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激光重熔对铁基/TiC复合涂层成形质量及性能研究

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应用激光 2023年第7期43卷 1-7页

作者：龚美美吴腾谢林圯师文庆黄江谢玉萍乔江伟广东海洋大学电子与信息工程学院广东湛江524088 广东精工钢结构有限公司广东佛山528100

为研究激光熔覆过程中重熔功率对熔覆层的形貌和性能影响,采用激光重熔技术,在Ti6Al4V钛合金表面制备了铁基/TiC复合涂层。采用着色渗透探伤剂和金相显微镜观察了熔覆层表面裂纹和气孔的分布情况,利用维氏硬度计和摩擦磨损测试仪表征了... 详细信息

为研究激光熔覆过程中重熔功率对熔覆层的形貌和性能影响,采用激光重熔技术,在Ti6Al4V钛合金表面制备了铁基/TiC复合涂层。采用着色渗透探伤剂和金相显微镜观察了熔覆层表面裂纹和气孔的分布情况,利用维氏硬度计和摩擦磨损测试仪表征了熔覆层的截面显微硬度和摩擦磨损性能。结果表明,重熔功率的增加能够有效地抑制熔覆层的裂纹和气孔;在力学性能方面,重熔后的熔覆层维氏硬度约是Ti6Al4V钛合金基体的8倍,当重熔功率为1200 W时,所制备的铁基/TiC复合涂层的平均维氏硬度达到最大值,约为1188 HV;此外,随着激光重熔功率增大,铁基/TiC复合涂层在磨擦磨损的过程中可以有效地阻止磨粒和摩擦副对熔覆层的微切削与塑性变形,同时,熔覆层的磨损量降低,摩擦系数降低。

关键词：激光重熔钛合金显微硬度耐磨性

Identification of the receptor of oncolytic virus M1 as a therapeutic predictor for multiple solid tumors

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1670-1680页

作者： Deli Song Xudong Jia Xincheng Liu linyi Hu Kaiying Lin Tong Xiao Yangyang qiao Jiayu Zhang Jia Dan Chunwa Wong Cheng Hu Ke Sai Shoufang Gong Max Sander Runling Shen Xiaoyu Chen Xiaoting Xiao Jiehong Chen Yanming Zhang Cailv Wei Xiao Xiao Jiankai Liang Qinfen Zhang Jun Hu Wenbo Zhu Guangmei Yan Yuan Lin Jing Cai Department of Pharmacology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China School of Life Sciences Sun Yat-sen UniversityGuangzhou 510275China Department of Urology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Neurosurgery/Neuro-oncology Sun Yat-sen University Cancer CenterGuangzhou 510060China Guangzhou Virotech Pharmaceutical Co.Ltd Guangzhou 510663China Department of Microbiology Zhongshan School of MedicineSun Yat-sen University510080 GuangzhouChina

Over the last decade,oncolytic virus(OV)therapy has shown its promising potential in tumor *** fact that not every patient can benefit from it highlights the importance for defining biomarkers that help predict patients’*** particular self-amplifying biotherapeutics,the anti-tumor effects of OVs are highly dependent on the host factors for viral infection and *** using weighted gene co-expression network analysis(WGCNA),we found matrix remodeling associated 8(MXRA8)is positively correlated with the oncolysis induced by oncolytic virus M1(OVM).

关键词： tumor therapeutic tumors

Effects of coronavirus disease 2019 vaccination on seizures in patients with epilepsy

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Chinese Medical Journal 2023年第5期136卷 571-577页

作者： Xiqin Fang Shan qiao Ranran Zhang Tingting Yang Zhihao Wang Qingxia Kong Meihua Sun Jianhong Geng Chunyan Fang Yanxiu Chen Yanping Sun Dongmei Zhang Lixing Qu Wei Shang Jianguo Wang Xuewu Liu Department of Neurology Qilu Hospital of Shandong UniversityJinanShandong 250000China Department of Neurology Institute of EpilepsyShandong UniversityJinanShandong 250000China Department of Neurology The First Affiliated Hospital of Shandong First Medical UniversityJinanShandong 250000China Department of Neurology Affiliated Hospital of Jining Medical CollegeJiningShandong 272000China Department of Neurology Tengzhou Central People’s HospitalJiningShandong 277599China Department of Neurology Affiliated Hospital of Weifang Medical CollegeWeifangShandong 261000China Department of Neurology Zhucheng People’s HospitalWeifangShandong 262200China Department of Neurology Liaocheng People’s HospitalLiaochengShandong 252000China Department of Neurology Affiliated Hospital of Qingdao UniversityQingdaoShandong 266000China Department of Neurology Linyi People’s HospitalLinyiShandong 276000China Department of Neurology Dezhou People’s HospitalDezhouShandong 253000China Department of Neurology Second Hospital of Shandong UniversityJinanShandong 250000China Department of Neurology Jinan Central HospitalJinanShandong 250000China.

Background:Given that seizures may be triggered by vaccination,this study aimed to evaluate the risk and correlative factors of seizures in patients with epilepsy(PWE)after being vaccinated against coronavirus disease 2019(COVID-19).Methods:This study retrospectively enrolled PWE who were vaccinated against COVID-19 in the epilepsy centers of 11 hospitals in *** divided the PWE into two groups as follows:(1)patients who developed seizures within 14 days of vaccination were assigned to the SAV(with seizures after vaccination)group;(2)patients who were seizure-free within 14 days of vaccination were assigned to the SFAV(seizure-free after vaccination)*** identify potential risk factors for seizure reccurence,the binary logistic regression analysis was ***,67 PWE who had not been vaccinated were also included for elucidating the effects of vaccination on seizures recurrence,and binary logistic regression analysis was performed to determine whether vaccination would affect the recurrence rate of PWE who had drug reduction or ***:The study included a total of 407 patients;of which,48(11.8%)developed seizures within 14 days after vaccination(SAV group),whereas 359(88.2%)remained seizure-free(SFAV group).The binary logistic regression analysis revealed that duration of seizure freedom(P<0.001)and withdrawal from anti-seizure medications(ASMs)or reduction in their dosage during the peri-vaccination period were significantly associated with the recurrence of seizures(odds ratio=7.384,95%confidence interval=1.732–31.488,P=0.007).In addition,32 of 33 patients(97.0%)who were seizure-free for more than three months before vaccination and had a normal electroencephalogram before vaccination did not have any seizures within 14 days of vaccination.A total of 92(22.6%)patients experienced non-epileptic adverse reactions after *** logistic regression analysis results showed that vaccine did not significantly affect the recurrence

关键词： Coronavirus disease 2019 Electroencephalogram Seizure Vaccine

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中试提取槐米中芦丁

齐鲁药事 2004年第7期23卷 52-53页

作者：乔瑾张兆勇王克东鲁南制药股份有限公司临沂276005

目的　中试提取槐米中芦丁。方法　利用超声波振动结合碱溶酸沉法中试提取芦丁。结果　芦丁提取率为89 3%,含量 93 8%。

关键词：芦丁超声波中试

Longer duration of initial invasive mechanical ventilation is still a crucial risk factor for moderate‑to‑severe bronchopulmonary dysplasia in very preterm infants:a multicentrer prospective study

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World Journal of Pediatrics 2023年第6期19卷 577-585页

作者： Cong Dou Yong-Hui Yu Qing-Cui Zhuo Jian-Hong Qi Lei Huang Yan-Jie Ding De-Juan Yang Li Li Dan Li Xiao-Kang Wang Yan Wang Xin qiao Xiang Zhang Bing-Jin Zhang Hai-Yan Jiang Zhong-Liang Li Simmy Reddy Department of Neonatology Maternal and Child Health Care Hospital of Shandong ProvinceShandong UniversityJinan 250014China Department of Neonatology Shandong Provincial Hospital affiliated to Shandong First Medical UniversityHuaiYin DistrictNo.324Jingwu RoadJinan 250021China Department of Neonatology Shandong Provincial HospitalShandong UniversityHuaiYin DistrictNo.324Jingwu RoadJinan 250021China Department of Neonatology Qilu Hospital of Shandong UniversityJinan 250012China Department of Neonatology Shandong Provincial Maternal and Child Health Care HospitalJinan 250014China Department of Neonatology Yantai Yuhuangding HospitalYantai 264000China Department of Neonatology The First Affiliated Hospital of Shandong First Medical UniversityJinan 250014China Department of Neonatology Linyi People’s HospitalLinyi 276000China Department of Neonatology Liaocheng People’s HospitalLiaocheng 252000China Department of Neonatology The Affiliated Taian City Central Hospital of Qingdao UniversityTaian 271000China Department of Neonatology Jinan Maternity and Child Healthcare HospitalJinan 250001China Department of Neonatology Hebei Petro China Central HospitalLangfang 065000China Department of Neonatology Shengli Olifield Central HospitalDongying 257000China Department of Neonatology The Third Hospital of Baogang GroupBaotou 014000China Department of Neonatology W.F.Maternal and Child Health HospitalWeifang 261011China Cheeloo College of Medicine Shandong UniversityJinan 250000China

Objectives We aimed to evaluate the risk factors for moderate-to-severe bronchopulmonary dysplasia(BPD)and focus on discussing its relationship with the duration of initial invasive mechanical ventilation(IMV)in very preterm neonates less than 32 weeks of gestational age(GA).Methods We performed a prospective cohort study involving infants born at 23–31 weeks of GA who were admitted to 47 different neonatal intensive care unit(NICU)hospitals in China from January 2018 to December *** data were obtained from the Sina-northern Neonatal Network(SNN)*** We identified 6538 very preterm infants,of whom 49.5%(3236/6538)received initial IMV support,and 12.6%(823/6538)were diagnosed with moderate-to-severe BPD *** median duration of initial IMV in the moderateto-severe BPD group was 26(17–41)days,while in the no or mild BPD group,it was 6(3–10)*** incidence rate of moderate-to-severe BPD and the median duration of initial IMV were quite different across different *** logistic regression analysis showed that the onset of moderate-to-severe BPD was significantly associated with the duration of initial IMV[adjusted odds ratio(AOR):1.97;95%confidence interval(CI):1.10–2.67],late-onset neonatal sepsis(LONS),and patent ductus arteriosus(PDA).Conclusion In this multicenter cohort study,the duration of initial IMV was still relatively long in very premature infants,and the longer duration of initial IMV accounts for the increased risk of moderate-to-severe BPD.

关键词： Bronchopulmonary dysplasia Invasive mechanical ventilation Multicenter cohort-Preterm infants Prospective

Behavioral problems and related factors in children of different aged patients with schizophrenia: A cross-sectional study

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Neural Regeneration Research 2007年第11期2卷 683-687页

作者： Huimin Qiu Guifang Zhao Yangu Wang Mingyou Chen Jintong Liu Jisheng Tang Aijun Cui Yuying Zheng Chengyou Zhu Ping Li Shansong Wang Chengyong Sun Xueyun qiao Wei Zhang Shengang Song Qingrong Li Department of Psychology Shandong Provincial Mental Health Center Ji＇nan 250014 Shandong Province China Department of Psychology Yinan County Psychiatric Hospital Yi＇nan County 276300 Shandong Province China Department of Psychology the Third People＇s Hospital of Heze Heze 274000 Shandong Province China Department of Psychology the Second People＇s Hospital of Dezhou Dezhou 253000 Shandong Province China Department of Psychology Rongjun Hospital of Linyi Linyi 276000 Shandong Province China Department of Psychology the Second People＇s Hospital of Wendeng Wendeng 264400 Shandong Province China Department of Psychology Shengli Youtian Hospital Dongying 257000 Shandong Province China Department of Psychology Rongjun Hospital of Laizhou Laizhou 216400 Shandong Province China Department of Psychology the Second People＇s Hospital of Zaozhuang Zaozhuang 277100 Shandong Province China Department of Psychology Military Retirement Hospital of Binzhou Binzhou 256600 Shandong Province China Department of Psychology the Fifth People＇s Hospital of Zibo Zibo 255000 Shandong Province China

BACKGROUND： With the age growing, changes of behavioral problems in children whose parents had schizophrenia, differences of related factors and ways for particular intervention should be further studied. OBJECTIVE： To survey the behavioral problems in children of different aged patients with chizophrenia and investigate the correlation between behavioral problems and related factors in different aged groups. DESIGN： Cross-sectional study. SETTING： Shandong Mental Health Center. PARTICIPANTS： A total of 364 patients with schizophrenia were selected from eleven psychiatric hospitals from June 1999 to June 2000. There were 179 males and 185 females, and their ages ranged from 28 to 45 years. All patients met modified diagnostic criteria of schizophrenia （the second edition）, China Classification of Mental Diseases and Diagnostic Criteria. Meanwhile, children of the 364 patients were grouped based on their ages, including 6 - 1 l years old group [n -217; 114 males and 103 females; mean age of （9±2） years] and 12 - 16 years old group [n = 147; 99 males and 48 females; mean age of （14±1） years]. The Chinese norms of Achenbach＇s Child Behavior Check List were regarded as the normal control group. METHODS： Children who received self-made mental health related factors inventory and Achenbach＇s Child Behavior Check List were involved in this study. All children and their parents provided the confirmed consent. Achenbach＇s Child Behavior Check List was used for parents to mainly evaluate children, and the results manifested various behavioral problems based on different sexes and different ages. Self-made mental health related factors inventory contained questionnaires for parents and children, respectively. In this study, home situation of parents as well as personality characteristics and educational styles of children were mainly evaluated. MAIN OUTCOME MEASURES： ① Scores of Achenbach＇s Child Behavior Check List in different aged children; ② Scores of self-made

关键词： schizophrenia paternity children's behaviors

特高压直流换流站中分层接入方式下特高压交流母线过电压

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高电压技术 2016年第12期42卷 3909-3916页

作者：董鹏黄少锋李振强乔小敏华北电力大学电气与电子工程学院北京102206 中国电力科学研究院北京100192 北京航天时代光电科技有限公司北京100085

针对±800 k V特高压直流系统首次采用逆变侧分层接入到1 000 k V特高压交流系统的需求,为了确定换流站中1 000 k V交流母线的过电压水平,分别在两种分层接入方案的多种严重工况下,对1 000 k V交流母线的工频暂时过电压和操作过电压水... 详细信息

针对±800 k V特高压直流系统首次采用逆变侧分层接入到1 000 k V特高压交流系统的需求,为了确定换流站中1 000 k V交流母线的过电压水平,分别在两种分层接入方案的多种严重工况下,对1 000 k V交流母线的工频暂时过电压和操作过电压水平进行了仿真计算。分析了最高过电压产生的原因,给出了最高过电压产生的工况以及过电压水平。方案1中泰州站相对地过电压标幺值最高为1.54,相间过电压标幺值最高为2.71;方案2中临沂站相对地过电压标幺值最高为1.57,相间过电压标幺值最高为2.97。提出了采用额定电压低的避雷器降低换流母线操作过电压的措施,为特高压换流站1 000 k V交流侧空气间隙距离的选取和绝缘配合提供依据。

关键词：特高压直流特高压交流换流站分层接入电磁暂态过电压

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科学发展观的人学意蕴

临沂师范学院学报 2007年第2期29卷 13-16页

作者：乔翔解放军外国语学院河南洛阳471003

科学发展观蕴含着丰富的人学内涵。科学发展观是促进人的全面发展的基本途径和保证,它把人的全面发展与社会经济、文化等方面的发展以及实现最广大人民的根本利益紧密结合起来,确立了以人为本的价值观,充分体现了科学发展观的人学意蕴。

关键词：科学发展观人学以人为本

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促进城乡一体化的公共财政体制对策探讨

临沂师范学院学报 2008年第5期30卷 94-97页

作者：乔栋临沂师范学院商学院山东临沂276000

探索建立促进城乡一体化发展的公共财政体制,是加快构建强化农业基础长效机制的重要任务之一。近年来,我国财政加大了对三农的投入力度,取得了可喜的成就,然而也存在一些问题,如农民隐性税费负担沉重、财政对三农的投入力度不足、农村... 详细信息

探索建立促进城乡一体化发展的公共财政体制,是加快构建强化农业基础长效机制的重要任务之一。近年来,我国财政加大了对三农的投入力度,取得了可喜的成就,然而也存在一些问题,如农民隐性税费负担沉重、财政对三农的投入力度不足、农村公共物品提供的资金投入保障体制尚未建立等。在此基础上,提出了建立适度倾斜于农村的税收制度、建立农村公共物品提供的资金投入保障体制、加大财政用于农业支出的投入规模、理顺财政管理体制、发挥公共财政的杠杆作用等对策。

关键词：公共财政城乡一体化支农三农农民负担