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线粒体糖尿病一例报道

中国糖尿病杂志 2024年第1期32卷 59-61页

作者：张金鑫高绪霞马立萍余英首都医科大学附属北京安贞医院全科医疗科 100029

线粒体糖尿病(MDM)是由线粒体DNA突变引起的进行性胰岛β细胞分泌功能缺陷型糖尿病,是较罕见的单基因遗传病,约占所有DM的1%。本文报道1例MDM患者及其家系。

关键词：线粒体糖尿病 A3243G位点基因检测

基于第一性原理的β-C_(3)N_(2)笼中原子嵌入引起的超硬磁性新材料设计

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Science China materials 2024年第6期67卷 2032-2038页

作者：孙丽萍付波涛常景 College of Physics and Electronic Engineering Sichuan Normal UniversityChengdu 610068China College of Physics and Electronic Engineering Center for Computational SciencesSichuan Normal UniversityChengdu 610068China

基于第一性原理计算,我们通过将客体原子嵌入β-C_(3)N_(2)笼状结构的内在空腔中,预测了机械超硬和可控磁性的共存.以氢掺杂(H@β-C_(3)N_(2))和氟掺杂(F@β-C_(3)N_(2))为例,我们的研究表明两种掺杂构型是稳定的,并发现它们分别属于反... 详细信息

基于第一性原理计算,我们通过将客体原子嵌入β-C_(3)N_(2)笼状结构的内在空腔中,预测了机械超硬和可控磁性的共存.以氢掺杂(H@β-C_(3)N_(2))和氟掺杂(F@β-C_(3)N_(2))为例,我们的研究表明两种掺杂构型是稳定的,并发现它们分别属于反铁磁半导体和铁磁半金属.这些有趣的磁相变源于它们在费米能级周围独特的能带结构,并可通过具有半填充占据的3D Hubbard模型和Stoner模型很好地解释.此外,H@β-C_(3)N_(2)和F@β-C_(3)N_(2)的高维氏硬度(49.0和48.2 GPa)表明它们具有笼状超硬材料特征.因此,氢和氟在β-C_(3)N_(2)笼中的掺杂分别产生了一种新型的超硬反铁磁半导体和超硬铁磁半金属,这些材料在极端条件下具有潜在的应用前景.我们的工作为设计具有优异机械性能和磁性的新型高性能多功能材料提供了一种有效的策略,这可能会为超硬材料未来在自旋电子学的应用提供理论依据.

关键词： first-principles calculations clathrateβ-C_(3)N_(2) super-hard materials ferromagnetic semi-metal

利用废岩棉制备高性能泡沫玻璃陶瓷的实验研究

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无机盐工业 2024年第1期56卷 96-101页

作者：战洪仁田丰张先珍马玉桂寇丽萍刘鹏沈阳化工大学机械与动力工程学院辽宁沈阳110142

以工业垃圾废岩棉和废玻璃为原料,以CaCO_(3)为发泡剂制备出高强度泡沫玻璃陶瓷。研究了废岩棉和废玻璃的添加量及烧结温度对泡沫玻璃陶瓷材料性能的影响。结果表明:随着废岩棉添加量的增加和烧结温度的提高,熔体黏度会降低,不利于气泡... 详细信息

以工业垃圾废岩棉和废玻璃为原料,以CaCO_(3)为发泡剂制备出高强度泡沫玻璃陶瓷。研究了废岩棉和废玻璃的添加量及烧结温度对泡沫玻璃陶瓷材料性能的影响。结果表明:随着废岩棉添加量的增加和烧结温度的提高,熔体黏度会降低,不利于气泡结构的稳定;在废岩棉添加量为40%、750℃烧结温度下得到的样品容重为0.54 g/cm^(3)、孔隙率为62.5%、抗压强度为4.76 MPa;样品主晶相为亚硅酸钙和石英晶相,加入TiO_(2)作为晶核剂后主晶相改变为榍石;TiO_(2)掺量为10%时,在750℃烧结20 min更经济,所得样品容重为0.82 g/cm^(3)、孔隙率为50%、抗压强度为7.76 MPa。

关键词：废岩棉废玻璃泡沫玻璃陶瓷 TiO_(2)成核剂

“择智”与“择志”:对强基计划人才选拔效果的实证研究

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国家教育行政学院学报 2024年第1期313卷 58-68页

作者：马莉萍倪奥华赵书艺王牛北京大学北京100871

随着强基计划的实施与推进,如何从实证层面分析基础学科拔尖创新人才选拔效果成为愈发重要的现实课题。基于强基计划某试点高校2020—2023年四届本科新生调查数据,采用定量为主、质性为辅的方法,从“智”和“志”两个维度比较强基学生... 详细信息

随着强基计划的实施与推进,如何从实证层面分析基础学科拔尖创新人才选拔效果成为愈发重要的现实课题。基于强基计划某试点高校2020—2023年四届本科新生调查数据,采用定量为主、质性为辅的方法,从“智”和“志”两个维度比较强基学生与同届同院系高考统招学生的异同。研究发现:从“智”的角度看,强基生的高考成绩显著低于同年级同院系的统招生,但能力素养自评显著高于统招生;从“志”的角度看,理工科院系强基生对专业了解程度更高,文科强基生的专业兴趣显著更低,但整体的学历预期及从事科研工作的意愿皆显著高于统招生。基于上述实证结果,本研究从国家和高校两个层面对拔尖创新人才的选拔提出政策建议。

关键词：强基计划人才选拔基础学科学术智力学术志趣

Mechanisms of melatonin in anti-aging and its regulation effects in radiation-induced premature senescence

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Radiation Medicine and Protection 2021年第1期2卷 33-37页

作者： liping ma Qingjie Liu Mei Tian Xuelei Tian Ling Gao Key Laboratory of Radiation Protection and Nuclear Emergency China CDCNational Institute for Radiological ProtectionChinese Center for Disease Control and PreventionBeijing100088China

Melatonin is an effective antioxidant hormone produced mainly by the pineal gland.Premature senescence refers to senescence induced by declined cell proliferation and physiological functions when cells are stimulated by nontelomeric signals.The anti-aging effect of melatonin is exerted by upregulating the expression of silent information regulator 1/Sirtuin 1(SIRT1),which reduces oxidative stress damage,decreases p53 activation,and inhibits the NF-κB pathway.Radiation can induce premature senescence through direct or indirect oxidative stress damage.The mechanism by which melatonin regulates radiation-induced premature senescence includes the inhibition of the p53-mediated senescence pathway through elimination of reactive oxygen species or p53 deacetylation induced by upregulation of SIRT1 expression.Melatonin exhibits different regulatory effects for different cells and types of radiation.

关键词： Melatonin Premature senescence Anti-aging Radiation p53

温针齐刺联合中药对膝骨关节炎患者炎症反应及日常活动能力的影响

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Journal of Acupuncture and Tuina Science 2024年第1期22卷 41-47页

作者：蔡建刚仲慧王利平张树芸马银菲洪珏 Zhangjiakou First Hospital Hebei ProvinceZhangjiakou 075000China 不详

目的:观察温针齐刺法联合中药对风寒湿痹型膝骨关节炎(KOA)患者炎症反应及日常活动能力的影响。方法:按照随机数字表法将101例风寒湿痹型KOA患者分为针药结合组与中药组。中药组50例采用口服防风膝痹汤治疗,针药结合组51例在中药组干预... 详细信息

目的:观察温针齐刺法联合中药对风寒湿痹型膝骨关节炎(KOA)患者炎症反应及日常活动能力的影响。方法:按照随机数字表法将101例风寒湿痹型KOA患者分为针药结合组与中药组。中药组50例采用口服防风膝痹汤治疗,针药结合组51例在中药组干预基础上加用温针齐刺法治疗。治疗前后比较两组患者的中医证候评分、炎症因子水平和膝关节活动功能,治疗后比较两组临床疗效。结果:研究过程中针药结合组脱落3例,中药组脱落2例,最终两组各48例纳入统计。针药结合组总有效率为95.8%,明显高于中药组的79.2%,组间差异有统计学意义(P<0.05)。治疗后,两组患者的中医证候评分与治疗前相比明显下降(P<0.05),针药结合组患者的中医证候评分低于中药组(P<0.05)。两组患者治疗后白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α及IL-1β水平与治疗前相比较均降低(P<0.05),针药结合组的三项炎症因子水平均低于中药组(P<0.05)。与治疗前相比,治疗后两组膝部疼痛程度、膝关节僵硬程度及日间活动程度分值均下降(P<0.05),针药结合组三项指标评分均低于中药组(P<0.05)。结论:温针齐刺法联合防风膝痹汤能有效降低风寒湿痹型KOA患者的炎症反应,增加患者日常活动能力,提高患者的生活质量。

关键词：针刺疗法温针疗法齐刺针药并用骨性关节炎,膝炎症随机对照试验

Twist1-induced miR-199a-3p promotes liver fibrosis by suppressing caveolin-2 and activating TGF-βpathway

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1732-1743页

作者： Xiaoxue Yang liping ma Rong Wei Tinghong Ye JianKang Zhou maoyao Wen Ruoting Men Rami I.Aqeilan Yong Peng Li Yang Department of Gastroenterology&Hepatology West China HospitalSichuan UniversityChengdu 610041China State Key Laboratory of Biotherapy and Cancer Centre West China HospitalSichuan Universityand Collaborative Innovation Centre for BiotherapyChengdu 610041China School of Bioscience and Technology Chengdu medical collegeChengdu 610500China Department of Immunology&Cancer Research Hebrew University-Hadassah Medical SchoolJerusalemIsrael

The activation of hepatic stellate cells(HSCs)participates in liver fibrosis,and emerging evidences indicate that microRNAs(miRNAs)are abnormally expressed during HSC activation.However,the potential roles of miRNAs in liver fibrosis still remain elusive.Therefore,this study aimed to investigate the role of miR-199a-3p in liver fibrosis and its underlying mechanism.We found that miR-199a-3p expression was dramatically upregulated during HSC activation in vitro,and during liver fibrogenesis in CCl4-treated rats,and its liver expression was increased in the patients with cirrhosis.By the luciferase assay and RT-qPCR,we revealed that the expression of miR-199a-3p in HSCs was driven by the transcription factor Twist1 which could be further induced by TGF-βtreatment.Functional studies showed that inhibition of miR-199a-3p in both human LX2 cells and rat HSCs significantly decreased the expression of fibrotic markers,such as fibronectin and connective tissue growth factor(CTGF),whereas the forced expression of miR-199a-3p exhibited opposite effects,demonstrating the role of miR-199a-3p in promoting HSC activation.Mechanistically,miR-199a-3p plays an important role in TGF-βsignalling pathway activation through targeting CAV2 that negatively regulates the expression of transforming growth factor-beta receptor type I(TGFβRI).Importantly,administration of antagomiR-199a-3p in the CCl4-treated mice significantly ameliorated hepatic fibrosis.In conclusion,Twist1-induced miR-199a-3p mediates the activation of HSCs by suppressing CAV2 expression and subsequently increasing TGFβRI expression to promote TGF-βpathway.Our findings highlight the therapeutic potential of miR-199a-3p for hepatic fibrosis.

关键词： Twist1 miR hepatic

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新能源汽车电子制动助力器建模与仿真研究

现代制造工程 2024年第6期 82-87页

作者：马利平李绍鹏赵艳平承姿辛林洪立河南工业大学漯河工学院漯河462000 河南金凯迪新能源科技有限公司漯河462000

针对新能源汽车制动时顶脚反弹、连续制动踏板踩不动和制动失效等问题,建立新能源汽车电子制动助力器力学模型并进行分析,基于maTLAB软件搭建新能源汽车三相永磁同步电机(Permanent magnet Synchronous Motor,PMSM)的矢量控制模型并进... 详细信息

针对新能源汽车制动时顶脚反弹、连续制动踏板踩不动和制动失效等问题,建立新能源汽车电子制动助力器力学模型并进行分析,基于maTLAB软件搭建新能源汽车三相永磁同步电机(Permanent magnet Synchronous Motor,PMSM)的矢量控制模型并进行仿真,同时联合CarSim软件和Simulink软件对新能源汽车三相PMSM的制动效果进行仿真验证,最后搭建实车测试平台进行试验。结果表明,具备新型电子制动助力器的新能源汽车拥有更高的制动性能,制动距离更短。

关键词：新能源汽车电子制动助力器制动失效仿真

Taming quantum dots’nucleation and growth enables stable and efficient blue-light-emitting devices

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Photonics Research 2022年第10期10卷 2359-2365页

作者： ZHIWEI ma JUNXIA HU liping TANG BINGBING LYU Center of materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Key Laboratory for Special Functional materials of the Ministry of Education Henan UniversityKaifeng 475004China School of Information Engineering Xinyang Agriculture and Forestry UniversityXinyang 464000China Department of Physics South University of Science and TechnologyShenzhen 518055China

Controlling quantum dots’emission,nanostructure,and energy level alignment to achieve stable and efficient blue emission is of great significance for electroluminescence devices but remains a challenge.Here,a series of blue ZnCdSeS/ZnS quantum dots was optimized in preparation by taming their nucleation and growth kinetics.Controlling anion precursor reactive properties to modulate quantum dots’nucleation and growth tailors their alloy core and continuous gradient energy band nanostructure.These results not only elevate the thermal stability of blue quantum dots but also further enhance the injection/transportation of carriers and improve the radiative recombination efficiency in the device.The blue ZnCdSeS/ZnS quantum dots applied in light-emitting devices show superior performance,including maximum current efficiency and external quantum efficiency of,respectively,8.2 cd/A and 15.8%for blue,2.6 cd/A and 10.0%for blue-violet,and 10.9 cd/A and 13.4%for sky-blue devices.The blue and sky-blue devices exhibit lifetimes of more than 10,000 h.The proposed methodology for tailoring quantum dots is expected to pave new guidelines for further facilitating visible optoelectronic device exploration.

关键词： quantum blue enable