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PCK1 dysregulation in cancer: metabolic reprogramming, oncogenic activation, and therapeutic opportunities

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Genes & Diseases 2023年第1期10卷 101-112页

作者： Jin Xiang Kai Wang ni Tang Key Laboratory of molecular Biology for Infectious Diseases(m.nistry of Education) Institute for Viral HepatitisDepartment of Infectious DiseasesThe Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

The last few decades have witnessed an advancement in our understanding of multiple cancer cell pathways related to metabolic *** of the most important cancer hallmarks,including aerobic glycolysis(the Warburg effect),the central carbon pathway,and multiple-branch metabolic pathway remodeling,enables tumor growth,progression,and *** carboxykinase1(PCK1),a key rate-limiting enzyme in gluconeogenesis,catalyzes the conversion of oxaloacetate to ***1 expression in gluconeogenic tissues is tightly regulated during *** tumor cells,PCK1 is regulated in a cell-autonomous manner rather than by hormones or nutrients in the extracellular ***,PCK1has ananti-oncogenic role in gluconeogenic organs(the liver and kidneys),but a tumor-promoting role in cancers arising from non-gluconeogenic *** studies have revealed that PCK1 has metabolic and non-metabolic roles in multiple signaling networks linking metabolic and oncogenic *** PCK1 expression results in the activation of oncogenic pathways,accompanied by metabolic reprogramming,to maintain *** this review,we summarize the mechanisms underlying PCK1 expression and regulation,and clarify the crosstalk between aberrant PCK1 expression,metabolic rewiring,and signaling pathway *** addition,we highlight the clinical relevance of PCK1 and its value as a putative cancer therapeutic target.

关键词： Gluconeogenesis metabolism Oncogenesis PCK1 Tumor

Study on friction performance and mechanism of slipper pair under different paired materials in high-pressure axial piston pump

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Friction 2020年第5期8卷 957-969页

作者： Huaichao WU Limei ZHAO Siliang ni Yongyong HE School of mechanical Engineering Guizhou UniversityGuiyang 550025China State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China

High-pressure axial piston pumps operate in high-speed and high-pressure environments. The contact state of the slipper against the swashplate can easily change from an oil film lubrication to a mixed oil film/asperity contact, or even dry friction. To improve the dry friction performance of slipper pairs and to avoid their potentially rapid failure, this study examined the effects of material matching on the dry friction performance of the slipper pair for high-pressure axial piston pumps. A FAIAX6 friction and wear tester was developed, and the dry friction coefficients of the slipper pairs matched with different materials were studied using this tester. Based on the thermo-mechanical coupling of the slipper pair with the working process, the contact surface temperatures of the slipper pairs matched with different materials were calculated and analyzed for the same working conditions. Following this, the effects of the material properties on the temperature increase at the slipper sliding contact surfaces were revealed. The reliabilities of the temperature calculations and analysis results were verified through orthogonal tests of slipper pairs matched with different materials. The results indicate that the influence of the material density on the friction coefficient is greater than that of the Poisson's ratio or the elastic modulus, and that the slipper material chosen should have a high thermal conductivity, low density, and low specific heat, whereas the swashplate material should be high in specific heat, density, and thermal conductivity;in addition, the slipper pair should be a type of hard material to match the type of soft material applied;that is, the hardness of the swashplate material should be greater than that of the slipper material.

关键词： axial piston pump slipper pair material matching dry friction temperature

Transcranial magnetic stimulation to understand pathophysiology and as potential treatment for neurodegenerative diseases

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Translational Neurodegeneration 2015年第1期4卷 184-195页

作者： Zhen ni Robert Chen Division of Neurology Krembil Neuroscience Centre and Toronto Western Research InstituteUniversity Health NetworkUniversity of TorontoTorontoONCanada mC-411 Toronto Western Hospital399 Bathurst StreetTorontoON M5T 2S8Canada

Common neurodegenerative diseases include Parkinson’s disease(PD),Alzheimer’s disease(AD),amyotrophic lateral sclerosis(ALS)and Huntington’s disease(HD).Transcranial magnetic stimulation(TmS)is a noninvasive and painless method to stimulate the human ***-and paired-pulse TmS paradigms are powerful ways to study the pathophysiological mechanisms of neurodegenerative *** evoked potential studied with single-pulse TmS is increased in PD,AD and ALS,but is decreased in *** in motor cortical excitability in neurodegenerative diseases may be related to functional deficits in cortical circuits or to compensatory *** or even absence of short interval intracortical inhibition induced by paired-pulse TmS is common in neurodegenerative diseases,suggesting that there are functional impairments of inhibitory cortical *** short latency afferent inhibition in AD,PD and HD may be related to the cortical cholinergic deficits in these *** plasticity tested by paired associative stimulation or theta burst stimulation is impaired in PD,AD and *** TmS(rTmS)refers to the application of trains of regularly repeating TmS ***-frequency facilitatory rTmS may improve motor symptoms in PD patients whereas low-frequency inhibitory stimulation is a potential treatment for levodopa induced *** delivered both to the left and right dorsolateral prefrontal cortex improves memory in AD *** motor cortical stimulation in low frequency may be useful for HD ***,the effects of treatment with multiple sessions of rTmS for neurodegenerative diseases need to be tested in large,sham-controlled studies in the future before they can be adopted for routine clinical practice.

关键词： Alzheimer’s disease Amyotrophic lateral sclerosis Huntington’s disease Parkinson’s disease Transcranial magnetic stimulation

Structural characterization of the{1122}twin boundary and the corresponding stress accommodation mechanisms in pure titanium

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Journal of materials Science & Technology 2021年第13期72卷 114-121页

作者： Bingqiang Wei Song ni Yong Liu min Song State Key Laboratory of Powder metallurgy Central South UniversityChangsha 410083China

{11-22}compression twin plays an important role in accommodating deformation along the c axis of HCP ***,the studies on the interface structure of{11-22}twin boundary(TB),especially the twin tip,and the corresponding local stress release mechanism are still *** work studied the interface characters of{11-22}TB of a deformed pure titanium by transmission electron ***{11-22}TB presented serrated character,consisting of coherent twin boundary(CTB)and(0002)_(T)//(11-2-2)_(m)or(11-2-2)_(T)//(0002)_(m)steps,and the twin tip was fully composed of the basal-pyramidal(BPy)and pyramidal-basal(PyB)*** twin tip presents asymmetric morphology and the step height at the twin tip is much larger than that away from the twin *** types of local stress accommodation mechanisms were observed:zonal dislocation emission and hexagonal close packed structure to facecentered cubic structure *** zonal dislocation was produced by the dissociation of the1/3dislocation that was nucleated at the twin tip and the phase transformation was introduced by emission of Shockley partial dislocations from the{11-22}twin boundary.

关键词： {1122} twin Twin boundary Twinning dislocation Stress accommodation Titanium

A Sand Control and Development model in Sandy Land Based on mixed Experiments of Arsenic Sandstone and Sand: A Case Study in mu Us Sandy Land in China

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Chinese Geographical Science 2013年第6期23卷 700-707页

作者： WANG ni XIE Jiancang HAN Jichang State Key Laboratory of Eco-Hydraulic Engineering in Shaanxi Xi'an University of Technology Shaanxi Estate Development Service Corporation

Serious desertification caused by human activity and climate change,in addition to water loss and soil erosion related to arsenic sandstone in the mu Us Sandy Land,lead to severe scarcity of soil and water resources,which causes worse local agricultural conditions *** physical properties of arsenic sandstone is complementary with that of sand,arsenic sandstone is therefore supposed to be blended to enhance water productivity and arability of sandy *** experiments are carried out to study the enhancement of water holding capacity of the mixture,the blending ratio of arsenic sandstone and sand,and the proper size of the arsenic sandstone particles,*** results of the experiments show that particle size of 4 cm with a ratio of 1∶2 between arsenic sandstone and sand are the proper parameters on *** water content and fertility increase after *** use efficiency in the mixture is 2.7 times higher than that in sand by the water release curves from ***,a new sand control and development model,including arsenic sandstone blending with sand,efficient water irrigation management and reasonable farming system,is put forward to control and develop sandy land so that water-saving agriculture could be *** of potato planting about 153.1 ha in area in the mu Us Sandy Land in China indicates that water consumption is 3018 m3/ha in the whole growth *** means that about 61%of irrigation water can be saved compared with water use in coarse sand without *** economic mode and positive feedback of sand resource-crop planting-soil resource are constructed,which changes sand into arable soil and make it possible to develop water-saving agriculture on *** proposed model will be helpful for soil-water resources utilization and management in the mu Us Sandy Land.

关键词： soil-water resource arsenic sandstone sand control and development model water-saving effect mu Us Sandy Land

Double carbon decorated lithium titanate as anode material with high rate performance for lithium-ion batteries

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Progress in Natural Science:materials International 2016年第3期26卷 283-288页

作者： Haifang ni Weili Song Lizhen Fan Institute of Advanced materials and Technology University of Science and Technology Beijing

Spinel lithium titanate(Li;Ti;O;) has the advantages of structural stability, however it suffers the disadvantages of low lithium-ion diffusion coefficient as well as low conductivity. In order to solve issues,we reported a simple method to prepare carbon-coated Li;Ti;O;/CNTs(C@Li;Ti;O;/CNTs) using stearic acid as surfactant and carbon source to prepare carbon coated nanosized particles. The obtained Li;Ti;O;particles of 100 nm in size are coated with the carbon layers pyrolyzed from stearic acid and dispersed in CNTs matrix homogeneously. These results show that the synthesized C@Li;Ti;O;/CNTs material used as anode materials for lithium ion batteries, presenting a better high-rate performance(147 m Ahg;at20 C). The key factors affecting the high-rate properties of the C@Li;Ti;O;/CNTs composite may be related to the synergistic effects of the CNTs matrix and the carbon- coating layers with conductivity enhancement. Additionally, the amorphous carbon coating is an effective route to ameliorate the rate capability of Li;Ti;O;/CNTs.

关键词： Lithium titanate Carbon nanotubes Lithium-ion batteries Anode materials

Combined effect of the use of carbon fiber and seawater and the molecular structure on the tribological behavior of polymer materials

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Friction 2018年第2期6卷 183-194页

作者： Zhiqiang WANG Jing ni Dianrong GAO School of mechanical Engineering Hangzhou Dianzi University State Key Laboratory of Fluid Power and mechatronic Systems Zhejiang University College of mechanical Engineering Yanshan University

The combined effect of the use of carbon fiber and seawater and the molecular structure on the tribological behavior of various polymer materials under natural seawater lubrication was investigated. After the investigation, the wear morphology of the contact surface was observed by a laser scanning confocal microscope, and the texture of the wear scars and tracks were presented in 3 D profiles. moreover, the mechanism of mixed lubrication and wear resistance was analyzed. The results demonstrated that the friction coefficient of carbon fiber-reinforced polyetheretherketone(CFRPEEK) is the lowest and fluctuates at approximately 0.11. moreover, the seven polymer materials in ascending order of friction coefficients are CFRPEEK, carbon fiber-reinforced polyamide-imide, polytetrafluoroethylene, polyoxymethylene, polyetheretherketone(PEEK), acrylonitrile butadiene styrene resin, and glass fiber–epoxy resin. more critically, the simultaneous incorporation of deposition, polymeric scrap, hydrophilic groups, and seawater resulted in a decrease in the friction and wear of polymer materials under seawater lubrication. This observation implies that a synergistic friction-reducing and wear-resistant effect exists between carbon fiber, seawater, and the molecular structure of PEEK. As a result, a highly effective polymer material was discovered, CFRPEEK, which has the lowest friction coefficient of 0.11 and lowest wear rate of 2 × 10^(–5) mm^3?(N?m)^(-1) among the polymer materials; this validates the selection of dual friction pairs for seawater hydraulic components.

关键词： friction coefficient wear molecular structure polymer materials seawater lubrication

Room temperature polymerization of alkyl isocyanates catalyzed by rare earth Schiff base complexes

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Science China Chemistry 2009年第11期52卷 1843-1850页

作者： XiongFa Yang XuFeng ni ZhiQuan Shen Key Laboratory of macromolecular Synthesis and Functionalization Ministry of Education Institute of Polymer Science Zhejiang University Hangzhou 310027 China

The polymerization of alkyl isocyanates catalyzed by rare earth chloride salen complexes/triisobutyl aluminum (Ln(H2salen)2Cl3·2C2H7OH/Al(i-Bu)3) at room temperature was investigated. The influences of ligand structure, catalyst composition, polymerization temperature, polymerization time, the concentration of catalyst and monomer, and the polymerization solvent on the polymerization of isocyanates were studied. It was found that under the polymerization conditions, examined La(H2salenA)2Cl3·2C2-H7OH/Al(i-Bu)3 (H2salenA= N,N′-disalicylideneethylene diamine) is a fairly high efficient catalyst for the polymerization of n-hexyl isocyanate (n-HexNCO) to prepare high molecular weight poly(n-hexyl isocyanate) (PHNCO) with narrower molecular weight distribution at room temperature. PHNCO could be prepared with yield of 74.0%, number-average molecular weight (m n) of 40.20×104 and mWD of 1.79 under the following optimum conditions: [Al]/[La] = 30 (molar ratio), [n-HexNCO]/[La] = 100 (molar ratio), [n-HexNCO] = 3.43 mol/L polymerization at 20°C for 12 h in toluene. In the same polymerization conditions, poly (n-octyl isocyanate) (PONCO) with yield of 67.3%, and poly(n-butyl isocyanate) (PBNCO) with yield of 45.5%, could be prepared respectively. The kinetics of the polymerization of n-HexNCO was also investigated and found to be first-order with respect to both monomer and catalyst concentrations.

关键词： rare earth catalyst Schiff base complex polymerization alkyl isocyanate

Pareto-based multi-objective node placement of industrial wireless sensor networks using binary differential evolution harmony search

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Advances in manufacturing 2016年第1期4卷 66-78页

作者： Ling Wang Lu An Hao-Qi ni Wei Ye Panos m. Pardalos min-Rui Fei Shanghai Key Laboratory of Power Station AutomationTechnology School of Mechatronics Engineering andAutomation Shanghai University Shanghai 200072 People'sRepublic of China Department of Industrial and Systems Engineering Centerfor Applied Optimization University of Florida GainesvilleFlorida 32611 USA

The reliability and real time of industrial wireless sensor networks （IWSNs） are the absolute requirements for industrial systems, which are two fore- most obstacles for the large-scale applications of IWSNs. This paper studies the multi-objective node placement problem to guarantee the reliability and real time of IWSNs from the perspective of systems. A novel multi-objective node deployment model is proposed in which the reliabil- ity, real time, costs and scalability of IWSNs are addressed. Considering that the optimal node placement is an NP-hard problem, a new multi-objective binary differential evolu- tion harmony search （mOBDEHS） is developed to tackle it, which is inspired by the mechanism of harmony search and differential evolution. Three large-scale node deploy- ment problems are generated as the benCHmarks to verify the proposed model and algorithm. The experimental results demonstrate that the developed model is valid and can be used to design large-scale IWSNs with guaranteed reliability and real-time performance efficiently. moreover, the comparison results indicate that the proposed mOB- DEHS is an effective tool for multi-objective node place- ment problems and superior to Pareto-based binary differential evolution algorithms, nondominated sorting genetic algorithm II （NSGA-II） and modified NSGA-II.

关键词： Industrial wireless sensor networks (IWSNs)Node placement Harmony search Differential evolutionPareto Real time Reliability