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世界核心医学期刊文摘（儿科学分册） 2006年第6期2卷 19-19页

作者： Rosenthal M. Ug.le B. lipowsky g. Küster H. 刘莉 Department for Neonatolog. and Pediatric Intensive Care University Children's Hospital Soldtmannstr. 15 17487 Greifswald Germany

The aim of this prospective observational study was to compare a bedside test with the reference laboratory method in routine postnatal g.ucose monitoring. Term newborns with increased risk or clinical sig.s of hypog.ycemia were screened with a bedside test. In case of a g.ucose value below 2.25 mmolL, a second blood sample was taken and a duplicate g.ucose measurement done in the laboratory using.a bedside test (Accutrend sensor) and the reference laboratorymethod (hexokinase method) at the same time and from the same sample. From 110 term newborns, 122 blood samples were obtained for duplicate measurements (median 1.69 mmolL, SD 0.45 mmolL). Of these 122, Accutrend correctly identified 97%as being.g. scattering. the maximal over-and underestimation was 0.89 and 1.39 mmolL, respectively. Only 75%of the results from the Accutrend were within ±20%of the result of the laboratory method. If the cutoff for low g.ucose concentrations was set 0.6 mmolL hig.er for the bedside test as compared to the laboratory method, all patients except one would have been correctly identified as hypog.ycemic. Conclusion: When using.the Accutrend sensor, sing.e infants with even marked hypog.ycemia mig.t be missed. Some delay in receiving.accurate measurements mig.t be more helpful for clinical decisions and long.term outcome than immediate but potentially misleading.results.

关键词：新生儿低血糖血糖测定值床旁检测分析仪 0.6mmol/L 电子实验室方法实验室检查方法足月新生儿前瞻性观察

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Influence of thickness and permeability of endothelial surface layer on transmission of shear stress in capillaries

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Science China(Physics,Mechanics & Astronomy) 2015年第7期58卷 90-98页

作者： ZHANg.Song.eng.ZHANg.Xiang.un TIAN Yu MENg.Yong.ang.lipowsky Herbert State Key Laboratory of Tribolog. Tsinghua University Department of Bioeng.neering Pennsylvania State University University Park

The molecular coating.on the surface of microvascular endothelium has been identified as a barrier to transvascular exchang. of solutes. With a thickness of hundreds of nanometers, this endothelial surface layer （ESL） has been treated as a porous do- main within which fluid shear stresses are dissipated and transmitted to the solid matrix to initiate mechanotransduction events. The present study aims to examine the effects of the ESL thickness and permeability on the transmission of shear stress throug.out the ESL. Our results indicate that fluid shear stresses rapidly decrease to insig.ificant levels within a thin transition layer near the outer boundary of the ESL with a thickness on the order of ten nanometers. The thickness of the transition zone between free fluid and the porous layer was found to be proportional to the square root of the Darcy permeability. As the per- meability is reduced ten-fold, the interfacial fluid and solid matrix shear stress g.adients increase exponentially two-fold. While the interracial fluid shear stress is positively related to the ESL thickness, the transmitted matrix stress is reduced by about 50% as the ESL thickness is decreased from 500 to 100 nm, which may occur under patholog.cal conditions. Thus, thickness and permeability of the ESL are two main factors that determine flow features and the apportionment of shear stress- es between the fluid and solid phases of the ESL. These results may shed lig.t on the mechanisms of force transmission throug. the ESL and the patholog.cal events caused by alterations in thickness and permeability of the ESL.

关键词： endothelial surface layer transition layer Brinkman equation shear stress transmission g.ycocalyx thickness perme-ability

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