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Tenecteplase versus alteplase in treatment of acute ST-segment elevation myocardial infarction:A randomized non-inferiority trial

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Chinese Medical Journal 2024年第3期137卷 312-319页

作者： Xingshan Zhao Yidan Zhu Zheng Zhang Guizhou Tao Haiyan Xu Guanchang Cheng Wen Gao liping Ma liping qi Xiaoyan Yan Haibo Wang qingde Xia Yuwang Yang Wanke Li Juwen Rong Limei Wang Yutian Ding qiang Guo Wanjun Dang Chen Yao qin Yang Runlin Gao Yangfeng Wu Shubin qiao Department of Cardiology Beijing Jishuitan HospitalCapital Medical UniversityThe Fourth Clinical Medical College of Peking UniversityBeijing 100035China Peking University Clinical Research Institute Peking University First HospitalBeijing 100191China Department of Cardiology The First Hospital of Lanzhou UniversityLanzhouGansu 730013China Department of Cardiology The First Affiliated Hospital of Liaoning Medical UniversityJinzhouLiaoning 110002China Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100037China Department of Cardiology Huaihe Hospital of Henan UniversityKaifengHenan 450001China Department of Cardiology Bayannur HospitalBayannurInner Mongolia 015208China Department of Cardiology Puyang People’s HospitalPuyangHenan 457099China Department of Cardiology Xingtai Third HospitalXingtaiHebei 054099China Department of Cardiology Lintao County People’s HospitalDingxiGansu 730599China Department of Cardiology Dancheng County People’s HospitalZhoukouHenan 477150China Department of Cardiology The First People’s Hospital of LingbaoSanmenxiaHenan 472500China Department of Cardiology Shanyin County People’s HospitalShuozhouShanxi 036999China Department of Cardiology Uxin Banner People’s HospitalOrdosInner Mongolia 017399China Department of Cardiology Lingqiu County People’s HospitalDatongShanxi 034499China Department of Cardiology Huaibin County People’s HospitalXinyangHenan 464411China Department of Cardiology Tianzhu County People’s HospitalWuweiGansu 733200China Guangzhou Recomgen Biotech Co. LtdGuangzhouGuangdong 510530China

Background:A phase II trial on recombinant human tenecteplase tissue-type plasminogen activator(rhTNK-tPA)has previously shown its preliminary efficacy in ST elevation myocardial infarction(STEMI)patients.This study was designed as a pivotal postmarketing trial to compare its efficacy and safety with rrecombinant human tissue-type plasminogen activator alteplase(rt-PA)in Chinese patients with STEMI.Methods:In this multicenter,randomized,open-label,non-inferiority trial,patients with acute STEMI were randomly assigned(1:1)to receive an intravenous bolus of 16 mg rhTNK-tPA or an intravenous bolus of 8 mg rt-PA followed by an infusion of 42 mg in 90 min.The primary endpoint was recanalization defined by thrombolysis in myocardial infarction(TIMI)flow grade 2 or 3.The secondary endpoint was clinically justified recanalization.Other endpoints included 30-day major adverse cardiovascular and cerebrovascular events(MACCEs)and safety endpoints.Results:From July 2016 to September 2019,767 eligible patients were randomly assigned to receive rhTNK-tPA(n=384)or rt-PA(n=383).Among them,369 patients had coronary angiography data on TIMI flow,and 711 patients had data on clinically justified recanalization.Both used a–15%difference as the non-inferiority efficacy margin.In comparison to rt-PA,both the proportion of patients with TIMI grade 2 or 3 flow(78.3%[148/189]vs.81.7%[147/180];differences:–3.4%;95%confidence interval[CI]:–11.5%,4.8%)and clinically justified recanalization(85.4%[305/357]vs.85.9%[304/354];difference:–0.5%;95%CI:–5.6%,4.7%)in the rhTNK-tPA group were non-inferior.The occurrence of 30-day MACCEs(10.2%[39/384]vs.11.0%[42/383];hazard ratio:0.96;95%CI:0.61,1.50)did not differ significantly between groups.No safety outcomes significantly differed between groups.Conclusion:rhTNK-tPA was non-inferior to rt-PA in the effect of improving recanalization of the infarct-related artery,a validated surrogate of clinical outcomes,among Chinese patients with acute STEMI.Trial registration:www.ClinicalTrials.gov(No.NCT028355

关键词： Thrombolytic therapy rhTNK-tPA Randomized controlled trial ST elevation myocardial infarction

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Genetic variant reanalysis reveals a case of Sandhoff disease with onset of infantile epileptic spasm syndrome

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Acta Epileptologica 2024年第1期7卷 67-73页

作者： qi Zhang liping Zou qian Lu qiuhong Wang Shuo Dun Jing Wang Medical School of Chinese PLA Beijing100853China Department of Pediatrics the First Medical Center of PLA General HospitalBeijing100853China

Background Sandhoff disease(SD)i s an autosomal recessive lysosomal disease with clinical manifestations such as epilepsy,psychomotor retardation and developmental delay.However,infantile SD with onset of infantile epilepsy spasm syndrome(IESS)is extremely rare.Case presentation The case presented here was a 22-month-old boy,who presented with IESS and psychomotor retardation/regression at 6 months of age.The patient showed progressive aggravation of seizures and excessive startle responses.The whole exome sequencing data,which initially revealed negative results,were reanalyzed and indicated a homozygous mutation at the c.1613+4del splice site of the HEXB gene.The activities ofβ-hexosaminidase A and total hexosaminidase were significantly decreased.The fundus examination showed cherry red spots at the macula.Conclusions IESS can be an epileptic phenotype of infantile SD.Clinical phenotypes should be adequately collected in genetic testing.In the case of negative sequencing results,gene variant reanalysis can be performed when the patients show clinically suspicious indications.

关键词： Infantile Sandhoff disease Gene variant reanalysis HEXB gene Infantile epilepsy spasm syndrome Cherry red spot Human phenotype ontology

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Palladium-Catalyzed Methionine-Facilitated β and γ C(sp^(3))–H Arylation of N-Terminal Aliphatic Amino Acids of Peptides

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Chinese Journal of Chemistry 2022年第21期40卷 2502-2506页

作者： Xiangxiang Chen Bo Li Huarong Tong liping qi Gang He Gong Chen State Key Laboratory and Institute of Elemento-Organic Chemistry College of ChemistryNankai UniversityTianjin 300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China

A new method for post-assembly modification of peptides via the Pd-catalyzed endogenous group-directed sp^(3) C—H arylation with aryl iodides is developed.The sulfide side chain of methionine(Met)residue can facilitate the arylation of bothβandγmethyl C—H bonds of N-terminal aliphatic amino acids of peptides via formation of 5 or 6-membered palladacycle intermediates.The reactions can proceed in moderate to good yield and with excellent diastereoselectivity.

关键词： Methionine Endogenous directing group C(sp^(3))-H arylation Palladium Peptides

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Natural variation of an autophagy-family gene among rice subspecies affects grain size and weight

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The Crop Journal 2024年第1期12卷 121-132页

作者： Shiying Huang Peng Wang Caijing Li qingwen Zhou Tao Huang Yicong Cai qin Cheng Hui Wang qi Zhong Zhihao Chen liping Chen Haohua He Jianmin Bian Key Laboratory of Crop Physiology Ecology and Genetic BreedingMinistry of Education.Jiangxi Agricultural UniversityNanchang 330045JiangxiChina Weill Cornell Medical Immunology and Microbiology1300 York AvenueBox 62New YorkNY 10065USA

Elucidating the genetic basis of natural variation in grain size and weight among rice varieties can help breeders develop high-yielding varieties.We identified a novel gene,GW3a(Grain Weight 3a)(LOC_Os03g27350),that affects rice grain size and weight.gw3a mutants showed higher total starch content and dry matter accumulation than the wild type(WT),Nipponbare,suggesting that GW3a negatively regulates grain size and weight.Moreover,our study found that GW3a interacted with OsATG8 by cleaving it,suggesting that GW3a may be involved in the assembly of autophagosomes and starch degradation in plants.The haplotype analysis of GW3a showed functional differences between indica and japonica rice.Taken together,we conclude that GW3a is expressed in the autophagosome pathway regulating starch metabolism in rice,affecting yield-related traits,such as grain size,grain weight and thousand grain weight(TGW).Our findings also shed new light on autophagy-mediated yield trait regulation,proposing a possible strategy for the genetic improvement of high-yield germplasm in rice.

关键词： Grain size GW3a Autophagy Starch content

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Shouhui Tongbian Capsule in treatment of constipation: Treatment and mechanism development

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Chinese Herbal Medicines 2024年第2期16卷 239-247页

作者： liping Gong Hang Du Xin Guo Jianchao Li Xiaomin Zhu Xianhui Shen Zhiyan Huang Kaiyi Wu Guimin Zhang Rong Sun The Second Hospital of Shandong University Jinan 250033China State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine Lunan Pharmaceutical Group Co.Ltd.Linyi 276006China Tianjin University of Traditional Chinese Medicine Tianjin 301617China Shandong University of Traditional Chinese Medicine Jinan 250355China Advanced Medical Research Institute Shandong UniversityJinan 250012China

Constipation is common in the diseases of the digestive system in clinics.With the change in diet structure and the increase in life pressure,the prevalence rate increases year by year.In traditional Chinese medicine(TCM),the location of the disease of constipation is in the large intestine,which is related to the dysfunction of lung,spleen,liver,kidney and other viscera.Its pathogenesis is conductive dysfunction of large intestine.Based on the theory,Shouhui Tongbian Capsule(SHTB)is composed of eight traditional Chinese medicines,including Polygoni multiflori Radix(Heshouwu in Chinese),Aloe(Luhui in Chinese),Cassiae Semen(Juemingzi in Chinese),Ginseng Radix et Rhizoma(Renshen in Chinese),Lycii Fructus(Gouqizi in Chinese),Asini Corii Colla(Ejiao in Chinese),Aurantii Fructus Immaturus(Zhishi in Chinese),and Atractylodis Macrocephalae Rhizoma(Baizhu in Chinese),which could help to release excessive turbid,and nourishing yin and supplementing qi in the treatment.This study has been carried out to review the latest advances of SHTB in the treatment of constipation.The results showed that significant effect of SHTB was found in the treatment of constipation,such as functional constipation,and constipation associated with tumor chemotherapy,colitis,type 2 diabetes and chronic cardiac failure.Besides,obvious adverse reactions were not observed.SHTB could effectively treat five types of constipation,provide direction for the future exploration of SHTB in the treatment of other types of constipation。

关键词： constipation gastrointestinal hormones interstitial cells of cajal intestinal fluid secretion intestinal motility Shouhui Tongbian Capsule

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Spectral CT imaging parameters and Ki-67 labeling index in lung adenocarcinoma

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Chinese Journal of Cancer Research 2020年第1期32卷 96-104页

作者： Mailin Chen Xiaoting Li Yiyuan Wei liping qi Ying-Shi Sun Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of RadiologyPeking University Cancer Hospital&InstituteBeijing 100142China

Objective: To explore the correlation between the spectral computed tomography(CT) imaging parameters and the Ki-67 labeling index in lung adenocarcinoma.Methods: Spectral CT imaging parameters [iodine concentrations of lesions(ICLs) in the arterial phase(ICLa)and venous phase(ICLv), normalized IC in the aorta(NICa/NICv), slope of the spectral HU curve(λHUa/λHUv)and monochromatic CT number enhancement on 40 keV and 70 keV images(CT40 keVa/v, CT70keVa/v)] in 34 lung adenocarcinomas were analyzed, and common molecular markers, including the Ki-67 labeling index, were detected with immunohistochemistry. Different Ki-67 labeling indexes were measured and grouped into four grades according to the number of positive-stained cells(grade 0, ≤1%;1%30%). One-way analysis of variance(ANOVA) was used to compare the four different grades, and the Bonferroni method was used to correct the P value for multiple comparisons. A Spearman correlation analysis was performed to further research a quantitative correlation between the Ki-67 labeling index and spectral CT imaging parameters.Results: CT40keVa, CT40 keVv, CT70keVa and CT70keVv increased as the grade increased, and CT70keVa and CT70keVv were statistically significant(P<0.05). These four parameters and the Ki-67 labeling index showed a moderate positive correlation with lung adenocarcinoma nodules. ICL, NIC and λHU in the arterial and venous phases were not significantly different among the four grades.Conclusions: The spectral CT imaging parameters CT40keVa, CT40keVv, CT70keVa and CT70keVv gradually increased with Ki-67 expression and showed a moderate positive correlation with lung adenocarcinomas.Therefore, spectral CT imaging parameter-enhanced monochromatic CT numbers at 70 keV may indicate the extent of proliferation of lung adenocarcinomas.

关键词： Computed tomography spectral CT lung adenocarcinoma Ki-67 labeling index

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基于跳聚集现象随机波动率短期利率模型的影响研究

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工程数学学报 2024年第1期41卷 17-38页

作者：张新军江良林琦宋丽平莆田学院金融数学福建省高校重点实验室莆田351100 莆田学院福建省金融信息处理重点实验室莆田351100 莆田学院应用数学福建省高校重点实验室莆田351100

构建了具有自我激励机制跳的随机波动率短期利率模型,应用Hawkes过程描述自我激励机制的跳,从而刻画了跳的聚集现象。基于微分算子展开给出精确的矩函数,进一步应用广义矩方法给出模型的参数估计值和统计推断。实证结果揭示了在随机波... 详细信息

构建了具有自我激励机制跳的随机波动率短期利率模型,应用Hawkes过程描述自我激励机制的跳,从而刻画了跳的聚集现象。基于微分算子展开给出精确的矩函数,进一步应用广义矩方法给出模型的参数估计值和统计推断。实证结果揭示了在随机波动模型条件下,引入自我激励机制跳的模型将不会明显地改变了拟合效果,但是在统计意义上接受强度满足Hawkes过程,而且所构建的模型也能很好地刻画跳的聚集现象。最后,使用过滤方法给出随机波动率、跳的幅度、跳的概率和随机跳强度的估计,特别是跳的概率估计值可作为市场压力测试的一个重要指标。

关键词：短期利率模型随机波动率跳的聚集 Hawkes过程

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肿瘤科护士工作生活质量与死亡应对能力的相关性研究

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中国护理管理 2024年第5期24卷 707-712页

作者：王奕敏祁丽萍赵琴琴颜君中山大学肿瘤防治中心影像科广州市510060 中山大学肿瘤防治中心放疗科广州市510060 中山大学肿瘤防治中心神经外科广州市510060 中山大学护理学院

目的:调查肿瘤科护士工作生活质量及死亡应对能力现状,探讨肿瘤科护士工作生活质量与死亡应对能力的相关性。方法:采用便利抽样法,于2020年7月—8月选取广州市某2家三级甲等肿瘤专科医院193名护士为研究对象,使用一般资料调查表、工作... 详细信息

目的:调查肿瘤科护士工作生活质量及死亡应对能力现状,探讨肿瘤科护士工作生活质量与死亡应对能力的相关性。方法:采用便利抽样法,于2020年7月—8月选取广州市某2家三级甲等肿瘤专科医院193名护士为研究对象,使用一般资料调查表、工作生活质量量表(第2版)、死亡应对能力量表进行现场调查。结果:工作生活质量总分为(106.89±16.46)分,处于中等水平。死亡应对能力总分为(128.29±27.83)分。工作生活质量总分与死亡应对能力总分呈正相关(r=0.161,P<0.05)。结论:肿瘤科护士工作生活质量及死亡应对能力处于中等水平;死亡应对能力是工作生活质量的重要影响因素。管理者可通过加强临终护理培训、心理辅导等措施提高护士死亡应对能力,以改善护士工作生活质量,稳定护理队伍。

关键词：肿瘤科护士工作生活质量死亡应对能力

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金属空心球复合材料重力铸造工艺研究

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中国材料进展 2024年第5期43卷 420-428页

作者：亓昌杨孟欣于晨崔丽萍杨姝大连理工大学汽车工程学院工业装备结构分析国家重点实验室辽宁大连116024 大连理工大学宁波研究院浙江宁波315016

基于对金属空心球复合材料的结构分析,采用金属型重力铸造法制备金属空心球复合材料。介绍了金属空心球复合材料金属型重力铸造工艺流程,并设计了一种成本低廉、简易成型、且能多次使用的金属型模具,且对金属空心球复合材料进行了实验... 详细信息

基于对金属空心球复合材料的结构分析,采用金属型重力铸造法制备金属空心球复合材料。介绍了金属空心球复合材料金属型重力铸造工艺流程,并设计了一种成本低廉、简易成型、且能多次使用的金属型模具,且对金属空心球复合材料进行了实验试制及材料验证。结果表明,采用金属型重力铸造法能够制备出孔壁结构完整且孔洞随机分布的金属空心球复合材料,能实现空心球单一设计与梯度设计;金属空心球复合材料基体与空心球壁组织较为致密,且形成了厚度为25~30μm的界面层;金属空心球复合材料的应力-应变曲线具有明显的弹性阶段、塑性平台阶段和致密化阶段,且采用空心球梯度设计的金属空心球复合材料相较于空心球单一设计的金属空心球复合材料,其基本力学性能有明显的提升。最后,与传统的闭孔泡沫铝材料进行了对比分析,金属空心球复合材料整体稳定性更高,吸能效果更强。

关键词：金属空心球复合材料重力铸造模具设计铸造工艺实验验证

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Study on the four qi of Pfaffia glomerata based on the metabolomics technology and comparison of Dangshen(Radix Codonopsis) in the equivalent substitution prescription

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Journal of Traditional Chinese Medicine 2024年第4期 713-721页

作者： SONG Zhenguang YANG Bin WANG Fei YAN Dongmei ZHOU Xiaoqing HUANG liping GAO Xuemei LI Bin HUANG Luqi Academician Workstation Jiangxi University of Chinese Medicine State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China School of PharmacyChengdu University of Traditional Chinese Medicine National Resource Center for Chinese Materia Medica Chinese Academy of Chinese Medical Sciences(CACMS)

OBJECTIVE: To explore the four qi of Pfaffia glomerata(PG) and endow this foreign folk herb with the properties of Chinese medicine, make it Chinese medicinal and localized, and could be used as a Chinese medicine. METHODS: The normal group, six cold herb groups, six hot herb groups, six cool herb groups, PG prescription group(PGPG), and Dangshen(Radix Codonopsis) prescription group(CPPG) were prepared with corresponding concentrations of water extracts, these herb extracts were administered by gavage to SpragueDawley rats, and the 12 h urine at night on the 29th day of the SD rats in each group were collected, Liquid Chromatograph Mass Spectrometer system was used to analyze them, the best discriminant models for the medicinal properties of cold-hot and cold-cool were set up, so as to the medicinal properties of PGPG, CPPG and PG were predicted. Based on the Progenesis qi, Human Metabolome Database, Kyoto Encyclopedia of Genes and Genomes, MetaboAnalyst 5.0 database, we enriched metabolic pathway and classification mechanism of medicinal properties of cold-cool Chinese herbs and the molecular mechanism of PG prescription. RESULTS: We established a best model of cold-hot herbal discrimination in the positive ion mode, then the probability that PGPG was predicted cold property was 88.9%. Furthermore, a model of cold-cool herbal discrimination was established, then the probability of PGPG containing the cool property was 77.8%. In addition, typical cold and cool herbs mainly affected nine biomarkers such as tyrosine-proline,(R)-3',7-Dihydroxy-2',4'-dimethoxyisoflavane in rats. The regulation trend of PGPG on markers was basically as same as the cool herbs and mainly involved in regulating the two pathways of cytochrome P450 and purine metabolism. CONCLUSION: The results showed PGPG had a cool medicinal property as same as CPPG, and the regulation trend of PGPG on markers was consistent with cool herbs. Therefore, the medicine properties PG and CP should be consistent, and the Traditional Chinese Medicine property o

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