卷 551-563页

作者： Chi ZHANG Le GU Yuze MAO liqin wang Research Lab of Space & Aerospace Tribology Harbin Institute of Technology

In this paper, an equation for the calculation of the frictional torque of a dry-lubricated tapered roller bearing(TRB) is provided in which the effect of the roller skewing is emphasized. Calculations were performed to investigate the effect of the roller skewing on the torque of dry-lubricated TRB for two representative preload methods, that is, axial force preload and axial displacement preload. The results show that a proper roller skewing angle under axial force preload benefits the reduction of the TRB torque. However, the roller skewing angle should not exceed a certain critical value;otherwise, it will cause a steep rise in the TRB torque. Finally, the critical value of the roller skewing angle as a function of the friction coefficient and cage pocket clearance is presented. The developed torque model provides a tool for the internal design and torque optimization of dry-lubricated TRBs.

关键词： tapered roller bearing frictional torque roller skewing dry lubrication

Characterizing permeability-porosity relationships of porous rocks using a stress sensitivity model in consideration of elastic-structural deformation and tortuosity sensitivity

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3437-3451页

作者： Ronghe Xu liqin wang Xiaoli Zhao Yuze Mao MIIT Key Laboratory of Aerospace Bearing Technology and Equipment Harbin Institute of TechnologyHarbin150001China State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin150001China Shanghai Aerospace Control Technology Institute Shanghai201100China

Clarifying the relationship between stress sensitivities of permeability and porosity is of great significance in guiding underground resource *** and more studies focus on how to construct stress sensitivity models to describe the relationship and obtain a comprehensive stress sensitivity of porous ***,the limitations of elastic deformation calculation and incompleteness of considered tortuosity sensitivity lead to the fact that the existing stress sensitivity models are still unsatisfactory in terms of accuracy and ***,a more accurate and generic stress sensitivity model considering elastic-structural deformation of capillary cross-section and tortuosity sensitivity is proposed in this *** elastic deformation is derived from the fractal scaling model and Hooke's *** the effects of elastic-structural deformation on tortuosity sensitivity,an empirical formula is proposed,and the conditions for its applicability are *** predictive performance of the proposed model for the permeability-porosity relationships is validated in several sets of publicly available experimental *** experimental data are from different rocks under different pressure *** mean and standard deviation of relative errors of predicted stress sensitivity with respect to experimental data are 2.63%and 1.91%.Compared with other models,the proposed model has higher accuracy and better predictive generalization *** is also found that the porosity sensitivity exponent a,which can describe permeability-porosity relationships,is 2 when only elastic deformation is considered.a decreases from 2 when structural deformation is also *** addition,a may be greater than 3 due to the increase in tortuosity sensitivity when tortuosity sensitivity is considered even if the rock is not fractured.

关键词： Stress sensitivity model Permeability-porosity relationships Elastic-structural deformation Tortuosity stress sensitivity

The Viewpoint of Righteousness and Benefit in China's Diplomacy:Learning from the Traditional and Building the Contemporary

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Fudan Journal of the Humanities and Social Sciences 2020年第4期13卷 473-493页

作者： liqin wang Qin Zhu Building Zhonghe Tongji UniversityNo.1239Siping RoadShanghai 200092China Institute of International Studies Fudan UniversityHandan Road 220Shanghai 200433China

The contemporary viewpoint of righteousness and benefit,proposed by President Xi Jinping of China in 2013,initially originated from the traditional concept during the Spring and Autumn period and the Warring States period over 2000 years *** the evolution,traditional views are usually individual-and domestic-level based;feudal kings were assumed the subject(dominant stakeholder)of practice with the people objects(passive takers);the subject and object enjoyed a hierarchical relationship in the domestic *** contemporary concept focuses fully on the international level,viewing Chinese state as the subject and its neighbors(as well as some developing countries)as objects;they maintain an equal relationship in the international *** upgraded analysis level and the changed subject and object as well as the altered relationship between them drive China's diplomacy to practice the contemporary righteousness-benefit ***,the group of subject players expanded to include not only Chinese government but also Chinese enterprises,whose responsibilities still need additional *** China case,the government is assumed to take the major responsibility in practicing righteousness,with enterprises for *** and objects enjoy a mutually beneficial relationship with each other;China,as the subject of practicing righteousness,naturally has the expectations to get righteousness in return from the *** contemporary viewpoint of righteousness and benefit will work as a practicing guidance to China's diplomacy,entailing a working mechanism to put it into *** implementation of such viewpoint fails to take route,correction mechanism from economic side will be needed as war is not always considered the ideal way.

关键词： Righteousness Benefit Traditional Contemporary China's diplomacy

Thermal analysis of lubricated three-dimensional contact bodies considering interface roughness

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Frontiers of Mechanical Engineering 2022年第2期17卷 177-191页

作者： Jiqiang WU liqin wang Zhen LI Peng LIU Chuanwei ZHANG MIIT Key Laboratory of Aerospace Bearing Technology and Equipment Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150080China

Surface roughness and thermal action are of remarkable importance in the lubrication performance of mechanical components,especially in extreme ***,available studies mainly focus on the full-film lubrication conditions without considering temperature rise and real 3D surface roughness due to the complexity of surface topography and temperature ***,studies on the interfacial thermal behaviors of 3D rough surface lubricated contact in an extended range of working conditions remain *** this paper,a deterministic mixed thermal elastohydrodynamic lubrication model considering real 3D surface roughness and thermal effects is *** this model,pressure and temperature are coupled with each other,the computation of elastic deformation is accelerated through the discrete convolution and fast Fourier transform method,the temperature field is calculated with the column sweeping technique,and the semi-system method is introduced to improve convergence and numerical stability under severe *** model is validated by comparing its results with available published numerical and experimental *** thermal behaviors of the contact interface are studied in a wide range of working *** influences of surface roughness and thermal effect on lubrication performance are *** results show that the proposed model can be used as a powerful analysis tool for lubrication performance and temperature prediction in various heavy-load,high-speed lubricated components over a wide range of lubrication conditions.

关键词： thermal elastohydrodynamic lubrication surface roughness effect thermal effect temperature characteristics severe conditions

Insights into in-situ TiB/dual-phase Ti alloy interface and its high load-bearing capacity

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Journal of Materials Science & Technology 2022年第24期119卷 156-166页

作者： Qi An Lujun Huang Qi Qian Yong Jiang Shuai wang Rui Zhang Lin Geng liqin wang School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Materials Science and Engineering Central South UniversityChangsha 410083China School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150001China

To better understand the strengthening mechanism of in-situ formed TiB reinforcements in dual-phase Ti6 Al4 V alloy,the interface characters and properties ofα-Ti/β-Ti/TiB system were thoroughly investigated with the combined use of high-resolution transmission electron microscopy(HRTEM),abinitio calculations,and indentation *** ab-initio calculations suggest that the highly coherent(100)_(TiB)/(121)_(β-Ti)phase boundary(PB)has fairly low interface energy of 0.082 J/m^(2)with an exceptionally high adhesion strength of 6.04 J/m^(2),owing to the formation of strong interfacial Ti–B ionic *** semi-coherent(201)_(TiB)/(0001)_(α-Ti)interface shows a relatively higher interface energy of 1.442 J/m^(2)but still with a fairly high adhesion strength of 4.95 J/m^(2).With the obtained interfacial energetics,thermodynamics analyses were further carried out to explore the nucleation mechanism ofα-Ti in TiB reinforced Ti6Al4V *** to the heterogeneous nucleation at TiB/β-Ti interface,the homogeneous nucleation ofα-Ti within theβ-Ti phase can be more energy-preferred,due to its lower nucleation energy barrier and critical *** indentation tests under various loads of different modes confirmed a remarkably enhanced load-bearing capacity of dual-phase Ti6Al4V alloys,under the critical significance of the strong interfacial bonding achieved by reinforcements of in-situ formed TiB.

关键词： Dual-phase Ti6Al4V alloy In-situ TiB Interface Ab-initio calculation Indentation test

Iterative FEA Method for Load Distribution of Flexible Supporting Thin-section Ball Bearing

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Journal of Harbin Institute of Technology(New Series) 2015年第1期22卷 9-14页

作者： Ju Shu liqin wang Yuze Mao Yuting Ding School of Mechatronics Engineering Harbin Institute of Technology

To figure out the load distribution of thin-section rolling bearing supported by flexible structure with squirrel cage and the distribution's influence on bearing life,an iterative FEA method is proposed to use the result calculated from the Quasi-Dynamic model based on the rigid support hypothesis. The contact angle,contact position and stiffness of equivalent spring are modified during the iterative FEA to optimize the FEA model,and then the bearings' life can be predicted when the error is below 0.5%. It can be concluded that from the analysis results the load distribution under flexible support is more uniform than that of the rigid support,while the maximum load decreases by 11.2% and bearing life increases by 14.7%. The analysis result of different values of thickness of bearing house,rings and hollow shaft demonstrates the thicknesses of bearing house and hollow shaft have a greater influence on the load's uniformity and bearing's life than those of the rings.

关键词： flexible support with squirrel cage iterative FEA

Sustainable all-weather CO2 utilization by mimicking natural photosynthesis in a single material

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National Science Review 2024年第2期11卷 177-187页

作者： Xianjin Shi Yu Huang Ran Long Zhenyu wang liqin wang Junji Cao Gangqiang Zhu Yujie Xiong State Key Laboratory of Loess and Quaternary Geology(SKLLQG) Key Laboratory of Aerosol Chemistry and Physics Institute of Earth EnvironmentChinese Academy of Sciences Center of Excellence in Quaternary Science and Global Change Chinese Academy of Sciences University of Chinese Academy of Sciences Hefei National Research Center for Physical Sciences at the Microscale School of Chemistry and Materials Science and National Synchrotron Radiation Laboratory University of Science and Technology of China Institute of Atmospheric Physics Chinese Academy of Sciences School of Physics and Information Technology Shaanxi Normal University

Solar-driven CO2conversion into hydrocarbon fuels is a sustainable approach to synchronously alleviating the energy crisis and achieving net ***,the dependence of the conversion process on solar illumination hinders its practical application due to the intermittent availability of sunlight at night and on cloudy or rainy ***,we report a model material of Pt-loaded hexagonal tungsten trioxide（Pt/h-WO3） for decoupling light and dark reaction processes,demonstrating the sustainable CO2conversion under dark conditions for the first *** such a material system,hydrogen atoms can be produced by photocatalytic water splitting under solar illumination,stored together with electrons in the h-WO3through the transition of W6+to W5+and spontaneously released to trigger catalytic CO2reduction under dark ***,we demonstrate using natural light that CH4production can persist at night and on rainy days,proving the accomplishment of all-weather CO2conversion via a sustainable way.

关键词： sustainable CO2 utilization artificial photosynthesis all-weather application charge storage

Thermal shock of subsurface material with plastic flow during scuffing

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Friction 2023年第1期11卷 64-75页

作者： Chuanwei ZHANG Han ZHAI Dong SUN Dezhi ZHENG Xiaoli ZHAO Le GU liqin wang MIIT Key Laboratory of Aerospace Bearing Technology and Equipment Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150080China

The thermal shock of subsurface material with shear instability and severe plastic flow during scuffing was *** scuffing damage of M50 steel was tested using a high-speed rolling-sliding contact test rig,and the transient temperature during scuffing was calculated using the Fourier transform method considering the effects of both frictional heat and plastic *** results show that a thermal shock with a rapid rise and subsequent rapid decrease in the contact temperature is generated in the subsurface *** frictional power intensity generates a high temperature rise,leading to the austenitization of the subsurface ***,the plastic flow is generated in the subsurface layer under the high shear stress,and the resulting plastic strain energy generates a further temperature ***,a rapid decrease in the contact temperature quenches the material,resulting in clear shear slip bands and retained austenite in the subsurface layers of the M50 steel.

关键词： scuffing thermal shock high temperature plastic flow