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Endorepellin downregulation promotes angiogenesis after experimental traumatic brain injury

Neural Regeneration Research 2024年第5期19卷 1092-1097页

作者： Qian Zhang Yao Jing Qiuyuan Gong Lin Cai Ren Wang Dianxu Yang liping Wang Meijie Qu Hao Chen Yaohui Tang Hengli Tian Jun ding Zhiming Xu Department of Gerontology Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurosurgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina School of Biomedical Engineering and Med-X Research Institute Shanghai Jiao Tong UniversityShanghaiChina Department of Neurology Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Endorepellin plays a key role in the regulation of angiogenesis,but its effects on angiogenesis after traumatic brain injury are unclear.This study explored the effects of endorepellin on angiogenesis and neurobehavioral outcomes after traumatic brain injury in mice.Mice were randomly divided into four groups:sham,controlled cortical impact only,adeno-associated virus(AAV)-green fluorescent protein,and AAV-shEndorepellin-green fluorescent protein groups.In the controlled cortical impact model,the transduction of AAV-shEndorepellin-green fluorescent protein downregulated endorepellin while increasing the number of CD31+/Ki-67+proliferating endothelial cells and the functional microvessel density in mouse brain.These changes resulted in improved neurological function compared with controlled cortical impact mice.Western blotting revealed increased expression of vascular endothelial growth factor and angiopoietin-1 in mice treated with AAV-shEndorepellin-green fluorescent protein.Synchrotron radiation angiography showed that endorepellin downregulation promoted angiogenesis and increased cortical neovascularization,which may further improve neurobehavioral outcomes.Furthermore,an in vitro study showed that downregulation of endorepellin increased tube formation by human umbilical vein endothelial cells compared with a control.Mechanistic analysis found that endorepellin downregulation may mediate angiogenesis by activating vascular endothelial growth factor-and angiopoietin-1-related signaling pathways.

关键词： angiogenesis controlled cortical impact endorepellin neurological function traumatic brain injury

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Fluorescence sensor based on IFE between AEP@UCNPs and oxTMB for the determination of Cdin paddy rice combined with HRP enzyme inhibition mechanism

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Food Science and Human Wellness 2024年

作者： Haizhen ding Shuai Hou Siqi Zhao liping Guo Ao Sun Qiuhui Hu Leiqing Pan Qiang Liu Chao ding College of Food Science and Technology Nanjing Agricultural University Collaborative Innovation Center for Modern Grain Circulation and Safety Key Laboratory of Grains and Oils Quality Control and Processing College of Food Science and Engineering Nanjing University of Finance and Economics

Cadmium ion (Cd2+) detection technology plays a prominent role in food safety and human health. Herein， we designed and constructed an 2-aminoethyl dihydrogen phosphate (AEP)@upconversion nanoparticles (UCNPs) fluorescence sensor for quantitative detection of Cd2+in paddy rice based on Inner filter effect (IFE) combined with enzyme inhibition mechanism. The AEP modification UCNPs can offer a stable fluorescence donor at 658 nm and be quenched by the oxidized tetramethylbenzidine (oxTMB) catalyzed by horseradish peroxidase (HRP) enzymes. Without addition of Cd2+， the fluorescence of AEP@UCNPs fluorescence sensor was weaken due to the IFE between AEP@UCNPs and oxTMB. With addition of Cd2+， HRP enzyme activity was inhibited by Cd2+， leading to the decreased oxTMB， resulting in the enhance upconversion fluorescence intensity. As a result， the fluorescence intensity signal at 658 nm of the IFE-based AEP@UCNPs fluorescence sensor increased linearly with the increase in Cd2+in a wide range from 0.5 μmol/L to 6? μmol/L and the limit of detection (LOD) was 24.6 nmol/L. In addition， our proposed IFE-based AEP@UCNPs fluorescence sensor can achieve Cd2+detection in paddy rice in 30 min.

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Tenecteplase versus alteplase in treatment of acute ST-segment elevation myocardial infarction:A randomized non-inferiority trial

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Chinese Medical Journal 2024年第3期137卷 312-319页

作者： Xingshan Zhao Yidan Zhu Zheng Zhang Guizhou Tao Haiyan Xu Guanchang Cheng Wen Gao liping Ma liping Qi Xiaoyan Yan Haibo Wang Qingde Xia Yuwang Yang Wanke Li Juwen Rong Limei Wang Yutian ding Qiang Guo Wanjun Dang Chen Yao Qin Yang Runlin Gao Yangfeng Wu Shubin Qiao Department of Cardiology Beijing Jishuitan HospitalCapital Medical UniversityThe Fourth Clinical Medical College of Peking UniversityBeijing 100035China Peking University Clinical Research Institute Peking University First HospitalBeijing 100191China Department of Cardiology The First Hospital of Lanzhou UniversityLanzhouGansu 730013China Department of Cardiology The First Affiliated Hospital of Liaoning Medical UniversityJinzhouLiaoning 110002China Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100037China Department of Cardiology Huaihe Hospital of Henan UniversityKaifengHenan 450001China Department of Cardiology Bayannur HospitalBayannurInner Mongolia 015208China Department of Cardiology Puyang People’s HospitalPuyangHenan 457099China Department of Cardiology Xingtai Third HospitalXingtaiHebei 054099China Department of Cardiology Lintao County People’s HospitalDingxiGansu 730599China Department of Cardiology Dancheng County People’s HospitalZhoukouHenan 477150China Department of Cardiology The First People’s Hospital of LingbaoSanmenxiaHenan 472500China Department of Cardiology Shanyin County People’s HospitalShuozhouShanxi 036999China Department of Cardiology Uxin Banner People’s HospitalOrdosInner Mongolia 017399China Department of Cardiology Lingqiu County People’s HospitalDatongShanxi 034499China Department of Cardiology Huaibin County People’s HospitalXinyangHenan 464411China Department of Cardiology Tianzhu County People’s HospitalWuweiGansu 733200China Guangzhou Recomgen Biotech Co. LtdGuangzhouGuangdong 510530China

Background:A phase II trial on recombinant human tenecteplase tissue-type plasminogen activator(rhTNK-tPA)has previously shown its preliminary efficacy in ST elevation myocardial infarction(STEMI)patients.This study was designed as a pivotal postmarketing trial to compare its efficacy and safety with rrecombinant human tissue-type plasminogen activator alteplase(rt-PA)in Chinese patients with STEMI.Methods:In this multicenter,randomized,open-label,non-inferiority trial,patients with acute STEMI were randomly assigned(1:1)to receive an intravenous bolus of 16 mg rhTNK-tPA or an intravenous bolus of 8 mg rt-PA followed by an infusion of 42 mg in 90 min.The primary endpoint was recanalization defined by thrombolysis in myocardial infarction(TIMI)flow grade 2 or 3.The secondary endpoint was clinically justified recanalization.Other endpoints included 30-day major adverse cardiovascular and cerebrovascular events(MACCEs)and safety endpoints.Results:From July 2016 to September 2019,767 eligible patients were randomly assigned to receive rhTNK-tPA(n=384)or rt-PA(n=383).Among them,369 patients had coronary angiography data on TIMI flow,and 711 patients had data on clinically justified recanalization.Both used a–15%difference as the non-inferiority efficacy margin.In comparison to rt-PA,both the proportion of patients with TIMI grade 2 or 3 flow(78.3%[148/189]vs.81.7%[147/180];differences:–3.4%;95%confidence interval[CI]:–11.5%,4.8%)and clinically justified recanalization(85.4%[305/357]vs.85.9%[304/354];difference:–0.5%;95%CI:–5.6%,4.7%)in the rhTNK-tPA group were non-inferior.The occurrence of 30-day MACCEs(10.2%[39/384]vs.11.0%[42/383];hazard ratio:0.96;95%CI:0.61,1.50)did not differ significantly between groups.No safety outcomes significantly differed between groups.Conclusion:rhTNK-tPA was non-inferior to rt-PA in the effect of improving recanalization of the infarct-related artery,a validated surrogate of clinical outcomes,among Chinese patients with acute STEMI.Trial registration:www.ClinicalTrials.gov(No.NCT028355

关键词： Thrombolytic therapy rhTNK-tPA Randomized controlled trial ST elevation myocardial infarction

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Structure-fluorescence relationships in pyrrole appended o-carborane crystalline materials

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Chinese Chemical Letters 2022年第5期33卷 2532-2536页

作者： Dan Wang Gang Wang Ke Liu Jing Li Zhaolong Wang Jing Liu liping ding Rong Miao Yu Fang Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an 710062China

Based on three rationally designed pyrrole-appended o-carborane derivatives,we present that fluores-cence properties of crystalline materials are highly dependent on intermolecular interaction and steric hinderance.Though the three molecules are similar in structure,single crystals of the three compounds showed obvious difference in molecular stacking and fluorescence behavior.Systematic studies indicate that fluorescence quantum yields,thermo-response as well as mechano-response are highly dependent on intermolecular interaction and steric hindrance.In the three crystalline materials,the CB-NMe crys-tals with weaker intermolecular interaction and looser molecular packing showed superior fluorescence quantum yield and temperature sensitivity.Accordingly,surface temperature detection strip with favor-able reversibility is prepared by doping CB-NMe into the polymer.In addition,the CB-NMe aggregates can be used for monitoring bovine serum albumin(BSA)denaturation,as temperature response of the aggregates can be reversed when co-assembled with BSA.

关键词： Fluorescence o-Carborane crystal Steric hinderance Molecular packing Temperature sensing

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新型装配式冷弯薄壁型钢墙体抗侧性能分析

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东南大学学报（自然科学版） 2024年第1期54卷 135-141页

作者：王莉萍伍欣雨胡萌刘劲丁发兴中南大学土木工程学院长沙410075 中南大学湖南省装配式建筑工程技术研究中心长沙410075 湖南城市学院土木工程学院益阳413000

为了研究使用矩形钢管连接的新型全预制冷弯薄壁型钢复合墙体的抗侧性能,设计了6个足尺试件,并进行了水平低周往复加载试验,分析了龙骨间距、覆面板类型、单面或双面覆板等因素对新型复合墙体试件抗侧性能的影响.新型墙体的覆面板为OSB... 详细信息

为了研究使用矩形钢管连接的新型全预制冷弯薄壁型钢复合墙体的抗侧性能,设计了6个足尺试件,并进行了水平低周往复加载试验,分析了龙骨间距、覆面板类型、单面或双面覆板等因素对新型复合墙体试件抗侧性能的影响.新型墙体的覆面板为OSB板与硅晶钙板.试验结果表明:使用矩形钢管连接的新型复合墙体具有良好的整体抗震性能;单面或双面覆板对墙体抗侧性能影响显著,双面覆板的新型复合墙体的屈服荷载约为单面覆板新型复合墙体的2倍;龙骨间距和覆面板材料对墙体抗侧性能的影响相对较小.在试验基础上,使用OpenSEES软件建立了试验墙体的有限元分析模型,并针对矩形钢管壁厚、周边螺钉间距取值进行了参数分析.参数分析结果表明,矩形钢管连接件壁厚取值推荐为2.5 mm,周边螺钉间距推荐取50~100 mm.

关键词：冷弯薄壁型钢复合墙体 OSB板硅晶钙板低周往复加载试验数值模拟

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Highly rectified ion transport through 2D WSe2/MoS2 bi-layered membranes

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Chinese Chemical Letters 2018年第6期29卷 892-894页

作者： Yaping Feng liping ding Danyan Ji Lili Wang Wei Guo CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China Center for Physiochemical Analysis and Measurement Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

Two-dimensional（2 D） nanofluidic systems provide a highly efficient way to integrate a huge amount of cascading lamellar nanofluidic channels into macroscopic membrane materials for practical use in, for example, molecular separation, water treatment, and energy storage. Besides the well-studied graphenebased materials, other 2 D nanomaterials, such as the transition metal dichalcogenides（TMDCs）, are expected as promising alternatives. Here, we report strong ionic current rectification（ICR） effect found in Mo S2/WSe2 bi-layered membrane structure. The preferential direction for ion transport is from the WSe2 layers to the Mo S2 layers. The maximum ICR ratio approaches 35 at intermediate electrolyte concentration. More intriguingly, by exchanging the deposition order of the Mo S2 and WSe2 layers, the observed ICR effect can be reversed. These evidences justify that the highly rectified ion transport phenomenon results from the asymmetry in the reconstructed 2 D layered materials. This work is the first discovery of ICR effect in 2 D nanofluidic heterostructures, and provides further opportunities for innovative nanofluidic devices and materials.

关键词： Ion transport Rectification 2D materials Nanofluidics Heterostructure

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焊接多腔双钢板-混凝土组合剪力墙抗震性能分析

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华南理工大学学报（自然科学版） 2024年第1期52卷 15-25页

作者：丁发兴蔡勇强王莉萍孙浩吕飞黄修文中南大学土木工程学院湖南长沙410075 中铁三局集团有限公司山西太原030000

大多数双钢板-混凝土组合剪力墙采用螺栓连接或焊接肋的方式使钢板和混凝土协同工作。然而,这种连接方式可能导致整体性和塑性变形效率较低,且制作复杂,焊接多腔双钢板-混凝土组合剪力墙能够有效地避免这些问题。为了深入研究焊接多腔... 详细信息

大多数双钢板-混凝土组合剪力墙采用螺栓连接或焊接肋的方式使钢板和混凝土协同工作。然而,这种连接方式可能导致整体性和塑性变形效率较低,且制作复杂,焊接多腔双钢板-混凝土组合剪力墙能够有效地避免这些问题。为了深入研究焊接多腔双钢板-混凝土组合剪力墙的抗震性能,基于约束混凝土真三轴塑性-损伤本构模型和钢材弹塑性混合强化-韧性损伤本构模型,建立了组合剪力墙的精细化三维实体-壳模型,将模拟所得的滞回曲线、骨架曲线、刚度退化曲线、弹性刚度、承载力、累积耗能、等效阻尼粘滞系数和延性系数与已有拟静力试验结果相比较,发现两者吻合较好。分析结果表明:轴压比对组合剪力墙模型算例刚度和承载力的影响较小,而随剪跨比增大,组合剪力墙模型算例的刚度和承载力呈线性降低;轴压比对组合剪力墙模型算例总塑性耗能的影响较小,而剪跨比的影响较大,剪力墙总塑性耗能随剪跨比增大而降低;轴压比和剪跨比都不会改变算例各部件的耗能分配机制,即组合剪力墙模型算例以外钢板和内隔板耗能为主。

关键词：双钢板-混凝土组合剪力墙抗震性能塑性耗能有限元分析

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PSCAD的发电机准同期并列综合实验设计

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实验室研究与探索 2024年第4期43卷 164-168页

作者：司马莉萍丁涛尹航武汉大学电气与自动化学院武汉430072

针对电力系统自动化实验教学中存在的不足,设计了同步发电机准同期并列综合实验。实验模型采用PSCAD/EMTDC,建立了包含发电机及并网系统、原动机及其调速器、励磁系统、准同期并列控制单元、电压向量的动态显示等关键部件。依托实验模... 详细信息

针对电力系统自动化实验教学中存在的不足,设计了同步发电机准同期并列综合实验。实验模型采用PSCAD/EMTDC,建立了包含发电机及并网系统、原动机及其调速器、励磁系统、准同期并列控制单元、电压向量的动态显示等关键部件。依托实验模型设计了循序渐进的教学实验项目,主要有机组启动与并网的验证性实验、不同并列条件影响的分析性实验、频率差和电压差调节的设计性实验。该实验将电路、电机学、自动控制理论、电力系统分析等多门专业核心课程贯穿起来,提升了学生综合运用知识解决复杂工程问题的能力。

关键词：准同期并列电力系统计算机辅助设计同步发电机综合实验

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制种玉米去雄无人机旋切装置设计与试验

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农业机械学报 2024年第4期55卷 53-63页

作者：陈立平欧鸿张瑞瑞丁晨琛伊铜川海锦辉广西大学机械工程学院南宁530004 北京市农林科学院智能装备技术研究中心北京100097

针对制种玉米母本植株由地面去雄机械去雄后存在遗漏雄穗及机械化补漏去雄装备缺乏等问题,提出了一种适配四旋翼无人机的旋切装置。基于去雄无人机作业特点与稳定性影响因素,分析了刀具切割雄穗时的受力及其对无人机反扭力矩的影响,并... 详细信息

针对制种玉米母本植株由地面去雄机械去雄后存在遗漏雄穗及机械化补漏去雄装备缺乏等问题,提出了一种适配四旋翼无人机的旋切装置。基于去雄无人机作业特点与稳定性影响因素,分析了刀具切割雄穗时的受力及其对无人机反扭力矩的影响,并轻量化设计了旋切装置总体结构,确定了旋切装置的旋切范围为44~150 mm,可展范围为541~1318 mm,总质量为4.03 kg。通过旋切部件切割建模与仿真,选取了竖直进给切割的旋切方式,并由台架试验得到了旋切装置切割反扭力矩最小时的最优参数组合。在上述基础上将旋切装置与无人机集成开展田间试验。研究表明,当旋切转速3954 r/min、竖直进给速度5.9 mm/s、刀具刃角32°时,旋切装置单位切割力为10.54 MPa,能完全切除雄穗,去雄无人机田间叶片损伤率为14.58%,高度波动率为1.88%,满足制种玉米去雄要求。

关键词：制种玉米去雄无人机进给切割旋切装置

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ON THE NONEXISTENCE OF NONTRIVIAL SMALL CYCLES OF THE μ FUNCTION IN 3x+ 1 CONJECTURE

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Journal of Systems Science & Complexity 2012年第6期25卷 1215-1222页

作者： Dengguo FENG Xiubin FAN liping ding Zhangyi WANG State Key Laboratory of Information Security Institute of SoftwareChinese Academy of Sciences Institute of Software Chinese Academy of Sciences

这份报纸在 1 推测的 3x + 学习递归的序列的性质。作者介绍这个概念吗？

关键词：周期点猜想通项公式递归数列西门子证明作者函数

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