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DNA image cytometry test for primary screening of esophageal cancer: a population-based multi-center study in high-risk areas in China

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Chinese Journal of Cancer Research 2016年第4期28卷 404-412页

作者： Meng wang Changqing Hao Qing Ma Guohui Song Shanrui Ma Deli Zhao Lin Zhao Xinqing Li Wenqiang Wei Department of Cancer Epidemiology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences & Peking Union Medical College Department of Endoscopy Linzhou Cancer Hospital Department of Epidemiology Cixian Cancer Hospital Department of Cancer Center Feicheng People Hospital Medical Record Room Xuanwu Hosital

Objective： To evaluate the feasibility of DNA image cytometry （DNA-ICM） as a primary screening method for esophageal squamous cell cancer （ESCC）. Methods： A total of 5,382 local residents aged 40-69 years from three high-risk areas in China （linzhou in Henan province, Feicheng in Shandong province and Cixian in Hebei province） from 2008 to 2011 were recruited in this population-based screening study. And 2,526 subjects declined to receive endoscopic biopsy examination with Lugol＇s iodine staining, while 9 and 815 subjects were excluded from liquid-based cytology and DNA-ICM test respectively due to slide quality. Finally, 2,856, 5,373 and 4,567 subjects were enrolled in the analysis for endoscopic biopsy examination, liquid-based cytology and DNA-ICM test, respectively. Sensitivity （SE）, specificity （SP）, negative predictive values （NPV） and positive predictive values （PPV） as well as their 95% confidence intervals （95% CI） for DNA-ICM, liquid-based cytology and the combination of the two methods were calculated. Receiver operating characteristic （ROC） curves were applied to determine the cutoff point of DNA-ICM for esophageal cancer. Results： DNA-ICM results were significantly correlative with esophageal cancer and precancer lesions （X2= 18.016, P〈0.001）. The cutoff points were 5,802, 5,803 and 8,002 based on dissimilar pathological types of low grade intraepithelial neoplasia （LGIN）, high grade intraepithelial neoplasia （HGIN）, and ESCC, respectively, and 5,803 was chosen in this study considering the SE and SP. The SE, SP, PPV, NPV of DNA-ICM test （cutoff point 5,803） combined with liquid-based cytology [threshold atypical squamous cells of undetermined significance （ASCUS）] were separately 72.1% （95% CI： 70.3%-73.9%）, 43.3% （95% CI. 41.3%-45.3%）, 22.8% （95% CI： 21.1%-24.5%） and 87.0% （95% CI： 85.7%-88.3%） for LGIN, 85.7% （95% CI： 84.3%-87.1%）, 41.3% （95% CI： 39.3%-43.3%）, 4.6% （95% CI： 3.8%-5.4%） and 98.9% （95% CI： 98.5%-99.3%） for HGIN, and 96.0% （95% CI： 95.2%

关键词： DNA image cytometry esophageal cancer cutoff point

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Evaluation of routine biopsies in endoscopic screening for esophagogastric junction cancer

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World Journal of Gastroenterology 2014年第17期20卷 5074-5081页

作者： Xin Niu Wen-Qiang Wei Chang-Qing Hao Guo-Hui Song Jun Li Zhao-Lai Hua Yong-Wei Li Jun Chang Xin-Zheng wang De-Li Zhao Guo-Qing wang Evelyn Hsieh You-Lin Qiao Department of Cancer Epidemiology Cancer Institute/Cancer HospitalChinese Academy of Medical SciencesPeking Union Medical College Department of Endoscopy Linzhou Cancer Hospital Cixian Cancer Institute/Cancer Hospital Yanting Cancer Hospital Yangzhong Cancer Hospital Shexian Cancer Registry Taixing Center for Disease Control Yangcheng Cancer Hospital Department of Endoscopy People’s Hospital of Feicheng Department of Internal Medicine Yale School of MedicineNew HavenCT 06520-1942United States

AIM: To explore whether routine biopsies at the high incidence spot of esophagogastric junction (EGJ) cancer are justified in endoscopic screening.

关键词： Esophagogastric junction cancer High incidence spot Screening Endoscopy Biopsy

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Histochemical studies on intestinal metaplasia adjacent to gastric cardia adenocarcinoma in subjects at high-incidence area in Henan, north China

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World Journal of Gastroenterology 2005年第30期11卷 4634-4637页

作者： She-Gan Gao Li-Dong wang Zong-Min Fan Ji-Lin Li Xin He Rui-Feng Guo Dong-Ling Xie Xin-Wei He Shan-Shan Gao Hua-Qin Guo Jun-Kuan wang Xiao-Shan Feng Bao-Gen Ma Laboratory for Cancer Research College of Medicine Zhengzhou University Zhengzhou 450052 Henan Province China Department of Pathology Linzhou Esophageal Cancer Hospital Linzhou Henan Province China Dep-artment of Clinical Oncology The First Affiliated Hospital of Henan Science and Technology University Luoyang 471001 Henan Province China Department of Oncology Henan Tumor Hospital Zhengzhou 450003 Henan Province China

AIM： To characterize the histochemical type and pattern of intestinal metaplasia （IM） adjacent to gastric cardia adenocarcinoma （GCA） and distal gastric cancer （GC） in Unzhou, Henan Province, China. METHODS： Alcian-blue-periodic acid Schiff and high iron diamine-Alcian blue histochemical methods were performed on 142 cases of IM, including 49 cases of GCA and 93 cases of GC. All the patients were from linzhou, Henan Province, China, the highest incidence area for both GCA and squamous cell carcinoma. Radio- or chemotherapy was not applied to these patients before surgery. RESULTS： The detection rate of IM in tissues adjacent to GCA tissues was 44.9%, which was significantly lower than that in GC tissues （80.64%, P〈0.01）. The rates of both incomplete small intestinal and colonic IM types identified by histochemistry in GCA tissues （31.82% and 63.64%, respectively） were significantly higher than those in GC （5.33% and 21.33%, respectively, P〈0.01）. CONCLUSION： IM in GCA and GC should be considered as a separate entity. Further research is needed to evaluate whether neoplastic progression of IM is related to its mucin profile in GCA.

关键词： Gastric cardia Intestinal metaplasia Histochemistry

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新型烟草包衣丸化种子大田直播探究

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农机使用与维修 2021年第5期 8-11页

作者：张幸博李建华商慧文刘林州姚健王龙飞河南省烟草公司许昌市公司河南许昌461000

为提高烟苗质量,加长烟株的大田生育期,彰显优质烟叶风格特色,通过对常规烟草包衣丸化种子以适宜材质做放大处理,采用种子丸化大田直播,研究对包衣丸化种子萌发及大田期农艺性状和烤后经济性状的影响。结果表明采用烟草种子放大直播技术... 详细信息

为提高烟苗质量,加长烟株的大田生育期,彰显优质烟叶风格特色,通过对常规烟草包衣丸化种子以适宜材质做放大处理,采用种子丸化大田直播,研究对包衣丸化种子萌发及大田期农艺性状和烤后经济性状的影响。结果表明采用烟草种子放大直播技术,能够有效促进烟株根系的生长发育,改善大田期烟叶的农艺性状,延长了烟株的大田生育期,中上等烟比例提高,烟农收益增加,有利于彰显浓香型烟叶风格特色。

关键词：烟叶种子包衣丸化直播技术农艺性状

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Efficacy of endoscopic treatment on patients with severe dysplasia/carcinoma in situ of esophageal squamous cell carcinoma: A prospective cohort study

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Chinese Journal of Cancer Research 2019年第2期31卷 357-365页

作者： Meng wang Changqing Hao Shuanghua Xie Shanrui Ma Qing Ma Rongshou Zheng Ru Chen Xinqing Li Wenqiang Wei Office of Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Endoscopy Linzhou Cancer Hospital

Objective: To explore the natural history of severe dysplasia/carcinoma in situ(SD/CIS) patients and to evaluate the efficacy of endoscopic treatment to SD/CIS ***: Between January 2005 and December 2009, a population-based prospective screening program on esophageal squamous cell carcinoma(ESCC) was performed in linzhou, China, with endoscopic screening plus iodine staining. All the eligible histologically confirmed SD/CIS patients were followed up through the door-todoor follow-up and local cancer registry. The endpoint was diagnosed as ESCC or the December 31 st, ***-Meier survival analysis and Log-rank test were used to compare the survival rates among treated and untreated ***: A total of 175 SD/CIS patients were enrolled and grouped by whether they received endoscopic treatment. Eleven-year cumulative incidence rates for untreated and treated SD/CIS patients were 10.7% [95%confidence interval(95% CI): 6.9-16.1] and 3.2%(95% CI: 1.4-7.0), respectively. The ESCC incidence free survival rate, and all-cause incidence and mortality free survival rates were all significantly higher in the treated patients vs. untreated patients(P=0.043, P=0.008 and P=0.015, respectively). The ESCC mortality free survival rate showed no significant differences between the two groups(P=0.847).Conclusions: The cumulative incidence rate of SD/CIS patients to ESCC was much lower than previously reported. The Kaplan-Meier survival analysis showed that endoscopic treatment could increase the ESCC and allcause disease-free survival rates of SD/CIS patients significantly.

关键词： Endoscopy esophageal squamous cell carcinoma precancerous lesions management mass screening

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基于知识链的管理

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天津大学学报（社会科学版） 2003年第2期5卷 133-136页

作者：徐建锁王正欧李淑伟天津大学管理学院天津300072 林州市委党校河南456550

论述了知识链的有关概念和特点,通过分析以往的知识链模型,提出了改进的知识链模型;对知识链管理的机制进行了分析;从控制论的角度,对知识链内部知识成长的机制进行了分析,并指出知识链内部知识转移的影响因素,为知识管理的发展提供了... 详细信息

论述了知识链的有关概念和特点,通过分析以往的知识链模型,提出了改进的知识链模型;对知识链管理的机制进行了分析;从控制论的角度,对知识链内部知识成长的机制进行了分析,并指出知识链内部知识转移的影响因素,为知识管理的发展提供了一定的理论依据。

关键词：知识管理知识链知识链模型

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金城津、关的设置及其交通路线

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兰州大学学报（社会科学版） 2018年第1期46卷 147-157页

作者：王蕾兰州大学敦煌学研究所甘肃兰州730000

北周、隋代是中原王朝经由分裂到统一的重要时期,然而此时西北方向的吐谷浑与突厥对边境侵寇不止,为了加强河陇地区的防御体系,北周设置金城津,隋代又改津为关。北周时期金城郡治东迁至汉金城县,即今甘肃省兰州市城关区,金城关就位于其... 详细信息

北周、隋代是中原王朝经由分裂到统一的重要时期,然而此时西北方向的吐谷浑与突厥对边境侵寇不止,为了加强河陇地区的防御体系,北周设置金城津,隋代又改津为关。北周时期金城郡治东迁至汉金城县,即今甘肃省兰州市城关区,金城关就位于其西北二里的黄河沿岸。随着金城郡治的迁移,政治军事中心也随之东迁,金城关成为金城河上通往凉州、临州、河州、鄯州路线中最重要的交通枢纽。

关键词：金城津金城关河陇防御郡治东迁交通枢纽

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Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

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Frontiers of Medicine 2023年第2期17卷 290-303页

作者： Yubing Zhou Xinyu He Yanan Jiang Zitong wang Yin Yu Wenjie Wu Chenyang Zhang Jincheng Li Yaping Guo Xinhuan Chen Zhicai Liu Jimin Zhao Kangdong Liu Zigang Dong The Pathophysiology Department School of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhou 450000China The China-US(Henan)Hormel Cancer Institute Zhengzhou 450000China State Key Laboratory of Esophageal Cancer Prevention and Treatment Zhengzhou 450000China Provincial Cooperative Innovation Center for Cancer Chemoprevention Zhengzhou UniversityZhengzhou 450000China Cancer Chemoprevention International Collaboration Laboratory Zhengzhou 450000China Oncology Department The Tumor Hospital of Linzhou CityLinzhou 456500China

Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer death worldwide. It is urgent to develop new drugs to improve the prognosis of ESCC patients. Here, we found benzydamine, a locally acting non-steroidal anti-inflammatory drug, had potent cytotoxic effect on ESCC cells. Benzydamine could suppress ESCC proliferation in vivo and in vitro. In terms of mechanism, CDK2 was identified as a target of benzydamine by molecular docking, pull-down assay and in vitro kinase assay. Specifically, benzydamine inhibited the growth of ESCC cells by inhibiting CDK2 activity and affecting downstream phosphorylation of MCM2, c-Myc and Rb, resulting in cell cycle arrest. Our study illustrates that benzydamine inhibits the growth of ESCC cells by downregulating the CDK2 pathway.

关键词： benzydamine cyclin-dependent kinase 2 patient-derived xenograft esophageal squamous cell carcinoma

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Nd:YAG激光治疗白内障术后睫状环阻滞性青光眼的疗效分析

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临床眼科杂志 2017年第4期25卷 362-364页

作者：卢文胜王晓冰韩冬赵云郝翠霞高宁洲高雅梅吕建华河北省眼科医院河北邢台054001

目的探讨Nd:YAG激光治疗白内障术后继发睫状环阻滞性青光眼的效果及安全性。方法回顾性分析我院17例白内障术后继发睫状环阻滞性青光眼病例,其中单纯白内障术后6例,白内障联合青光眼术后11例,采取Nd:YAG激光切开晶状体后囊及前部玻璃体... 详细信息

目的探讨Nd:YAG激光治疗白内障术后继发睫状环阻滞性青光眼的效果及安全性。方法回顾性分析我院17例白内障术后继发睫状环阻滞性青光眼病例,其中单纯白内障术后6例,白内障联合青光眼术后11例,采取Nd:YAG激光切开晶状体后囊及前部玻璃体,使玻璃体水囊与前房沟通。3只眼接受3次激光治疗,5只眼接受2次激光治疗,9只眼接受1次激光治疗。检查患者术前及术后1、3 d、1周,1、3个月的眼压及前房深度,进行统计学分析。结果术后随访3个月,术后1 d眼压明显下降,前房加深,较术前有统计学差异;术后3 d眼部情况趋于稳定,与术后1周、1个月及3个月无统计学差异。结论对白内障术后继发睫状环阻滞性青光眼,及时采取Nd:YAG激光治疗,沟通前房与玻璃体水囊,重建房水正常流出通道,可有效缓解睫状环阻滞性青光眼,降低眼压,保护视功能。

关键词：睫状环阻滞性青光眼 Nd:YAG激光疗效

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汤川瘿蜂寄生性天敌调查及其优势天敌长尾小蜂生物学特性

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林业科学 2023年第6期59卷 112-117页

作者：张元臣鲍梦楠薛爽王璞王兴云张坤朋王景顺安阳工学院生物与食品工程学院安阳455000 河南省太行山林业有害生物野外科学观测研究站林州456550 南京林业大学生物与环境学院南京210037

【目的】明确汤川瘿蜂虫瘿内寄生性天敌种类,研究其优势天敌的生物学特性,为利用寄生性天敌防治汤川瘿蜂提供科学依据。【方法】对汤川瘿蜂虫瘿进行林间调查、室内解剖和室内试验,明确虫瘿内寄生性天敌种类及其优势天敌长尾小蜂的生物... 详细信息

【目的】明确汤川瘿蜂虫瘿内寄生性天敌种类,研究其优势天敌的生物学特性,为利用寄生性天敌防治汤川瘿蜂提供科学依据。【方法】对汤川瘿蜂虫瘿进行林间调查、室内解剖和室内试验,明确虫瘿内寄生性天敌种类及其优势天敌长尾小蜂的生物学特性。【结果】汤川瘿蜂无性世代虫瘿内主要有长尾小蜂、金小蜂和啮小蜂3种寄生性天敌,其中长尾小蜂为优势天敌。长尾小蜂1年发生1代,以幼虫在无性虫瘿内越冬,越冬成虫10月下旬开始出瘿,产卵于无性虫瘿内。2019和2020年连续2年虫瘿调查发现,长尾小蜂对汤川瘿蜂无性世代寄生率分别为18.00%和21.86%。寄生蜂羽化期持续81~85天,雌雄虫羽化高峰期分别在11月下旬和11月中旬,羽化时间集中在上午8:00―12:00,雌雄性比为1∶2。长尾小蜂善跳跃,有假死性,雌雄成虫羽化后当天即可交配,有多次交配现象。补充蜂蜜水可显著延长雄性长尾小蜂寿命,对雌性长尾小蜂寿命没有显著影响。【结论】汤川瘿蜂无性世代虫瘿内有长尾小蜂、金小蜂和啮小蜂3种寄生性天敌,长尾小蜂对汤川瘿蜂寄生率最高,为优势寄生蜂种,可作为防治汤川瘿蜂的重要手段。

关键词：汤川瘿蜂长尾小蜂虫瘿生物学特性寄生天敌

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