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Food plant extracts for sleep-related skin health: Mechanisms and prospects

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Food Bioscience 2022年第5期49卷 109-118页

作者： Bingwei He Yueyue Chen Shishuai Yu Yining Hao Feifei Wang liping qu Yunnan Botanee Bio-technology Group Co Ltd.YunnanChina Shanghai Jiyan Bio-pharmaceutical Co Ltd.ShanghaiChina Yunnan Yunke Characteristic Plant Extraction Laboratory Co. Ltd.YunnanChina

Chronic sleep deficiency, a public health epidemic, triggers an elevated risk for physical and mental disorders and may cause unpleasant sensations or experiences in daily life. Importantly, sleep-associated skin diseases attract public attention because most people have anxiety about their facial appearance in modern society. Amounts of health food, especially derived from edible and efficient plant extracts, have been developed for skincare via improvement of sleep quality. Mechanisms of good sleep and healthy skin have been studied, however, the relationship between sleep-promoting herbs and skincare is less elucidated. In this review, we summarize the main signaling pathways of neurotransmitter-mediated skin beauty and list dozens of functional plant extracts for sleep assistance. We conclude several plant candidates for oral cosmetics application through sleep-related neurotransmitters regulation. This review provides pieces of evidence for the application of oral cosmetic food derived from plant extracts in sleep-related beauty.

关键词： Chronic sleep deficiency Skin diseases Neurotransmitters Plant extracts Health food Oral cosmetics

Gut microbiome-based thiamine metabolism contributes to the protective effect of one acidic polysaccharide from Selaginella uncinata(Desv.)Spring against inflammatory bowel disease

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Journal of Pharmaceutical Analysis 2024年第2期14卷 177-195页

作者： Haochen Hui Zhuoya Wang Xuerong Zhao Lina Xu Lianhong Yin Feifei Wang liping qu Jinyong Peng Department of Pharmaceutical Analysis College of PharmacyDalian Medical UniversityDalianLiaoning116044China Innovation Materials Research and Development Center Botanee Research InstituteYunnan Botanee Bio-technology Group Co.Ltd.Kunming650106China Department of Traditional Chinese Medicine Pharmacology School of PharmacyAnhui University of Chinese MedicineHefei230012China

Inflammatory bowel disease(IBD)is a serious disorder,and exploration of active compounds to treat it is *** acidic polysaccharide named SUSP-4 was purified from Selaginella uncinata(Desv.)Spring,which contained galacturonic acid,galactose,xylose,arabinose,and rhamnose with the main chain structure of→4)-α-d-GalAp-(1→and→6)-β-d-Galp-(1→and the branched structure of→5)-α-l-Araf-(1→.Animal experiments showed that compared with Model group,SUSP-4 significantly improved body weight status,disease activity index(DAI),colonic shortening,and histopathological damage,and elevated occludin and zonula occludens protein 1(ZO-1)expression in mice induced by dextran sulfate sodium salt(DSS).16S ribosomal RNA(rRNA)sequencing indicated that SUSP-4 markedly downregulated the level of Akkermansia and *** results confirmed that SUSP-4 obviously elevated thiamine levels compared with Model mice by adjusting thiamine metabolism,which was further confirmed by a targeted metabolism *** transplantation experiments showed that SUSP-4 exerted an anti-IBD effect by altering the intestinal flora in mice.A mechanistic study showed that SUSP-4 markedly inhibited macrophage activation by decreasing the levels of phospho-nuclear factor kappa-B(p-NF-κB)and cyclooxygenase-2(COX-2)and elevating NF-E2-related factor 2(Nrf2)levels compared with Model *** conclusion,SUSP-4 affected thiamine metabolism by regulating Akkermania and inhibited macrophage activation to adjust NF-κB/Nrf2/COX-2-mediated inflammation and oxidative stress against *** is the first time that plant polysaccharides have been shown to affect thiamine metabolism against IBD,showing great potential for in-depth research and development applications.

关键词： Gut microbiota Inflammatory bowel disease Polysaccharide Selaginella uncinata(Desv.)Spring Thiamine metabolism

Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling

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Journal of Pharmaceutical Analysis 2023年第10期13卷 1153-1167页

作者： Zhang Mao Haochen Hui Xuerong Zhao Lina Xu Yan Qi Lianhong Yin liping qu Lan Han Jinyong Peng Department of Pharmaceutical Analysis College of PharmacyDalian Medical UniversityDalianShenyang116044China Innovation Materials Research and Development Center Botanee Research InstituteYunnan Botanee Bio-technology Group Co.Ltd.Kunming650106China Department of Traditional Chinese Medicine Pharmacology School of PharmacyAnhui University of Chinese MedicineHefei230012China Department of Pharmacology School of PharmacyWeifang Medical UniversityWeifangShandong261053China

It is necessary to explore potent therapeutic agents via regulating gut microbiota and metabolism to combat Parkinson's disease(PD).Dioscin,a bioactive steroidal saponin,shows various ***,its effects and mechanisms against PD are *** this study,dioscin dramatically alleviated neuroinflammation and oxidative stress,and restored the disorders of mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP).16 S rDNA sequencing assay demonstrated that dioscin reversed MPTP-induced gut dysbiosis to decrease Firmicutes-to-Bacteroidetes ratio and the abundances of Enterococcus,Streptococcus,Bacteroides and Lactobacillus genera,which further inhibited bile salt hydrolase(BSH)activity and blocked bile acid(BA)*** microbiome transplantation test showed that the anti-PD effect of dioscin was gut *** addition,non-targeted fecal metabolomics assays revealed many differential metabolites in adjusting steroid biosynthesis and primary bile acid ***,targeted bile acid metabolomics assay indicated that dioscin increased the levels of ursodeoxycholic acid,tauroursodeoxycholic acid,taurodeoxycholic acid and bmuricholic acid in feces and *** addition,ursodeoxycholic acid administration markedly improved the protective effects of dioscin against PD in *** test indicated that dioscin significantly up-regulated the levels of takeda G protein-coupled receptor 5(TGR5),glucagon-like peptide-1 receptor(GLP-1R),GLP-1,superoxide dismutase(SOD),and down-regulated NADPH oxidases 2(NOX2)and nuclear factor-kappaB(NF-kB)*** data indicated that dioscin ameliorated PD phenotype by restoring gut dysbiosis and regulating bile acid-mediated oxidative stress and neuroinflammation via targeting GLP-1 signal in MPTP-induced PD mice,suggesting that the compound should be considered as a prebiotic agent to treat PD in the future.

关键词： Parkinson's disease Dioscin Gut microbiota Bile acid metabolism GLP-1

Safety and efficacy of Compound Huangdai Tablets combined with all-trans retinoic acid for treatment of acute promyelocytic leukemia:Clinical evidence and potential mechanisms

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Chinese Herbal Medicines 2022年第1期14卷 154-165页

作者： Qianqian Huang Tao Wang Yan Xiong liping qu Qiaozhi Yin Wenjun Zou College of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China School of Medical and Life Sciences Chengdu University of Traditional Chinese MedicineChengdu 610041China

Objective:To evaluate the safety and efficacy of Compound Huangdai Tablets(Realgar-Indigo Naturalis formula,RIF)combined with all-trans retinoic acid(ATRA)to treat acute promyelocytic leukemia(APL).Methods:This study was registered in PROSPERO(CRD42018108118).The relevant literatures on RIF treatment of APL were systematically searched in the following databases:China National Knowledge Infrastructure,Wanfang,VIP Medical Information System,Chinese Biomedical Database,EMBASE,Cochrane Library,and *** quality of the included studies was evaluated and Review Manager 5.3 software and Stata 13.0 software were used to perform the *** addition,this study used the method of network pharmacology to conduct a preliminary exploration of the mechanism of RIF on ***:The study included 12 studies involving 775 APL *** Meta-analysis showed that there was no significant difference(P>0.05)between the RIF group and the arsenic trioxide(ATO)group for primary outcomes,secondary outcomes apart from liver *** incidence of liver dysfunction(P=0.006)in the RIF group were significantly lower than those in the ATO *** addition,the cost of maintenance therapy in the RIF group was significantly lower(P<0.05)than the ATO ***,the active ingredients in RIF mainly act on targets proteins such as ACHE,NCOA2,RXRA,and then play a role in the treatment of APL through regulating multiple molecular mechanisms,such as TP53 regulates transcription of cell cycle genes,nuclear receptor transcription ***:There was no significant difference in efficacy of oral RIF combined with ATRA compared with intravenous ATO combined with ATRA for the treatment of *** oral RIF exposed patients to less risk,offered more convenience and had lower *** can treat APL by multi-target and multipathway interventions that inducing apoptosis of APL cells and inhibiting the proliferation of APL cells,and so ***,oral RIF in the treatment

关键词： acute promyelocytic leukemia all-trans retinoic acid network pharmacology Realgar-Indigo Naturalis formula

Organic-free,Ultrafast Synthesis of K-CHA Nano-aggregates with Various Morphologies and Their Adsorption Performances

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Chemical Research in Chinese Universities 2024年第6期40卷 1151-1159页

作者： CHU Kailiang WANG Yaquan LIU Wenrong BU Lingzhen HUANG Yitong GUO Niandong qu liping SANG Juncai LI Yaoning SU Xuemei ZHANG Xian Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering&TechnologyTianjin UniversityTianjin 300072P.R.China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192P.R.China

K-Chabazite(K-CHA)zeolites were synthesized with an ultrafast procedure through an eco-friendly and cost-effective“one-pot”*** solely employing colloidal silica and aluminum hydroxide in the K^(+)/Sr^(2+)system without the assistance of seeds,fluorides or organic structure as directing agents,the K-CHA nano-aggregates were successfully synthesized in a few *** crystallization behavior of the gels with different SiO_(2)/Al_(2)O_(3) molar ratios(SARs)was investigated using X-ray diffraction(XRD);scanning electron microscope(SEM);X-ray fluorescence(XRF);27Al and 29Si magic angle spinning nuclear magnetic resonance(MAS NMR);Fourier-transform infrared spectra(FTIR);UV-Raman *** the nucleation rates were changed with the SARs,three kinds of K-CHA nano-aggregates,namely,hamburger-,disk-and walnut-shaped,were obtained.A possible formation mechanism of the K-CHA nano-aggregates was ***,the walnut-shaped sample with an SAR of 7 possessed the largest pore volume and specific surface area,resulting in the highest methane adsorption ***,it exhibited a CH_(4)/N_(2) selectivity of more than 3 under relative pressures ranging from 0 to *** work offers guidance for modifying the stacking modes of other nano-sized zeolites.

关键词： Chabazite Organic structure directing agent(OSDA)-free Nano-aggregate Methane Adsorption separation

Synthesis of LSX Using Seed-iteration Approach with High N_(2) Adsorption Capacity for Air Separation

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Chemical Research in Chinese Universities 2024年第6期40卷 1192-1200页

作者： HUANG Yitong WANG Yaquan LIU Wenrong BU Lingzhen qu liping CHU Kailiang GUO Niandong ZHANG Xian SU Xuemei LI Yaoning SANG Juncai Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072P.R.China

A series of low silica X zeolites (LSX) was synthesized through a seed-iteration approach,based on the seed addition strategy,and then loaded with lithium ions by an ion exchanging method to obtain high N_(2) adsorption *** zeolites were characterized by X-ray diffraction (XRD);scanning electron microscopy (SEM);Fourier transform infrared spectra (FTIR);thermogravimetric analysis (TGA);N_(2) adsorption-desorption,and the adsorption capacity of N2 and O_(2) was evaluated by the vacuum pressure swing adsorption (VPSA) *** results showed that the nucleation period of the synthetic process could be effectively shortened by adding seed;as the seed iterations increased,the specific surface area and pore volume of the zeolites increased;the higher specific surface area and the pore volume,the higher the extent of the N2 adsorption capacity,with the maximum reaching 28.05 cm^(3)/***,there were no significant differences in the adsorbed capacity of O_(2) by each ***,the N2/O_(2) separation factor also increased gradually with iterations,with the maximum up to 6.61.

关键词： Seed-iteration Low silica X zeolite(LSX) Air separation

An SLAM algorithm based on improved UKF

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An SLAM algorithm based on improved UKF

Research on BOF steelmaking endpoint control based on neural network

第24届中国控制与决策会议

作者： liping qu, Shuiqing He, Yongyin qu Department of Electric Information Engineering College University of Beihua, Jilin 132021, China

Because of using system nonlinear model directly UKF overcomes the shortcomings of the methods such as EKF that they easily introduces truncation errors in the process of lining model .So it is widely used in SLAM problem. Because the square root of filter has the advantages that it can ensure the covariance matrix nonnegative, a square root version of the UKF was included in the SLAM problem that improve the performance of UKF-SLAM algorithm. Simulation result shows that this algorithm is effective.

关键词： Mobile Robot SLAM Unscented Kalman filter

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Research on BOF steelmaking endpoint control based on neural...

基于生态供需视角的生态安全格局构建与优化——以长三角地区为例

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作者： liping qu, Xiuju Zhang, Yongyin qu Department of Electric Information Engineering College University of Beihua Jilin City, Jilin Province, China

BOF （Basic Oxygen Furnace） steelmaking is a very complex industry process and the endpoint control is an important operation in the later period of BOF steelmaking. Owing to the environment is so harsh and the temperature is so high that it is very difficult to measure the temperature and contents continuously and accurately, therefore, we can not use normal method of process control. This paper makes use of the advantage of the RBF （Radial Basis Function） neural network （NN） that has quick convergence velocity and can avoid the relative extreme value effectively;the prediction model of endpoint steel temperature and the endpoint carbon content is established. On the basis of prediction model, the dynamic endpoint control method based on BP NN is proposed to calculate the need of coolant and blown oxygen during the reblowing. The simulation result shows that the new method overcomes the shortcoming that the control model based on the heat balance and the oxygen balance is not accurate in the traditional method, and increases the endpoint hitting ratio.

关键词： BOF steelmaking endpoint control RBF neural network

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生态学报 2019年第20期39卷 7525-7537页

作者：张豆渠丽萍张桀滈中国地质大学公共管理学院

生态安全格局构建是保障区域生态安全与提升人类福祉的基本途径之一。以长三角地区为案例区,通过生境质量评估、生态系统服务重要性评价和景观连通性分析识别区域生态源地,在利用生态系统服务价值化方法辨别高生态需求区的基础上,运用... 详细信息

生态安全格局构建是保障区域生态安全与提升人类福祉的基本途径之一。以长三角地区为案例区,通过生境质量评估、生态系统服务重要性评价和景观连通性分析识别区域生态源地,在利用生态系统服务价值化方法辨别高生态需求区的基础上,运用最小累积阻力模型提取源地与高需求地之间的生态廊道,以构建并优化区域生态安全格局。研究结果表明:长三角地区生态源地总面积64911km2,占全区的32.51%,主要分布于皖南和浙中;区域中高与较高生态需求斑块总面积占全区46.60%,主要位于上海市和江苏省;区域生态廊道总长度11188.85km,源间廊道主要分布于长江沿岸和区域南部,需求廊道主要位于区域东中北部。研究首次将生态需求评价纳入生态廊道建设框架,为生态安全格局构建提供新思路,结果可为生态空间保护规划提供参考。

关键词：生态安全格局生态供需生态廊道 MSPA 长三角地区