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Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng lin Tianyuan Fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen liping li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

A new Synbiotic supplementation ameliorates ulcerative colitis via modulating microbial homeostasis， protecting intestinal barrier integrity， and maintaining immunity homeostasis in mice

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Food Science and Human Wellness 2025年

作者： Yongbo Kang liping li Jing Guo Yue Cai Ying Yang Department of microbiology and immunology， School of Basic Medical Sciences， Shanxi Medical University Department of Endocrinology Affiliated Hospital of Yunnan University

Ulcerative colitis [UC] is established by a chronic， diffuse inflammation of colonic mucosa with poorly defined etiology， and without sufficient treatment or cure available for remission. In this context， there is a growing recognition and consensus that synbiotic supplement may be promising and impactful strategies towards ameliorating UC and related inflammatory disorders， garnering significant attention from researchers as an alternative therapy. Herein， we innovatively prepared a novel synbiotic combination including Lactobacillus acidophilus， Bifidobacterium infants and prebiotics konjac glucomannan oligosaccharides [KGMO] to explore the potential therapeutic effects in dextran sodium sulfate [DSS] induced UC mouse model. The results demonstrated that the synbiotic effectively improved colitis symptoms in mice by mitigating weight loss， disease activity index [DAI]， colonic pathological damage， and colonic oxidative stress. it also observed that the synbiotic preserve intestinal barrier function integrity， reduces metabolic endotoxemia as well as inhibits the TLR4/NF-κB， NLRP3/Caspase-1， and Nrf2/Keap1 signaling pathway. Furthermore， the synbiotic modulated microbial homeostasis directly by enhancing beneficial microbes and reducing potentially harmful bacteria. In addition， microbiome phenotype prediction and bacterial functional potential prediction analysis demonstrated that the synbiotic supplementation regulated gut microbiota function involving inflammatory injury， metabolism， immune response， and pathopoiesia. Especially， the synbiotic not only restored the balance of Th1/Th2 cells as well as Th17/Treg cells along with specific inflammatory factors expression， but also maintained bile acid homeostasis by regulating FXR/FGF15 signaling pathway. Especially important is that the synbiotic was as effective as mesalazine against UC. According to above data， it is seen that this novel synbiotic could be a good candidate drug for ameliorating UC through its ant

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中国共病加权指数与老年人卫生服务利用的关联性研究

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中国全科医学 2025年第1期28卷 65-70页

作者：李丽萍廖婧高鑫源王力赖颖斯中山大学公共卫生学院广东省广州市510000 广东省肇庆市疾病预防控制中心传染病预防控制科 526000

背景慢性病共病给老年人卫生服务带来挑战,探索老年人慢性病共病负担对卫生服务利用的影响具有重要意义。中国共病加权指数(CMWI)是衡量我国中老年人群共病负担的指标,目前尚缺乏CMWI与卫生服务利用关联性的队列研究。目的探索老年人慢... 详细信息

背景慢性病共病给老年人卫生服务带来挑战,探索老年人慢性病共病负担对卫生服务利用的影响具有重要意义。中国共病加权指数(CMWI)是衡量我国中老年人群共病负担的指标,目前尚缺乏CMWI与卫生服务利用关联性的队列研究。目的探索老年人慢性病共病负担与卫生服务利用的关联,为改善老年人慢性病共病干预与管理提供科学依据。方法于2021年12月—2024年1月,以广东省肇庆市四会市为例,收集该市全民健康信息平台中2017—2021年的居民电子健康档案信息,建立老年人健康体检自然人群队列。以该时间段内首次体检时间为基线,使用CMWI衡量老年人基线的慢性病共病负担,采用负二项回归分析个体基线的CMWI分别与其在随访时间内利用的总门诊次数、慢性病相关门诊次数、总住院次数以及慢性病相关住院次数的关联性。结果39989例老年人中,14991例(55.18%)患有慢性病共病,CMWI值为1.3(0,2.3);在平均1268 d随访时间内,26141例(65.37%)利用过门诊服务,总门诊次数为2(0,6)次,慢性病相关门诊次数为1(0,4)次;7332例(18.34%)利用过住院服务,总住院次数为0(0,0)次,慢性病相关住院次数为0(0,0)次。不同年龄、性别、文化程度及CMWI的老年人卫生服务利用比较,差异有统计学意义(P0.05)。在调整年龄、性别、居住地、文化程度后,负二项回归分析结果显示,CMWI是老年人卫生服务利用次数增加的危险因素(IRR>1),CMWI每增加1个单位,总门诊次数增加1.210次(95%CI=1.196~1.224次),慢性病相关门诊次数增加1.276次(95%CI=1.259~1.292次),总住院次数增加1.277次(95%CI=1.244~1.312次),慢性病相关住院次数增加1.286次(95%CI=1.252~1.321次)。结论CMWI是老年人卫生服务利用次数增加的危险因素,老年人卫生服务利用次数随CMWI值增大而增加,应重视老年人的慢性病共病负担,为改进我国老年人慢性病共病干预与管理提供科学依据。

关键词：慢性病共病老年人卫生服务利用负二项回归中国共病加权指数

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光伏企业财务管理研究——以A企业为例

现代工业经济和信息化 2025年第1期15卷 155-156+159页

作者：李立平国家电投集团云南国际电力投资有限公司

采用案例研究方法，选择中国光伏发电行业的龙头公司作为研究对象，通过分析其财务报表、年度报告、以及相关的公开数据，采用比较分析，对比企业不同的财务管理策略及其成效。评估财务管理的影响。研究发现财务管理在光伏发电企业中发... 详细信息

采用案例研究方法，选择中国光伏发电行业的龙头公司作为研究对象，通过分析其财务报表、年度报告、以及相关的公开数据，采用比较分析，对比企业不同的财务管理策略及其成效。评估财务管理的影响。研究发现财务管理在光伏发电企业中发挥着至关重要的作用。

关键词：光伏行业财务管理财务会计企业发展

Performance Analysis of Thermal Energy System with linear System Method

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Journal of Thermal Science 2007年第3期16卷 231-236页

作者： liping li Chunfa ZHANG School of Energy and Power North China Electric Power University Baoding 071003 China

The paper addresses the system performance of coal-fired power unit with changed auxiliary system or other local heat disturbance. The idea of state space model is imported and the universal formula for the calculation of system performance output is deduced on the system state equation. Two important vector of system are worked out under linear system assumption and transform. The transfer matrix is the characteristics of system itself and is constant for a similar condition, which greatly facilitates the analysis. The concept of thermal disturbance vector is proposed to construct the thermal disturbance input easily. The method can be helpful for analyzing any thermal disturbance input satisfying the assumption and also for supplementing the correction means of performance test. An example of 600MW power unit is presented to demonstrate its availability.

关键词： matrix vector power unit performance linear system method thermodynamic analysis.

基于STIRPAT模型的长三角区域四省市碳排放预测

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环境工程技术学报 2025年第1期15卷 81-89页

作者：杨霖王敏李丽平杨儒浦生态环境部环境与经济政策研究中心

基于STIRPAT模型,通过岭回归方法分别定量分析长三角区域四省市(安徽、江苏、上海和浙江)的人口规模、人均GDP、城市化率、能源消耗强度、能源结构、第二产业增加值占比与碳排放量的关系,设置3种情景预测模式,预测长三角区域四省市的碳... 详细信息

基于STIRPAT模型,通过岭回归方法分别定量分析长三角区域四省市(安徽、江苏、上海和浙江)的人口规模、人均GDP、城市化率、能源消耗强度、能源结构、第二产业增加值占比与碳排放量的关系,设置3种情景预测模式,预测长三角区域四省市的碳排放量发展趋势。结果表明:安徽省碳排放量影响最显著的变量是能源强度,能源强度每增加1%,碳排放量将下降0.524%,其余三省市碳排放量影响最显著的自变量均为人均GDP,人均GDP每增加1%,江苏、上海和浙江三省碳排放量分别增加1.734%、1.434%和1.355%。长三角区域在基准情景、低碳情景和强化低碳情景下分别于2035年、2030年和2025年达到碳排放峰值。人口增长速度、经济发展水平和能源强度是影响未来长三角四省市碳排放量增长的主要因素。建议长三角区域四省市制定分阶段、分地区差异化的碳达峰目标,对于煤炭依赖程度较高的安徽省,要努力构建多元化的低碳能源体系,利用长三角东部地区丰富的自然资源承接劳动密集型产业;上海、江苏、浙江三省市在加大科技创新助力产业转型升级的同时,也要合理控制人口数量,增强公民环保意识。

关键词：碳排放 STIRPAT模型岭回归发展情景长三角区域

Using self-location to calibrate the errors of observer positions for source localization

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Journal of Systems Engineering and Electronics 2014年第2期25卷 194-202页

作者： Wanchun li Wanyi Zhang liping li School of Electronic Engineering University of Electronic Science and Technology of China

The uncertainty of observers＇ positions can lead to significantly degrading in source localization accuracy. This pa-per proposes a method of using self-location for calibrating the positions of observer stations in source localization to reduce the errors of the observer positions and improve the accuracy of the source localization. The relative distance measurements of the two coordinative observers are used for the linear minimum mean square error （LMMSE） estimator. The results of computer si-mulations prove the feasibility and effectiveness of the proposed method. With the general estimation errors of observers＇ positions, the MSE of the source localization with self-location calibration, which is significantly lower than that without self-location calibra-tion, is approximating to the Cramer-Rao lower bound （CRLB）.

关键词： self-location errors of the observer positions linearminimum mean square error (LMMSE) estimator accuracy of thesource localization Cramer-Rao lower bound (CRLB).

基于冲击回波法的盾构隧道壁后注浆质量检测研究

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东南大学学报(自然科学版) 2025年第1期55卷 213-221页

作者：陈迪杨李利平王旌巴兴之房忠栋张延欢山东大学齐鲁交通学院济南250101 山东大学土建与水利学院济南250061 山东大学(齐河)新材料与智能装备研究院德州251114

为了提高盾构隧道壁后注浆质量,开展了基于冲击回波法的盾构隧道壁后注浆质量检测的研究,提出了壁后注浆状态的检测方法及壁后注浆层厚度的修正公式。考虑壁后注浆的凝固特性及纵波在管片-壁后注浆层界面传播规律,提出了壁后注浆的最佳... 详细信息

为了提高盾构隧道壁后注浆质量,开展了基于冲击回波法的盾构隧道壁后注浆质量检测的研究,提出了壁后注浆状态的检测方法及壁后注浆层厚度的修正公式。考虑壁后注浆的凝固特性及纵波在管片-壁后注浆层界面传播规律,提出了壁后注浆的最佳检测时机和不同地层条件下的检测方案。通过模型试验和现场试验验证了该方法的可行性及准确性。结果表明,随着浆液强度的增加,纵波在管片-壁后注浆层界面主要转换为透射纵波。随着凝结时间增大至570 min,解译的壁后注浆层厚度值趋于稳定,计算精度和准确率分别为厘米级和95%。结合不同地层的推进效率,确定了最优检测时机为注浆后的10~14环。该研究成果可为盾构隧道壁后注浆质量快速精准检测提供理论依据与技术支撑。

关键词：盾构隧道壁后注浆冲击回波法质量检测注浆厚度工程应用

Photocatalytic Hydrogen Evolution Performance for Hydroxyl-rich Porous Carbon Nitride

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Chemical Research in Chinese Universities 2020年第6期36卷 1053-1058页

作者： WANG Yan li liping li Guangshe State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012P.R.China

Metal-free photocatalyst C3N4 has been well investigated,while how to create hydroxyl-rich porous C3N4 remains a great ***,we report a facile approach to address this issue by developing a novel two-step process:(i)precursor achieved via freeze-drying the mixture o f urea,thiourea and NH4CI;(ii)subsequent thermal polydensation o f the *** sample characterization demonstrated the formation o f C3N4 featured by unique hydroxyl-rich porous structure with an extended tri-s-triazine *** applied as photocatalyst for water splitting under UV-Vis light irradiation,the sample displays a high hydrogen evolution rate o f 243.4μmol·g^-1·h^-1about 4 times higher than that o f C3N4 prepared by conventional *** a performance enhancement could be due to the porous structure and surface hydroxyl-rich functional groups that promote multiple-times reflection and light absorption,increase the active site numbers,and improve carrier transfer/separation efficiency.

关键词： Hydroxyl-rich Porous structure Carrier transfer/separation efficiency Hydrogen evolution